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概要と使いどころ
Finds, qualifies, and reaches prospects through cold outreach — list building, qualification criteria, cold email and multi-channel sequences, and the follow-up that actually gets replies. Use this to build a prospect list, write cold outreach, fix a sequence that is not getting responses, define qualification criteria, or decide whether a segment is worth pursuing.
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Rewrites technical research content into a structured lay summary that cross-disciplinary teams can quickly understand and act on. Use when the user wants to explain research to colleagues outside their specialty — clinicians, wet-lab scientists, bioinformaticians, product managers, or leadership. Trigger on: "lay summary", "explain my research to the team", "non-technical summary", "cross-disciplinary summary", "translate my findings", "align our team on the study", or any request to communicate research goals, findings, or next steps to a mixed or non-specialist audience. Part of the AIPOCH Academic Writing skill hub. Sits midstream: after research content is clarified, before downstream deliverables like slide decks or graphical abstracts.
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Research what Chinese internet users actually said in the last 30 days across Weibo, Xiaohongshu (RED), Bilibili, Zhihu, Douyin, WeChat public accounts, Baidu and Toutiao: engagement-weighted ranking, cross-platform clustering, cited Markdown/JSON/HTML reports. Also shows today's cross-platform hot-search board (全网热榜, --hot) and can add Hacker News / GitHub / Reddit or an installed upstream last30days for X/YouTube/TikTok.
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Configure cross-env for cross-platform environment variable setting in npm scripts and CLI commands.
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Perform cross-artifact consistency and coverage analysis across constitution, specification, plan, and task artifacts to detect gaps, conflicts, and misalignments before implementation.
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Design microservices architectures with service boundaries, event-driven communication, and resilience patterns. Use when building distributed systems, decomposing monoliths, or implementing microservices.
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Implement distributed tracing with Jaeger and Tempo to track requests across microservices and identify performance bottlenecks. Use when debugging microservices, analyzing request flows, or implementing observability for distributed systems.
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List, find, and show Azure resources across subscriptions or resource groups. Handles prompts like "list the websites in my subscription", "list my web apps", "show my app services", "list virtual machines", "list my VMs", "show storage accounts", "find container apps", and "what resources do I have". USE FOR: list websites, list web apps, list app services, show websites in subscription, resource inventory, find resources by tag, tag analysis, orphaned resource discovery (not for cost analysis), unattached disks, count resources by type, cross-subscription lookup, and Azure Resource Graph queries. DO NOT USE FOR: deploying/changing resources (use azure-deploy), cost optimization (use cost-optimization from the optional azure-cost plugin), or non-Azure clouds.
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Plan, deploy, operate, and troubleshoot multi-rack (rack scale) deployments of Azure Local — preintegrated racks scaling to hundreds of machines, built on Network Fabric Controller, Cluster Manager, SAN storage, and managed network fabric. Use for the Microsoft.NetworkCloud and Microsoft.ManagedNetworkFabric control plane. NOT for standard 1-16 node Azure Local, and NOT for rack-aware clusters (two racks as availability zones, up to 8 nodes, synchronous replication) — those are standard scale. WHEN: multi-rack, rack scale Azure Local, aggregation rack, compute rack, Network Fabric Controller, NFC, Cluster Manager, network fabric, isolation domain, az networkcloud, az networkfabric, multi-rack logical network, multi-rack Arc VM.
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Build, deploy, evaluate, optimize, fine-tune, and manage Microsoft Foundry agents, models, and resources end to end. USE FOR: foundry, azd ai agent, azd provision/deploy, hosted agent scaffold/develop/run/deploy/troubleshoot, prompt agent create, create agent, update agent, add tool to agent, invoke agent, agent.yaml, agent insights, pull agent insights, evaluate agent, batch eval, continuous eval, continuous monitoring, agent CI/CD, optimize prompt, improve prompt, prompt optimizer, optimize agent instructions, Agent Optimizer scaffold, dataset curation from traces, deploy model, model fine-tuning (SFT/DPO/RFT), Foundry project, RBAC, role assignment, permissions, quota, capacity, region, deployment failure, AI Services, create Foundry resource, knowledge index, customize deployment, onboard, availability, training-data, grader, distillation, large file upload. DO NOT USE FOR: Azure Functions, App Service, general Azure deploy (use azure-deploy), general Azure prep (use azure-prepare).
