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概要と使いどころ
Use when the user wants to find creators, influencers, affiliates, or social accounts in a niche for outreach, partnerships, sponsorships, UGC, seeding, or competitive research. Produces scored prospect lists from public social data.
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Azure Key Vault SDK for Python. Use for secrets, keys, and certificates management with secure storage. Triggers: "key vault", "SecretClient", "KeyClient", "CertificateClient", "secrets", "encryption keys".
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Azure Event Hubs SDK for Python streaming. Use for high-throughput event ingestion, producers, consumers, and checkpointing. Triggers: "event hubs", "EventHubProducerClient", "EventHubConsumerClient", "streaming", "partitions".
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Assign pathogen lineages and track variants using Nextclade and pangolin for viral surveillance. Monitor variant prevalence and identify emerging variants of concern. Use when classifying viral sequences, tracking lineage dynamics, or monitoring for variants of concern.
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Use when the user asks to "amplify influencer content with paid media", "set up whitelisting or Spark Ads", "decide which posts to boost", "repurpose influencer content", "turn one video into multiple ads", or "build a UGC asset library"; produces (paid mode) a content-selection scorecard, a paid amplification strategy (whitelisting/boosting/dark posts), audience targeting, and a budget+optimization plan, or (repurpose mode) a rights-tracked content inventory, a 1-video-to-10+-asset repurposing map, per-format transformation specs, and a 30-day distribution plan. Not for gating whether a deliverable is publishable or FTC-compliant — use creator-content-auditor; not for the always-on brand posting calendar — use social-calendar-builder; not for drafting a net-new idea into platform-native packages — use social-creative-builder. 复用达人内容 / 内容放量.
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Use when the user asks to "draft an influencer contract", "review these agreement terms", or "build a partnership template"; produces a full influencer agreement framework (scope, compensation, usage rights, exclusivity, FTC disclosure), a clause-by-clause review with red flags, and a negotiation cheat sheet. Not for outreach negotiation before a deal exists — use outreach-manager. 达人合同/合作协议条款审查
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Advises on Amazon RDS open-source engines (MySQL, MariaDB, PostgreSQL) for instance creation, upgrade planning, commitment pricing, proxy evaluation, and Blue/Green deployments. Handles any RDS MySQL, MariaDB, or PostgreSQL question, including create a production-ready RDS MySQL instance, provision an RDS PostgreSQL database, run the RDS upgrade advisor for my RDS MySQL instance, what are my upgrade options, upgrade RDS MariaDB from 10.6 to the latest version, should I buy reserved instances or a savings plan for db.r7g.2xlarge RDS MySQL, change a VARCHAR to INT column on RDS MySQL 8.0 with Blue/Green, and does RDS Proxy help when PgBouncer already runs in transaction mode. Covers instance creation with production best practices, describe-db-instances and describe-db-engine-versions upgrade-target workflow, live prechecks via SSM or direct connection, RI versus DSP commitment pricing, RDS Proxy versus PgBouncer, and Blue/Green lifecycle with binlog replay compatibility.
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Analyze a target's TLS configuration — negotiated protocol version, cipher suite, certificate chain, expiry, and downgrade vectors. Use when: SOC2 auditor flagged your endpoint for "weak TLS" but you don't know which control failed (TSC CC6.7 transmission integrity vs CC6.6 encryption) or which cipher is the problem. Threshold: any negotiated TLSv1.0 or TLSv1.1, OR a cipher with RC4 / 3DES / null / EXPORT, OR a cert with under 30 days to expiry, OR a chain that fails hostname verification. Trigger with: "audit tls", "check ssl config", "weak tls", "analyze tls".
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Guides performance investigation, benchmarking, and optimization of the Grida Canvas web editor (TypeScript reducer, Immer, React hooks). Use when profiling reducer dispatch cost, diagnosing slow interactions (drag, resize, color change), writing or running editor benchmarks, instrumenting with PerfObserver, or optimizing the JS-side state management pipeline.
