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概要と使いどころ
Identify tumor neoantigens from somatic mutations using pVACtools for personalized cancer immunotherapy. Predict mutant peptides that bind patient HLA and may elicit T-cell responses. Use when identifying vaccine targets or checkpoint inhibitor response biomarkers from tumor sequencing data.
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Score and prioritize neoantigens and epitopes for immunogenicity using multi-factor models combining MHC binding, processing, expression, and sequence features. Rank candidates for vaccine design. Use when prioritizing epitopes for vaccine development or identifying the most immunogenic neoantigens.
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Targeted metabolomics analysis using MRM/SRM with standard curves. Covers absolute quantification, method validation, and quality assessment. Use when quantifying specific metabolites using calibration curves and internal standards.
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Predict TCR-epitope specificity using ERGO-II and deep learning models for T-cell receptor antigen recognition. Match TCRs to their cognate epitopes or predict TCR targets. Use when analyzing TCR repertoire specificity or identifying antigen-reactive T-cells.
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Search arXiv physics, math, and computer science preprints using natural language queries. Powered by Valyu semantic search.
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Stops defensive writing across the entire paper lifecycle — writing, revising, cutting, and organizing experiments. Treats the paper as a press conference, not a project summary, lab log, or self-audit: identify the single most publishable strength of the work and build the most favorable, complete, and persuasive narrative around it. Never present everything evenly, never volunteer weakness, never write an experiment diary, never attack the paper on the reviewer's behalf. Triggers: polish my paper, revise manuscript, write abstract, write introduction, write conclusion, shorten paper, rebuttal, respond to reviewers, organize experiments, defensive writing, AI-flavored academic writing.
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论文写作、修改、压缩和实验组织全流程中阻止【防御性写作】。把论文视为一场学术发布会， 而不是项目总结、实验日志或自我审查报告：识别这项工作最值得发表的价值，围绕它建立 最有利、最完整、最有说服力的叙事。不平均展示、不主动示弱、不写实验流水账、不替审稿人 攻击自己。 触发词：论文润色、论文修改、写摘要、写引言、写结论、压缩论文、rebuttal、回复审稿意见、 组织实验、论文AI味、防御性写作、心虚。
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Use when the user asks to "package our proof points", "build reusable stat cards and case snippets", or "put proof where each pillar makes its claim"; turns claims-ledger-approved proofs into reusable proof modules — stat cards, case snippets, testimonial blocks, comparison proofs — each pinned to a message-house pillar and the ledger claim ID it substantiates, and flags any pillar making a claim with no approved proof behind it. Never adjudicates a proof: unverified or ledger-absent proofs are marked '[needs source]' and routed to the claims candidates. Not for adjudicating or substantiating claims — use offer-claims-registry; not for fabricating a benchmark to fill a gap — a missing proof is flagged, not invented; not for scoring narrative quality — use narrative-quality-auditor. 证据模块/证据卡/客户案例/主张对齐
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Guides migration, provisioning, search, log-analytics, trace-analytics, and Agentic AI Assistant workflows for Amazon OpenSearch Service and Serverless across six capabilities — migration (Solr/ES/self-managed into AOS/AOSS, schema/query translation, sizing, cutover); provisioning (domain + AOSS lifecycle, upgrades, FGAC, monitoring); search (vector / semantic / hybrid / RAG with Bedrock); log-analytics (PPL, OSI, anomaly detection, Dashboards); trace-analytics (OTel spans, service maps, Data Prepper); ai-assistant (natural language data exploration, incident investigation, root cause analysis). Triggers on OpenSearch, AOS, AOSS, Elasticsearch, Solr, vector/k-NN/semantic/hybrid search, RAG, log analytics, PPL, trace analytics, ISM, FAISS, HNSW, Migration Assistant, UltraWarm, OR1, query my data, analyze logs, investigate errors, root cause analysis.
