800 件 ・ 関連度順
概要と使いどころ
Write idiomatic GDScript for Godot 4.7: static typing, the node lifecycle (_ready/_process/_physics_process), @export/@onready/@tool annotations, signals, and await for asynchronous flow. Use when editing .gd scripts in a Godot project (project.godot), writing or debugging GDScript, or porting 3.x GDScript to 4.x (function signatures, yield to await, export to @export).
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Detect insecure JWT (JSON Web Token) implementations in a codebase using a two-phase approach: first map all JWT issuance and verification sites to understand the token lifecycle and signing configuration, then check each verification site for exploitable weaknesses such as algorithm confusion, missing signature verification, weak secrets, header injection, and missing claim validation. Requires sast/architecture.md (run sast-analysis first). Outputs findings to sast/jwt-results.md. If no JWT usage is found in Phase 1, Phase 2 is skipped. Use when asked to find JWT, token forgery, or authentication bypass bugs.
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Use when targeting Communications Earth & Environment or deciding whether an earth, environmental, or planetary-science manuscript fits this venue. Encodes the journal's fit, the solid-and-complete-advance bar, Nature Portfolio reporting/data standards, house style, official-submission re-check, and desk-reject heuristics.
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Use when building exhibits for an Academy of Management Annals (Annals) review — the signature framework figure, who-studied-what synthesis tables, and search/coverage exhibits that summarize across a literature. Designs review exhibits; it does not produce original-estimate regression tables (an Annals review reports no new data of its own).
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Assigns GO terms, Pfam/InterPro domains, KEGG orthologs, EC numbers, and product names to predicted proteins using eggNOG-mapper (orthology), InterProScan (domain signatures), and KofamScan (KEGG), routing specialized functions to dbCAN/antiSMASH/AMRFinderPlus/SignalP. Covers the orthology-vs-domain-vs-homology paradigms, the annotation-error percolation cascade, domain-presence-is-not-function, GO IEA circularity in enrichment, evidence tiering, and bit-score/coverage thresholds. Use when adding functional annotation to predicted genes, choosing between eggNOG-mapper and InterProScan, or judging how much to trust a functional label.
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Infer gene regulatory networks from bulk or general expression data with mutual-information (ARACNe) and tree-ensemble (GENIE3, GRNBoost2) methods, and infer transcription-factor protein activity from regulons with VIPER and msVIPER. Covers the activity-not-edges paradigm, the undirected-association caveat, the DREAM5 wisdom-of-crowds and method-complementarity result, AUPRC-over-AUROC evaluation, and gold-standard incompleteness. Use when inferring a regulatory network from a bulk expression matrix, finding master regulators, or scoring TF activity from a signature. For single-cell motif-pruned regulons see scenic-regulons; for co-expression modules see coexpression-networks.
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Analyzes pooled CRISPR screens with MAGeCK (Li et al 2014), covering count generation (mageck count), the RRA two-condition workflow (mageck test using alpha-RRA over per-sgRNA negative-binomial p-values), the MLE multi-condition workflow (mageck mle with explicit design matrix and beta-score output), normalization choice (median vs total vs control-sgRNA vs spike-in), sgRNA efficiency injection, paired-sample testing, time-course design, drug-screen versus dropout-screen design matrices, MAGeCKFlute and MAGeCK-VISPR downstream visualization, and decision logic for when to use MAGeCK vs JACKS / BAGEL2 / drugZ / Chronos. Use when running a fresh CRISPR screen analysis, picking RRA vs MLE for the experimental design, choosing a normalization method from QC signatures, debugging MLE convergence failure or NaN beta scores, comparing MAGeCK output across tools, or building a batch-aware multi-cell-line / multi-condition MLE design matrix.
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Designs and analyzes in vivo CRISPR screens in animal tumor models, organoids, and immune-cell adoptive transfers. Covers bottleneck math (250x cells/sgRNA requires ~25M cells implanted; impossible for most syngeneic models, forcing focused libraries), focused library design (Manguso 2017 Nature 547:413 immune screen; Chen 2015 tumor screens), CRISPR-StAR intrinsic-control screening (Uijttewaal 2025 Nat Biotechnol 43:1848), clonal-dynamics-limited detection, tumor-explant DNA recovery, syngeneic vs xenograft vs PDX considerations, and the relationship to downstream MAGeCK / drugZ analysis. Use when designing in vivo CRISPR screens for tumor / immune / metastasis biology, choosing focused vs genome-wide for animal models, addressing bottleneck-induced clonal collapse, picking the syngeneic / xenograft / PDX model, integrating in vivo with in vitro results, or applying CRISPR-StAR for animal experiments.
