「bi」の検索結果

Detects allele-specific transcription factor or histone modification binding from heterozygous-variant ChIP-seq using WASP (reference-bias filter; mandatory upstream), RASQUAL (joint QTL + bias-corrected testing), BaalChIP (Bayesian beta-binomial with copy-number-aware overdispersion), and AlleleSeq (personalized diploid genome). Handles imprinted-locus awareness, X-inactivation artifacts, cancer copy-number imbalance, and integration with downstream caQTL / bQTL mapping. Use when identifying variants with allelic effects on TF binding, fine-mapping causal regulatory variants, validating deep-learning variant predictions, or characterizing cis-acting regulatory effects.

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Identifies differentially bound ChIP-seq regions between conditions using DiffBind, csaw (sliding windows), DESeq2/edgeR/PyDESeq2 on count matrices, NormR (control-aware), or MAnorm2. Distinguishes three distinct normalization problems (composition bias, trended bias, global shifts) and matches each to its appropriate fix including spike-in scaling. Use when comparing ChIP-seq binding between experimental conditions, choosing normalization for global vs local changes, integrating spike-in data, or reconciling DiffBind/DESeq2 disagreement.

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Infer cis-regulatory connections (peak-to-peak co-accessibility) from scATAC-seq using Cicero, ArchR getCoAccessibility, or SCENIC+. Use when linking enhancer accessibility to promoter accessibility, identifying enhancer-gene pairs from chromatin alone (without paired RNA), running gene-regulatory inference combining ATAC + RNA, or comparing predicted regulatory contacts against Hi-C/Micro-C ground truth.

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When the user requests to add academic papers to a BibTeX bibliography file while maintaining format consistency and sourcing from appropriate repositories. This skill handles 1) Reading existing BibTeX files to understand formatting conventions, 2) Searching for academic papers across multiple sources (OpenReview for conference papers, arXiv for preprints), 3) Extracting proper BibTeX metadata from conference pages or arXiv entries, 4) Determining appropriate citation format (@article vs @inproceedings) based on publication venue, 5) Appending new entries while preserving existing file structure and formatting. Triggers include requests to 'add to ref.bib', 'update bibliography', 'cite papers', or when working with academic reference files.

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This skill detects and analyzes arbitrage opportunities across cryptocurrency exchanges and DeFi protocols. It aggregates prices from multiple sources Detect profitable arbitrage opportunities across CEX, DEX, and cross-chain markets in real-time. Use when scanning for price spreads, finding arbitrage paths, comparing exchange prices, or analyzing triangular arbitrage opportunities. Trigger with phrases like "find arbitrage", "scan for arb", "price spread", "exchange arbitrage", "triangular arb", "DEX price difference", or "cross-exchange opportunity".

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Gateway to 400+ bioinformatics skills from bioSkills and ClawBio. Covers genomics, transcriptomics, single-cell, variant calling, pharmacogenomics, metagenomics, structural biology, and more. Fetches domain-specific reference material on demand.

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Tests and exploits deep link (URL scheme and App Link) vulnerabilities in Android and iOS mobile applications to identify unauthorized access, data injection, intent hijacking, and redirect manipulation. Use when assessing mobile app attack surface through custom URI schemes, Android App Links, iOS Universal Links, or intent-based navigation. Activates for requests involving deep link security testing, URL scheme exploitation, mobile intent abuse, or link hijacking.

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リポジトリから外部経由で悪用できる脆弱性を探し、入力から危険な処理までの経路、再現手順、影響を確認して報奨金制度向けの報告を支援するスキル。

• 外部リクエストで届く脆弱性の調査
• 静的解析の結果を精査したいとき
• 最小限の再現手順と影響の整理

JavaのQuarkusサービスを設計・レビューするスキル。REST API、Panacheでのデータアクセス、Camelでのメッセージ連携や非同期処理の実装パターンを示します。

• REST APIの責務を分けたいとき
• CamelとRabbitMQの連携
• Panacheの保存処理を見直したいとき

Use when the user wants to customize keyboard shortcuts, rebind keys, add chord bindings, or modify ~/.claude/keybindings.json. Examples: "rebind ctrl+s", "add a chord shortcut", "change the submit key", "customize keybindings".

