「alternatives」の検索結果

Performs alchemical free-energy calculations including relative binding free energy (RBFE / FEP+) and absolute binding free energy (ABFE) via OpenFE, FEP+, GROMACS, AMBER pmemd, and OpenMM with explicit lambda window scheduling, soft-core potentials, REST2 enhanced sampling, MBAR/BAR analysis, and cycle closure validation. Compares ML alternatives (Boltz-2 affinity, DeepDock). Use when ranking analogs by binding affinity beyond docking accuracy, performing prospective lead optimization, or validating SAR predictions.

日本語の概要は準備中です。原文の説明を表示しています。

Use this skill when the user's prompt requires (1) researching a topic across multiple sources, comparing options or alternatives, analyzing trends or history, understanding markets or industries, or reviewing literature or studies and (2) synthesizing that research into a comprehensive, narrative report. If you're planning to search the web or internal knowledge bases, consider using this skill. This skill coordinates research subagents, so use it only when you have a tool for spawning subagents (the Agent or Task tool); otherwise, research the question directly.

日本語の概要は準備中です。原文の説明を表示しています。

投行 strategic-alternatives pitch book — trading comps / precedent transactions / valuation football field / DCF sensitivity / 战略选项矩阵 / 流程建议。改写 assets/template.html 保留 IB-specific chrome / disclosure bands / source labels。用于 Board / sell-side 讨论材料。**不是** VC 融资 deck。工作流改自 Anthropic financial-services Pitch Agent (Apache-2.0)。

日本語の概要は準備中です。原文の説明を表示しています。

Recommend context-appropriate QA tools while preserving observed availability, constraints, and safer alternatives.

日本語の概要は準備中です。原文の説明を表示しています。

Build accessible web applications following WCAG 2.1/2.2 guidelines with proper semantic HTML, ARIA attributes, keyboard navigation, screen reader support, and inclusive design. Use when implementing ARIA labels and roles, ensuring keyboard navigation, supporting screen readers, providing text alternatives for images, managing focus, creating accessible forms, building inclusive UI components, testing with accessibility tools, meeting WCAG compliance levels, or designing for users with disabilities.

日本語の概要は準備中です。原文の説明を表示しています。

Facilitate ideation, explore alternatives, and refine concepts through structured brainstorming techniques before implementation. Use when starting new projects, designing features, exploring solutions, evaluating tradeoffs, challenging assumptions, generating creative ideas, planning architecture, or refining rough concepts into detailed designs.

日本語の概要は準備中です。原文の説明を表示しています。

When the user wants to create sales collateral, pitch decks, one-pagers, objection handling docs, or demo scripts. Also use when the user mentions 'sales deck,' 'pitch deck,' 'one-pager,' 'leave-behind,' 'objection handling,' 'deal-specific ROI analysis,' 'demo script,' 'talk track,' 'sales playbook,' 'proposal template,' 'buyer persona card,' 'help my sales team,' 'sales materials,' or 'what should I give my sales reps.' Use this for any document or asset that helps a sales team close deals. For competitor comparison pages and battle cards, see competitor-alternatives. For marketing website copy, see copywriting. For cold outreach emails, see cold-email.

日本語の概要は準備中です。原文の説明を表示しています。

Score an unbuilt business idea on desirability, viability, feasibility, distribution wedge, why-now, founder-market-fit, market size, alternatives, defensibility, capital intensity, and regulatory/ethical risk — and return a GO / ITERATE / KILL verdict with kill criteria and a next kill test. Load when the user asks to evaluate a business idea, score a startup idea, screen an idea, decide whether to pursue this venture, do an idea review, or says "is this a good business idea", "should I build this", "evaluate this startup", "screen this idea", "go/no-go on this idea", "kill or pursue". Sub-skill of `venture-exploration`. Calls `fermi` for sizing, `assumption-mapping` for hidden beliefs, optional `pre-mortem` / `adversarial-hat` for high-stakes ideas. Does NOT evaluate built products — for that use `reality-check`.