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Apply meta-principles of software craftsmanship: DRY, orthogonality, tracer bullets, and design by contract. Use when the user mentions "best practices", "pragmatic approach", "broken windows", "tracer bullet", "software craftsmanship", "avoid technical debt", "code ownership", or "how do I become a better developer". Also trigger when evaluating build-vs-buy decisions, designing estimation approaches, or choosing between reversible and irreversible architectural decisions. Covers estimation, domain languages, and reversibility. For code-level quality, see clean-code. For refactoring techniques, see refactoring-patterns.
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Owns legal, contracts, intellectual property, regulatory compliance, privacy, security governance, enterprise risk, and audit readiness. Use this to review a contract or commitment, assess regulatory or privacy exposure, evaluate an IP or licensing question, judge the risk in a business decision, prepare for an audit or certification, or when a plan may create obligations the business cannot meet. Also use to decide whether a risk should be accepted, mitigated, or refused.
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Owns where the business plays and how it wins over a multi-year horizon — portfolio choices, corporate development, strategic partnerships, and planning under uncertainty. Use this for a decision about which markets or businesses to be in, whether to build, buy, or partner, how to allocate capital across business lines, or when a long-horizon bet needs framing. Distinct from `chief-executive`, which arbitrates present-quarter conflicts.
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Use when building a ceRNA regulatory network from a key gene list by combining bundled miRNA-mRNA and miRNA-lncRNA database files, with flat-file CSV exports and PDF visualization in a single output directory. NOT for: differential expression, single-cell analysis, enrichment analysis, or workflows without a key gene list.
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Find Key Opinion Leaders (KOLs) in a given domain by combining web research with LinkedIn post search. Given a company/idea and target domain, generates authority keywords, searches LinkedIn posts to find prolific authors with high engagement, and merges with web-researched influencers. Use when someone wants to "find influencers in X space" or "who are the KOLs for Y industry."
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Find and evaluate creators, influencers, affiliates, and UGC partners using audience fit, content fit, authentic product adjacency, engagement quality, public contactability, commerce signals, and brand-safety evidence—not follower count alone.
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Loads, converts, and manipulates Hi-C contact matrices in cooler format (.cool/.mcool/.scool) and Juicer .hic, using cooler (Python + CLI), hic2cool, and hictk. Covers the single-resolution mcool URI (file.mcool::/resolutions/<bp>), the load-bearing divisive-vs-multiplicative weight-naming rule (KR/VC/VC_SQRT auto-divisive vs cooler's multiplicative weight), what survives .hic<->.cool conversion (FRAG matrices and norm vectors do not), raw-vs-balanced coarsening, the .pairs upper-triangle/chromsize-order contract, and chrom-naming/bin-table provenance. Use when loading a cooler, converting .hic to .mcool, selecting a resolution, building a cooler from pairs or a matrix, coarsening/zoomifying, importing Juicer norm vectors, or debugging all-NaN balanced matrices and chr1-vs-1 empty fetches.
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Detects cancer and infers tissue-of-origin from cfDNA methylation by choosing conversion chemistry (bisulfite vs EM-seq vs TAPS vs cfMeDIP), calling read-level methylation haplotypes rather than averaged beta values, and deconvolving a hematopoietic-dominated cfDNA mixture against a methylation atlas via NNLS/quadratic programming. Encodes the GRAIL/CCGA thesis that thousands of tissue-specific markers make methylation outperform sparse mutations for multi-cancer early detection (MCED) and localization, and that single concordantly-methylated fragments give ppm-level sensitivity. Uses MethylDackel for extraction (mbias-then-extract), MEDIPS/QSEA for enrichment data, scipy.optimize.nnls for deconvolution. Use when building an MCED or methylation-MRD assay, picking a conversion chemistry for low-input plasma, or deconvolving tissue-of-origin from cfDNA.
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Orders and orients assembled contigs into chromosome-scale scaffolds from long-range linking data, inserting N-gap spacers (adds no sequence). Covers Hi-C/Omni-C scaffolding (YaHS, SALSA2, 3D-DNA/Juicer), Hi-C read-mapping prerequisites (map each end separately, no mate rescue, dedup, enzyme-aware), reading the contact map for misjoins/inversions/false-duplications, manual curation in Juicebox/PretextView (the VGP/DToL standard), reference-guided scaffolding (RagTag) and its karyotype-erasure hazard, genetic-map (ALLMAPS) and Bionano optical-map integration, chimera-breaking before scaffolding, gap-filling, and telomere/contig-vs-scaffold-N50 QC (tidk). Use when turning contigs into chromosomes with Hi-C, integrating a linkage map or optical map, choosing a scaffolder by available linking data, or judging whether a chromosome-scale assembly is trustworthy.
