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Current Playwright (1.64) patterns for writing, debugging, and scaling reliable test suites. Use for any Playwright task, even ones you think you know, because the guides cover APIs and CLI flags newer than most training data. Covers writing or fixing tests, locators, a failing or flaky test, a trace.zip or error message, playwright.config and projects, network mocking, auth, visual and accessibility testing, Docker and CI sharding, playwright-cli browser automation, Playwright Test Agents, page objects, migrating from Cypress or Selenium, and QA work: test case design, bug reports from failures, automating manual test cases, and reviewing tests. TypeScript and JavaScript.

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Step-by-step migration guides for moving to Playwright from Cypress or Selenium/WebDriver — command mappings, architecture changes, and incremental adoption strategies.

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Full spec-driven pipeline — walks brief → tokens → shape (spec) → craft (build) → converge → ship in one guided run. Writes `.ui-craft/spec.md`. Run when starting a net-new surface from scratch. Invoke when the user asks for sddesign on their UI, or mentions 'sddesign' alongside design / UI / frontend work.

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生成 PowerX 功能使用指导文档（人性化、可执行、与实现对齐）。强制包含业务背景、模块关系、流程图、泳道图、页面/接口/命令步骤、验收、排障、回滚与代码映射。

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Guide for upgrading Stripe API versions and SDKs

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Step-by-step migration guides for moving to Playwright from Cypress or Selenium/WebDriver — command mappings, architecture changes, and incremental adoption strategies.

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React and Next.js performance optimization guidelines from Vercel Engineering. This skill should be used when writing, reviewing, or refactoring React/Next.js code to ensure optimal performance patterns. Triggers on tasks involving React components, Next.js pages, data fetching, bundle optimization, or performance improvements.

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Postgres best practices maintained by Supabase, for Postgres running anywhere. Load this skill BEFORE writing or changing anything that lives in a Postgres database: creating or altering tables and columns (including choosing column types), schema design, migrations and declarative schema files, RLS policies and the tests that verify them, indexes, triggers, database functions, queues and scheduled jobs (pg_cron, pgmq), vector/semantic search (pgvector), and restoring dumps (pg_restore) or importing data. Also load it when diagnosing slow queries, high CPU, timeouts, EXPLAIN plans, connection exhaustion, locking, bloat, or rows visible to the wrong user or tenant. This is not just a performance guide — schema, migration, security, and SQL authoring tasks need these rules too, even for a one-column change or a single query.

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Guide for implementing smooth, native-feeling animations using React's View Transition API (`<ViewTransition>` component, `addTransitionType`, and CSS view transition pseudo-elements). Use this skill whenever the user wants to add page transitions, animate route changes, create shared element animations, animate enter/exit of components, animate list reorder, implement directional (forward/back) navigation animations, or integrate view transitions in Next.js. Also use when the user mentions view transitions, `startViewTransition`, `ViewTransition`, transition types, or asks about animating between UI states in React without third-party animation libraries.

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Guides Stripe integration decisions across API selection (Checkout Sessions vs PaymentIntents), Connect platform setup (Accounts v2, controller properties), billing/subscriptions, tax and registrations (Stripe Tax, automatic_tax, product tax codes), Treasury financial accounts, integration options (Checkout, Payment Element), migrating from deprecated Stripe APIs, and security best practices (API key management, restricted keys, webhooks, OAuth). Use when building, modifying, or reviewing any Stripe integration, including accepting payments, building marketplaces, integrating Stripe, processing payments, setting up subscriptions, collecting sales tax, VAT, or GST, creating connected accounts, or implementing secure key handling.

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Complete guide for building accessible, high-UX forms in modern stacks (React/Next.js, Tailwind, Zod). Includes specific patterns for clickable areas, range sliders, output-inspired design, and WCAG compliance.

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Guide to Sonner, the React toast library — install and wire up the Toaster, pick the right toast() call, promise and loading toasts, updating, dismissing and persisting toasts, styling, theming and icons, positioning and multiple toasters. Use when working with Sonner or troubleshooting it — toasts that don't appear, appear twice, lose their styles, ignore Tailwind classes, sit behind a modal, or don't follow dark mode.