日本語の概要は準備中です。原文の説明を表示しています。

Record durable project decisions with rationale, alternatives, assumptions, status, and revisit triggers. Load when the user says record this decision, we decided, decision log, why did we choose, revisit this later, or capture architectural/process rationale.

日本語の概要は準備中です。原文の説明を表示しています。

Deprecate APIs, features, or systems safely — announce, migrate consumers, sunset on a timeline, and document alternatives. Load when removing an old API, migrating users between implementations, sunsetting a feature, or the user asks about deprecation policy, migration guides, or breaking changes. Not for deleting dead code with zero consumers (use code-simplification). Distinct from meta `deprecate-skill` (skill library retirement).

日本語の概要は準備中です。原文の説明を表示しています。

Designs donor/repair templates for precise CRISPR knock-ins -- choosing the format (ssODN, long-ssDNA/Easi-CRISPR, dsDNA/plasmid, AAV6), sizing homology arms, placing the cut within ~10 bp of the edit, and adding a mandatory codon-checked blocking (PAM/seed) mutation so the edited allele is not re-cut. Frames the HDR-vs-NHEJ-vs-MMEJ pathway competition, the MMEJ (PITCh) and homology-independent (HITI/HMEJ) alternatives for post-mitotic cells, ssODN strand/asymmetry choice, phosphorothioate end-protection, and ranked HDR enhancers. Use when designing a donor for a point mutation, epitope/fluorophore tag, allele replacement, or knock-in, or when HDR efficiency is low. Guide design and base/prime editing are separate skills.

日本語の概要は準備中です。原文の説明を表示しています。

Differential abundance (DA) and differential state (DS) analysis for flow and mass cytometry - tests which cell populations change in frequency or marker expression between conditions using diffcyt (edgeR/voom/GLMM for DA, limma/LMM for DS), with cydar, CITRUS, and compositional methods (sccomp, scCODA, DCATS) as alternatives. Covers the sample-is-the-experimental-unit principle, design/contrast and mixed-model formulas, compositionality of cluster proportions, and FDR across clusters. Use when comparing populations between groups, choosing a DA method, handling paired/batch designs, or deciding whether compositional correction is needed.

日本語の概要は準備中です。原文の説明を表示しています。

Corrects the gene-independent copy-number artifact in CRISPR-Cas9 screens (Aguirre 2016 / Munoz 2016 Cancer Discov) where amplified loci appear essential from DNA-damage burden of simultaneous cuts. Covers the p53-dependent G2-arrest mechanism, CRISPRcleanR (Iorio 2018) unsupervised pre-hoc correction, CERES (Meyers 2017) joint CN + gene-effect model, Chronos (Dempster 2021) DepMap-standard population-dynamics + CN model with lowest residual bias, the decision tree by data availability, the Spearman LFC-vs-CN diagnostic, focal-amplification examples (ERBB2 in HER2+, MYC in colorectal, FGFR1 in head and neck), and CRISPRi/a alternatives that bypass the artifact. Use when screening cancer cell lines, diagnosing essentiality at amplified loci, choosing CRISPRcleanR / CERES / Chronos, deciding whether CN correction is needed before MAGeCK / BAGEL2 / drugZ, or switching from Cas9 to CRISPRi.

日本語の概要は準備中です。原文の説明を表示しています。

Performs alchemical free-energy calculations including relative binding free energy (RBFE / FEP+) and absolute binding free energy (ABFE) via OpenFE, FEP+, GROMACS, AMBER pmemd, and OpenMM with explicit lambda window scheduling, soft-core potentials, REST2 enhanced sampling, MBAR/BAR analysis, and cycle closure validation. Compares ML alternatives (Boltz-2 affinity, DeepDock). Use when ranking analogs by binding affinity beyond docking accuracy, performing prospective lead optimization, or validating SAR predictions.

