「xp」の検索結果

Designs genomics experiments so technical nuisance variation (batch, lane, plate, flow cell, operator, reagent lot, processing day) is balanced against the biological variable of interest and therefore estimable rather than confounded, using constrained sample-to-batch assignment (designit, OSAT), the confounder/mediator/collider distinction, and the principle that no post-hoc correction recovers a fully confounded design. Covers detecting hidden batches with surrogate variable analysis, a decision table for downstream correction (ComBat-seq, RUVSeq, SVA) whose execution is deferred to differential-expression/batch-correction, and reproducibility metadata. Use when assigning samples to sequencing batches/lanes/plates, avoiding batch-condition confounding, deciding whether a design is salvageable by correction, choosing a correction method, or estimating the number of hidden batches. For the experimental unit, randomization, and blocking concepts see experimental-design/randomization-blocking.

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Build weighted gene co-expression networks to identify modules of co-regulated genes, relate them to phenotypes, and find hub genes using WGCNA, hdWGCNA, MEGENA, CEMiTool, and Gaussian graphical models. Covers signed-network choice, soft-threshold selection, module preservation, and the marginal-vs-partial-correlation distinction. Use when finding co-expression modules, identifying hub genes, relating gene networks to clinical or experimental traits, or building single-cell co-expression networks. For directed TF-target inference see scenic-regulons and grn-inference; for condition rewiring see differential-networks.

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Live developer experience audit. Uses the browse tool to actually TEST the developer experience: navigates docs, tries the getting started flow, times TTHW, screenshots error messages, evaluates CLI help text. Produces a DX scorecard with evidence. Compares against /plan-devex-review scores if they exist (the boomerang: plan said 3 minutes, reality says 8). Use when asked to "test the DX", "DX audit", "developer experience test", or "try the onboarding". Proactively suggest after shipping a developer-facing feature. (gstack) Voice triggers (speech-to-text aliases): "dx audit", "test the developer experience", "try the onboarding", "developer experience test".

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CEO/founder-mode plan review. Rethink the problem, find the 10-star product, challenge premises, expand scope when it creates a better product. Four modes: SCOPE EXPANSION (dream big), SELECTIVE EXPANSION (hold scope + cherry-pick expansions), HOLD SCOPE (maximum rigor), SCOPE REDUCTION (strip to essentials). Use when asked to "think bigger", "expand scope", "strategy review", "rethink this", or "is this ambitious enough". Proactively suggest when the user is questioning scope or ambition of a plan, or when the plan feels like it could be thinking bigger. (gstack)

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Interactive developer experience plan review. Explores developer personas, benchmarks against competitors, designs magical moments, and traces friction points before scoring. Three modes: DX EXPANSION (competitive advantage), DX POLISH (bulletproof every touchpoint), DX TRIAGE (critical gaps only). Use when asked to "DX review", "developer experience audit", "devex review", or "API design review". Proactively suggest when the user has a plan for developer-facing products (APIs, CLIs, SDKs, libraries, platforms, docs). (gstack) Voice triggers (speech-to-text aliases): "dx review", "developer experience review", "devex review", "devex audit", "API design review", "onboarding review".

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Route Expo application, EAS, native module, styling, deployment, and upgrade work to focused Expo skills. Use when building or operating an Expo or Expo Router project.

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Turn assumptions, funnel opportunities, and product questions into a prioritised, feasibility-checked experiment backlog. Filters by traffic reality, metric latency, and method feasibility — not just ICE/RICE scoring. Maintains a living portfolio with status (idea → designed → running → readout → archived). Load when the user says "what should we test next", "build an experiment backlog", "prioritise our tests", "where should we experiment", "what's worth testing", or when the experimentation orchestrator routes here.