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Identify and avoid common Claude API anti-patterns and integration mistakes. Use when reviewing code, onboarding developers, or debugging subtle issues with Anthropic integrations. Trigger with phrases like "anthropic pitfalls", "claude anti-patterns", "claude mistakes", "anthropic common issues", "claude gotchas".
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Anti-debugging detection and bypass playbook. Use when reversing protected binaries that detect debuggers via ptrace, PEB flags, timing checks, or signal/exception handlers on Linux and Windows.
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Designs the warehouse and semantic layer — source-to-mart structure, dimensional modeling, grain, slowly changing dimensions, and the metric layer analytics reads through. Use this to design or restructure a warehouse, model a new source, decide on grain or table structure, build a semantic or metric layer, or diagnose why queries are slow, wrong, or impossible to write.
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Use semantic consistency auditor for academic writing workflows that need structured execution, explicit assumptions, and clear output boundaries.
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Use this skill to implement hybrid search combining BM25 keyword search with semantic vector search using Reciprocal Rank Fusion (RRF). **Trigger when user asks to:** - Combine keyword and semantic search - Implement hybrid search or multi-modal retrieval - Use BM25/pg_textsearch with pgvector together - Implement RRF (Reciprocal Rank Fusion) for search - Build search that handles both exact terms and meaning **Keywords:** hybrid search, BM25, pg_textsearch, RRF, reciprocal rank fusion, keyword search, full-text search, reranking, cross-encoder Covers: pg_textsearch BM25 index setup, parallel query patterns, client-side RRF fusion (Python/TypeScript), weighting strategies, and optional ML reranking.
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Use this skill for any PostgreSQL database work — table design, indexing, data types, constraints, extensions (pgvector, PostGIS, TimescaleDB), search, and migrations. **Trigger when user asks to:** - Explore an existing PostgreSQL database to understand its objects and relationships - Design or modify PostgreSQL tables, schemas, or data models - Choose data types, constraints, indexes, or partitioning strategies - Work with pgvector embeddings, semantic search, or RAG - Set up full-text search, hybrid search, or BM25 ranking - Use PostGIS for spatial/geographic data - Set up TimescaleDB hypertables for time-series data - Migrate tables to hypertables or evaluate migration candidates - Plan or execute safe schema migrations with zero downtime **Keywords:** PostgreSQL, Postgres, SQL, schema, table design, indexes, constraints, pgvector, PostGIS, TimescaleDB, hypertable, semantic search, hybrid search, BM25, time-series, migration
日本語の概要は準備中です。原文の説明を表示しています。
Microsoft Semantic Kernel planner and plugin setup for orchestrated AI
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Implement efficient similarity search with vector databases. Use when building semantic search, implementing nearest neighbor queries, or optimizing retrieval performance.
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Analyzes keyword usage in provided content, calculates density, suggests semantic variations and LSI keywords based on the topic. Prevents over-optimization. Use PROACTIVELY for content optimization.
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Master Python 3.12+ with modern features, async programming, performance optimization, and production-ready practices. Expert in the latest Python ecosystem including uv, ruff, pydantic, and FastAPI. Use PROACTIVELY for Python development, optimization, or advanced Python patterns.
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Build Retrieval-Augmented Generation (RAG) systems for LLM applications with vector databases and semantic search. Use when implementing knowledge-grounded AI, building document Q&A systems, or integrating LLMs with external knowledge bases.
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Build financial models, backtest trading strategies, and analyze market data. Implements risk metrics, portfolio optimization, and statistical arbitrage. Use PROACTIVELY for quantitative finance, trading algorithms, or risk analysis.
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Build high-performance async APIs with FastAPI, SQLAlchemy 2.0, and Pydantic V2. Master microservices, WebSockets, and modern Python async patterns. Use PROACTIVELY for FastAPI development, async optimization, or API architecture.
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Select and optimize embedding models for semantic search and RAG applications. Use when choosing embedding models, implementing chunking strategies, or optimizing embedding quality for specific domains.
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You are a technical debt expert specializing in identifying, quantifying, and prioritizing technical debt in software projects. Analyze the codebase to uncover debt, assess its impact, and create acti
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