「clinical」の検索結果

Analyzes genetic variant effects on gene expression (RNA-seq), chromatin accessibility (DNASE), histone marks (ChIP), and transcription factors using the AlphaGenome API. Use when the user asks about non-coding variant effects, pathogenicity, clinical significance, disease associations, functional effects, gene expression changes, splicing disruption, or regulatory effects in promoters and enhancers. Also use for resolving biological terms to tissue/cell-type ontologies (UBERON/CL) or analyzing variants in chr:pos:ref>alt format.

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Search PubMed for scientific literature, including published clinical trials. Fetch abstracts and full text. Link published research to biological databases (gene, protein, nucleotide, PubChem) to discover associations between papers and specific compounds or genes. Verify medical spelling, match raw citations, and cache result sets for bulk processing. Interfaces NCBI E-utilities and PMC BioC APIs.

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Tracks ctDNA dynamics over time for treatment response monitoring using serial liquid biopsy samples. Analyzes tumor fraction trends, mutation clearance kinetics, and defines molecular response criteria. Use when monitoring patients during therapy or detecting molecular relapse before clinical progression.

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Detect antimicrobial resistance genes using AMRFinderPlus, ResFinder, and CARD. Screen isolates and metagenomes for resistance determinants. Use when characterizing resistance profiles in clinical isolates, surveillance samples, or metagenomic data.

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Deep learning-based variant calling from long reads using Clair3 for SNPs and small indels. Use when calling germline variants from ONT or PacBio alignments, particularly when high accuracy is needed for clinical or research applications.

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Annotate CNVs with genes, pathways, and clinical significance. Use when interpreting CNV calls or identifying affected genes from copy number analysis.

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Extract and analyze mutational signatures from somatic variants using SigProfiler or MutationalPatterns to characterize mutagenic processes. Use when identifying DNA damage mechanisms or etiology in cancer genomes.

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Calculate polygenic risk scores using PRSice-2, LDpred2, or PRS-CS from GWAS summary statistics. Use when predicting disease risk from genome-wide genetic variants.

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Call HLA alleles from NGS data using OptiType, HLA-HD, or arcasHLA for immunogenomics applications. Use when determining HLA genotype for transplant matching, neoantigen prediction, or pharmacogenomic screening.

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Query gnomAD for population allele frequencies to assess variant rarity. Use when filtering variants by population frequency for rare disease analysis or determining if a variant is common in the general population.

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Query dbSNP for rsID lookups, variant annotations, and cross-references to other databases. Use when mapping between rsIDs and genomic coordinates or retrieving basic variant information.

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Run an evidence-backed Abridge production readiness decision across clinical, privacy, security, EHR, training, support, and rollback owners. Use when preparing a pilot or cohort expansion. Trigger with "review Abridge go-live".

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Measure and improve Abridge workflow latency and friction using privacy-safe health-system evidence. Use when clinicians report slow capture, note readiness, review, or EHR handoff. Trigger with "measure Abridge performance".

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Plan and control a staged Abridge rollout across clinical cohorts and EHR workflows without pretending to deploy vendor infrastructure. Use when preparing an Abridge pilot or expansion. Trigger with "plan the Abridge rollout".

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Define an Abridge reference architecture that separates vendor, EHR, identity, device, customer, and clinical authority boundaries. Use when reviewing an enterprise Abridge design. Trigger with "design the Abridge architecture".

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Use this skill when the user asks about Ni Haisha / 倪海厦 TCM course material, especially Shang Han Lun / 伤寒论, Jingui / 金匮要略, Zhongjing Xinfa / 仲景心法, clinical cases / 临床案例 / 倪师医案, Bagang Bianzheng / 八纲辨证, Fuyang Forum / 扶阳论坛, Yijinjing / 易筋经, Liang Dong dialogue / 梁冬对话倪师, Stanford lecture / 斯坦福大学演讲, Tianji / 天纪 / 易经 / 阳宅 / 紫微斗数, Huangdi Neijing / 黄帝内经, Shennong Bencao / 神农本草, acupuncture / 针灸, meridians, acupoints, acupuncture depth safety / 危险进针深度 / 气胸风险, six-channel pattern identification, symptom-to-formula routing, formula comparison, lesson review, board/PPT screenshot evidence, or course-derived study notes. This skill is for educational distillation and study support only, not medical diagnosis, prescriptions, dosage, individualized treatment, or self-administered acupuncture.

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Analyzes clinical diagnostic accuracy studies for bias using the QUADAS-2 tool. Use when Claude needs to assess the quality, risk of bias, or applicability of diagnostic accuracy studies (e.g., "Assess this paper using QUADAS-2").

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Clinical Research Bias Assessment - Case-Control Study (NOS) v2.3.0. Use when you need to assess the bias of a case-control study using the Newcastle-Ottawa Scale (NOS) criteria, or when evaluating the quality of a medical paper.

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Use when converting medical text between academic and patient-friendly tones, translating medical jargon for patients, adapting research papers for public audiences, or rewriting clinical notes for patient handouts. Maintains medical accuracy while adjusting readability level.

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Generate USMLE Step 1/2 style clinical cases with patient history, physical.

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Generate ethical, compliant, and patient-friendly recruitment advertisements for clinical trials.

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Use when writing medical school personal statements, residency application essays, fellowship statements, or graduate school admissions essays. Crafts compelling narratives highlighting clinical experiences, research achievements, and career motivations for healthcare education applications.

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Generate professional prior authorization request letters for insurance companies with proper clinical justification and formatting.

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Clinical-grade PII/PHI detection and de-identification for healthcare text data. Scans all 18 HIPAA identifier categories with confidence scoring, generates audit logs, supports custom regex patterns, and produces de-identified output while preserving document structure.

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