「md」の検索結果

INVOKE THIS SKILL when building ANY Deep Agents application. Covers create_deep_agent(), harness architecture, SKILL.md format, and configuration options.

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Generates an x-ray.md pre-audit report covering overview, enhanced threat model (protocol-type profiling, git-weighted attack surfaces, temporal risk analysis, composability dependency mapping), invariants, integrations, docs quality, test analysis, and developer/git history. Triggers on 'x-ray', 'audit readiness', 'readiness report', 'pre-audit report', 'prep this protocol', 'protocol prep', 'summarize this protocol'.

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Manages a Fabric SQL database item, the OLTP SQL Server engine, including running T-SQL through sqlcmd, temporal and vector similarity search, schema and sys.tables inspection, dacpac deployment, and Query Store, blocked sessions and regressed-plan investigation. Use for any query or change against a SQL database item. Warehouse, lakehouse SQL endpoint and mirrored items belong to sqldw-cli.

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Create, structure, and package agent skills. Use when designing new skills, updating existing skills, or helping users build skills with scripts, references, and assets. Triggers on requests to create skills, write SKILL.md files, or structure skill directories.

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The intake stage of a Meta ad harness. Researches the brand first, states what it assumes, and asks only what it cannot infer and what would change money, claims or legal exposure if guessed wrong — at most four questions a turn, in plain business language. Writes the brand's stable facts (ads/brand.md), the campaign brief, and a log of what was asked vs assumed. Use it when someone wants to run Meta ads and the brand's ad facts are not yet recorded.

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QC gate for a generated static ad image — verify the file opens, matches the requested dimensions, shows the correct product/subject (right shape, colour, label, logo), and has no garbled text or severe artifacts. Records pass/fail/needs-human in verification.md. Used as the final check in the static ad remix flow before shipping.

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Assemble the FREE steps of the flat-vector-explainer video format — a flat-illustration host character (who, where, tone, voice and music come from the recipe choices) walks a countable N-step product routine, one step per beat, and Remotion composites every chip/numeral/tagline/slate/CTA as an animated DOM overlay ON TOP of the Kling i2v character clips (text is NEVER baked into a keyframe — i2v warps type), the closing 'N products' grid is a PIL composite of the REAL product photos (not AI), full-sentence VO drives word-by-word burned captions over a VO-forward music bed, and the ~50s animated silent master is re-cut to a 30s deliverable FROM the animated master (never a static intermediate). Documentation-grade — ships config.example.json + PIPELINE.md + a README of the free assembly; the paid gen steps (keyframes, Kling i2v, VO, music) are separate capabilities the recipe orchestrates. Use for the flat-vector-explainer format.

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创建、设计、修改、重构和验证 AgentDock Skill 时使用；负责 Agent Skills 兼容的 SKILL.md、可移植核心、引用、辅助脚本、测试、安全边界和本地真实验证。

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Modern .NET project structure including .slnx solution format, Directory.Build.props, central package management, SourceLink, version management with RELEASE_NOTES.md, and SDK pinning with global.json.

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Extracts cfDNA fragmentomics features (DELFI genome-wide short/long ratios, WPS nucleosome positioning, Griffin GC-corrected accessibility profiles, end-motifs/MDS, OCF) for cancer detection and tissue-of-origin from plasma WGS. Centers on the nuclease-footprint reframe (every feature re-reads one nucleosome object), the mandatory GC correction, and the cross-protocol non-comparability that breaks naive classifiers. Runs FinaleToolkit (real CLI/Python, MIT) and the Griffin Snakemake pipeline; DELFI is a method, not a package. Use when deriving fragment-based signal from cfDNA, choosing a feature family for detection vs subtyping, or diagnosing why a fragmentomic model failed validation.

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Assembles microbial-community sequencing into metagenome-assembled genomes (MAGs) with metaFlye (ONT), metaSPAdes/MEGAHIT (Illumina), and hifiasm-meta/metaMDBG (PacBio HiFi), then recovers genomes via multi-binner consolidation (MetaBAT2, MaxBin2, CONCOCT, SemiBin2, VAMB -> DAS_Tool) and QCs them against MIMAG with CheckM2, GUNC, and GTDB-Tk. Covers why a metagenome is not a genome (uneven coverage, micro-diversity, strain collapse to consensus), differential-coverage binning, co-assembly vs per-sample, the rRNA-operon collapse that fails short-read MAGs, and strain resolution with inStrain. Use when reconstructing genomes from a microbiome, soil, ocean, or gut community, recovering MAGs, or resolving strain-level variation.

