「reference」の検索結果

Drug-combination synergy analysis — quantify whether two drugs together are synergistic, additive, or antagonistic using the standard reference models (Bliss independence, HSA / highest single agent, Loewe additivity, ZIP, and the Chou-Talalay Combination Index). Use when you have measured single-drug and combination effects (inhibition/viability) and need a synergy score. Explains which model to use, what data each one needs, and how to read the score. NOT for looking up pre-computed synergy in a database (use the SYNERGxDB tool / cell-line-profiling skill).

日本語の概要は準備中です。原文の説明を表示しています。

Enzyme kinetics — Michaelis-Menten Km, Vmax, kcat (turnover), and kcat/Km (catalytic efficiency / specificity constant) from substrate-velocity data, plus inhibition-mechanism analysis (competitive / uncompetitive / non-competitive, Ki). Fits the MM equation by nonlinear regression (and reports Lineweaver-Burk for reference). Use when you have substrate concentrations and initial reaction velocities and need kinetic parameters or to classify an inhibitor. NOT for BRENDA database lookups of published constants (use the BRENDA tools).

日本語の概要は準備中です。原文の説明を表示しています。

Experimental data: discover and acquire raw or near-raw measurements, sample-level observations, and reusable datasets from sequencing, transcriptomics, single-cell, perturbation, proteomics, metabolomics, genomics, and structural-biology repositories. Use for study or sample metadata, matrices, reads, spectra, experimental structures, and downloadable research artifacts—not curated database assertions or reference marker collections.

日本語の概要は準備中です。原文の説明を表示しています。

Generates 3D conformer ensembles using RDKit ETKDGv3 with knowledge-enhanced distance geometry, MMFF94/UFF force-field optimization, CREST + GFN2-xTB semi-empirical refinement, and macrocycle-aware torsion preferences. Provides explicit decision rules for single vs ensemble conformer use, RMSD pruning, energy windows, conformer count, and force-field choice. Use when preparing 3D ligands for docking, generating descriptor input for 3D QSAR, or sampling macrocycle/peptide conformational ensembles.

日本語の概要は準備中です。原文の説明を表示しています。

Turns untargeted LC-MS/MS features (m/z, RT, MS/MS) into confidence-stratified metabolite annotations using spectral-library matching (matchms), in-silico tools (SIRIUS/CSI:FingerID, MetFrag) and molecular networking, and assigns a defensible MSI/Schymanski confidence level to each. Use when naming detected features, scoring MS/MS against a reference library, running SIRIUS, or deciding what confidence level an evidence set actually supports. For upstream feature extraction see metabolomics/xcms-preprocessing and metabolomics/msdial-preprocessing; for downstream enrichment that must respect these levels see metabolomics/pathway-mapping; for lipid-specific structural annotation see metabolomics/lipidomics.

日本語の概要は準備中です。原文の説明を表示しています。

Maps metabolomics results to biological pathways via over-representation (ORA), metabolite-set enrichment (MSEA/QEA), mummichog/PSEA on raw m/z peaks, and network-diffusion enrichment (FELLA), with correct background-set construction and honest interpretive ceilings. Use when interpreting differential metabolites or an untargeted LC-MS feature table in pathway context, choosing ORA vs MSEA vs mummichog vs topology, or setting the reference/background set. For annotation confidence levels feeding ORA see metabolomics/metabolite-annotation; for gene-set concepts see pathway-analysis/go-enrichment and pathway-analysis/gsea; for joint gene+metabolite pathways see multi-omics-integration/mofa-integration.

日本語の概要は準備中です。原文の説明を表示しています。

Investigate errors, incidents, or product ideas using both internet research and repo-wide codebase research, then propose a concrete changeset plan with clarifying questions before any implementation. Use when a user asks to investigate, root-cause, or plan changes, or when an Issue or PR is referenced and needs a plan.

日本語の概要は準備中です。原文の説明を表示しています。

Use to process automated PR review feedback (Copilot, Greptile, Codex) and iterate until all AI threads are addressed, checks are green, and the PR is merge-ready. Trigger when the user says "address review feedback", "recycle reviews", or references an automated reviewer.

