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Quality control for pooled CRISPR screens covering library representation, Gini index, log-skew, replicate Pearson and Spearman concordance, essentialome precision-recall AUC against CEGv2 (Hart 2017), Cas9 cut-toxicity diagnostics, copy-number amplicon detection (Aguirre 2016 / Munoz 2016), bottleneck propagation through plasmid pool, infection, selection, and endpoint stages, MOI verification, and DepMap-style screen-quality scoring. Use when assessing screen quality before hit calling, deciding whether to repeat or rescue a screen, diagnosing low-confidence hits, choosing between MAGeCK / BAGEL2 / Chronos based on quality grade, picking a normalization strategy from QC signatures, or evaluating whether an in-vivo screen retained adequate library complexity.

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Queries gnomAD v4 (807k samples), v3, v2.1.1, and constraint metrics with grpmax FAF95, bottleneck-group exclusion, LOEUF interpretation, SV/CNV/mtDNA catalogs, and Whiffin max-credible-AF framework. Use when filtering rare variants, applying ACMG BS1/BA1, ranking genes by LoF intolerance, or selecting between v2 (GRCh37 + chrX/Y constraint) and v4 (GRCh38 + 807k samples).

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Fits structural equation models to GWAS summary statistics using GenomicSEM (Grotzinger 2019), including common-factor models, confirmatory factor models, ESEM, common-factor GWAS with Q_SNP heterogeneity, multivariate Wald tests, and stratified GenomicSEM partitioned heritability. Reconciles results against MTAG multi-trait analysis. Handles sample overlap via the LDSC sampling-covariance matrix, identifies and resolves Heywood cases, and verifies model fit with CFI / RMSEA. Use when modeling latent genetic architecture across correlated traits, running multivariate GWAS on a shared factor, distinguishing factor-mediated from trait-specific SNP effects, or comparing GenomicSEM common-factor results against MTAG when both depend on accurate sampling covariance.

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Generate competitive SEO content briefs with per-section word counts, competitor scoring, keyword density guidance, and page-type templates. Supports both new page briefs and improve-existing-page briefs. Use when user says "content brief", "write a brief", "content outline", "blog brief", "service page brief", "brief for", "writing brief", "content plan", or "outline for".

日本語の概要は準備中です。原文の説明を表示しています。

Technical SEO audit across 9 categories: crawlability, indexability, security, URL structure, mobile, Core Web Vitals, structured data, JavaScript rendering, and IndexNow protocol. Use when user says "technical SEO", "crawl issues", "robots.txt", "Core Web Vitals", "site speed", or "security headers".

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Retiring a dead table by moving it to the deprecated schema and clearing every reference in both repos. Use when asked to deprecate or retire a table, when a table is no longer used, or to take a table offline without dropping it. NOT for relocating a still-used table (use db-move-table-schema).

日本語の概要は準備中です。原文の説明を表示しています。

Find and identify the CBasePlayerPawn::CommitSuicide virtual function's vtable slot in the CS2 server binary using IDA Pro MCP. Use this skill when reverse engineering server.dll or libserver.so to locate the self-inflicted-death handler (used by the "kill"/bot_kill console commands and related gameplay code) by RTTI-walking CBasePlayerPawn's primary vtable and reading its known slot index directly, then confirming the body matches CommitSuicide(bool bExplode, bool bForce) semantics. Trigger: CBasePlayerPawn_CommitSuicide

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Find and identify the CBaseEntity_SpawnRadius function in the CS2 server binary using IDA Pro MCP. Use this skill when reverse engineering CS2 server.dll or libserver.so to locate the radius-aware spawn helper that resolves an entity's effect/trigger radius from either its float argument or the "radius" keyvalue, then applies it and reads the entity's "hammerUniqueId" keyvalue. Resolved via the two econ/ hammer keyvalue literals "radius" and "hammerUniqueId": the single function that references BOTH is the target. Trigger: CBaseEntity_SpawnRadius, SpawnRadius

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Generate blog articles for Qiita and Zenn from GitHub release information. Use when creating release notes or technical articles that follow specific markdown formats with frontmatter. Supports generating articles from release data, creating custom formatted articles, and saving articles to specified repositories for both Qiita and Zenn platforms

日本語の概要は準備中です。原文の説明を表示しています。

Convex UI component patterns from the live Storybook preview. Use when building React components, forms, modals, navigation, feedback states, or app layouts that should match the current Convex design system. Applies to both shared primitives and dashboard style product UI.

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Convex is the backend agents get right on the first try: an all-TypeScript reactive platform where the database, server functions, scheduling, file storage, auth, and realtime sync are one type-safe system, every function is a transaction, and `tsc` catches most mistakes before deploy. Ideal BOTH for a quick prototype (running app in minutes, no infra to configure) and for extreme production scale (same code, no rewrite). Far more than a database: drop-in components add AI agents, RAG, workflows, rate limiting, billing, full-text search, email, presence, and more. Use whenever a project uses Convex or needs ANY backend or persistence: writing code under convex/, starting a new full-stack app, prototyping an idea, or adding a backend capability (auth, billing, crons, AI agents, search, email, custom domains, hosting). Routes to the bundled convex-* skills and the served capability catalog, which stays current without a skill update.