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Resolves free-text scientific labels to ontology term IDs and validates existing CURIEs against the EBI Ontology Lookup Service (OLS4). Also looks up prefixes in Bioregistry, resolves compact identifiers via Identifiers.org, maps lab shorthand with ZOOMA, and builds Ontobee term pages. Use whenever an ontology identifier must be produced or checked - annotating tissue, cell type, disease, phenotype, assay, chemical, organism, sex, or developmental stage fields; preparing metadata for GEO, ENA, BioSamples, CELLxGENE, HCA, or ISA-Tab submission; auditing a metadata table of term IDs; checking whether a term is obsolete and what replaced it; or deciding HPO vs HP. Triggers include "ontology term", "ontology ID", "CURIE", "controlled vocabulary", "UBERON", "CL:", "MONDO", "HPO", "EFO", "ChEBI", "NCBITaxon", "GO term", "PATO", "Zooma", "Bioregistry", "Identifiers.org", "Ontobee", "annotate this tissue/cell type/disease", and any request to emit or verify an identifier shaped like PREFIX:0001234.

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Organizes, queries, validates, and converts Brain Imaging Data Structure (BIDS) datasets. Supports organizing neuroscience and biomedical data (MRI, EEG, MEG, iEEG, PET, microscopy, NIRS, motion capture, EMG, MR spectroscopy, behavioral), querying BIDS layouts, validating compliance, converting DICOM to BIDS, writing metadata sidecars, or creating BIDS derivatives.

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Detects and analyzes malicious behavior in mobile applications through behavioral analysis, permission abuse detection, network traffic monitoring, and dynamic instrumentation. Use when analyzing suspicious mobile applications for data exfiltration, command-and-control communication, credential stealing, SMS interception, or other malware indicators. Activates for requests involving mobile malware analysis, app behavior monitoring, trojan detection, or suspicious app investigation.

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Generates guidance for reliability, resilience, availability, redundancy, fault-tolerance, and disaster recovery (DR) for Google Cloud workloads based on the design principles and recommendations in the Google Cloud Well-Architected Framework. Use when the user asks to evaluate, design, or improve the reliability, resilience, availability, or disaster recovery capabilities of Google Cloud workloads.

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Provides data-retrieval best practices, tool selection guidance, and performant SQL query syntax for BigQuery telemetry across INFORMATION_SCHEMA, Cloud Monitoring, and the REST API. Use when the telemetry to fetch is already known, selecting telemetry tools, writing performant INFORMATION_SCHEMA queries, retrieving telemetry for diagnosing single-job performance bottlenecks, investigating slot contention, job concurrency and queue latency, analyzing reservation capacity, utilization and autoscaling saturation, or auditing capacity-based and on-demand compute and storage resource billable usage. Don't use for root-cause diagnosis or symptom troubleshooting when the cause is unknown (use bigquery-troubleshooting first), or for writing or optimizing business logic SQL (use bigquery-optimization).

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Leverages BigQuery's built-in machine learning and GenAI capabilities for advanced data analytics. Use when you need to write SQL queries that perform time-series forecasting, predict values, detect outliers or anomalies, find key drivers, perform semantic search or vector search, classify text, calculate similarity, summarize content, translate language, evaluate models, filter by semantic conditions, measure the causal effect of an intervention, compute correlations between columns, detect change points or structural breaks, extract trend or seasonality components, or leverage generative AI capabilities in BigQuery. Do not use for general BigQuery dataset, table, or job management requests.

