「nct」の検索結果

Quantum mechanics simulations and analysis using QuTiP (Quantum Toolbox in Python). Use when working with quantum systems including: (1) quantum states (kets, bras, density matrices), (2) quantum operators and gates, (3) time evolution and dynamics (Schrödinger, master equations, Monte Carlo), (4) open quantum systems with dissipation, (5) quantum measurements and entanglement, (6) visualization (Bloch sphere, Wigner functions), (7) steady states and correlation functions, or (8) advanced methods (Floquet theory, HEOM, stochastic solvers). Handles both closed and open quantum systems across various domains including quantum optics, quantum computing, and condensed matter physics.

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Master ES6+ features including async/await, destructuring, spread operators, arrow functions, promises, modules, iterators, generators, and functional programming patterns for writing clean, efficient JavaScript code. Use when refactoring legacy code, implementing modern patterns, or optimizing JavaScript applications.

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Assess and migrate cross-cloud workloads to Azure with reports and code conversion. Supports Lambda→Functions, Beanstalk/Heroku/App Engine→App Service, Fargate/Kubernetes/Cloud Run/Spring Boot→Container Apps. WHEN: migrate Lambda to Functions, AWS to Azure, migrate Beanstalk, migrate Heroku, migrate App Engine, Cloud Run migration, Fargate to ACA, ECS/Kubernetes/GKE/EKS to Container Apps, Spring Boot to Container Apps, cross-cloud migration.

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Assess and upgrade Azure workloads between plans, tiers, or SKUs, or modernize Azure SDK dependencies in source code. WHEN: upgrade Consumption to Flex Consumption, upgrade Azure Functions plan, change hosting plan, function app SKU, migrate App Service to Container Apps, modernize legacy Azure Java SDKs (com.microsoft.azure to com.azure), migrate Azure Cache for Redis (ACR/ACRE) to Azure Managed Redis (AMR).

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Debug Azure production issues on Azure using AppLens, Azure Monitor, resource health, and safe triage. WHEN: debug production issues, troubleshoot app service, app service high CPU, app service deployment failure, troubleshoot container apps, container app 503 or target port mismatch, troubleshoot functions, function telemetry missing or stopped after a config/connection-string change, troubleshoot AKS, VM RDP, Linux SSH, VM black screen, can't connect to VM, reset VM password, NSG or firewall blocking, kubectl cannot connect, kube-system/CoreDNS failures, pod pending, crashloop, node not ready, upgrade failures, analyze logs, KQL, insights, image pull failures, cold start issues, health probe failures, resource health, root cause of errors, troubleshoot event hubs, troubleshoot service bus, messaging SDK error, AMQP connection failure, message lock lost, lock renewal during long-running processing, service bus dead letter.

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Pre-deployment validation for Azure readiness. Run deep checks on configuration, infrastructure (Bicep or Terraform), RBAC role assignments, managed identity permissions, and prerequisites before deploying. WHEN: validate my app, check deployment readiness, run preflight checks, verify configuration, check if ready to deploy, validate azure.yaml, validate Bicep, test before deploying, troubleshoot deployment errors, validate Azure Functions, validate function app, validate serverless deployment, verify RBAC roles, check role assignments, review managed identity permissions, what-if analysis, validate Container Apps deployment.

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Prepare azd-based Azure projects for deployment: generates azure.yaml, infrastructure (Bicep/Terraform), and Dockerfiles for the Azure Developer CLI (azd) workflow. USE ONLY when the user explicitly wants to use azd as the deployment tool, or the project already has an azure.yaml file. DO NOT USE FOR: non-azd deployments, Python App Service code-only deploys (use python-appservice-deploy), or cross-cloud migration (use azure-cloud-migrate). WHEN: prepare app for azd, create azure.yaml, set up azd infrastructure, modernize app for Azure with azd, deploy with azd, function app, timer trigger, service bus trigger, event-driven function, managed identity, generate Bicep, generate Terraform, create and deploy to Azure.

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Capture a user's real writing voice from 5-20 prior samples, store a local voice.yaml fingerprint, and enforce it on newsjack drafts so AI tells disappear. Measures voice with named stylometry lenses (Burrows's Delta function-word vector, MATTR lexical diversity, sentence-length burstiness, Biber Dimension-1 register, opener-POS profile, punctuation rates) and gates drafts against the fingerprint as bands, not vibes.

