「issue」の検索結果

Full Self Driving — autonomous release loop that processes all auto-dev-eligible GitHub issues until none remain, by repeatedly running /pipeline auto-dev then /homework.

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Monitor Claude Code releases and auto-generate GitHub issues for each new version

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Analyze a natural language idea against the project codebase and return structured issue specs

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Troubleshoot and debug LiveAvatar integration issues. Use when the user's LiveAvatar integration isn't working, the avatar is silent, audio is garbled, sessions fail to start, events aren't received, or they're getting API errors.

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Use when taking a repo open source, or hardening one that already is. Run /oss-launch and it scans the repo (stack, existing files, git remote, secrets), asks only what it cannot infer, then generates a tailored OSS file collection (README, LICENSE, CONTRIBUTING, CODE_OF_CONDUCT, SECURITY, CHANGELOG, .gitignore, .github/ issue + PR templates, CI/CD). Also covers launch (GitHub metadata, badges, Show HN, Reddit, YouTube), release cadence (SemVer + CHANGELOG), and demo-GIF generation. Triggers on "open source this", "OSS checklist", "prep for launch", "make this repo public", "add a license / contributing / security policy", "Show HN", "release workflow", "star growth", "get contributors".

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Develop, challenge, and document Chisel processor microarchitecture designs before implementation. Use when discussing or writing design documents for processor pipelines, queues, issue logic, rename, ROB, LSU, caches, MSHRs, forwarding, wakeup, replay, flush, privilege, exceptions, or other cycle-accurate hardware mechanisms; when converting design conversations into stable Markdown specifications; or when reviewing a proposed Chisel CPU design for correctness, timing, area, verification cost, and cross-document consistency.

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Diagnose and optimize timing-critical Chisel RTL for FPGA implementation while preserving cycle semantics. Use for Vivado timing bottlenecks, long ready or admission paths, queue and issue selection, free-list bank mapping, priority encoders, one-hot arbitration, wide muxes, late-arriving forwarding or override data, high-fanout controls, cross-module predicates, register-boundary changes, emitted-Verilog inspection, or routed-DCP A/B analysis. Also use when a source-level simplification needs proof that it changes timing without changing architectural state.

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Audit an existing UI for usability, hierarchy, accessibility, and conversion problems. Reviews a live URL, screenshot, or codebase against heuristics and reports prioritized issues with fixes. Use when the user says "audit this UI", "what's wrong with this screen", "UX review", "find the problems", "why is this confusing", or has existing interface to critique. Part of the Product Design set. Can drive a browser for live audits.

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Use when optimizing Docker builds with BuildKit, designing multi-stage Dockerfiles, leveraging cache mounts, building multi-arch images, choosing distroless vs alpine, or signing images with cosign. Triggers: docker build slow, layer cache not hitting, npm install / pip install reruns, multi-stage final image bloat, glibc vs musl issues, RUN --mount=type=cache, BUILDKIT_INLINE_CACHE, registry cache exporters, qemu emulation for arm64, COPY ordering for cache. NOT for Docker daemon admin, Kubernetes-specific image policies, container security scanning workflows, or Buildpacks (different paradigm).

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Describe patterns that may indicate bad-faith or manipulative communication including gish gallop, whataboutism, tone policing, motte-and-bailey, sealioning, lying by omission, deflection, and strategic evasion. Use when the user suspects manipulation, notices repeated non-engagement, wants to analyze debate tactics, or mentions 'bad faith', 'deflection', 'manipulation', 'dodging the question', 'avoiding the issue', 'gaslighting', 'moving goalposts'. Describes behavioral patterns without making psychological diagnoses.

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Extracts cfDNA fragmentomics features (DELFI genome-wide short/long ratios, WPS nucleosome positioning, Griffin GC-corrected accessibility profiles, end-motifs/MDS, OCF) for cancer detection and tissue-of-origin from plasma WGS. Centers on the nuclease-footprint reframe (every feature re-reads one nucleosome object), the mandatory GC correction, and the cross-protocol non-comparability that breaks naive classifiers. Runs FinaleToolkit (real CLI/Python, MIT) and the Griffin Snakemake pipeline; DELFI is a method, not a package. Use when deriving fragment-based signal from cfDNA, choosing a feature family for detection vs subtyping, or diagnosing why a fragmentomic model failed validation.

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Detects differential alternative splicing between conditions using rMATS-turbo (binomial LRT on junction counts), leafcutter (Dirichlet-multinomial GLM on intron clusters), MAJIQ V3 deltapsi/HET (Bayesian posterior on LSVs), SUPPA2 (empirical-null on TPM-derived PSI), or Shiba (junction-imbalance-corrected, 2025 SOTA at low coverage). Reports FDR-corrected significance and delta PSI effect sizes. Tools differ in statistical model, annotation dependence, calibration regime, and replicate-count requirements. Use when comparing splicing patterns between treatment groups, tissues, or disease states.

