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Apply Boyd's OODA loop to navigate fast-moving, uncertain, or competitive situations — Observe what is actually happening, Orient through mental models and context, Decide on the clearest path, Act quickly, then loop again. Load when the situation is changing faster than the current plan, when a competitive response is needed, when the user is stuck in analysis paralysis in a dynamic environment, when shipping under uncertainty, or when deep-thinking diagnoses a fast-moving / competitive frame. Triggers on "what should we do right now", "the situation is changing", "how do we respond to this", "competitive response", "we need to move fast", or "we're stuck deciding". Based on John Boyd's OODA loop — Observe, Orient, Decide, Act — adapted for product and business contexts (OODA Canvas 2026).

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Orchestrator for the experimentation skill suite — turn assumptions and product questions into rigorous, well-instrumented experiments and decision-grade readouts. Routes through backlog → spec → runbook → readout based on user need and existing artefacts. Platform-agnostic with PostHog as the primary binding. Load when the user asks to design an experiment, A/B test something, set up an experiment, run a holdout, test a hypothesis, decide what to test next, read out experiment results, analyse a test, or says "should we A/B test this", "experiment on the landing page", "is this lift real", "ship or kill this test", "what should we test next", "build an experiment backlog", "test the pricing page", "validate this with an experiment".

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Instrument a shipped product's AI agents with tracing and observability so you can see what they did, why outputs happened, and what each run cost. Plain-language primer plus free-tier-first backend selection (Langfuse, Phoenix, LangSmith, Braintrust) and OpenTelemetry/OpenInference instrumentation. Load when the user asks to add observability, add tracing, instrument my agents, see what my agent is doing in production, set up Langfuse or Phoenix or LangSmith, debug why my agent gave a bad answer, or track LLM cost per request. Also fires when agent-system-architecture or setup-evaluation requires an observability plan for an agent-chain product. NOT for tracing the coding agent itself — that is run-trace. Precondition for runtime-learning-loop.

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Simplify application code for clarity without changing behavior — refactor after tests pass, reduce nesting and duplication, match project conventions. Load when refactoring for readability, cleaning up after a feature ships, or when code review flags complexity. Also triggers on "simplify this code", "code simplification", "make this easier to read", "reduce complexity", "refactor for clarity". Not for compress/split/prune-skill (skill-library files). Pairs with technical-debt-audit.

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Harden an application against common security risks — validate inputs at boundaries, least-privilege access, safe secrets handling, dependency hygiene, and secure defaults. Load when shipping user-facing code, adding auth/session flows, handling untrusted data, exposing APIs, or the user asks for "security hardening", "OWASP hardening", "secure this feature". Not for skill-library security gates (use secure-skill family).

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Translate an approved experiment spec into a launch runbook — platform binding (PostHog primary), feature flag setup, assignment unit, exposure event definition, instrumentation QA, dashboard wiring, ramp plan, monitoring, and rollback procedure. Platform-agnostic core with one strong PostHog adapter shipped; GrowthBook, Statsig, LaunchDarkly, Optimizely, and Eppo documented as a single mapping table the user adapts. Load when a spec is approved and ready to launch, or when the user says "set up the experiment", "wire this up in PostHog", "implement the test", "create the runbook", "launch checklist for this test", or when the experimentation orchestrator routes here.

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Create branch, atomic commits, push, and open a pull request with terse, exact messages. Conventional branch + commit format. PR title ≤70 chars, body says "why", not "what". Use when the user says "create pr", "create pullrequest", "create pull request", "make pr", "open pr", "open pullrequest", "open pull request", "submit pr", "raise pr", "/create-pr", or asks to ship/send changes as a pull request (PR/pullrequest/pull-request, any spelling).

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Automate Attio CRM operations -- search records, query contacts and companies with advanced filters, manage notes, list attributes, and navigate your relationship data -- using natural language through the Composio MCP integration.

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A set of resources to help me write all kinds of internal communications, using the formats that my company likes to use. Claude should use this skill whenever asked to write some sort of internal communications (status reports, leadership updates, 3P updates, company newsletters, FAQs, incident reports, project updates, etc.).

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Analyzes meeting transcripts and recordings to uncover behavioral patterns, communication insights, and actionable feedback. Identifies when you avoid conflict, use filler words, dominate conversations, or miss opportunities to listen. Perfect for professionals seeking to improve their communication and leadership skills.

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Assists in writing high-quality content by conducting research, adding citations, improving hooks, iterating on outlines, and providing real-time feedback on each section. Transforms your writing process from solo effort to collaborative partnership.

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Run end-to-end deploy pipelines across Stripe, Supabase, and Vercel using the Composio CLI. Promote Stripe products, push Supabase migrations, ship Vercel deployments, and verify with post-deploy checks — all from one script.

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AI operational modes (brainstorm, implement, debug, review, teach, ship, orchestrate). Use to adapt behavior based on task type.

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Expert C4 Component-level documentation specialist. Synthesizes C4 Code-level documentation into Component-level architecture, defining component boundaries, interfaces, and relationships.

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Find and evaluate influencers for brand partnerships, verify authenticity, and track collaboration performance across Instagram, Facebook, YouTube, and TikTok.

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You are an AI product engineer who has shipped LLM features to millions of users. You've debugged hallucinations at 3am, optimized prompts to reduce costs by 80%, and built safety systems that caught thousands of harmful outputs. You know that demos are easy and production is hard.

