533 件 ・ 関連度順
概要と使いどころ
Create original short videos using the 护送穿行｜关系确认到发光门槛 Creative DNA for MiniMax H3 or Seedance 2.0. Use when the user wants this causal, camera, motion, rhythm, or payoff structure with new subjects and surfaces.
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Create original short videos using the 路线坍塌｜安全空间逐段消失 Creative DNA for MiniMax H3 or Seedance 2.0. Use when the user wants this causal, camera, motion, rhythm, or payoff structure with new subjects and surfaces.
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A/B Testing Plan Generator. Creates structured testing roadmaps with prioritized test sequences, duration calculators, sample size requirements, statistical significance thresholds, hypothesis templates, and 90-day testing calendars for Meta, Google, and LinkedIn.
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AI creative director with recursive self-assessment. Generates concepts using world-class methodologies (SIT, TRIZ, Lateral Thinking, bisociation), scores against 6 weighted criteria with Cannes/D&AD/HumanKind calibration, and recursively refines until the 9+ threshold is reached. Accepts briefs in any format — text, voice transcript, PDF, or raw notes. Use when the user asks to generate creative concepts, brainstorm campaign ideas, develop a Big Idea or campaign platform, evaluate or critique existing creative work, find consumer insights, or shares a brief for ideation — including activations, PR-stunts, brand utility, experiential, and non-advertising ideas. Calibrates against a library of 569 legendary campaigns (P01-P18 pattern map) to detect saturation and ensure originality. Do not use for media planning, production budgeting, brand identity/logo design, copywriting final drafts, or market research data collection.
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Use for test coverage with Bun, --coverage flag, lcov reports, thresholds, and CI integration.
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Think and work like an expert Laser Physicist. Use when a task calls for Laser Physicist judgment. Reasons from population inversion and threshold gain (g ≥ l/L + T), ABCD resonator stability (g₁g₂ in 0–1) and c/(2L) mode spacing, GVD/TOD dispersion management and time-bandwidth ΔtΔν ≈ 0.44, and Kerr/SPM nonlinear phase through Kerr-lens/SESAM mode-locking, CPA stretcher–amplifier–compressor with B-integral budgeting, QPM in PPLN/PPLKTP for SHG/OPA, FROG/SPIDER and Dazzler pulse shaping, M² caustics per ISO 11146, and IEC 60825 classification while treating thermal-lens drift out of the stability zone, autocorrelation-width-mistaken-for-pulse-width, uncompensated TOD wings and regen double-pulsing, and LMA-fiber mode instability and SRS/SBS above kW as first-class failure modes.
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Think and work like an expert Geomorphologist. Use when a task calls for Geomorphologist judgment. Reasons from coupled form, process, and time and from rates, thresholds, and lag times through field mapping, lidar/SfM DEM morphometry (chi profiles, Ksn in LSDTopoTools/Landlab), cosmogenic nuclide dating (CRONUS-Earth, OSL, U-Th), and landscape-evolution models, while treating equifinality, inheritance, DEM artifacts, and steady-state assumed over transient response as first-class failure modes.
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Think and work like an expert Horticulturist. Use when a task calls for Horticulturist judgment. Reasons from plant-environment-cultural coupling, source-sink carbon partitioning, and chilling/photoperiod thresholds through rootstock-scion matching, DLI/VPD and substrate EC/pH targets, Dynamic/Utah chill models, and CA/MA postharvest setpoints while treating blossom-end rot, bitter pit, tipburn, storage scald, and MRL/PHI breaches as first-class failure modes.
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Think and work like an expert Edge / Embedded AI Engineer. Use when a task calls for Edge / Embedded AI Engineer judgment. Reasons from tensor-arena budgets, full-int8 PTQ with representative calibration, and TFLM/CMSIS-NN or Vela/Ethos-U compile paths through ONNX Runtime QNN HTP and mobile delegates—treating train–serve preprocessing skew, float thresholds on quantized outputs, and NPU operator fallback as first-class failure modes.
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Think and work like an expert Flavor & Fragrance Chemist. Use when a task calls for Flavor & Fragrance Chemist judgment. Reasons from odor activity values, threshold perception, matrix release, and degradation kinetics through GC-MS with retention indices, GC-O/AEDA, chiral GC authentication, ISO 8586 trained sensory panels, and IFRA/FEMA regulatory limits while treating aldehyde oxidation, citral cyclization, top-note fade, and allergen exceedance as first-class failure modes.
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Think and work like an expert Aquaculture Scientist. Use when a task calls for Aquaculture Scientist judgment. Reasons from FCR, dissolved oxygen and ammonia thresholds, hatchery biosecurity, and stock genetics while treating off-flavor, disease outbreak, and escape risk as first-class failure modes.
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Think and work like an expert Agricultural Entomologist. Use when a task calls for Agricultural Entomologist judgment. Reasons from pest population dynamics, economic injury levels and thresholds, and degree-day phenology through systematic scouting, IRAC mode-of-action rotation, RCBD efficacy trials, and conservation biocontrol while treating misidentification, secondary pest flares from enemy removal, resistance under repeated MoA, and trap-catch-without-field-verification as first-class failure modes.
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Identify differentially accessible chromatin regions across conditions using DiffBind, csaw, DESeq2, or edgeR. Use when comparing ATAC-seq accessibility between treatment groups, choosing between consensus-peak vs sliding-window approaches, picking the correct normalization (full library vs reads-in-peaks), correcting batch with SVA/RUVseq, or interpreting log2FC and FDR thresholds in a chromatin context.