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Integration patterns for combining Agent-to-Agent (A2A) Protocol with Model Context Protocol (MCP) for hybrid agent communication. Use when building systems that need both agent-to-agent communication and agent-to-tool integration, implementing composite architectures, or when user mentions A2A+MCP integration, hybrid protocols, or multi-agent tool access.

日本語の概要は準備中です。原文の説明を表示しています。

AI agent and chatbot patterns including personas, pipelines, and messaging integrations. Use when building conversational agents, creating AI personas, designing insight pipelines, or integrating with Slack/Kakao platforms.

日本語の概要は準備中です。原文の説明を表示しています。

Performance optimization guidelines for OneKey React/React Native applications. Use when optimizing app performance, fixing UI freezes/lag, reducing re-renders, handling concurrent operations, or analyzing performance bottlenecks. Triggers on performance, optimization, optimize, slow, lag, freeze, hang, jank, stutter, memory, leak, concurrent, batching, batch, memoization, memo, bridge, windowSize, contentVisibility, FlashList, re-render, fps, tti, bundle.

日本語の概要は準備中です。原文の説明を表示しています。

[22] UNDERSTAND. Deep research from all sources — internal (code, git, logs) AND external (web, docs, best practices). Use when choosing libraries, investigating solutions, understanding legal/technical questions, comparing approaches, or anytime you need comprehensive knowledge from both project context and world knowledge. Triggers on "research", "investigate", "find best approach", "what do others do", "compare options", or complex questions requiring multiple sources.

日本語の概要は準備中です。原文の説明を表示しています。

Write copy following Sentry brand guidelines. Use when writing UI text, error messages, empty states, onboarding flows, 404 pages, documentation, marketing copy, or any user-facing content. Covers both Plain Speech (default) and Sentry Voice tones.

日本語の概要は準備中です。原文の説明を表示しています。

Build table storage applications using the Azure Tables SDK for Java. Works with both Azure Table Storage and Cosmos DB Table API.

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Explains how to run NemoClaw on a remote GPU instance, including the deprecated Brev compatibility path and the preferred installer plus onboard flow. Use when deploying NemoClaw to a remote VM, onboarding a Brev instance, or migrating away from the legacy `nemoclaw deploy` wrapper. Trigger keywords - deploy nemoclaw remote gpu, nemoclaw brev cloud deployment, nemoclaw sandbox hardening, container security, docker capabilities, process limits, nemoclaw telegram, telegram bot openclaw agent, openshell channel messaging.

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Use this skill for internal architecture work around config-driven, registry-driven, and pattern-driven feature design in the nuxt-ui-tools repository. Covers how to organize variant-heavy features, where to put implementations, and how to keep both internals and public APIs standardized.

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Use this skill any time a .pptx file is involved in any way — as input, output, or both. This includes: creating slide decks, pitch decks, or presentations; reading, parsing, or extracting text from any .pptx file (even if the extracted content will be used elsewhere, like in an email or summary); editing, modifying, or updating existing presentations; combining or splitting slide files; working with templates, layouts, speaker notes, or comments. Trigger whenever the user mentions "deck," "slides," "presentation," or references a .pptx filename, regardless of what they plan to do with the content afterward. If a .pptx file needs to be opened, created, or touched, use this skill.

日本語の概要は準備中です。原文の説明を表示しています。

Large Language and Vision Assistant. Enables visual instruction tuning and image-based conversations. Combines CLIP vision encoder with Vicuna/LLaMA language models. Supports multi-turn image chat, visual question answering, and instruction following. Use for vision-language chatbots or image understanding tasks. Best for conversational image analysis.

日本語の概要は準備中です。原文の説明を表示しています。

Comprehensive performance analysis, bottleneck detection, and optimization recommendations for Claude Flow swarms

日本語の概要は準備中です。原文の説明を表示しています。

Supermemory is a state-of-the-art memory and context infrastructure for AI agents. Use this skill when building applications that need persistent memory, user personalization, long-term context retention, or semantic search across knowledge bases. It provides Memory API for learned user context, User Profiles for static/dynamic facts, and RAG for semantic search. Perfect for chatbots, assistants, and knowledge-intensive applications.

日本語の概要は準備中です。原文の説明を表示しています。

Use this skill any time a .pptx file is involved in any way — as input, output, or both. This includes: creating slide decks, pitch decks, or presentations; reading, parsing, or extracting text from any .pptx file (even if the extracted content will be used elsewhere, like in an email or summary); editing, modifying, or updating existing presentations; combining or splitting slide files; working with templates, layouts, speaker notes, or comments. Trigger whenever the user mentions "deck," "slides," "presentation," or references a .pptx filename, regardless of what they plan to do with the content afterward. If a .pptx file needs to be opened, created, or touched, use this skill.

日本語の概要は準備中です。原文の説明を表示しています。