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Build enhancer-driven gene regulatory networks (eGRNs) by integrating single-cell RNA-seq and ATAC-seq using SCENIC+, CellOracle base GRNs, Pando, FigR, DIRECT-NET, TRIPOD, and scMEGA. Covers the accessibility-defines-enhancers principle, peak-to-gene linking and its cell-composition confound, the paired-vs-unpaired decision, and TF-region-gene eRegulon triplets. Use when analyzing 10x multiome or paired/unpaired scRNA+scATAC to infer cis-regulatory GRNs. For RNA-only regulons see scenic-regulons; for in silico TF perturbation see perturbation-simulation.
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Annotate copy number variant segments with overlapping genes, dosage-sensitivity scores, cancer driver databases, population frequencies, and clinical-variant content. Covers bedtools/pybedtools interval intersection, AnnotSV comprehensive annotation and ranking, ClinGen haploinsufficiency/triplosensitivity scoring, gnomAD-SV/DGV frequency filtering, COSMIC Cancer Gene Census, and ClinVar overlap. Use when interpreting which genes a CNV affects, distinguishing the driver gene of a focal event from passengers, filtering against population CNVs, separating whole-gene from partial-gene overlap, or preparing CNVs for clinical classification.
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Annotates ChIP-seq peaks to genomic features, nearest genes, ENCODE candidate cis-regulatory elements (cCREs), and regulatory domains. Uses ChIPseeker (R), HOMER annotatePeaks.pl (CLI), pyranges (Python), GREAT/rGREAT (regulatory domain gene-set enrichment), ChIP-Enrich (locus-length-adjusted), ENCODE SCREEN cCRE classification (PLS/pELS/dELS/CA-CTCF/CA-H3K4me3), and ENCODE-rE2G for cell-type-specific enhancer-gene linking. Handles nearest-TSS vs host-gene ambiguity, promoter window definition, and feature priority. Use when assigning genomic context to peaks, linking enhancer peaks to target genes, classifying peaks against ENCODE cCRE registry, or running gene-set enrichment on peak-associated genes.
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Maps GWAS-implicated loci to candidate effector (causal) genes by integrating variant-to-gene (V2G) features via Open Targets L2G (Mountjoy 2021), MAGMA gene-based association (de Leeuw 2015), FUMA SNP2GENE, cS2G combined SNP-to-gene scores (Gazal 2022), Polygenic Priority Scores (PoPS, Weeks 2023), FLAMES, INQUISIT, DEPICT, and enhancer-gene predictors (ABC, ENCODE-rE2G). Use when narrowing a GWAS lead locus to a candidate causal gene, picking between proximity, eQTL-based, and similarity-based prioritizers, integrating multi-evidence streams (fine-mapping, colocalization, ABC enhancer-gene, distance, chromatin), reconciling discordant L2G vs PoPS calls, prioritizing tissue-specific eQTL evidence, or triangulating across at least three independent lines of evidence for a publication-grade effector-gene nomination.
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Reference for MATLAB audiostreamer (Audio Toolbox R2025a+). Without this skill, agents consistently default to legacy audioDeviceWriter/audioDeviceReader or base MATLAB sound(), producing less capable code. Use when writing code for audio playback, recording, full-duplex device I/O, real-time audio measurements, or audio I/O processing with callbacks. Also use when debugging audiostreamer errors, dropouts, or latency issues, or migrating from audioDeviceReader, audioDeviceWriter, audioPlayerRecorder, or audioplayer/audiorecorder.
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Manage SSL/TLS certificates with Let's Encrypt and internal PKI. Configure secure HTTPS, certificate renewal, and cipher suites. Use when implementing secure communications.
日本語の概要は準備中です。原文の説明を表示しています。