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MHC (major histocompatibility complex) molecules are cell surface complexes that present antigens to T cells. The repertoire of antigens presented in a given genetic background largely depends on the sequence of the encoded MHC molecules, and thus, in humans, on the highly variable HLA (human leukocyte antigen) genes of the hyperpolymorphic HLA locus. More than 28,000 different HLA alleles have been reported, with significant differences in allele frequencies between human populations worldwide

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This package is a implementation of biclustering ensemble method MoSBi (Molecular signature Identification from Biclustering). MoSBi provides standardized interfaces for biclustering results and can combine their results with a multi-algorithm ensemble approach to compute robust ensemble biclusters on molecular omics data. This is done by computing similarity networks of biclusters and filtering for overlaps using a custom error model. After that, the louvain modularity it used to extract biclus

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Provides delayed computation of a matrix of residuals after fitting a linear model to each column of an input matrix. Also supports partial computation of residuals where selected factors are to be preserved in the output matrix. Implements

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This package takes a list of p-values resulting from the simultaneous testing of many hypotheses and estimates their q-values and local FDR values. The q-value of a test measures the proportion of false positives incurred (called the false

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Cyber threat intelligence production — the intelligence cycle, IOC extraction/normalization/enrichment, STIX/TAXII and MISP, structured analytic models (Diamond, Kill Chain, ATT&CK), source scoring, actor/campaign tracking, and finished intelligence reporting

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健身私教 — 为客户设计、指导和推进个性化训练方案的专业工艺, 有别于团课教练、物理治疗师或运动队教练: (a) 训练方案设计与周期化 (线性 / 波动 / 板块周期化 Bompa & Haff; NSCA《力量训练与体能训练精要》行业圣经; Schoenfeld 肌肥大机制; Helms/Valdez/Morgan 肌肉与力量金字塔; 共轭训练法 Simmons/Westside; Starting Strength 线性渐进 Rippetoe; Renaissance Periodization 训练量地标 Israetel); (b) 动作评估与筛查 (FMS 功能性动作筛查 Gray Cook; NASM CEx 纠正性训练连续体 抑制-拉伸-激活-整合; 关节逐级方法 Cook/Boyle; 姿势与代偿模式识别; PAR-Q+ 与 ACSM 运动前筛查指南); (c) 教学与指令 (外部 vs 内部注意焦点 Wulf; 差异化学习 Schöllhorn; 约束导向方法 Davids/Renshaw; RIR/RPE 自动调节 Zourdos/Helms; 动机访谈在健身中的应用 Rollnick/Miller); (d) 营养指导的执业边界 (宏量营养素周期化; Precision Nutrition / ISSN 立场声明的循证建议; 边界: 私教提供一般性指导, 医学营养治疗需 RD/RDN 资质; 能量可用性与 RED-S Mountjoy IOC 共识); (e) 商业与客户管理 (客户留存与方案依从; 咨询与销售伦理; 线上教练平台与规模化 Goodman PTDC; 方案交付工具 TrueCoach/Trainerize/TrainHeroic; 课时定价模型; 独立教练 vs 健身房雇员); (f) 专项方向 (运动表现 CSCS; 纠正性训练 CES; 老年健身 SFN; 产前产后; 青少年 YSCA; 适应性 / 无障碍健身; 健美 / 形体; 力量举; 耐力运动 S&C)。诚实处理: 兄弟科学 vs 循证之争, 补剂行业利益冲突, 合成代谢激素使用现状 (诚实但不推广: 匿名调查约 30% 有经验男性健身者使用过 — 业内估, Kanayama/Pope/Hudson 记录健康风险, WADA 禁用清单用于竞技语境), 体型焦虑与进食障碍风险 (男性私教肌肉变形症, 正食症倾向, NEDA 负责任语言指南), 健身房掠夺性销售 (高压推销、误导性对比照、长约锁定), 执业边界违规 (私教诊断伤病或超范围开饮食处方), 线上教练认证造假 (周末速成、未经认可的认证)。不含: 物理治疗 / 康复治疗 (持照医疗职业), 不含: 团课教练 (Les Mills/Zumba/CrossFit 分馆教练 — 相邻但不同), 不含: 精英竞技运动教练 (团队项目周期化, 不同职业路径), 不含: 营养作为主业 (临床营养学需单独资质)。 (Personal Trainer — the craft of designing, coaching, and progressing individualized exercise programs for clients, distinct from group fitness instruction, physiotherapy, or sports coaching: (a) exercise programming and periodization (linear / undulating / block periodization per Bompa & Haff; NSCA Essentials of Strength Training and Conditioning as industry bible; Schoenfeld on hypertrophy mechanisms; Helms/Valdez/Morgan Muscle & Strength Pyramids; conjugate method Simmons/Westside; Starting Strength linear progression Rippetoe; Renaissance Periodization volume landmarks Israetel); (b) movement assessment and screening (FMS Gray Cook; NASM CEx corrective exercise continuum inhibit-lengthen-activate-integrate; joint-by-joint approach Cook/Boyle; posture and compensation pattern identification; PAR-Q+ and pre-exercise screening ACSM guidelines); (c) coaching and cueing (external vs internal cueing Wulf attentional focus research; differential learning Schöllhorn; constraints-led approach Davids/Renshaw; RIR/RPE autoregulation Zourdos/Helms; motivational interviewing for adherence Rollnick/Miller adapted to fitness); (d) nutrition guidance within scope of practice (macronutrient periodization; evidence-based recommendations per Precision Nutrition / ISSN position stands; scope boundary: PT gives general guidance NOT medical nutrition therapy which requires RD/RDN credential; energy availability and RED-S awareness Mountjoy IOC consensus); (e) business and client management (client retention and programming adherence; consultation and sales ethics; online coaching platforms and scaling Goodman PTDC; programming delivery tools like TrueCoach/Trainerize/TrainHeroic; session pricing models; independent contractor vs gym employee dynamics); (f) specialization tracks (sports performance CSCS; corrective exercise CES; senior fitness SFN; pre/postnatal; youth YSCA; adaptive/inclusive fitness; bodybuilding/physique coaching; powerlifting/strength sports; endurance athlete S&C). Evidence-based practice as the core ethos: Schoenfeld/Krieger meta-analyses on volume-response, Helms systematic reviews on protein/resistance training, Brad Schoenfeld's MASS journal bridging research to practice, Menno Henselmans and Eric Helms as practitioner-researchers, Greg Nuckols Stronger By Science as translation layer. Chinese fitness industry context: rapid growth of personal training in commercial gyms (Keep/Lefit/Megafit chains), NSCA-CPT and ACE-CPT as dominant certifications alongside local CSFA (China Sport and Fitness Association) credential, '体适能' (physical fitness) as formal term, online coaching boom post-COVID, PT business models in tier 1-3 cities diverge sharply. Honest treatment of: bro science vs evidence-based d

