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Generates complete two-sample Mendelian randomization research designs from a user-provided outcome, exposure or exposure family, and robustness direction. Use when a study centers on summary-statistics causal inference with instrument selection, harmonization, IVW-primary estimation, complementary estimators, sensitivity analyses, optional multivariable upgrades, and conservative evidence interpretation. Covers five study patterns and always outputs Lite / Standard / Advanced / Publication+ with a recommended primary plan, stepwise workflow, figure plan, validation hierarchy, minimal executable version, publication upgrade path, and strictly verified literature retrieval.

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Plans confounder control, variable adjustment logic, and bias mitigation strategies at the protocol stage for clinical, epidemiologic, translational, observational, and biomarker studies. Always use this skill when a user needs to identify major confounders, decide which variables should or should not be adjusted for, compare matching/stratification/weighting approaches, anticipate selection or measurement bias, or pressure-test a study design before execution. Focus on bias sensing, causal structure awareness, variable-role classification, and critical design review rather than generic statistical advice.

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Generates complete dual-disease shared-transcriptome biomarker and hub-gene research designs from a user-provided disease pair and shared-biology direction. Always use this skill whenever a user wants to design, plan, or build a non-oncology two-disease transcriptome study centered on per-disease differential expression, shared-signal intersection or concordance, PPI-based hub-gene prioritization, diagnostic evaluation across both diseases, immune infiltration context, pathway interpretation, and optional orthogonal validation. Covers five study patterns (shared-DEG-first workflow, hub-gene-first shared-biomarker workflow, hybrid shared-biomarker compression workflow, immune-context shared-biomarker workflow, orthogonal validation workflow) and always outputs four workload configs (Lite / Standard / Advanced / Publication+) with recommended primary plan, step-by-step workflow, figure plan, validation strategy, minimal executable version, publication upgrade path...

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Generates complete comorbidity-oriented shared-biomarker bioinformatics research designs from a user-provided disease pair and validation direction. Use when a study links two clinically related diseases through shared DEGs, enrichment, PPI hub genes, machine-learning feature selection, public diagnostic validation, gene-regulatory networks, immune infiltration, and optional downstream follow-up. Covers five study patterns (shared-DEG discovery, hub-gene prioritization, machine-learning biomarker selection, immune/regulatory interpretation, multi-layer validation) and always outputs Lite / Standard / Advanced / Publication+ with a recommended primary plan, stepwise workflow, figure plan, validation hierarchy, minimal executable version, publication upgrade path, and strictly verified literature retrieval.

日本語の概要は準備中です。原文の説明を表示しています。

Use anki-card-creator for academic writing workflows that need structured execution, explicit assumptions, and clear output boundaries for study-card generation.

日本語の概要は準備中です。原文の説明を表示しています。

Generates complete Mendelian randomization study designs from a user-provided exposure and outcome direction. Always use this skill whenever a user wants to design, plan, or build a Mendelian randomization study — even if phrased as "help me write a paper on X", "design an MR study for Y", or "I want to test whether A causally affects B using GWAS". Covers core two-sample MR design, optional bidirectional follow-up, optional multivariable MR, IV selection logic, ancestry alignment, harmonization, IVW as the default primary estimator, weighted median / MR-Egger / MR-PRESSO / leave-one-out sensitivity analyses, Steiger directionality, heterogeneity / pleiotropy checks, and explicit claim-boundary control. Always outputs four workload configs (Lite / Standard / Advanced / Publication+) with a recommended primary plan, stepwise workflow, method rationale, validation ladder, figure plan, minimal executable version, and strictly verified literature guidance with no fabricated references.

日本語の概要は準備中です。原文の説明を表示しています。

Generates complete Mendelian Randomization + single-cell transcriptomics (scRNA-seq) research designs from a user-provided direction. Always use this skill whenever a user wants to design, plan, or build a study combining MR and single-cell data — even if phrased as "help me write a paper on X", "design a bioinformatics study for Y", or "I want to study Z using MR and scRNA". Covers five study patterns (mechanism gene-set, key-cell, candidate-gene reverse validation, exposure-disease-cell triangulation, translational biomarker) and always outputs four workload configs (Lite / Standard / Advanced / Publication+) with recommended primary plan, step-by-step workflow, figure plan, validation strategy, minimal executable version, publication upgrade path, and a strictly verified reference literature retrieval layer with real references only.

