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概要と使いどころ
Load gene expression count matrices from various formats including CSV, TSV, featureCounts, Salmon, kallisto, and 10X. Use when importing quantification results for downstream analysis.
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Bisulfite sequencing read alignment using Bismark with bowtie2/hisat2. Handles genome preparation and produces BAM files with methylation information. Use when aligning WGBS, RRBS, or other bisulfite-converted sequencing reads to a reference genome.
日本語の概要は準備中です。原文の説明を表示しています。
Reads, validates, and prepares CDISC SDTM and ADaM clinical trial data for analysis. Covers SDTM domain joins (DM, AE, EX, VS, LB, DS), ADaM architecture (ADSL, BDS, OCCDS, ADTTE) with traceability, treatment-emergent AE conventions, baseline derivation, SUPPQUAL/NSV handling, Define-XML 2.1, and Pinnacle 21 / CORE validation. Use when working with clinical trial datasets in CDISC SDTM/ADaM format, preparing analysis-ready data, or validating for regulatory submission.
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Selects informative features for biomarker discovery using Boruta all-relevant selection, mRMR minimum redundancy, and LASSO regularization. Use when identifying biomarkers from high-dimensional omics data.
日本語の概要は準備中です。原文の説明を表示しています。
Create, manipulate, and convert bedGraph files for genome browser visualization. Covers bedGraph format, conversion to/from bigWig, normalization, and signal processing. Use when handling coverage and signal tracks from ChIP-seq, ATAC-seq, or RNA-seq.
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Designs Bayesian clinical trials including Phase I dose-finding (BOIN, CRM, EWOC, mTPI-2), meta-analytic-predictive (MAP) priors with robust mixtures for external data borrowing, EXNEX for basket trials, hierarchical models for safety AE (Berry-Berry), Bayesian platform trials (I-SPY 2, GBM AGILE, REMAP-CAP), and posterior probability stopping rules. Covers FDA Bayesian Devices Guidance (2010), FDA Bayesian Methodology in Drugs Draft (January 2026), BOIN Fit-for-Purpose qualification (December 2021), and Project Optimus dose-optimisation. Use when designing dose-finding studies, platform trials, or sensitivity analyses with informative priors.
日本語の概要は準備中です。原文の説明を表示しています。
Statistical testing for differentially abundant proteins between conditions. Covers preprocessing (log2 transformation, normalization), limma and DEqMS workflows with empirical Bayes moderation, fold change shrinkage for accurate effect size estimation, and Python alternatives. Use when identifying proteins with significant abundance changes between experimental groups.
日本語の概要は準備中です。原文の説明を表示しています。
Bulk-query Ensembl BioMart (and other BioMart instances) for cross-database ID mapping, gene/transcript/exon coordinates, and ortholog tables. Use when batch-converting Ensembl IDs to other namespaces (HGNC, RefSeq, UniProt, Entrez), pulling gene coordinate tables for thousands of genes, building ortholog wide-tables across species, or replacing slow Ensembl REST loops with one-shot bulk export. Encodes BioMart's XML query format, R biomaRt vs Python pybiomart trade-off, mart-vs-dataset hierarchy, and the URL endpoint that's BioMart-specific (separate from rest.ensembl.org).
日本語の概要は準備中です。原文の説明を表示しています。
Workflow for foundational sequence parsing, conversion, compression handling, and interval-aware file validation.
日本語の概要は準備中です。原文の説明を表示しています。
Solubility-optimized protein sequence design using SolubleMPNN. Use this skill when: (1) Designing for E. coli expression, (2) Optimizing solubility of designed proteins, (3) Reducing aggregation propensity, (4) Need high-yield expression, (5) Avoiding inclusion body formation. For standard design, use proteinmpnn. For ligand-aware design, use ligandmpnn.
日本語の概要は準備中です。原文の説明を表示しています。
Discover and invoke 1,676 deduplicated biomedical AI agent skills from the Awesome Bio Agent Skills repository (20 source repos, 15 categories). Use this skill as a router whenever a user needs a bioinformatics/biomedical task (genomics, transcriptomics, single-cell, proteomics, protein design, clinical, epigenomics, multi-omics, pathway, metagenomics, database queries, visualization, workflows): search the index, locate the best-matching skill, fetch its SKILL.md, and follow it.
日本語の概要は準備中です。原文の説明を表示しています。
Extract and analyze pricing information from competitor websites. Identifies pricing tiers, features per tier, billing models, and positioning relative to market alternatives. Ideal for competitive pricing strategy and market positioning research.
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Build targeted outreach lists with verified contact information, professional context, and conversation starters. Combines Apollo company data, LinkedIn profiling, and email verification to produce ready-to-send outreach campaigns for sales, PR, and partnership teams.
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Generate data-backed content briefs by analyzing Google SERP results, competitor content, keyword intent, and audience questions. Produces writer-ready briefs with target queries, required subtopics, recommended format, word count, and competitive differentiation angles.
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Research potential leads with verified contact information, professional backgrounds, company context, and social presence. Combines LinkedIn profiling, email verification, company enrichment, and social signals for sales-ready prospect intelligence.
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Generate content ideas backed by real audience demand data from Reddit questions, YouTube search gaps, Twitter discussions, and web search trends. Identifies proven topics, underserved questions, and content formats that outperform in your niche.
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Parse and extract structured content from PDFs, Word documents, and other file formats. Converts documents into clean, machine-readable text for analysis, summarization, data extraction, and content processing workflows.
日本語の概要は準備中です。原文の説明を表示しています。
Create, implement, or review video template frame glitch title work with format, accessibility, performance, and visual-verification controls. Use when the requested deliverable depends on video template frame glitch title.
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Analyze content performance across YouTube, TikTok, Instagram, and Twitter to identify what works. Compares engagement rates, format effectiveness, posting cadence impact, and audience response patterns across platforms for content strategy optimization.
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Create, implement, or review video template frame light leak cinema work with format, accessibility, performance, and visual-verification controls. Use when the requested deliverable depends on video template frame light leak cinema.
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Create, implement, or review oversized cursor work with format, accessibility, performance, and visual-verification controls. Use when the requested deliverable depends on oversized cursor.
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Create, implement, or review penpot ui/ux design work with format, accessibility, performance, and visual-verification controls. Use when the requested deliverable depends on penpot ui/ux design.
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Create, implement, or review plantuml ascii work with format, accessibility, performance, and visual-verification controls. Use when the requested deliverable depends on plantuml ascii.
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Create, implement, or review playground work with format, accessibility, performance, and visual-verification controls. Use when the requested deliverable depends on playground.
日本語の概要は準備中です。原文の説明を表示しています。