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Biochemical metabolism of macronutrients and key micronutrients — digestion, absorption, transport, utilization, and excretion — with emphasis on the pathways that matter for dietary-guideline debates (insulin response, lipoprotein metabolism, one-carbon metabolism, iron homeostasis). Use when a question asks what happens biochemically to a food after it is eaten, or when a claim about "metabolic effect" needs to be tested against mechanism.

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Use when you need to check whether an organisation/domain has been claimed by a ransomware group, profile a specific ransomware group (TTPs, leak-site infra, IOCs, YARA), or aggregate ransomware victim claims by country/sector/timeframe. Backed by ransomware.live's leak-site scrapes — 27k+ victims across 330+ groups. Commonly invoked by /domain-investigation, /ransomware-ecosystem, /threat-actor-profiling, and detection-engineering workflows. Reads $RANSOMWARE_LIVE.

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Use when you need Liberty91 platform intelligence — what actually happened (deduplicated Threat Events with every source, Admiralty reliability/credibility and verification stage), whether an IOC is already known to your account, the canonical threat library (actors, malware, vulnerabilities, clusters, ATT&CK TTPs), alert matches, or which of your customer organizations an occurrence affects — or when you need to push intelligence back: ingesting your own report, generating an intelligence package, or uploading an organization document. Also supplies event provenance fields, when the platform returns them, and Threat Library alias resolution to /source-provenance and /quality-of-information-check. Two-way, first-party integration. Commonly invoked by /ip-investigation and friends, /ioc-enrichment-workflow, /threat-actor-profiling, /campaign-tracking and /vulnerability-intelligence. Reads $LIBERTY91_API_KEY.

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Use when you need CrowdStrike Falcon Intelligence on an indicator (IOC reputation for an IP, domain, hash, or URL — malicious confidence, linked actors, malware families, reports) OR on an adversary (threat-actor profile, origin/target search, MITRE ATT&CK TTPs, finished intel reports). Answers questions like "look up 1.1.1.1", "what TTPs does Charming Kitten use?", "which threat actors operate from Russia?", and "latest report on Mustang Panda". Commonly invoked by the four /*-investigation skills, /ioc-enrichment-workflow, /threat-actor-profiling, and the regional espionage cells. Other agents/skills can chain this for vendor-authoritative actor and finished-intel context. Requires a Falcon Intelligence subscription.