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Plan tests for an API endpoint or service — functional, negative, and contract. Use when asked to test an API, write API test cases, plan REST/GraphQL endpoint testing, or validate an API contract. Produces an API test plan — per-endpoint cases (status codes, schema, auth, validation, errors), boundary/negative cases, contract checks, and non-functional notes — so the API is verified beyond the happy 200.

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Build a tiered classroom behavior intervention plan (BIP) for a K-12 student, grounded in the function of the behavior. Use when asked to plan a behavior intervention, address a disruptive or off-task pattern, write a BIP, or set up positive behavior supports. Produces a function hypothesis, prevention/antecedent strategies, teaching of a replacement behavior, a response plan for when it happens, and a simple data-tracking method — positive and skill-building, not punitive.

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Convex backend development guidelines. Use when writing Convex functions, schemas, queries, mutations, actions, or any backend code in a Convex project. Triggers on tasks involving Convex database operations, real-time subscriptions, file storage, or serverless functions.

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**UTILITY SKILL** - Explain code snippets, functions, and algorithms in plain language. USE FOR: explain code, what does this code do, break down this function, help me understand this, walk through this algorithm, clarify this logic, explain this snippet, describe what happens here. DO NOT USE FOR: writing new code (use code generation), fixing bugs (use debugging), refactoring (use refactoring skills), code review with action items. INVOKES: file reading tools to access code, language detection for tailored explanations. FOR SINGLE OPERATIONS: If the user just needs to see file contents, use file reading tools directly.

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Detect missing authentication and broken function-level authorization vulnerabilities in a codebase using a three-phase approach: recon (map endpoints and the role/permission system), batched verify (check auth/authz in parallel subagents, 3 endpoints each), and merge (consolidate batch results). Covers unauthenticated access and vertical privilege escalation (e.g., regular user accessing admin-only functions). Requires sast/architecture.md (run sast-analysis first). Outputs findings to sast/missingauth-results.md. Use when asked to find missing auth, broken access control, or privilege escalation bugs.

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Use when optimizing the performance of an existing native scalar expression in the datafusion-comet-spark-expr crate (native/spark-expr/) — casts, string/JSON/array/math kernels that run per-row or per-batch. Covers benchmarking, keeping output bit-identical, and the no-regression gate. Not for adding new expressions (use implement-comet-expression) or wiring upstream functions (use wire-datafusion-function).

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Discovers, classifies, filters, and quantifies full-length transcript isoforms from PacBio Iso-Seq/Kinnex (HiFi) and Oxford Nanopore (cDNA/direct-RNA) long reads, using the isoseq+pigeon pipeline, SQANTI3, and ONT tools (IsoQuant, FLAIR, Bambu, StringTie2). Covers why a novel isoform is an artifact until proven otherwise (RT template-switching, intra-priming, and 5' degradation manufacture junctions and truncations), the SQANTI3 structural categories and their trust order, the Kinnex skera-split step, orthogonal CAGE/poly-A/short-read-junction validation, and why long-read isoform quantification needs EM. Use when building a full-length isoform catalog, classifying/filtering long-read transcripts, running Iso-Seq or ONT cDNA/dRNA analysis, or judging novel-isoform reliability.

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Analyzes base-editing screens for variant function. Covers library design (Hanna 2021 ClinVar-scale CBE screen benchmarked on BRCA1/2, Cuella-Martin 2021 DDR saturation), CBE vs ABE chemistry choice (BE3/BE4 vs ABE7.10/ABE8.20/ABE8e), editing-window math (positions 4-8 from PAM-distal end; 4-7 for ABE7.10), bystander-edit quantification and the variant-call ambiguity it creates, sgRNA-efficiency filtering before hit calling, indel byproduct interpretation, the substitution-vs-indel diagnostic, variant annotation against ClinVar / COSMIC, and the Broad be-validation-pipeline. Use when designing a BE variant screen, choosing CBE vs ABE for a specific edit, interpreting bystander-confounded hits, distinguishing functional signal from indel artifact, integrating CRISPResso2 output with screen scoring, or deciding BE vs PE for SNV installation.

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Detects differential alternative splicing between conditions using rMATS-turbo (binomial LRT on junction counts), leafcutter (Dirichlet-multinomial GLM on intron clusters), MAJIQ V3 deltapsi/HET (Bayesian posterior on LSVs), SUPPA2 (empirical-null on TPM-derived PSI), or Shiba (junction-imbalance-corrected, 2025 SOTA at low coverage). Reports FDR-corrected significance and delta PSI effect sizes. Tools differ in statistical model, annotation dependence, calibration regime, and replicate-count requirements. Use when comparing splicing patterns between treatment groups, tissues, or disease states.