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Designs a realistic, execution-aware biomedical study version under explicit constraints of samples, time, budget, data access, lab capacity, team skill, and validation resources. Always use this skill when the user has a real study idea, a candidate route, or a partially framed project but cannot assume ideal conditions. If critical feasibility inputs are missing, first clarify what resources are currently available, what resources may be obtainable, and what resources are realistically unavailable. Do not invent access, capabilities, collaborations, or validation resources. Focus first on feasibility-constrained study framing, route narrowing, dependency control, and minimum viable study design.

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Reverse-engineers the methods section of a biomedical paper into a structured, reproducible workflow. Use this skill when a user wants to understand how a study was actually executed, extract data sources, inclusion/exclusion logic, preprocessing, analytical sequence, software/tools, validation path, and critical parameters, or build a replication checklist from a paper, abstract, DOI, PMID, title, screenshot, or partial methods text. Do not treat this as generic summarization. Focus on reconstructing the operational method pipeline, surfacing missing reproducibility details, and distinguishing explicitly reported steps from inferred or unresolved ones. Never fabricate references, methods details, identifiers, software versions, parameters, datasets, or validation steps.

日本語の概要は準備中です。原文の説明を表示しています。

Generates complete bidirectional multi-phenotype Mendelian randomization research designs from a user-provided exposure family and outcome family. Always use this skill whenever a user wants to design, plan, or build a genome-wide causal-inference study based on publicly available GWAS summary statistics, especially when the article logic includes multiple exposures, multiple outcomes or subtypes, bidirectional MR, IV filtering, IVW as the main estimator, weighted median / MR-Egger / MR-PRESSO sensitivity analyses, leave-one-out testing, heterogeneity / pleiotropy checks, and multiple-testing control with FDR. Covers five study patterns (single-family bidirectional MR, multi-phenotype screening MR, subtype-resolved MR, phenome-style bidirectional causal map, mechanism-prioritized MR follow-up) and always outputs four workload configs (Lite / Standard / Advanced / Publication+) with recommended primary plan, step-by-step workflow, figure plan, validation strategy, minimal executable version...

日本語の概要は準備中です。原文の説明を表示しています。

A comprehensive auditor for any agent skill — including Manus, OpenClaw/ClawHub, Claude, LobeHub, or custom SKILL.md-based skills. Use this skill whenever a user wants to evaluate, audit, review, score, or quality-check an agent skill before publishing, updating, or deploying. Covers two hard veto gates (structural redlines + research integrity redlines), static quality scoring across 25 criteria (ISO 25010 + OpenSSF + Agent), dynamic test input generation, multi-mode execution testing, multi-layer output evaluation with five specialized category rubrics (Evidence Insight / Protocol Design / Data Analysis / Academic Writing / Other), a Research Veto that applies to all four research categories, human eval viewer generation, actionable P0/P1/P2 optimization recommendations, and automatic skill improvement that outputs a polished, production-ready SKILL.md. Also use whenever a user says "audit my skill", "evaluate my skill", "improve my skill", or wants a corrected version after evaluation.

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Use when evaluating Jim Simons / Renaissance-style quantitative strategies: many weak signals, statistical validation, signal decay, portfolio construction, execution cost, and model risk.

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Use whenever you run statistical analysis for the social sciences (regression, hypothesis tests, econometrics) or read Stata (.dta) / SPSS (.sav) data in this workspace. Enforces an execute-don't-interpret boundary (surface estimates, don't volunteer causal claims), checks the analysis against a preregistration plan for HARKing, verifies reproducible seeds, and reproduces .dta/.sav estimates via R. Flags integrity risks; never certifies the analysis is sound.

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Use when a task needs an app on the user's own screen — a native desktop application (instrument control software, Origin, GraphPad, ImageJ, a reference manager, a spreadsheet), or a desktop browser window that needs window-level control. Read before the first `computer` call. Covers the observe-act-observe loop, why element indexes go stale, which action to prefer for which control, what "unverified" means and why it must never be reported as success, and the recovery for each error code. Not for page-level web automation (use the browser connector) and not for anything that can be done from the shell.

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Use this skill when creating database schemas or tables for Timescale, TimescaleDB, TigerData, or Tiger Cloud, especially for time-series, IoT, metrics, events, or log data. Use this to improve the performance of any insert-heavy table. **Trigger when user asks to:** - Create or design SQL schemas/tables AND Timescale/TimescaleDB/TigerData/Tiger Cloud is available - Set up hypertables, compression, retention policies, or continuous aggregates - Configure partition columns, segment_by, order_by, or chunk intervals - Optimize time-series database performance or storage - Create tables for sensors, metrics, telemetry, events, or transaction logs **Keywords:** CREATE TABLE, hypertable, Timescale, TimescaleDB, time-series, IoT, metrics, sensor data, compression policy, continuous aggregates, columnstore, retention policy, chunk interval, segment_by, order_by Step-by-step instructions for hypertable creation, column selection, compression policies, retention, continuous aggregates, and indexes.