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Structures a clear, actionable malware analysis report covering summary, sample identity, capabilities, IOCs, ATT&CK mapping, and detection guidance for both technical and decision-making audiences. Activates for requests to write, structure, or review a malware analysis or reverse-engineering report.

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Operationalizes a threat intelligence report into hunts: extracting IOCs and TTPs, mapping behaviors to ATT&CK and available telemetry, prioritizing durable behavioral indicators over volatile atomic ones, and producing concrete hunt queries. Activates for requests to hunt from a threat report, operationalize CTI, or turn an intel report into detections.

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Analyzes malicious and vulnerable Windows kernel drivers (.sys) by parsing the PE for the native subsystem, identifying DriverEntry/IRP dispatch and IOCTL handlers, and flagging BYOVD and kernel-callback abuse. Activates for requests to analyze a Windows driver, examine a .sys sample, or assess a BYOVD/kernel driver threat.

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Use when a task needs the judgment of a Biochemist — determining enzyme kinetics (Km/Vmax, inhibition mechanism) from rate data, choosing a structural-biology method (X-ray crystallography, cryo-EM, or NMR) for a target, designing or interpreting a binding assay (ITC, SPR, fluorescence polarization), or selecting a protein-purification strategy and diagnosing why a prep failed.

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Install bioinformatics tools for ENCODE data analysis. Covers CLI tools (BWA, STAR, samtools, MACS2), R/Bioconductor packages (DESeq2, Seurat, ChIPseeker), Python packages (Scanpy, deeptools), and Nextflow pipeline infrastructure. Generates conda environments, R install scripts, and Python requirements. Use when the user needs to set up a bioinformatics workstation, install tools for a specific assay, create reproducible environments, or troubleshoot dependency issues. Trigger on: install tools, set up environment, conda create, bioinformatics setup, install R packages, install Bioconductor, install pipeline tools.

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AudioCraft: MusicGen text-to-music, AudioGen text-to-sound.

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Expert-level medical device design covering regulatory pathways, design controls, biocompatibility, sterilization, risk management, and verification and validation.

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Expert-level biomaterials covering biocompatibility, metals, ceramics, and polymers for medical implants, surface modification, host response, and regulatory considerations.

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Expert-level biochemistry knowledge. Use when working with proteins, enzymes, metabolism, DNA, RNA, carbohydrates, lipids, cell signaling, or bioenergetics. Also use when the user mentions 'enzyme kinetics', 'metabolism', 'glycolysis', 'Krebs cycle', 'DNA replication', 'protein folding', 'amino acids', 'ATP', 'oxidative phosphorylation', 'gene expression', 'lipid bilayer', or 'signal transduction'.

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Correlates disparate security incidents, IOCs, and adversary behaviors across time and organizations to identify unified threat campaigns, attribute them to common threat actors, and extract shared indicators for improved detection. Use when multiple incidents exhibit overlapping indicators, when sector-wide attack campaigns require cross-organizational analysis, or when building campaign-level intelligence products. Activates for requests involving campaign analysis, incident clustering, cross-organizational IOC correlation, or MISP correlation engine.

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MISP (Malware Information Sharing Platform) is an open-source threat intelligence platform for gathering, sharing, storing, and correlating Indicators of Compromise (IOCs) of targeted attacks, threat

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Build an automated pipeline to defang indicators of compromise (URLs, IPs, domains, emails) for safe sharing and distribute them in STIX format through TAXII feeds and threat intelligence platforms.

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Builds automated threat intelligence feed integration pipelines connecting STIX/TAXII feeds, open-source threat intel, and commercial TI platforms into SIEM and security tools for real-time IOC matching and alerting. Use when SOC teams need to operationalize threat intelligence by automating feed ingestion, normalization, scoring, and distribution to detection systems.

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Analyzes structured and unstructured threat intelligence feeds to extract actionable indicators, adversary tactics, and campaign context. Use when ingesting commercial or open-source CTI feeds, evaluating feed quality, normalizing data into STIX 2.1 format, or enriching existing IOCs with campaign attribution. Activates for requests involving ThreatConnect, Recorded Future, Mandiant Advantage, MISP, AlienVault OTX, or automated feed aggregation pipelines.

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