「framework」の検索結果

Normalizes ChIP-seq data using exogenous spike-in (ChIP-Rx with Drosophila chromatin per Orlando 2014 / Egan 2016; E. coli carryover for CUT&RUN/CUT&Tag). Distinguishes RRPM from Rx-Input scaling, integrates with DiffBind / DESeq2 / edgeR / csaw via sizeFactors and DiffBind library-size vectors, and applies the Patel et al 2024 *Nat Biotechnol* review's failure-mode framework to validate that normalization is correctly applied at the read level (not peak counts). Use when global signal shifts are expected (HDACi, BETi, EZH2i, dosage, target knockdown), when ChIPseqSpikeInFree detects post-hoc shifts, or when validating internal-control regions before publication.

日本語の概要は準備中です。原文の説明を表示しています。

Analyzes chemical libraries by scaffold using Bemis-Murcko scaffolds, generic frameworks, cyclic skeletons, matched molecular pair (MMP) analysis via mmpdb, R-group decomposition, Free-Wilson analysis, scaffold hopping, and chemotype-aware ML train/test splits. Use when identifying chemotype clusters in a library, deriving SAR transformation rules, decomposing series into R-groups, performing scaffold-balanced QSAR splits, or planning analog campaigns.

日本語の概要は準備中です。原文の説明を表示しています。

Predicts whether a DNA variant alters mRNA splicing using sequence-based deep-learning tools — SpliceAI (10kb context dilated CNN, clinical default), Pangolin (multi-tissue), MMSplice (modular per-region CNN with calibrated ΔPSI), SpliceTransformer/TrASPr (tissue-aware transformers), SpliceVault (empirical 300K-RNA lookup of likely mis-splicing outcomes), CADD-Splice (composite score). Applies the ClinGen SVI 2023 framework for ACMG/AMP variant interpretation (PVS1, PP3, BP4 evidence codes), HGVS splicing nomenclature (c.123+1G>A, c.123-3T>G, r.spl?), extended-window scoring for deep-intronic pseudoexons, tissue-specific predictions, branchpoint variant detection (BPHunter, LaBranchoR), and splice-switching ASO design. Use when interpreting splice impact of clinical variants, prioritizing VUS, identifying deep-intronic pathogenic variants, or designing ASOs.

日本語の概要は準備中です。原文の説明を表示しています。

Use when a carrier needs to build an internal dispatcher training program, onboard new dispatchers, or certify dispatcher competency. Covers job description, required skills, training modules, certification frameworks (CDS, CTP), shadowing, evaluation, and career path.

日本語の概要は準備中です。原文の説明を表示しています。

Use this skill when the user asks about driver discipline — when to coach vs warn vs suspend vs terminate, progressive discipline frameworks, at-will employment in trucking, documenting violations, separating "willful violation" from "human error," and how to handle a driver who refuses corrective action. Reference state employment law + ATA SMP.

日本語の概要は準備中です。原文の説明を表示しています。

Use this skill when the user asks about cybersecurity for a trucking carrier — protecting ELD data, customer information, financial systems, EDI integrations, fleet telematics, ransomware risk, vendor / shipper data sharing, incident response, and FMCSA cyber-recommendations. Reference NIST + CISA cybersecurity frameworks.

日本語の概要は準備中です。原文の説明を表示しています。

Perform language and framework specific security best-practice reviews and suggest improvements. Use when the user explicitly requests security best practices guidance, a security review/report, or secure-by-default coding help. Trigger only for supported languages (python, javascript/typescript, go), and not for general debugging or non-security tasks.

日本語の概要は準備中です。原文の説明を表示しています。

Detects leaky abstractions in PHP code. Identifies implementation details exposed in interfaces, concrete returns from abstract methods, framework leakage into domain, and infrastructure concerns in application layer.

日本語の概要は準備中です。原文の説明を表示しています。

ABP Framework cross-cutting patterns including authorization, background jobs, distributed events, multi-tenancy, and module configuration. Use when: (1) defining permissions, (2) creating background jobs, (3) publishing/handling distributed events, (4) configuring modules.

日本語の概要は準備中です。原文の説明を表示しています。

Implement REST APIs in ABP Framework with AppServices, DTOs, pagination, filtering, and authorization. Use when building API endpoints for ABP applications.

日本語の概要は準備中です。原文の説明を表示しています。

ABP Framework application layer patterns including AppServices, DTOs, Mapperly mapping, Unit of Work, and common patterns like Filter DTOs and ResponseModel. Use when: (1) creating AppServices, (2) mapping DTOs with Mapperly, (3) implementing list filtering, (4) wrapping API responses.