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Translate an approved experiment spec into a launch runbook — platform binding (PostHog primary), feature flag setup, assignment unit, exposure event definition, instrumentation QA, dashboard wiring, ramp plan, monitoring, and rollback procedure. Platform-agnostic core with one strong PostHog adapter shipped; GrowthBook, Statsig, LaunchDarkly, Optimizely, and Eppo documented as a single mapping table the user adapts. Load when a spec is approved and ready to launch, or when the user says "set up the experiment", "wire this up in PostHog", "implement the test", "create the runbook", "launch checklist for this test", or when the experimentation orchestrator routes here.

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Analyse experiment results, run validity checks (SRM, exposure parity, data integrity, novelty/primacy), interpret causally, make a ship/iterate/kill decision against the pre-declared rule, and append to cumulative learnings. Forces honest readouts — strips significance claims from underpowered or peek-violating tests; never lets directional results masquerade as causal wins. Load when results exist, or when the user says "read out this experiment", "analyse the test", "did the test win", "interpret the results", "what did we learn", "ship or kill", or when the experimentation orchestrator routes here.

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Balances Hi-C contact matrices (ICE via cooler.balance_cooler, KR/SCALE/VC context), computes distance-decay expected with cooltools (expected_cis per-diagonal P(s), expected_trans scalar), builds observed/expected (O/E) matrices, and diagnoses polymer state from the P(s) log-derivative. Covers the within-matrix-vs-cross-sample distinction (balancing is NOT a normalizer), the equal-visibility assumption that CNV/aneuploidy violates (use raw counts for copy-number), cis-only balancing, mad_max/blacklist masking before balancing, multiplicative cooler weights vs divisive juicer weights, and the resolution-vs-depth budget. Use when balancing a .cool/.mcool, computing expected or P(s), making O/E matrices for compartments/loops, deciding ICE vs KR vs SCALE, choosing a resolution for a given depth, or troubleshooting NaN/all-NaN balanced matrices; route cross-sample comparison to hic-differential.

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Build weighted gene co-expression networks to identify modules of co-regulated genes, relate them to phenotypes, and find hub genes using WGCNA, hdWGCNA, MEGENA, CEMiTool, and Gaussian graphical models. Covers signed-network choice, soft-threshold selection, module preservation, and the marginal-vs-partial-correlation distinction. Use when finding co-expression modules, identifying hub genes, relating gene networks to clinical or experimental traits, or building single-cell co-expression networks. For directed TF-target inference see scenic-regulons and grn-inference; for condition rewiring see differential-networks.

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Stores and operates on sparse expression matrices for single-cell and large bulk RNA-seq, covering dgCMatrix/dgRMatrix/dgTMatrix when-each-is-fast, the dgCMatrix (CSC, R) <-> CSR (Python) implicit transpose, AnnData (cells-rows) <-> SingleCellExperiment (cells-cols) orientation flip, HDF5/h5ad vs Zarr cloud-native shift, HDF5SummarizedExperiment + DelayedArray for out-of-memory bulk, scanpy backed mode for large h5ad, the ~10-15% density crossover where dense beats sparse, 10X format proliferation (MTX vs CellRanger H5 vs h5ad), the dense-conversion memory blow-up, and Dask + Zarr for consortium-scale matrices. Use when choosing sparse format, working with single-cell-sized matrices, importing/exporting 10X, debugging R/Python interop transposes, processing matrices too large for RAM, or building cloud-native pipelines.

日本語の概要は準備中です。原文の説明を表示しています。

Designs genomics experiments so technical nuisance variation (batch, lane, plate, flow cell, operator, reagent lot, processing day) is balanced against the biological variable of interest and therefore estimable rather than confounded, using constrained sample-to-batch assignment (designit, OSAT), the confounder/mediator/collider distinction, and the principle that no post-hoc correction recovers a fully confounded design. Covers detecting hidden batches with surrogate variable analysis, a decision table for downstream correction (ComBat-seq, RUVSeq, SVA) whose execution is deferred to differential-expression/batch-correction, and reproducibility metadata. Use when assigning samples to sequencing batches/lanes/plates, avoiding batch-condition confounding, deciding whether a design is salvageable by correction, choosing a correction method, or estimating the number of hidden batches. For the experimental unit, randomization, and blocking concepts see experimental-design/randomization-blocking.