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Guides a one-question-at-a-time design interview, captures alignment in agent/EVE-BRIEF.md, then scaffolds and implements a runnable eve agent with verbose teaching comments. Use when the user wants to create a new eve agent, build an agent from scratch, or invokes /create-agent.

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Build office space programs through guided workplace strategy: area splits, room schedules, and planned seat counts. Use to program or size a workplace; not for code occupant-load calculations.

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Guided, hands-on course teaching architects how to use Codex or Claude Code — six short modules, each built around an exercise on a bundled sandbox project (a fictional Brooklyn art museum expansion). Resumable across sessions via PROGRESS.md. Use when the user runs $learn or /as:learn, says they're new to AI-assisted project work, or asks how to learn it.

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Reviews code for security vulnerabilities and guides secure implementation using OWASP Top 10:2025, ASVS 5.0, the OWASP Top 10 for LLM Applications (2026), and the OWASP Top 10 for Agentic Applications (2026). Use when reviewing code or a diff for security issues, implementing authentication, authorization, sessions, or cryptography, handling untrusted input, files, or URLs, hardening config, dependencies, or CI, or building LLM and AI agent features.

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Guide to quality filtering raw VCF files before computing summary stats (Ts/Tv ratio, variant counts, AF distributions). Covers detecting raw VCFs via FILTER column and QUAL inspection, QUAL-based filtering with bcftools, Ts/Tv interpretation, and when NOT to filter. Read before any variant-level QC task. See bcftools-variant-manipulation for advanced filters, gatk-variant-calling for caller config, samtools-bam-processing for upstream alignment QC.

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Guide to interpreting BUSCO completeness statuses: why Duplicated BUSCOs count as complete, parsing output files, computing/comparing completeness across proteomes/genomes, common counting mistakes. Use when running BUSCO QC, comparing assemblies, or reporting completeness. See also: prokka-genome-annotation for annotation workflows feeding BUSCO.

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Query the ClinPGx (formerly PharmGKB) REST API plus the CPIC PostgREST companion API for pharmacogenomic clinical annotations, CPIC/DPWG dosing guidelines, gene-drug pairs, variant-drug associations, FDA/EMA drug labels, and PGx pathways. Two-host architecture: api.clinpgx.org for annotation records, api.cpicpgx.org for genotype→recommendation lookups. No auth. For germline pathogenicity use clinvar-database; for somatic cancer PGx use cosmic-database or opentargets-database; for drug bioactivity use chembl-database-bioactivity.

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Cell type annotation strategy for scRNA-seq: name clusters manually from canonical markers, transfer labels from a reference (CellTypist, popV), or do both and validate one against the other. Covers matching tissue and developmental stage, marker evidence, annotation confidence, doublets, unresolved clusters. Use when planning or troubleshooting how to annotate cells.

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Structure-activity relationship (SAR) analysis guide for drug discovery including molecular descriptor analysis, scaffold analysis, and activity cliff detection.

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Three-tiered approach to omics data analysis (transcriptomics, proteomics) covering validated pipelines, standard workflows, and custom methods

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Scientific manuscript writing: IMRAD, citation styles (APA/AMA/Vancouver/IEEE), figures/tables, reporting guidelines (CONSORT/STROBE/PRISMA/ARRIVE), writing principles (clarity/conciseness/accuracy), venue-specific style. For LaTeX see companion assets.

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AiZynthFinder retrosynthetic route planning (CASP) from AstraZeneca Molecular AI. Monte Carlo tree search guided by a template-based neural expansion policy recursively disconnects a target SMILES until precursors are found in a purchasable stock. Covers config.yml (v4 format), aizynthcli batch screening, the AiZynthFinder/AiZynthExpander Python API, one-step disconnections, custom stocks via smiles2stock, scorers, Retro*/breadth-first/DFPN search alternatives, and reading output.json.gz / trees.json. Use for synthesis route planning, synthesizability screening, and building-block/precursor search. For reaction barriers use neb-irc-activation-energy; for 2D reaction scheme drawing use rdkit-chemdraw-cdxml.

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