1,374 件 ・ 関連度順
概要と使いどころ
Analyze yesterday's prompts to surface one technical concept worth understanding, delivered as a concise morning lesson with everyday analogy + engineer vocabulary. Use when "morning lesson", "prompt mirror", "today's learning", "what should I learn", or via scheduled automation each morning.
日本語の概要は準備中です。原文の説明を表示しています。
Facilitate structured post-incident reviews to identify root causes, document what worked and failed, and produce actionable recommendations to improve future incident response.
日本語の概要は準備中です。原文の説明を表示しています。
Establish SAML 2.0 identity federation between on-premises Active Directory and Azure AD (Microsoft Entra ID) for seamless cross-domain authentication and SSO to cloud applications.
日本語の概要は準備中です。原文の説明を表示しています。
Mendelian randomization (MR) causal inference — does an exposure, risk factor, or biomarker CAUSALLY affect a disease/outcome, using genetic variants as instrumental variables (IEU OpenGWAS / EpiGraphDB MR-EvE). Use this whenever the user asks if X causes Y, whether an observational association is actually causal or just correlation, if a biomarker/trait is a causal risk factor, wants to triangulate epidemiology against genetic evidence, or mentions Mendelian randomization, instrumental-variable analysis, two-sample MR, or genetic causal evidence — even if they never say "MR" (e.g. "is LDL cholesterol actually causal for heart disease?", "does BMI cause type 2 diabetes or just correlate?", "is CRP a causal driver of stroke?"). Covers trait-label resolution, MR effect direction/magnitude, instrument quality (MOE score), method agreement (IVW vs MR-Egger vs weighted median), bidirectional MR for reverse causation, and distinguishing causation from genetic correlation. Not for plain GWAS association lookups (use the GWAS skills) or fitting your own instruments from raw summary statistics.
日本語の概要は準備中です。原文の説明を表示しています。
Lipid analysis and lipid-disease associations using LIPID MAPS classification, HMDB metabolite data, KEGG/Reactome lipid pathways (sphingolipid, eicosanoid, steroid, fatty acid), and PubChem chemical info. Use for lipid identification, lipid metabolism pathway mapping, and lipid-associated disease analysis (cardiovascular, diabetes, NAFLD).
日本語の概要は準備中です。原文の説明を表示しています。
Build AI invoice processing systems. TRIGGERS - Use when user needs help with ai-invoice-processor related tasks.
日本語の概要は準備中です。原文の説明を表示しています。
Design document processing pipelines for extraction and routing. TRIGGERS - Use when user needs help with ai-document-processor related tasks.
日本語の概要は準備中です。原文の説明を表示しています。
Build AI batch processing systems for scale. TRIGGERS - Use when user needs help with ai-batch-processor related tasks.
日本語の概要は準備中です。原文の説明を表示しています。
Build AI audio processing pipelines. TRIGGERS - Use when user needs help with ai-audio-processor related tasks.
日本語の概要は準備中です。原文の説明を表示しています。
Guide for adult content payment processor selection, merchant account application, compliance, webhook integration, and fallback strategies (CCBill, SegPay, AllSecure, Epoch, Telegram Stars, crypto)
日本語の概要は準備中です。原文の説明を表示しています。
ZMK Firmware (オープンソースキーボードファームウェア) リファレンス。 Getting Started (hardware, user-setup, customization, zmk-cli)、 Features (bluetooth, split keyboards, encoders, displays, lighting, pointing, studio, low-power)、 Keymaps (keycodes, modifiers, combos, conditional layers)、 Behaviors (タップ・ホールド、レイヤー、マクロ、tap-dance, sticky-key)、 Input Processors、Hardware Integration、Troubleshooting (building, flashing, connection, hardware issues)。
NVIDIA CUDA GPU 並列コンピューティングリファレンス。 CUDA C++ / CUDA Python, kernel, nvcc, Unified Memory, CUDA Graphs, Cooperative Groups, Driver API, マルチ GPU。 PTX ISA 命令セット, state space, MMA 命令。 Blackwell チューニング, Streaming Multiprocessor, NVLink。 CUTLASS / CuTe DSL / CuTe C++ GEMM, Tensor Core, tcgen05, Operator API, nsight-compute, compute-sanitizer。