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Structures biological experiments so inference is valid by construction, covering Fisher's principles (randomization, replication, local control), the experimental-vs-observational unit distinction and pseudoreplication (Hurlbert 1984; Lazic 2018), randomization mechanics (complete, restricted, stratified, rerandomization, run-order), blocking layouts (randomized complete block, Latin square, incomplete block), factorial designs and interactions, and the split-plot/nested error strata hidden inside multi-batch genomics. Use when deciding the experimental unit and what counts as a replicate, planning randomization and run order, choosing a blocked/factorial/split-plot/nested layout, avoiding pseudoreplication in cell-culture or animal studies, or specifying the random-effects structure of the analysis model. For assigning samples to sequencing batches/lanes/plates and batch-effect correction see experimental-design/batch-design; for regulated clinical-trial randomization see clinical-biostatistics.

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Calculates statistical power for high-dimensional genomics experiments (bulk RNA-seq, scRNA-seq, ATAC-seq, ChIP-seq, methylation, proteomics) under negative-binomial count models using RNASeqPower, PROPER, and simulation via powsimR, distinguishing per-gene from marginal (transcriptome-wide) power, the role of mean expression and dispersion, and the sequencing-depth-versus-replicate tradeoff. Covers simulation as the honest default for overdispersed counts, FDR-aware average power versus single-test power, observed/post-hoc power as an anti-pattern, and the winner's-curse / Type-S / Type-M consequences of underpowering. Use when planning replicate number for a sequencing experiment, deciding whether to add depth or samples, choosing closed-form versus simulation power, estimating power from pilot dispersions, or justifying replication in a grant. For clinical-trial power see clinical-biostatistics/power-and-sample-size; for the inverse sample-size question see experimental-design/sample-size.

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Builds comprehensive design systems and design bibles with production-ready CSS. Expert in design tokens, component libraries, CSS architecture. Use for design system creation, token architecture, component documentation, style guide generation. Activate on "design system", "design tokens", "CSS architecture", "component library", "style guide", "design bible". NOT for typography deep-dives (use typography-expert), color theory mathematics (use color-theory-palette-harmony-expert), brand identity strategy (use web-design-expert), or actual UI implementation (use web-design-expert or native-app-designer).

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Diagnose when intuitive judgment, agent confidence, or expert routing can be trusted by classifying environment validity, feedback quality, and task-boundary fit. Use for confidence calibration, agent routing, expertise audits, and escalation design. NOT for deterministic implementation tasks, pure syntax debugging, or domains with explicit verifiable answers.

日本語の概要は準備中です。原文の説明を表示しています。

Diagnose when intuitive judgment, agent confidence, or expert routing can be trusted by classifying environment validity, feedback quality, and task-boundary fit. Use for confidence calibration, agent routing, expertise audits, and escalation design. NOT for deterministic implementation tasks, pure syntax debugging, or domains with explicit verifiable answers.

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Expert 3D modeling specialist with deep knowledge of topology, UV mapping, game-ready and film-ready pipelines, DCC tool workflows (Blender, Maya, ZBrush, 3ds Max, Houdini), retopology, LOD systems, and export pipelines. This skill represents years of production experience distilled into actionable guidance. Use when "3d model, 3d modeling, mesh topology, uv unwrap, uv mapping, retopology, retopo, low poly, high poly, subdivision, subdiv, edge flow, edge loops, polygon modeling, box modeling, hard surface, organic modeling, sculpting, zbrush, blender modeling, maya modeling, 3ds max, LOD, level of detail, game ready mesh, film ready, baking normals, high to low, fbx export, gltf export, texel density, 3d, modeling, topology, uv, game-dev, vfx, blender, maya, zbrush, retopology, lod, hard-surface, organic, sculpting" mentioned.