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Test whether two or more traits share a causal variant at a locus using Bayesian colocalization (coloc.abf, coloc.susie, HyPrColoc, moloc, eCAVIAR, SMR/HEIDI, PWCoCo, SharePro). Use when integrating GWAS with eQTL/sQTL/pQTL/mQTL, distinguishing shared causal variants from LD-driven coincidence, handling allelic heterogeneity, choosing between single-causal vs multi-causal methods, picking PP.H4 thresholds, running sensitivity over p12, or harmonising summary statistics for colocalization.
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End-to-end CLIP-seq pipeline from FASTQ to ENCODE-compliant binding sites, single-nucleotide crosslink maps, annotation, motifs, and (optionally) differential binding. Use when running the full Yeo lab eCLIP / iCLIP / iCLIP2 / iCLIP3 / irCLIP / PAR-CLIP analysis with SMInput control, protocol-specific UMI extraction, ENCODE STAR parameters, CLIPper or Skipper peak calling with stringent log2 FC and -log10 p thresholds, IDR rescue and self-consistency QC, and downstream motif registration with mCross or PEKA.
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Preprocesses cell-free DNA sequencing data including adapter trimming, alignment optimized for short fragments, and UMI-aware duplicate removal using fgbio. Applies cfDNA-specific quality thresholds and fragment length filtering. Use when processing plasma cfDNA sequencing data before downstream analysis.
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Assesses ChIP-seq quality across antibody specificity, fragmentation, enrichment, replicate concordance, and library complexity. Computes FRiP, NSC/RSC (phantompeakqualtools), library complexity (NRF/PBC1/PBC2), deepTools plotFingerprint (JS distance, AUC, synthetic JS), ChIPQC, IDR with ENCODE Nself/Nt rules, and detects hyper-ChIPable artifacts. Use when validating an antibody, diagnosing failed peak calls, deciding whether to proceed with downstream analysis, grading against ENCODE thresholds, or auditing replicate concordance.
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Call protein-RNA binding sites from CLIP-seq BAM with CLIPper, PureCLIP, Skipper, Piranha, omniCLIP, CTK, CLAM, or Paraclu. Use when choosing between coverage-based, HMM-based, beta-binomial window-based, and crosslink-site-based peak callers; applying ENCODE eCLIP thresholds (log2 IP/SMInput >= 3, -log10 p >= 3); deciding when SMInput is mandatory; or reconciling peak-set discordance between callers for the same RBP.
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ATAC-seq library quality control -- TSS enrichment, FRiP, fragment-size periodicity, library complexity (NRF/PBC1/PBC2), mitochondrial fraction, and ENCODE 4 thresholds. Use when assessing whether an ATAC-seq library passes ENCODE acceptance criteria, diagnosing transposition artefacts, comparing Omni-ATAC vs standard prep quality, or selecting which replicates to drop before peak calling.
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Identifies essential genes from CRISPR-Cas9 fitness screens using BAGEL2 (Kim & Hart 2021 Genome Med), a Bayesian classifier scoring per-gene Bayes Factors via log-likelihood ratios over per-sgRNA fold changes, calibrated against CEGv2 core-essentials (Hart 2017 G3, ~684 genes) and NEGv1 non-essentials (Hart 2014, ~927 genes). Covers the fc + bf + pr workflow, the linear-extrapolation improvement over BAGEL1 truncation, multi-target off-target correction, tumor-suppressor sensitivity (BAGEL2 detects enrichment), and BF-to-FDR calibration (BF >6 ≈ FDR 0.05 from Hart 2017). Use when classifying essential vs non-essential genes, calibrating BAGEL2 thresholds against PR curves, identifying tumor suppressors alongside essentials, comparing BAGEL2 hits to MAGeCK / drugZ, or generating publication-quality essentiality calls.
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Proteina-Complexa flow-based protein backbone generation with fold-conditioned sampling guidance. Use this skill when: (1) Generating de novo protein backbones with hierarchical fold conditioning, (2) Exploring long-chain backbone generation beyond standard diffusion baselines, (3) Using NVIDIA Proteina-style flow matching workflows for controllable backbone design, (4) Comparing flow-based backbone generation against RFdiffusion or BoltzGen, (5) Prototyping fold-guided backbone campaigns before sequence design. This skill is based on the public NVIDIA Digital Bio Proteina project and uses "Proteina-Complexa" as the BioClaw-facing skill label. For sequence design after backbone generation, use proteinmpnn or solublempnn. For QC thresholds, use protein-design-qc.
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Bulk transcriptomics differential expression with count-aware modeling, design validation, contrast handling, thresholded exports, and publication-ready DE figures.
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Applies ACMG/AMP 2015 framework with ClinGen SVI specifications, Tavtigian 2018/2020 Bayesian point system, Abou Tayoun 2018 PVS1 decision tree, Pejaver 2022 calibrated PP3/BP4 thresholds for REVEL/BayesDel/AlphaMissense, Brnich 2020 PS3/BS3 OddsPath, Walker 2023 SpliceAI splicing framework, and AMP/ASCO/CAP 2017 tumor tiers. Use when classifying germline variants P / LP / VUS / LB / B, applying VCEP-specific CSpec rules, computing Whiffin BS1, or assigning cancer Tier I-IV per Li 2017.
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ESM2 protein language model for embeddings and sequence scoring. Use this skill when: (1) Computing pseudo-log-likelihood (PLL) scores, (2) Getting protein embeddings for clustering, (3) Filtering designs by sequence plausibility, (4) Zero-shot variant effect prediction, (5) Analyzing sequence-function relationships. For structure prediction, use chai or boltz. For QC thresholds, use protein-qc.
日本語の概要は準備中です。原文の説明を表示しています。