日本語の概要は準備中です。原文の説明を表示しています。

Analyze an idea, proposal, change, claim, or decision from facts through problem, value, mechanism, consequences, evidence, alternatives, and action. Use when the user asks what something is for, why it matters, whether it is worth doing, what impact it has, or how to decide. Do not use for simple factual lookup or straightforward execution.

日本語の概要は準備中です。原文の説明を表示しています。

When the user wants to create sales collateral, pitch decks, one-pagers, objection handling docs, or demo scripts. Also use when the user mentions 'sales deck,' 'pitch deck,' 'one-pager,' 'leave-behind,' 'objection handling,' 'deal-specific ROI analysis,' 'demo script,' 'talk track,' 'sales playbook,' 'proposal template,' 'buyer persona card,' 'help my sales team,' 'sales materials,' or 'what should I give my sales reps.' Use this for any document or asset that helps a sales team close deals. For competitor comparison pages and battle cards, see competitor-alternatives. For marketing website copy, see copywriting. For cold outreach emails, see cold-email.

日本語の概要は準備中です。原文の説明を表示しています。

Create distinctive React and Tailwind interfaces with strong hierarchy and polished implementation. Use when building or redesigning pages, flows, or components, or when another better-react-web-ui skill needs shared design guidance. Pair with add-ui for direct implementation or requested alternatives.

日本語の概要は準備中です。原文の説明を表示しています。

Implement or refine UI motion, gestures, and transitions. Use when the user asks for animation, hover or press motion, drag or swipe behavior, transition timing, or reduced-motion alternatives. Mentioning a drawer, toast, or hover state alone does not request animation.

日本語の概要は準備中です。原文の説明を表示しています。

Create or redesign React and Tailwind sections, pages, flows, shells, and components. Use when the user wants new UI or a redesign. Implement one requested or selected direction directly, or generate distinct alternatives when the user asks to compare options.

日本語の概要は準備中です。原文の説明を表示しています。

Create a Beads-first refactor plan through detailed interview, repo verification, alternatives, scope boundaries, testing decisions, and tiny working increments. Use when the user wants to plan a refactor, write a refactoring RFC, or turn a risky change into safe incremental work.

日本語の概要は準備中です。原文の説明を表示しています。

Complete guide for xUnit test output and logging. Use when you need to implement test output, diagnostic logging, or ILogger alternatives in xUnit tests. Covers ITestOutputHelper injection, AbstractLogger pattern, structured output design. Includes XUnitLogger, CompositeLogger, performance test diagnostic tool implementations. Keywords: ITestOutputHelper, ILogger testing, test output xunit, test output, test logging, AbstractLogger, XUnitLogger, CompositeLogger, testOutputHelper.WriteLine, test diagnostics, logger mock, test log, structured output, Received().Log

日本語の概要は準備中です。原文の説明を表示しています。

Use for non-trivial, design-bearing, or architecture-affecting work before execution planning. Creates or updates a versioned spec under planning/specs/active/ with design intent, alternatives, risks, and acceptance criteria.

日本語の概要は準備中です。原文の説明を表示しています。

Use for non-trivial feature, behavior, workflow, or architecture work before execution planning. Create or update a versioned spec under planning/specs/active with design intent, alternatives, risks, acceptance criteria, and planning readiness.

日本語の概要は準備中です。原文の説明を表示しています。

Market positioning strategy using the April Dunford framework, enriched with JTBD discovery, Moore positioning statement, and Neumeier's Onliness Test. Produces a complete positioning document, positioning statement, competitive alternatives map, and market category analysis. Use when the user wants to define or refine their market positioning, find their unique position, differentiate from competitors, craft a positioning statement, choose a market category, or figure out "how should we position this product." Triggers for "positioning", "how to position", "market position", "differentiation strategy", "positioning statement", "competitive positioning", "category strategy", "where do we fit in the market", "how are we different", "unique value proposition", or any request to define, sharpen, or rethink positioning. Works standalone — no prior startup-design or startup-competitors session needed, but leverages their output if available.

日本語の概要は準備中です。原文の説明を表示しています。