日本語の概要は準備中です。原文の説明を表示しています。

Surface current and recent Stellar Community Fund (SCF) round activity. Use when a user says "current SCF round", "what's happening with SCF", "active SCF submissions", "should I apply to SCF this round", "SCF deadline", "who is applying to SCF right now", "SCF round status", or "show me this round's submissions". Fetches live data from communityfund.stellar.org and cross-references with the LumenLoop ecosystem DB to flag repeat builders and category trends.

日本語の概要は準備中です。原文の説明を表示しています。

Build localized client XAML controls with correct lifecycle, culture refresh, resource references, ownership, and validation.

日本語の概要は準備中です。原文の説明を表示しています。

Maintain entity references, ownership links, target relationships, deletion cleanup, and network-safe relation state.

日本語の概要は準備中です。原文の説明を表示しています。

Edit maps, map prototypes, grids, placements, entity references, and serialized compatibility safely.

日本語の概要は準備中です。原文の説明を表示しています。

Auto-detect project tech stack and generate stack-specific references for domain skills

日本語の概要は準備中です。原文の説明を表示しています。

When the user wants to create or update their product marketing context document. Also use when the user mentions 'product context,' 'marketing context,' 'set up context,' 'positioning,' or wants to avoid repeating foundational information across marketing tasks. Creates `.claude/product-marketing-context.md` that other marketing skills reference.

日本語の概要は準備中です。原文の説明を表示しています。

Check documentation references, sync docs to code changes, and detect translation drift. Use for documentation maintenance in a repository.

日本語の概要は準備中です。原文の説明を表示しています。

Extract applicant details, employment history, income, and references from a rental application form into structured JSON for tenant screening.

日本語の概要は準備中です。原文の説明を表示しています。

Extract timekeeper entries, disbursements, matter references, and billing summaries from law firm invoices.

日本語の概要は準備中です。原文の説明を表示しています。

Extract shipper, consignee, order references, carton lines, weights, and package totals from packing lists.

日本語の概要は準備中です。原文の説明を表示しています。

Extract company information, submitted identity-document references, and beneficial ownership data from onboarding packets.

日本語の概要は準備中です。原文の説明を表示しています。

Extract carrier invoice, shipment references, rates, accessorials, taxes, and total charges from freight bills.

日本語の概要は準備中です。原文の説明を表示しています。

Create, migrate, improve, or debug detailed vehicle assets for CARLA using Blender and Unreal, including reference-based geometry, materials, wheels, physics, lights, and runtime validation. Use for vehicle asset authoring rather than ordinary traffic spawning or map decoration.

日本語の概要は準備中です。原文の説明を表示しています。

age file encryption reference — the modern, simple alternative to GPG. Covers key generation, X25519 encryption, SSH key support, passphrase mode, pipe patterns, SOPS integration, YubiKey plugins, and security considerations. By Filippo Valsorda.

日本語の概要は準備中です。原文の説明を表示しています。

Admin authentication and authorization system reference — login flow, JWT, TOTP, sessions, RBAC

日本語の概要は準備中です。原文の説明を表示しています。

Automated WCAG 2.1 AA accessibility testing with axe-core and Lighthouse CI. Auto-detects frontend framework (React, Next.js, Vue, Angular, Svelte, Astro, Flutter, React Native), discovers all routes and interactive components, installs Playwright + axe-core for page-level scanning and jest-axe/vitest-axe for component-level testing. Generates tests for color contrast (4.5:1), alt text, form labels, ARIA attributes, heading order, landmark regions, focus visibility, keyboard navigation (tab order, focus traps, modal focus management, skip-to-content), screen reader compatibility (aria-live regions, error announcements, toast notifications), and Flutter Semantics validation (48dp touch targets, semanticLabel). Reports violations by severity (critical, serious, moderate, minor) with WCAG criterion references. Use when adding a11y testing, auditing accessibility compliance, fixing contrast issues, or validating keyboard and screen reader support.

日本語の概要は準備中です。原文の説明を表示しています。