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Analyzes differential transcript usage (DTU) and isoform switches with functional consequence prediction (NMD via 50nt rule, ORF disruption, protein domain loss/gain, signal peptide changes, IDR alterations, coding-potential shifts). Tools include IsoformSwitchAnalyzeR v2 (auto-selects satuRn for >5 reps else DEXSeq), the manual DRIMSeq -> DEXSeq/satuRn -> stageR DTU pipeline, and fishpond/swish for inferential-uncertainty-aware DTE. Distinguishes DTU from DGE and DTE; integrates external annotators (CPC2, Pfam, SignalP, IUPred2A or DeepTMHMM). Use when investigating how splicing differences alter protein function or trigger NMD-mediated degradation.

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Analyzes alternative splicing at single-cell resolution. The first decision is library chemistry — 10X 3' is fundamentally limited (RT primes from poly-A, R2 falls in 3' UTR, <0.1 junction read per cell per AS event). Plate-based full-length methods (Smart-seq3, FLASH-seq, VASA-seq, STORM-seq) and single-cell long-read (MAS-Iso-seq, scISOr-Seq2) are the chemistries that give per-cell isoform structure. Tools include MARVEL (R, Smart-seq integrated), BRIE2 (Bayesian PSI with regulatory features and ELBO_gain test), scQuint (junction-cluster, plate-based; not for 10X), SpliZ (annotation-free Z-score), Psix (graph-smoothness regulated AS), and Sierra (alternative polyadenylation, often confused with AS). Use when analyzing isoform usage in scRNA-seq, identifying cell-type-specific splicing, or determining whether scRNA-seq chemistry supports splicing analysis at all.

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Estimates SNP heritability and partitions it across functional annotations, cell types, and loci from GWAS summary statistics or individual-level genotypes. Implements LDSC, stratified LDSC with the baseline-LD model, Finucane 2018 cell-type prioritization, LDAK SumHer, HDL, HESS local heritability, BOLT-REML, GCTA-GREML, graphREML, and Popcorn cross-population genetic correlation. Use when computing total h2_SNP from summary stats, partitioning heritability across functional categories, prioritizing trait-relevant tissues or cell types from ENCODE/Roadmap chromatin marks, reconciling LDSC vs LDAK enrichment estimates, computing local heritability with HESS, estimating genetic correlation between traits, or producing publication-grade enrichment with calibrated sensitivity to model assumptions.

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Use when doing ANY task involving Supabase. Triggers: Supabase products (Database, Auth, Edge Functions, Realtime, Storage, Vectors, Cron, Queues); client libraries and SSR integrations (supabase-js, @supabase/ssr) in Next.js, React, SvelteKit, Astro, Remix; auth issues (login, logout, sessions, JWT, cookies, getSession, getUser, getClaims, RLS); Supabase CLI or MCP server; schema changes, migrations, declarative schemas, security audits, Postgres extensions (pg_graphql, pg_cron, pg_vector); debugging and troubleshooting errors or unexpected behavior on Supabase projects (HTTP errors, Postgres errors, RLS surprises, permission denied, schema cache issues, timeouts, Edge Function crashes, Realtime drops, Storage failures) and reading or querying logs (Logs Explorer, ClickHouse).

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Optimize MongoDB client connection configuration (pools, timeouts, patterns) for any supported driver language. Use this skill when working/updating/reviewing on functions that instantiate or configure a MongoDB client (eg, when calling `connect()`), configuring connection pools, troubleshooting connection errors (ECONNREFUSED, timeouts, pool exhaustion), optimizing performance issues related to connections. This includes scenarios like building serverless functions with MongoDB, creating API endpoints that use MongoDB, optimizing high-traffic MongoDB applications, creating long-running tasks and concurrency, or debugging connection-related failures.

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Generate or improve MATLAB help text (documentation comments) for a function, class, or script file following MathWorks standards (H1 line, syntax paragraphs, See Also, 75-char lines). Read BEFORE writing MATLAB help — default patterns (Inputs:/Outputs: lists, block comments, uppercase See Also) produce non-conforming output. Use when writing, rewriting, fixing, or reviewing MATLAB help comments or function documentation.

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AWS Step Functions workflow orchestration with state machines. Use when designing workflows, implementing error handling, configuring parallel execution, integrating with AWS services, or debugging executions.

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