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Tests APIs for excessive data exposure where endpoints return more data than the client application needs, relying on the frontend to filter sensitive fields. The tester intercepts API responses and analyzes them for leaked PII, internal identifiers, debug information, or sensitive business data that the UI does not display but the API transmits. This maps to OWASP API3:2023 Broken Object Property Level Authorization. Activates for requests involving API data leakage testing, excessive data exposure, response filtering bypass, or API over-fetching.

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Build animations in React Native and Expo, making the decisions in the order that determines whether they feel right — should it animate, which thread it runs on, which properties, spring or timing, how the gesture hands off, how it degrades. Writes the implementation with Reanimated, Gesture Handler, Expo Router and expo-haptics. Use when animating anything in an Expo app, adding gestures, sheets, screen transitions, press feedback or haptics, or fixing motion that stutters on device. For web animation use `animate`.

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Comprehensive secrets extraction methodology targeting CI/CD environments across all major platforms. Covers environment variable extraction from build contexts, exploitation of vault and secrets-manager misconfigurations (HashiCorp Vault, AWS Secrets Manager, Azure Key Vault, GCP Secret Manager), runner and agent token abuse for lateral movement, OIDC federation attacks exploiting trust relationships between CI/CD providers and cloud platforms, build log leakage analysis for inadvertently exposed credentials, cache poisoning techniques for credential exfiltration, platform-specific credential store exploitation (GitHub Actions secrets, GitLab CI variables, Jenkins credential providers), service connection and service account abuse in Azure DevOps and GCP, and Docker registry credential theft from build environments. Maps to MITRE ATT&CK T1552 (Unsecured Credentials) and its sub-techniques. Each section provides enumeration procedures, extraction techniques, and post-exploitation pivoting guidance for usi...

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Comprehensive Linux privilege escalation methodology for offensive security engagements. Covers the full attack surface from a low-privilege shell to root: SUID/SGID binary abuse via GTFOBins, Linux capabilities exploitation (cap_setuid, cap_dac_override, cap_dac_read_search), sudo misconfigurations including NOPASSWD rules and Baron Samedit (CVE-2021-3156), cron job abuse through writable scripts, PATH hijacking, and wildcard injection with tar/rsync/chown. Includes writable /etc/passwd attacks, NFS no_root_squash exploitation, kernel exploits (DirtyPipe CVE-2022-0847, DirtyCow CVE-2016-5195, PwnKit CVE-2021-4034), Docker group container escapes, LD_PRELOAD and LD_LIBRARY_PATH hijacking for shared library injection, systemd service misconfigurations, and sensitive file enumeration for credential harvesting. Integrates automated enumeration with LinPEAS, linux-exploit-suggester, pspy for process monitoring, and GTFOBins for binary exploitation. Each technique includes detection signatures and defender-sid...

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Comprehensive methodology for auditing and exploiting TLS/SSL implementations and misconfigurations across network services and mobile applications. Covers protocol downgrade attacks including POODLE (CVE-2014-3566) against SSLv3 CBC padding, DROWN (CVE-2016-0800) cross-protocol attack leveraging SSLv2 export ciphers to decrypt TLS sessions, and FREAK (CVE-2015-0204) forcing RSA export-grade key exchange. Addresses BEAST (CVE-2011-3389) exploiting CBC IV predictability in TLS 1.0, CRIME (CVE-2012-4929) and BREACH targeting TLS-level and HTTP-level compression oracles respectively, and Heartbleed (CVE-2014-0160) for OpenSSL memory disclosure. Covers certificate validation bypass techniques for applications with improper hostname verification or chain validation, certificate pinning bypass using Frida and Objection for mobile application interception, HSTS bypass via NTP manipulation and subdomain exploitation, TLS 1.3 0-RTT replay attacks against non-idempotent endpoints, mutual TLS (mTLS) authentication a...

日本語の概要は準備中です。原文の説明を表示しています。