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Quality control for pooled CRISPR screens covering library representation, Gini index, log-skew, replicate Pearson and Spearman concordance, essentialome precision-recall AUC against CEGv2 (Hart 2017), Cas9 cut-toxicity diagnostics, copy-number amplicon detection (Aguirre 2016 / Munoz 2016), bottleneck propagation through plasmid pool, infection, selection, and endpoint stages, MOI verification, and DepMap-style screen-quality scoring. Use when assessing screen quality before hit calling, deciding whether to repeat or rescue a screen, diagnosing low-confidence hits, choosing between MAGeCK / BAGEL2 / Chronos based on quality grade, picking a normalization strategy from QC signatures, or evaluating whether an in-vivo screen retained adequate library complexity.
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Compose multi-panel publication figures with patchwork, cowplot, gridExtra (R), or matplotlib GridSpec/subfigures (Python) including shared axes/legends/guides collection, panel labels in Nature/Cell convention, and journal-spec sizing. Covers patchwork ≥1.2.0 axes='collect' feature, Type-42 font embedding, and the cairo_pdf save path. Use when composing 2+ subpanels into a single figure for journal submission.
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Quantify homologous recombination deficiency (HRD) from tumor copy number using the three genomic-scar metrics — loss of heterozygosity (LOH), large-scale state transitions (LST), and telomeric allelic imbalance (TAI) — with scarHRD, and via the whole-genome HRDetect and CHORD models. Covers the genomic instability score, the PARP-inhibitor clinical context, whole-genome-doubling correction, and the scar-versus-state distinction. Use when computing an HRD score for PARP-inhibitor eligibility, deriving LOH/LST/TAI scars from allele-specific copy number, deciding between scar-based and mutational-signature HRD methods, or interpreting an HRD result in a BRCA-reverted or low-purity tumor.
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Analyzes CUT&RUN (Skene Henikoff 2017) and CUT&Tag (Kaya-Okur 2019) chromatin profiling data. Handles SEACR vs MACS2 peak calling (with the btaf375 2025 benchmark guidance), pA-MNase vs pA-Tn5 vs pAG-Tn5 chimera differences, E. coli spike-in carryover normalization, IgG-only control logic (no input), characteristic fragment-size signatures (25-75 bp for CUT&Tag), and lower depth requirements (5M reads typical vs 25M for ChIP). Use when calling peaks from CUT&RUN/CUT&Tag, scaling by E. coli spike-in carryover, choosing SEACR norm mode, or comparing CUT&RUN/Tag results to traditional ChIP.
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Calls microsatellite instability from WES/WGS/targeted-panel with MSIsensor, MSIsensor-pro, MSIsensor-ct (panel-aware), mSINGS, and MANTIS for FDA pembrolizumab MSI-H pan-tumor / Lynch syndrome / dMMR ICI biomarker. Use when stratifying ICI eligibility (Le 2015), pairing MSI with TMB-H (Sha 2020 / Salem 2018), screening Lynch syndrome (universal IHC + MSI), or distinguishing MSI-H tumors from POLE-exo hypermutator with overlapping signatures.
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Display and manipulate PDF documents using PDFKit. Use when embedding PDFView to show PDF files, creating or modifying PDFDocument instances, adding annotations (highlights, notes, signature widgets), extracting text with PDFSelection, navigating pages, generating thumbnails, filling PDF forms, or wrapping PDFView in SwiftUI.
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Add Apple Pencil drawing with PKCanvasView, PKToolPicker, PKDrawing serialization/export, stroke inspection, and PencilKit/PaperKit handoffs. Use when building drawing apps, annotation features, handwriting capture, signature fields, content-version-safe ink workflows, or Apple Pencil-powered experiences on iOS/iPadOS/visionOS.
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Use when building, modifying, or reviewing a Stripe App — or when the user describes something that implies one (e.g. "add a panel to the customer page", "customize my Stripe Dashboard", "react to Stripe events from my app", "connect my service to Stripe without sharing API keys"). Covers the full app development workflow (scaffold, preview, upload, versioning), UI extension architecture (sandboxed iframe, Stripe UI toolkit, viewports), extension types (UI extensions, backend-only, extension interfaces, embedded apps), authentication (platform keys, OAuth, restricted API keys), stripe-app.yaml manifest setup (permissions, viewports, CSP), webhook configuration for apps, Secret Store API, `fetchStripeSignature` auth, and marketplace publishing, plus submitting one agentic feedback report after a build. Use when the user mentions Stripe Apps, UI extensions, @stripe/ui-extension-sdk, @stripe/extensibility-sdk, script extensions, stripe-app.yaml, Dashboard extensions, or customizing the Stripe Dashboard.