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Estimates SNP heritability and partitions it across functional annotations, cell types, and loci from GWAS summary statistics or individual-level genotypes. Implements LDSC, stratified LDSC with the baseline-LD model, Finucane 2018 cell-type prioritization, LDAK SumHer, HDL, HESS local heritability, BOLT-REML, GCTA-GREML, graphREML, and Popcorn cross-population genetic correlation. Use when computing total h2_SNP from summary stats, partitioning heritability across functional categories, prioritizing trait-relevant tissues or cell types from ENCODE/Roadmap chromatin marks, reconciling LDSC vs LDAK enrichment estimates, computing local heritability with HESS, estimating genetic correlation between traits, or producing publication-grade enrichment with calibrated sensitivity to model assumptions.

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Calculates tumor mutational burden from WES/WGS/panel data with Friends of Cancer Research harmonization equations, per-assay calibration (FDA 10/Mb = 7.8 TSO500 = 8.4 OncomineTML), synonymous/indel/germline filtering, hypermutator tiering, blood TMB, and integration with HLA-LOH and neoantigen quality (Luksza 2017 fitness). Use when assessing ICI eligibility under tumor-specific cutoffs (McGrail 2021), comparing tissue vs bTMB, or auditing TMB-H reporting against ESMO 2024 and FDA pembrolizumab pan-tumor 2020.

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Maps GWAS-implicated loci to candidate effector (causal) genes by integrating variant-to-gene (V2G) features via Open Targets L2G (Mountjoy 2021), MAGMA gene-based association (de Leeuw 2015), FUMA SNP2GENE, cS2G combined SNP-to-gene scores (Gazal 2022), Polygenic Priority Scores (PoPS, Weeks 2023), FLAMES, INQUISIT, DEPICT, and enhancer-gene predictors (ABC, ENCODE-rE2G). Use when narrowing a GWAS lead locus to a candidate causal gene, picking between proximity, eQTL-based, and similarity-based prioritizers, integrating multi-evidence streams (fine-mapping, colocalization, ABC enhancer-gene, distance, chromatin), reconciling discordant L2G vs PoPS calls, prioritizing tissue-specific eQTL evidence, or triangulating across at least three independent lines of evidence for a publication-grade effector-gene nomination.

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Master authentication and authorization patterns including JWT, OAuth2, session management, and RBAC to build secure, scalable access control systems. Use when implementing auth systems, securing APIs, or debugging security issues.

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Write articles, guides, blog posts, tutorials, newsletter issues, and other long-form content in a distinctive voice derived from supplied examples or brand guidance. Use when the user wants polished written content longer than a paragraph, especially when voice consistency, structure, and credibility matter.

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This skill recommends that all patients with Cushing’s syndrome receive monitoring and adjunctive treatment for cortisol-dependent comorbidities including psychiatric disorders, diabetes, hypertension, hypokalemia, infections, dyslipidemia, osteoporosis, and poor physical fitness. Apply when managing any CS patient to address associated health issues; triggers include confirmed or suspected hypercortisolism, preoperative evaluation, postoperative follow‑up, or persistent hypercortisolism despite treatment.

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This skill advises regular visual examination of the mouth to monitor for osteonecrosis of the jaw and other dental issues in patients receiving antiresorptive agents. Trigger phrases include initiating bisphosphonate or denosumab therapy and requesting preventive dental care guidance.

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Review the changes since a fixed point (commit, branch, tag, or merge-base) along two axes — Standards (does the code follow this repo's documented coding standards?) and Spec (does the code match what the originating issue/PRD asked for?). Runs both reviews in parallel sub-agents and reports them side by side. Use when the user wants to review a branch, a PR, work-in-progress changes, or asks to "review since X".

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Turn the current conversation context into a PRD and publish it to the project issue tracker. Use when user wants to create a PRD from the current context.

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Create a detailed refactor plan with tiny commits via user interview, then file it as a GitHub issue. Use when user wants to plan a refactor, create a refactoring RFC, or break a refactor into safe incremental steps.

日本語の概要は準備中です。原文の説明を表示しています。

Linear: manage issues, projects, teams via GraphQL + curl.

日本語の概要は準備中です。原文の説明を表示しています。

Use when you need to address review or issue comments on an open GitHub Pull Request using the gh CLI.

日本語の概要は準備中です。原文の説明を表示しています。