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Comprehensive Linux privilege escalation methodology for offensive security engagements. Covers the full attack surface from a low-privilege shell to root: SUID/SGID binary abuse via GTFOBins, Linux capabilities exploitation (cap_setuid, cap_dac_override, cap_dac_read_search), sudo misconfigurations including NOPASSWD rules and Baron Samedit (CVE-2021-3156), cron job abuse through writable scripts, PATH hijacking, and wildcard injection with tar/rsync/chown. Includes writable /etc/passwd attacks, NFS no_root_squash exploitation, kernel exploits (DirtyPipe CVE-2022-0847, DirtyCow CVE-2016-5195, PwnKit CVE-2021-4034), Docker group container escapes, LD_PRELOAD and LD_LIBRARY_PATH hijacking for shared library injection, systemd service misconfigurations, and sensitive file enumeration for credential harvesting. Integrates automated enumeration with LinPEAS, linux-exploit-suggester, pspy for process monitoring, and GTFOBins for binary exploitation. Each technique includes detection signatures and defender-side visibility to support purple team operations. Maps to MITRE ATT&CK T1548 (Abuse Elevation Control Mechanism) and related sub-techniques. Designed for authorized penetration testing, red team engagements, and CTF competitions where you hold a low-privilege shell and need to escalate to root.

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Generate MSBuild binary logs (binlogs) for build diagnostics and analysis. USE FOR: adding /bl:{} to any dotnet build, test, pack, publish, or restore command to capture a full build execution trace, prerequisite for binlog-failure-analysis and build-perf-diagnostics skills, enabling post-build investigation of errors or performance. Requires MSBuild 17.8+ / .NET 8 SDK+ for {} placeholder; PowerShell must quote the complete switch as '-bl:{}'. DO NOT USE FOR: non-MSBuild build systems (npm, Maven, CMake), analyzing an existing binlog (use binlog-failure-analysis instead).

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Universal LaTeX document skill: create, compile, and convert any document to professional PDF with PNG previews. Supports resumes, reports, cover letters, invoices, academic papers, theses/dissertations, academic CVs, presentations (Beamer), scientific posters, formal letters, exams/quizzes, books, cheat sheets, reference cards, exam formula sheets, fillable PDF forms (hyperref form fields), conditional content (etoolbox toggles), mail merge from CSV/JSON (Jinja2 templates), version diffing (latexdiff), charts (pgfplots + matplotlib), tables (booktabs + CSV import), images (TikZ), Mermaid diagrams, AI-generated images, watermarks, landscape pages, bibliography/citations (BibTeX/biblatex), multi-language/CJK (auto XeLaTeX), algorithms/pseudocode, colored boxes (tcolorbox), SI units (siunitx), Pandoc format conversion (Markdown/DOCX/HTML ↔ LaTeX), and PDF-to-LaTeX conversion of handwritten or printed documents (math, business, legal, general). Compile script supports pdflatex, xelatex, lualatex with auto-detection, latexmk backend, texfot log filtering, PDF/A output, and verbosity control (--verbose/--quiet). Empirically optimized scaling: single agent 1-10 pages, split 11-20, batch-7 pipeline 21+. Use when user asks to: (1) create a resume/CV/cover letter, (2) write a LaTeX document, (3) create PDF with tables/charts/images, (4) compile a .tex file, (5) make a report/invoice/presentation, (6) anything involving LaTeX or pdflatex, (7) convert/OCR a PDF to LaTeX, (8) convert handwritten notes, (9) create charts/graphs/diagrams, (10) create slides, (11) write a thesis or dissertation, (12) create an academic CV, (13) create a poster, (14) create an exam/quiz, (15) create a book, (16) convert between document formats (Markdown, DOCX, HTML to/from LaTeX), (17) generate Mermaid diagrams for LaTeX, (18) create a formal business letter, (19) create a cheat sheet or reference card, (20) create an exam formula sheet or crib sheet, (21) condense lecture notes/PDFs into a cheat sheet, (22) create a fillable PDF form with text fields/checkboxes/dropdowns, (23) create a document with conditional content/toggles (show/hide sections), (24) generate batch/mail-merge documents from CSV/JSON data, (25) create a version diff PDF (latexdiff) highlighting changes between documents, (26) create a homework or assignment submission with problems and solutions, (27) create a lab report with data tables, graphs, and error analysis, (28) encrypt or password-protect a PDF, (29) merge multiple PDFs into one, (30) optimize/compress a PDF for web or email, (31) lint or check a LaTeX document for common issues, (32) count words in a LaTeX document, (33) analyze document statistics (figures, tables, citations), (34) fetch BibTeX from a DOI, (35) convert a Graphviz .dot file to PDF/PNG, (36) convert a PlantUML .puml file to PDF/PNG, (37) create a one-pager/fact sheet/executive summary, (38) create a datasheet or product specification sheet, (39) extract pages from a PDF (page ranges, odd/even), (40) check LaTeX package availability before compiling, (41) analyze citations and cross-reference with .bib files, (42) debug LaTeX compilation errors, (43) make a document accessible (PDF/A, tagged PDF), (44) create lecture notes or course handouts, (45) fill an existing PDF form (fillable fields or non-fillable with annotations), (46) extract text or tables from a PDF (pdfplumber, pypdf), (47) OCR a scanned PDF to text (pytesseract), (48) create a PDF programmatically with reportlab (Canvas, Platypus), (49) rotate or crop PDF pages (pypdf), (50) add a watermark to an existing PDF, (51) extract metadata from a PDF (title, author, subject).