Supabase (オープンソース Firebase 代替・BaaS) リファレンス。 PostgreSQL データベース、Auth (Email / OAuth / Magic Link / Phone / SSO)、Storage、 Edge Functions (Deno)、Realtime (subscriptions / presence / broadcast)、Vector embeddings、 supabase-js、supabase CLI、RLS (Row Level Security)、migrations。 PostgreSQL ベース。SQL Server / node-mssql は別スキル mssql。
Android アプリ開発 (Kotlin) の推奨アーキテクチャリファレンス。 Jetpack, androidx, UI layer, Domain layer, Data layer, state holder, UDF, SSOT, オフラインファースト, モジュール化, ViewModel, viewModelScope, SavedStateHandle, Lifecycle, repeatOnLifecycle, collectAsStateWithLifecycle, LiveData, Hilt による DI, Paging 3 によるページング処理。
Android アプリ開発 (Kotlin) のテストリファレンス。JUnit4, Espresso, テストピラミッド。 テストダブル, Mockito, MockK, Truth, Robolectric, coroutines/Flow/ViewModel テスト。 AndroidJUnit4, ActivityScenario, FragmentScenario, UiAutomator, AndroidTestOrchestrator。 createComposeRule, Compose UI テスト同期。
Claude Code (code.claude.com) の権限・セキュリティ・企業管理リファレンス。 permissions (allow / ask / deny), permission modes, auto mode, sandboxing (sandboxed Bash), sandbox environments, zero data retention, data usage, admin setup, server-managed settings, corporate launcher, network config, authentication (SSO), analytics, monitoring (OpenTelemetry), costs, large codebases。
Designs donor/repair templates for precise CRISPR knock-ins -- choosing the format (ssODN, long-ssDNA/Easi-CRISPR, dsDNA/plasmid, AAV6), sizing homology arms, placing the cut within ~10 bp of the edit, and adding a mandatory codon-checked blocking (PAM/seed) mutation so the edited allele is not re-cut. Frames the HDR-vs-NHEJ-vs-MMEJ pathway competition, the MMEJ (PITCh) and homology-independent (HITI/HMEJ) alternatives for post-mitotic cells, ssODN strand/asymmetry choice, phosphorothioate end-protection, and ranked HDR enhancers. Use when designing a donor for a point mutation, epitope/fluorophore tag, allele replacement, or knock-in, or when HDR efficiency is low. Guide design and base/prime editing are separate skills.
日本語の概要は準備中です。原文の説明を表示しています。
Delimits putative species boundaries from molecular data within the de Queiroz 2007 unified-lineage framework using ASAP (Puillandre 2021 successor to ABGD), mPTP C++ (Kapli 2017 successor to bPTP; bPTP is Python NOT R), GMYC single/multi-threshold (Pons 2006; Fujisawa 2013), multilocus BPP v4 with prior calibration from data (NOT defaults; Yang 2015), SNAPP + BFD* for SNP delimitation, DELINEATE (Sukumaran 2021) speciation-process modeling to address Sukumaran & Knowles 2017 PNAS critique that MSC delimits structure not species, integrative-taxonomy congruence (Padial 2010; Carstens 2013), Dsuite for introgression testing before sister claims (Malinsky 2021), and Meyer & Paulay 2005 barcoding-gap-absence caveat. Use when delineating species from DNA barcoding data, resolving cryptic complexes, choosing among ASAP/mPTP/BPP/DELINEATE, calibrating BPP priors, distinguishing introgression from ILS, or applying the Sukumaran-Knowles oversplitting correction.
日本語の概要は準備中です。原文の説明を表示しています。
Analyzes CRISPR drug-modifier (chemogenomic) screens with drugZ (Li & Hart 2019 Genome Med), a bidirectional Z-score method that identifies synthetic-lethal sensitizing genes and resistance-conferring suppressor genes from vehicle vs drug comparisons. Covers vehicle-anchored design (not Day-0), the bidirectional Z math giving 2-3x sensitivity over MAGeCK / STARS / edgeR / RIGER on drug screens, per-gene sumZ and normZ, synth (sensitizer) vs supp (suppressor) FDR, multi-dose handling, integration with control sgRNAs, and comparison with MAGeCK MLE with dose covariate. Use when running a drug-modifier CRISPR screen, identifying sensitizing or resistance genes for a drug candidate, choosing drugZ vs MAGeCK MLE for chemogenomic analysis, troubleshooting low-effect drug screens where MAGeCK lacks sensitivity, or designing a drug-screen layout (vehicle vs drug arms).