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Download raw sequencing reads from NCBI SRA using sra-tools (prefetch, fasterq-dump, vdb-validate) or the ENA mirror. Use when pulling FASTQ for SRR/ERR/DRR accessions, deciding between SRA-direct, ENA mirror, or AWS/GCP cloud mirror (STRIDES), handling --include-technical for 10x and other single-cell records, validating with MD5/vdb-validate, navigating SRR/SRX/SRS/SRP/PRJNA hierarchy, or finding accessions via pysradb. Encodes SRA cloud-egress economics, the fasterq-dump uncompressed-scratch trap, and the --max-size default that silently truncates large prefetches.

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Build local BLAST databases and run searches using NCBI BLAST+ command-line tools. Use when running >50 queries, building custom databases with -parse_seqids and -taxid, downloading prebuilt NCBI databases via update_blastdb.pl, choosing -task variants (megablast/dc-megablast/blastn/blastn-short), tuning soft/hard masking, scaling threads, or extracting hits with blastdbcmd. Encodes BLAST v5 vs v4 database format, taxonomy filtering, makeblastdb pitfalls.

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Find cross-database references between NCBI databases using Biopython Bio.Entrez (ELink). Use when navigating gene to protein/structure, sequence to publication, PubMed to GEO, BioProject to SRA runs, or discovering all link relationships for a record. Covers linkname semantics, cmd= variants, asymmetric link warnings, neighbor_history for >200 input IDs, and per-database link tables.

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Analyzes species-environment relationships with constrained ordination (CCA, RDA, db-RDA), variance partitioning, indicator species (indicspecies IndVal.g group-equalized), PERMANOVA paired MANDATORILY with PERMDISP (Anderson & Walsh 2013; dispersion confounds centroid tests), Joint Species Distribution Models (HMSC, sjSDM, gjam) with explicit rejection of "residual covariance equals biotic interaction", phylogenetic community ecology (SES_MPD/MNTD), trait-environment via RLQ + fourth-corner with corrected modeltype=6 (Dray 2014), bipartite network metrics (NODF, modularity) with curveball null (Strona 2014), and Mantel-test replacements (dbRDA, GDM) for spatial data. Use when testing how environmental gradients structure communities, identifying habitat indicator taxa, partitioning variance among predictors, deciding whether PERMANOVA significance is location vs dispersion, picking among HMSC/sjSDM/gjam, or replacing Mantel tests for landscape data.

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Designs PROTACs, molecular glues, and bivalent degraders with explicit handling of E3 ligase choice (VHL, CRBN, IAP, MDM2, KEAP1), linker design (length, composition, rigidity), ternary complex prediction (PRosettaC, DeepTernary, AlphaFold3), cooperativity (alpha), DC50 / Dmax characterization, hook effect, and prediction-experiment reconciliation. Use when designing targeted protein degraders, planning linker SAR, predicting ternary complex stability, or building generative degrader workflows.

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Performs alchemical free-energy calculations including relative binding free energy (RBFE / FEP+) and absolute binding free energy (ABFE) via OpenFE, FEP+, GROMACS, AMBER pmemd, and OpenMM with explicit lambda scheduling, soft-core potentials, MBAR/BAR analysis, cycle-closure validation, and protocol-appropriate enhanced sampling. Compares ML alternatives (Boltz-2 affinity, DeepDock). Use when ranking analogs by binding affinity beyond docking accuracy, performing prospective lead optimization, or validating SAR predictions.

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Detects aberrant splicing in single rare-disease patients vs a control panel using FRASER 2.0 (Bioconductor; Beta-binomial autoencoder on Intron Jaccard Index, default delta cutoff 0.1, q hyperparameter), OUTRIDER (gene-level outlier expression via autoencoder denoising), LeafcutterMD (Dirichlet-multinomial outlier mode of LeafCutter for annotation-free junctions), and DROP (Snakemake pipeline integrating FRASER2 + OUTRIDER + monoallelic expression for clinical diagnostics). The statistical model is fundamentally different from differential splicing — single-sample-vs-cohort outlier detection rather than two-group comparison. Standard tool in EU rare-disease (Solve-RD) and NIH UDN programs. Use when applying RNA-seq to undiagnosed Mendelian disease, validating predicted splice variants in clinical samples, or detecting cryptic splicing in disease tissue.