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[omh] Tailoring enabled OMH families: turning one OMH capability family on or off so an install can be tailored instead of taken whole. Use when the user says: capability-toggle, capability policy, disable memory, enable memory, disable coding orchestration, disable a capability family, enable a capability family, 메모리 기능 꺼줘.

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Assess and improve the reliability posture of PaaS Applications (Azure Functions and Azure App Service). Scans deployed resources for zone redundancy, ZRS storage, health probes, and multi-region failover. Presents a feature-pivoted checklist, then drives staged remediation (CLI or IaC patches) end-to-end with user confirmation. WHEN: "assess reliability", "check reliability", "zone redundant", "multi-region failover", "high availability", "disaster recovery", "single points of failure", "reliability posture", "resiliency".

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Generates complete dual-disease shared-transcriptome biomarker and hub-gene research designs from a user-provided disease pair and shared-biology direction. Always use this skill whenever a user wants to design, plan, or build a non-oncology two-disease transcriptome study centered on per-disease differential expression, shared-signal intersection or concordance, PPI-based hub-gene prioritization, diagnostic evaluation across both diseases, immune infiltration context, pathway interpretation, and optional orthogonal validation. Covers five study patterns (shared-DEG-first workflow, hub-gene-first shared-biomarker workflow, hybrid shared-biomarker compression workflow, immune-context shared-biomarker workflow, orthogonal validation workflow) and always outputs four workload configs (Lite / Standard / Advanced / Publication+) with recommended primary plan, step-by-step workflow, figure plan, validation strategy, minimal executable version, publication upgrade path...

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Generates complete comorbidity-oriented shared-biomarker bioinformatics research designs from a user-provided disease pair and validation direction. Use when a study links two clinically related diseases through shared DEGs, enrichment, PPI hub genes, machine-learning feature selection, public diagnostic validation, gene-regulatory networks, immune infiltration, and optional downstream follow-up. Covers five study patterns (shared-DEG discovery, hub-gene prioritization, machine-learning biomarker selection, immune/regulatory interpretation, multi-layer validation) and always outputs Lite / Standard / Advanced / Publication+ with a recommended primary plan, stepwise workflow, figure plan, validation hierarchy, minimal executable version, publication upgrade path, and strictly verified literature retrieval.

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Scans the biomarker landscape of a disease area by biomarker type, clinical/research use case, evidence layer, validation status, and maturity level. Use this skill when a user wants a field-level biomarker evidence map rather than a generic literature summary. Always separate exploratory biomarkers from externally validated or clinically embedded biomarkers, and never imply clinical maturity without explicit evidence support.

日本語の概要は準備中です。原文の説明を表示しています。