日本語の概要は準備中です。原文の説明を表示しています。
Identifies essential genes from CRISPR-Cas9 fitness screens using BAGEL2 (Kim & Hart 2021 Genome Med), a Bayesian classifier scoring per-gene Bayes Factors via log-likelihood ratios over per-sgRNA fold changes, calibrated against CEGv2 core-essentials (Hart 2017 G3, ~684 genes) and NEGv1 non-essentials (Hart 2014, ~927 genes). Covers the fc + bf + pr workflow, the linear-extrapolation improvement over BAGEL1 truncation, multi-target off-target correction, tumor-suppressor sensitivity (BAGEL2 detects enrichment), and BF-to-FDR calibration (BF >6 ≈ FDR 0.05 from Hart 2017). Use when classifying essential vs non-essential genes, calibrating BAGEL2 thresholds against PR curves, identifying tumor suppressors alongside essentials, comparing BAGEL2 hits to MAGeCK / drugZ, or generating publication-quality essentiality calls.
日本語の概要は準備中です。原文の説明を表示しています。
Estimate causal effects of an exposure on an outcome from GWAS summary statistics using genetic instruments. Implements IVW (fixed/random), MR-Egger, weighted median/mode, MR-RAPS, CAUSE, GSMR-HEIDI, MR-PRESSO, MVMR, MR-Clust, LCV, and LHC-MR via TwoSampleMR, MendelianRandomization, MR-PRESSO, cause, and lhcMR. Use when testing causal direction between traits, evaluating drug-target effects via cis-pQTL/cis-eQTL, performing multivariable mediation MR, distinguishing causation from correlated horizontal pleiotropy, or producing STROBE-MR-compliant sensitivity batteries.
日本語の概要は準備中です。原文の説明を表示しています。
Performs gene-level association from GWAS summary statistics via genetically predicted tissue expression using FUSION, PrediXcan, S-PrediXcan, S-MultiXcan, UTMOST, MOSTWAS, kTWAS, EpiXcan, TIGAR-V2, and probabilistic fine-mapping with FOCUS and MA-FOCUS. Use when running TWAS from GWAS sumstats, prioritising candidate causal genes from a GWAS lead locus, picking single-tissue vs cross-tissue models, identifying LD-induced TWAS false positives, choosing ancestry-matched prediction weights, fine-mapping co-regulated TWAS hits, or triangulating TWAS with cis-eQTL Mendelian randomization and colocalization to nominate a causal gene.
日本語の概要は準備中です。原文の説明を表示しています。
Administração de Ubuntu, Debian e AlmaLinux — systemd, cron, SSH, Fail2Ban, supervisor, disco, memória, rede e processos. Use quando o usuário disser "servidor", "linux", "systemd", "serviço não sobe", "disco cheio", "load alto", "SSH", "cron não roda", "processo travado".
日本語の概要は準備中です。原文の説明を表示しています。
Designs donor/repair templates for precise CRISPR knock-ins -- choosing the format (ssODN, long-ssDNA/Easi-CRISPR, dsDNA/plasmid, AAV6), sizing homology arms, placing the cut within ~10 bp of the edit, and adding a mandatory codon-checked blocking (PAM/seed) mutation so the edited allele is not re-cut. Frames the HDR-vs-NHEJ-vs-MMEJ pathway competition, the MMEJ (PITCh) and homology-independent (HITI/HMEJ) alternatives for post-mitotic cells, ssODN strand/asymmetry choice, phosphorothioate end-protection, and ranked HDR enhancers. Use when designing a donor for a point mutation, epitope/fluorophore tag, allele replacement, or knock-in, or when HDR efficiency is low. Guide design and base/prime editing are separate skills.
日本語の概要は準備中です。原文の説明を表示しています。