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Assess and migrate cross-cloud workloads to Azure with reports and code conversion. Supports Lambda→Functions, Beanstalk/Heroku/App Engine→App Service, Fargate/Kubernetes/Cloud Run/Spring Boot→Container Apps. WHEN: migrate Lambda to Functions, AWS to Azure, migrate Beanstalk, migrate Heroku, migrate App Engine, Cloud Run migration, Fargate to ACA, ECS/Kubernetes/GKE/EKS to Container Apps, Spring Boot to Container Apps, cross-cloud migration.
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Microsoft Cloud Security Benchmark (MCSB v2) control-domain taxonomy and NIST 800-53 / CIS Controls crosswalk for planning and reviewing Azure cloud resources.
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Use when asked Temu 全托管还是半托管, TikTok Shop 怎么入驻, 亚马逊和 Temu 选哪个, 跨境电商平台怎么选, 产品出海要哪些认证, or choose and launch on cross-border marketplaces (Temu, TikTok Shop, Amazon, SHEIN, AliExpress). Produces a platform fit matrix for the seller's product and capacity, the operating model of each shortlisted platform (fully managed, semi-managed or self-operated), the compliance checklist by target market, a 90-day launch plan, and the questions to ask each platform's account manager. For the product listing copy itself, use cross-border-listing.
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Build a prospect list of companies with decision makers, verified contact info, and hiring/intent signals. Use when asked to find leads by industry, build an account list with specific titles, prospect companies that are actively hiring, or create a targeted outreach list filtered by company size, location, and hiring activity.
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Tracks ctDNA across serial liquid-biopsy timepoints for molecular residual disease (MRD) and treatment-response monitoring, treating MRD as a binary integrated detection call across the patient's full variant set (with a defined LoD95 and per-sample specificity) rather than a per-timepoint VAF threshold, and handling undetectable samples as left-censored at the per-sample limit of detection rather than true zeros. Covers tumor-informed bespoke vs tumor-naive design, landmark vs surveillance sampling, molecular-response definitions and their non-standardization, censoring-aware clearance kinetics, and the multiple-testing structure of repeated surveillance. Use when monitoring ctDNA during therapy, calling molecular relapse before imaging, or estimating clearance half-life from serial samples.
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Detects TAD boundaries from balanced Hi-C contact matrices via the diamond-window insulation score (cooltools insulation) and HiCExplorer hicFindTADs, returning a continuous log2 insulation track, valley-prominence boundary_strength, and Li/Otsu-thresholded is_boundary flags across a list of window sizes. Covers the multi-scale window sweep (sub-TAD to compartment-domain), why the boundary is reproducible but the domain partition is not, cross-condition comparison via differential SCORE not differential partition, and the insulation-vs-compartment orthogonality. Use when calling TADs or domain boundaries, computing insulation scores, choosing a window size, ranking boundary strength, comparing boundaries across conditions, or annotating CTCF-backed boundaries; route domain rendering to hic-visualization and boundary-feature overlap to genome-intervals.
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Maps between gene identifier systems (Ensembl, Entrez, HGNC symbol, UniProt, RefSeq, MANE) using AnnotationDbi, biomaRt, mygene, pyensembl, and Ensembl REST. Encodes Ensembl version stripping with GENCODE _PAR_Y preservation, the Ziemann 2016 Excel autocorrect debacle and Bruford 2020 HGNC renames (SEPT*->SEPTIN*, MARCH*->MARCHF*, MARC*->MTARC*, DEC1->DELEC1), OCT4/POU5F1 alias resolution, biomaRt archive endpoints for release pinning, the `filters` (plural) gotcha, MANE Select for clinical reporting, cross-species orthology via Ensembl Compara / OMA / OrthoDB, and tx2gene construction for tximport. Use when converting gene IDs across systems, handling renamed symbols, building tx2gene, pinning to a specific Ensembl release for reproducibility, or mapping cross-species orthologs.
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Project gene annotations across genomes using TOGA (Kirilenko 2023 whole-genome-alignment chain-based projection with intactness classification), CESAR 2.0 (Sharma, Schwede & Hiller 2017 codon-aware exon projection), LiftOff (Shumate & Salzberg 2021 reference-based annotation transfer), Liftover (UCSC), GeMoMa (Keilwagen 2019 evidence-based projection), and Comparative Annotation Toolkit (CAT). Use when transferring annotations from a well-annotated reference to query genome(s), classifying gene-loss vs gene-intact across many genomes at scale, building Zoonomia-style comparative annotations across hundreds of mammals or birds (Kirilenko 2023), detecting pseudogenization, projecting alternative isoforms, or selecting between WGA-anchored (TOGA) vs ortholog-based (LiftOff) annotation transfer strategies.