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Use this skill whenever the user wants to create or improve a presentation for an academic context — conference papers, seminar talks, thesis defenses, grant briefings, lab meetings, invited lectures, or any presentation where the audience will evaluate reasoning and evidence. Triggers include: 'conference talk', 'seminar slides', 'thesis defense', 'research presentation', 'academic deck', 'academic presentation'. Also triggers when the user asks to 'make slides' in combination with academic content (e.g., 'make slides for my paper on X', 'create a presentation for my dissertation defense', 'build a deck for my grant proposal'). This skill governs CONTENT and STRUCTURE decisions. For the technical work of creating or editing the .pptx file itself, also read the pptx SKILL.md.

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Trigger when: (1) User wants to create an educational/explainer video, (2) User has a vague concept they want visualized, (3) User mentions "3b1b style" or "explain like 3Blue1Brown", (4) User wants to plan a Manim video or animation sequence, (5) User asks to "compose" or "plan" a math/science visualization. Transforms vague video ideas into detailed scene-by-scene plans (scenes.md). Conducts research, asks clarifying questions about audience/scope/focus, and outputs comprehensive scene specifications ready for implementation with ManimCE or ManimGL. Use this BEFORE writing any Manim code. This skill plans the video; use manimce-best-practices or manimgl-best-practices for implementation.

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Extract features from 1D signals using signalTimeFeatureExtractor, signalFrequencyFeatureExtractor, and signalTimeFrequencyFeatureExtractor. Use when computing time-domain features (amplitude, energy, shape factors), frequency-domain features (spectral location, power, bandwidth, PSD), or time-frequency features (spectral shape, instantaneous, ridges, wavelet, EMD-derived) on a per-frame basis. Use when the user asks to "extract features", "compute spectral features", "build a feature table for a classifier", "get per-frame statistics", "run feature extraction on this signal", or describes a vibration / biosignal / radar / sensor signal needing features for downstream ML or analysis. Includes optional GPU acceleration via canUseGPU and gpuArray. Does not cover filter design, audio-specific feature extraction (use audioFeatureExtractor in Audio Toolbox instead), batch dataset orchestration, or 2D / image features.

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Guide users or agents to the correct MATLAB tool for processing large tabular data in file-based formats (CSV, Parquet, delimited text, spreadsheets, MDF) that may not fit in memory. Use when a user or agent mentions large files, big data, out-of-memory errors, OOM, scaling up, tall arrays, datastores, or needs to process multiple tabular files. Covers the decision between datastore + tall, datastore + transform, and parallel execution. Also use when a user or agent has working in-memory code (readtable, parquetread) that runs out of memory and needs a migration path. Also covers building custom datastore classes for proprietary or non-standard formats — use when the task requires subclassing matlab.io.Datastore, implementing a custom reader, building an extensible datastore, or integrating a new file format with tall arrays or parallel computing. Do NOT use for MAT files (use matfile instead).

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Speed up local parfor, parfeval, or spmd by switching to a thread-based parallel pool. Trigger when a user describes slow or disappointing local parallel performance, even if they don't mention threads. Symptoms: parfor on a laptop/workstation is slower than expected or "only slightly faster than for"; parfor scales poorly with the number of workers; ticBytes/tocBytes, the Parallel Pool dashboard, mpiprofile, or system tools show large per-worker data transfer; large broadcast variables or sliced inputs make iterations slow; opening a process pool dominates a short workload; user mentions serialisation or data transfer overhead. Also trigger on any question about whether code or a function works on a thread pool. For non-pool MATLAB performance work (vectorisation, preallocation, profiling), defer to matlab-optimize-performance.

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Unified skill for all MATLAB and Simulink report generation tasks. Covers report generation, PDF report, document generation, mlreportgen, Report Generator, template, TitlePage, Chapter, multipage HTML, HTMLPage, html-multipage, custom reporter, customizeReporter, template hole, page header, page border, company style package, branded reporters, buildTemplates, Simulink report, model documentation, slreportgen, block diagram report, model report, subsystem documentation, SystemDiagramFinder, SystemIO, ExecutionOrder, LookupTable, template style, page footer, TemplateSrc, report package, table variants, multiple HTML pages, PDF report generation, Word report, DOM API, FormalTable, BaseTable, Figure, FormalImage, Section.

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