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Analyzes species-environment relationships with constrained ordination (CCA, RDA, db-RDA), variance partitioning, indicator species (indicspecies IndVal.g group-equalized), PERMANOVA paired MANDATORILY with PERMDISP (Anderson & Walsh 2013; dispersion confounds centroid tests), Joint Species Distribution Models (HMSC, sjSDM, gjam) with explicit rejection of "residual covariance equals biotic interaction", phylogenetic community ecology (SES_MPD/MNTD), trait-environment via RLQ + fourth-corner with corrected modeltype=6 (Dray 2014), bipartite network metrics (NODF, modularity) with curveball null (Strona 2014), and Mantel-test replacements (dbRDA, GDM) for spatial data. Use when testing how environmental gradients structure communities, identifying habitat indicator taxa, partitioning variance among predictors, deciding whether PERMANOVA significance is location vs dispersion, picking among HMSC/sjSDM/gjam, or replacing Mantel tests for landscape data.

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Compare gene co-expression and regulatory networks between biological conditions to find rewired relationships using DiffCorr, DiffCoEx, DINGO/iDINGO, and CoDiNA. Covers the differential-connectivity-is-not-differential-expression distinction, the pairwise multiple-testing explosion, marginal vs partial (direct) rewiring, and the underpowered-rewiring failure mode. Use when comparing co-expression networks between disease vs control, treatment, or developmental stages, or finding hub genes that rewire without changing mean expression. For single-condition modules see coexpression-networks; for differential expression of means see differential-expression/de-results.

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Batch effect correction for CRISPR screens covering ComBat empirical-Bayes, RUV, SVA, control-sgRNA normalization, and the model-based alternative of including batch as a covariate in MAGeCK MLE or Chronos. Covers screen-specific batch sources (passage cohort, library lot, infection day, sequencing run, Cas9 lot, FBS lot), PCA + variance-decomposition diagnostic to decide if correction is needed, when correction harms biology by over-correcting condition into batch, limma removeBatchEffect for visualization-only correction, and relationship to multi-condition design matrices. Use when combining screens for joint analysis, when passage cohort confounds biology, when DepMap-style panels need Chronos with batch covariates, when picking ComBat vs RUV, or when correction harms biology and should be replaced with explicit covariate modeling.

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Find cross-database references between NCBI databases using Biopython Bio.Entrez (ELink). Use when navigating gene to protein/structure, sequence to publication, PubMed to GEO, BioProject to SRA runs, or discovering all link relationships for a record. Covers linkname semantics, cmd= variants, asymmetric link warnings, neighbor_history for >200 input IDs, and per-database link tables.

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Designs and analyzes combinatorial CRISPR screens covering paired-Cas9 (Big Papi, Najm 2018), enhanced AsCas12a multiplex (enCas12a, DeWeirdt 2021), in4mer 4-guide-array Cas12a (Esmaeili Anvar N et al 2024 Nat Commun 15:3577) and the Inzolia paralog-pair library, paralog-buffering detection (Dede 2020 Genome Biol; Thompson 2021 Cell Reports 36:109597), genetic-interaction (GI) scoring as observed_double_LFC minus expected_additive_double_LFC, synthetic-lethal and synthetic-rescue interaction interpretation, the half-of-essentiality buffered by paralogs phenomenon, multiplex screen statistical analysis with MAGeCK MLE interaction terms, and the relationship to single-cell combinatorial Perturb-seq. Use when designing a paralog or pathway-pair screen, choosing between paired-Cas9 (Big Papi) and Cas12a multiplex (Inzolia), interpreting genetic interaction scores, identifying synthetic-lethal targets for drug development, or scaling beyond single-gene CRISPR screens.

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Designs and analyzes in vivo CRISPR screens in animal tumor models, organoids, and immune-cell adoptive transfers. Covers bottleneck math (250x cells/sgRNA requires ~25M cells implanted; impossible for most syngeneic models, forcing focused libraries), focused library design (Manguso 2017 Nature 547:413 immune screen; Chen 2015 tumor screens), CRISPR-StAR intrinsic-control screening (Uijttewaal 2025 Nat Biotechnol 43:1848), clonal-dynamics-limited detection, tumor-explant DNA recovery, syngeneic vs xenograft vs PDX considerations, and the relationship to downstream MAGeCK / drugZ analysis. Use when designing in vivo CRISPR screens for tumor / immune / metastasis biology, choosing focused vs genome-wide for animal models, addressing bottleneck-induced clonal collapse, picking the syngeneic / xenograft / PDX model, integrating in vivo with in vitro results, or applying CRISPR-StAR for animal experiments.

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Build UpSet plots to visualize set intersections beyond 4 sets (where Venn fails) using ComplexUpset (modern, ggplot2-grammar) or the unmaintained UpSetR, with explicit cardinality vs degree sorting, attribute panels, and query highlighting. Use when comparing overlap across many gene sets, peak sets, variant lists, or any set membership matrix where Venn diagrams become illegible.

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Decompose total effects into direct and indirect paths through mediators using mediation, CMAverse 4-way, HIMA/HIMA2 high-dimensional, BAMA, two-step / MVMR mediation, or double-ML medDML. Use when testing whether a molecular phenotype (expression, methylation, protein) mediates a treatment-outcome relationship, decomposing exposure-mediator interaction via VanderWeele 4-way, screening high-dimensional EWAS mediators, or running MR-based mediation when sequential ignorability is implausible.

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