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Looks up current LiveKit facts (API signatures, CLI flags, config options, model and provider support, SDK changelogs, pricing) from the docs instead of answering from memory. Use whenever a question touches LiveKit specifics: "does LiveKit support X", "what changed in agents 1.8", "what are the arguments to Y", "how much does LiveKit cost", "find an example of Z in the LiveKit repos", or before writing any LiveKit code. Other LiveKit skills load this one first. Covers the LiveKit Docs MCP server and the `lk docs` CLI.
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Export pcbComponent designs to Gerber files with RF connectors and fab service formatting for PCB manufacturing. TRIGGER: user asks to export a PCB design to Gerber, generate manufacturing files, or write out a pcbComponent for fabrication. Invoke BEFORE writing export code — gerberWrite signature (pcbComponent, connectors, filename) is non-obvious. SKIP: importing/reading PCB files (use matlab-read-pcb-layout), building PCB geometry (use matlab-assemble-pcb-layout), EM analysis (use matlab-analyze-em), material/stackup setup (use matlab-manage-pcb-material).
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Translate NI-DAQmx C function signatures into correct calldaqlib MATLAB calls. Use when the user mentions calldaqlib, any DAQmx* C function name (DAQmxCfgSampClkTiming, DAQmxExportSignal, DAQmxSetStartTrigRetriggerable, DAQmxGetSampClkRate, etc.), or needs NI-DAQmx functionality not exposed by the daq object. Covers: projection rules (taskHandle implicit, output pointers become return values, buffer-size args, enum-as-string), multi-task semantics, start() clobber, device-level empty-daq workaround, dictionary returns, string getter placeholder, array getter placeholder. Trigger contexts: low-level DAQ, escape hatch, retriggerable acquisition, shared timebase, export signal, connect terminals, external sample clock, trigger configuration, NI driver, C function translation.
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Use when writing MATLAB functions with arguments blocks — repeating arguments (arguments (Repeating)), .?ClassName property import in constructors, name-value forwarding with namedargs2cell, or migrating from inputParser or validateattributes. Also when reviewing signatures for implicit-conversion pitfalls (size reshaping, class coercion, computed defaults), or when restricting, constraining, or validating function inputs — scalar vs vector enforcement, type rejection, size checking. Also when asked to harden inputs, make a function more robust, tighten input checking, or rewrite for safer input acceptance — even without "validation" or "arguments block" wording. Triggers on: arguments block, mustBe validators, name-value arguments, varargin, inputParser, nargin/narginchk, restrict input, type checking, scalar constraint, harden inputs, defensive programming. Not for: App Designer callbacks, Simulink mask parameters, class inheritance, or runtime validation outside function or property declarations.
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Generate, verify, refine, and accelerate C/C++ or CUDA code from MATLAB with MATLAB Coder, Embedded Coder, GPU Coder, or MATLAB Test. Also covers writing codegen-ready MATLAB code: language constraints, coder.* directives, and optimization patterns. Triggers on: codegen, MEX, deploy MATLAB as C/C++, GPU Coder, coder.screener, coder.config, coder.gpuConfig, coder.typeof, coder.runTest, matlabtest.coder.TestCase, SIL, embedded config, no dynamic memory, EnableMexProfiling, coder.timeit, coder.perfCompare, %#codegen, writing codegen-ready MATLAB, code generation readiness, coder.varsize, coder.unroll, coder.noImplicitExpansionInFunction, coder.ceval, coder.inline, coder.extrinsic, coder.const, coder.classSignature, class codegen limitations, temporal types codegen, DMA-off, stack-only, host-target InstructionSetExtensions, SIMDAcceleration, OptimizeReductions, host SIMD tuning, host OpenMP, codegen performance.
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Use when adding a new messaging channel to Tel-Agent or changing an existing one — a transport under api/channels/, its official extension manifest, its settings card, tests, health and docs. Covers the file checklist, the two inbound shapes (dial-out and the public door), the credential and signature rules that are not negotiable, the declarative setup descriptor the generic card draws from, and the test shape every channel ships with.
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Internal implementation skill invoked by /add-native for pen, signature, ink, drawing, and handwriting capture workflows using @microsoft/power-apps-native-pen-input.
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Public entry point for native device capabilities and native controls — camera, image picker, barcode/QR scanner, document picker, file picker, secure storage, file system, sharing, haptic feedback, PDF generation/viewing, pen/signature capture, background GPS/geolocation tracking, or supported local file workflows — in a Power Apps mobile app. Also owns routing to internal camera/PDF/pen/geolocation implementation helpers and the guidance boundary between native wrappers and Dataverse File/Image host controls.
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