日本語の概要は準備中です。原文の説明を表示しています。

Use this skill for setting up vector similarity search with pgvector for AI/ML embeddings, RAG applications, or semantic search. **Trigger when user asks to:** - Store or search vector embeddings in PostgreSQL - Set up semantic search, similarity search, or nearest neighbor search - Create HNSW or IVFFlat indexes for vectors - Implement RAG (Retrieval Augmented Generation) with PostgreSQL - Optimize pgvector performance, recall, or memory usage - Use binary quantization for large vector datasets **Keywords:** pgvector, embeddings, semantic search, vector similarity, HNSW, IVFFlat, halfvec, cosine distance, nearest neighbor, RAG, LLM, AI search Covers: halfvec storage, HNSW index configuration (m, ef_construction, ef_search), quantization strategies, filtered search, bulk loading, and performance tuning.

日本語の概要は準備中です。原文の説明を表示しています。

Archive session learnings, debugging solutions, and deployment logs to .archive/yyyy-mm-dd/ as indexed markdown with searchable tags. Use when completing a significant task, resolving a tricky bug, deploying, or when the user says "archive this". Maintains .archive/MEMORY.md index for cross-session knowledge reuse.

日本語の概要は準備中です。原文の説明を表示しています。

Use this skill to build a multi-element Excel dashboard — Dashboard sheet on open, multiple formula-driven KPI cards, multiple charts, sparklines, and conditional formatting — from CSV or tabular input. Trigger on: 'dashboard', 'KPI dashboard', 'analytics dashboard', 'executive dashboard', 'metrics dashboard', 'CSV to dashboard', 'data visualization'. Output is a single .xlsx. Scene-layer on officecli-xlsx: inherits every xlsx hard rule. DO NOT invoke for: a single budget tracker / one-sheet CSV-with-formatting (use xlsx), a 3-statement / DCF / LBO financial model (use financial-model), a weekly report with ≤ 1 chart and < 10 rows (use xlsx).

日本語の概要は準備中です。原文の説明を表示しています。

Automates pre-development workflow for large-scale complex tasks. Use when the user mentions "rewrite", "migrate", "overhaul", "refactor entire project", "transform", "rebuild in [language]", "spec-driven", or describes any large-scale project transformation that requires planning before coding. Also triggers on Chinese keywords: "改造", "重写", "迁移", "重构", "大规模", "规范驱动". Performs full project analysis, task decomposition, documentation generation, project-level instruction and native memory surface resolution, progress tracking setup, and then executes the plan within the same session.

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Use Trivy vulnerability scanner in offline mode to discover security vulnerabilities in dependency files. This skill covers setting up offline scanning, executing Trivy against package lock files, and generating JSON vulnerability reports without requiring internet access.

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Optimize workload distribution across workers, processes, or nodes for efficient parallel execution. Use when asked to balance work distribution, improve parallel efficiency, reduce stragglers, implement load balancing, or optimize task scheduling. Covers static/dynamic partitioning, work stealing, and adaptive load balancing strategies.

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Transform sequential Python code into parallel/concurrent implementations. Use when asked to parallelize Python code, improve code performance through concurrency, convert loops to parallel execution, or identify parallelization opportunities. Handles CPU-bound (multiprocessing), I/O-bound (asyncio, threading), and data-parallel (vectorization) scenarios.

日本語の概要は準備中です。原文の説明を表示しています。

Use when configuring Maven plugins, setting up common plugins like compiler, surefire, jar, or creating custom plugin executions.

日本語の概要は準備中です。原文の説明を表示しています。

Use this skill when working with symbolic mathematics in Python. This skill should be used for symbolic computation tasks including solving equations algebraically, performing calculus operations (derivatives, integrals, limits), manipulating algebraic expressions, working with matrices symbolically, physics calculations, number theory problems, geometry computations, and generating executable code from mathematical expressions. Apply this skill when the user needs exact symbolic results rather than numerical approximations, or when working with mathematical formulas that contain variables and parameters.

日本語の概要は準備中です。原文の説明を表示しています。