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Cross-method decision tree for calling hits in pooled CRISPR screens. Catalogs statistical models (MAGeCK RRA, MAGeCK MLE, BAGEL2, drugZ, JACKS, Chronos, CERES), experimental designs each is built for, failure modes outside design domain, reconciliation when methods disagree, multiple-testing and effect-size thresholds, the order of operations (count -> QC -> CN-correct -> hit-call -> validate), the second-best-sgRNA conservative rule, and consensus-hit strategy. Use when choosing among MAGeCK / BAGEL2 / drugZ / JACKS / Chronos for a given design, reconciling disagreement across two or three methods on the same screen, deciding whether to require consensus, gating downstream validation by hit-confidence tier, or interpreting unstable hit lists across reruns.
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Segments the genome into chromatin states from combinatorial histone modification and chromatin factor ChIP-seq data. Uses ChromHMM (multivariate HMM on binarized signal, v1.27), Segway (Dynamic Bayesian Network on continuous signal), EpiSegMix (flexible-distribution HMM with duration modeling, 2024), EpiLogos (multi-biosample visualization), IDEAS (cell-type-aware joint), and full-stack ChromHMM (Vu Ernst 2022) for cross-cell-type segmentations. Handles state-count selection (15 vs 18 vs 25 states), binarization choice, OverlapEnrichment / NeighborhoodEnrichment downstream analysis, and cross-biosample integration. Use when learning chromatin states from a histone mark panel, characterizing learned states by genomic feature enrichment, or comparing chromatin landscapes across cell types.
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Performs retrosynthetic planning using AiZynthFinder (template-based MCTS), maintained or version-pinned template-free models, ASKCOS, and emerging RetroSynFormer with explicit handling of route scoring, configurable MCTS rewards, building-block availability, and forward-prediction checks. Use when assessing synthetic feasibility of generated or selected molecules, planning multi-step syntheses, building synthesis-aware design pipelines, or screening libraries for retro-route feasibility.
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Estimates bivariate genetic correlation (rg) between traits from GWAS summary statistics or individual-level genotypes using cross-trait LDSC, HDL, LAVA, rho-HESS, GREML-bivariate, Popcorn, and HDL-L. Use when quantifying shared genetic architecture between two traits, screening MR validity before causal inference, distinguishing global from locus-level rg, estimating trans-ancestry rg, separating partial from full causation via LCV gcp, or producing a STROBE-MR-compliant cross-trait sensitivity battery. Cross-trait LDSC intercept absorbs sample overlap and is NOT a bias; HDL is biased under sample overlap above ~5%. High rg between exposure and outcome motivates CHP-aware MR sensitivity (CAUSE, LHC-MR).
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Estimates SNP heritability and partitions it across functional annotations, cell types, and loci from GWAS summary statistics or individual-level genotypes. Implements LDSC, stratified LDSC with the baseline-LD model, Finucane 2018 cell-type prioritization, LDAK SumHer, HDL, HESS local heritability, BOLT-REML, GCTA-GREML, graphREML, and Popcorn cross-population genetic correlation. Use when computing total h2_SNP from summary stats, partitioning heritability across functional categories, prioritizing trait-relevant tissues or cell types from ENCODE/Roadmap chromatin marks, reconciling LDSC vs LDAK enrichment estimates, computing local heritability with HESS, estimating genetic correlation between traits, or producing publication-grade enrichment with calibrated sensitivity to model assumptions.
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Compute aerospace environment properties including atmosphere (ISA, COESA, NRLMSISE-00, non-standard, CIRA), gravity (spherical harmonic, WGS84, zonal, centrifugal), horizontal wind (HWM), magnetic field (WMM, IGRF), geoid height, geocentric radius, space weather data, planetary ephemeris, Earth orientation (polar motion, nutation, delta-UT1, CIP). Use when computing atmospheric density, temperature, pressure, gravity vectors, wind profiles, magnetic field components, geoid undulation, solar flux indices, planet positions, or Earth orientation parameters for aerospace vehicle analysis, spacecraft environment modeling, or navigation corrections.
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