日本語の概要は準備中です。原文の説明を表示しています。

ABP Framework domain layer patterns including entities, aggregates, repositories, domain services, and data seeding. Use when: (1) creating entities with proper base classes, (2) implementing custom repositories, (3) writing domain services, (4) seeding data.

日本語の概要は準備中です。原文の説明を表示しています。

Эксперт A/B тестирования. Используй для статистических тестов, экспериментов и ML-оптимизации.

日本語の概要は準備中です。原文の説明を表示しています。

5W1H Decision Framework Tool. Use for: (1) Systematic decision-making before creating todos, (2) Preventing duplicate implementation, (3) Detecting avoidance behavior, (4) Ensuring agile refactor compliance with executor/dispatcher separation

日本語の概要は準備中です。原文の説明を表示しています。

[02] META. Create new skills when existing ones don't cover the task. Analyze unique requirements, build framework (Frame → Research → Plan → Execute), integrate risks, and declare new skill. Use when facing novel problems that existing skills can't address.

日本語の概要は準備中です。原文の説明を表示しています。

Develops iOS/iPhone applications with XcodeGen, SwiftUI, and SPM. Triggers on XcodeGen project.yml configuration, SPM dependency issues, device deployment problems, code signing errors, camera/AVFoundation capture debugging, iOS version compatibility, or "Library not loaded @rpath" framework errors. Use when building iOS apps, fixing Xcode build failures, or deploying to real devices. Not for AVPlayer playback issues (seek/scrub/frame stepping → avfoundation-reference skill).

日本語の概要は準備中です。原文の説明を表示しています。

Codified expertise for returns authorization, receipt and inspection, disposition decisions, refund processing, fraud detection, and warranty claims management. Informed by returns operations managers with 15+ years experience. Includes grading frameworks, disposition economics, fraud pattern recognition, and vendor recovery processes. Use when handling product returns, reverse logistics, refund decisions, return fraud detection, or warranty claims.

日本語の概要は準備中です。原文の説明を表示しています。

Codified expertise for handling freight exceptions, shipment delays, damages, losses, and carrier disputes. Informed by logistics professionals with 15+ years operational experience. Includes escalation protocols, carrier-specific behaviors, claims procedures, and judgment frameworks. Use when handling shipping exceptions, freight claims, delivery issues, or carrier disputes.

日本語の概要は準備中です。原文の説明を表示しています。

Codified expertise for production scheduling, job sequencing, line balancing, changeover optimization, and bottleneck resolution in discrete and batch manufacturing. Informed by production schedulers with 15+ years experience. Includes TOC/drum-buffer-rope, SMED, OEE analysis, disruption response frameworks, and ERP/MES interaction patterns. Use when scheduling production, resolving bottlenecks, optimizing changeovers, responding to disruptions, or balancing manufacturing lines.

日本語の概要は準備中です。原文の説明を表示しています。

Decision framework for choosing between regex and LLM when parsing structured text — start with regex, add LLM only for low-confidence edge cases.

日本語の概要は準備中です。原文の説明を表示しています。

Codified expertise for managing carrier portfolios, negotiating freight rates, tracking carrier performance, allocating freight, and maintaining strategic carrier relationships. Informed by transportation managers with 15+ years experience. Includes scorecarding frameworks, RFP processes, market intelligence, and compliance vetting. Use when managing carriers, negotiating rates, evaluating carrier performance, or building freight strategies.

日本語の概要は準備中です。原文の説明を表示しています。

Codified expertise for demand forecasting, safety stock optimization, replenishment planning, and promotional lift estimation at multi-location retailers. Informed by demand planners with 15+ years experience managing hundreds of SKUs. Includes forecasting method selection, ABC/XYZ analysis, seasonal transition management, and vendor negotiation frameworks. Use when forecasting demand, setting safety stock, planning replenishment, managing promotions, or optimizing inventory levels.

日本語の概要は準備中です。原文の説明を表示しています。

Apple FoundationModels framework for on-device LLM — text generation, guided generation with @Generable, tool calling, and snapshot streaming in iOS 26+.

日本語の概要は準備中です。原文の説明を表示しています。

Codified expertise for electricity and gas procurement, tariff optimization, demand charge management, renewable PPA evaluation, and multi-facility energy cost management. Informed by energy procurement managers with 15+ years experience at large commercial and industrial consumers. Includes market structure analysis, hedging strategies, load profiling, and sustainability reporting frameworks. Use when procuring energy, optimizing tariffs, managing demand charges, evaluating PPAs, or developing energy strategies.

日本語の概要は準備中です。原文の説明を表示しています。