End-to-end post-GWAS causal inference pipeline orchestrating heritability partitioning, genetic correlation, Mendelian randomization with CHP-aware sensitivity (CAUSE / LHC-MR), colocalization, fine-mapping with SuSiE / FOCUS, mediation, TWAS triangulation, cis-pQTL drug-target MR, effector-gene prioritization (L2G / PoPS / cS2G), and GenomicSEM common-factor GWAS. Use when triangulating causal inference across multiple complementary methods, prioritizing tissues via stratified LDSC, nominating or de-risking drug targets, mapping a lead SNP to a candidate effector gene, modeling shared genetic architecture across correlated traits, or producing a STROBE-MR-compliant publication-grade evidence battery from GWAS summary statistics.
日本語の概要は準備中です。原文の説明を表示しています。
BioTender-max/awesome-bio-agent-skills☆ 2012026年7月2日 更新
generate, refine, validate, and render diagrams from natural language, notes, code snippets, schemas, tables, or existing diagram source. use for flowcharts, swimlanes, sequence diagrams, state diagrams, er diagrams, class diagrams, architecture/c4-style diagrams, dependency graphs, gantt charts, mind maps, user journeys, sankey-style flows, org charts, network graphs, and other visual models. supports mermaid by default, graphviz dot for complex graph layout, plantuml for uml-heavy engineering diagrams, and svg output when direct markup is more reliable.
日本語の概要は準備中です。原文の説明を表示しています。
skillmds/skillmd☆ 1982026年10月9日 更新
Use this skill for all requirements-related work in a MATLAB MBSE project using the Requirements Toolbox (slreq). Covers creating and populating requirement sets, derivation links, test case requirements, verification coverage, reading and tracing links across requirement sets and models, checking link health, allocating requirements to components (Implement links), and building traceability reports. Trigger when the user asks about slreq API, slreqx files, slmx link files, outLinks/inLinks, traceability matrices, coverage analysis, broken links, or mapping requirements to architecture components. Use proactively for any requirements or traceability task.
日本語の概要は準備中です。原文の説明を表示しています。
matlab/agent-skills-playground☆ 1852026年10月10日 更新
Use when designing multi-tenant SaaS architectures, implementing tenant isolation, data partitioning strategies, or building billing/metering systems - covers pooled, siloed, and hybrid modelsUse when ", " mentioned.
日本語の概要は準備中です。原文の説明を表示しています。
omer-metin/skills-for-antigravity☆ 1652026年1月22日 更新
Measure what matters. Event tracking design, attribution modeling, funnel analysis, experimentation platforms. The complete guide to understanding what your users actually do, not what you hope they do. Good analytics is invisible until you need it. Then it's the difference between guessing and knowing. Use when "analytics, tracking, events, funnel, conversion, attribution, segment, amplitude, mixpanel, posthog, ab testing, experiment, cohort, retention, measure, metrics, analytics, tracking, events, funnel, conversion, attribution, data" mentioned.
日本語の概要は準備中です。原文の説明を表示しています。
omer-metin/skills-for-antigravity☆ 1652026年1月22日 更新
AI Pricing Skill workflow skill. Use this skill when the user needs When the user wants to price an AI product, choose a charge metric, design pricing tiers, or optimize margins. Also use when the user mentions 'AI pricing,' 'usage-based pricing,' 'consumption pricing,' 'outcome pricing,' 'BYOK,' 'bring your own key,' 'per-seat pricing,' 'pricing tiers,' 'AI margins,' 'cost per token,' or 'pricing model.' This skill covers pricing strategy, packaging, and margin management for AI-native products. Do NOT use for technical implementation, code review, or software architecture and the operator should preserve the upstream workflow, copied support files, and provenance before merging or handing off.
日本語の概要は準備中です。原文の説明を表示しています。
diegosouzapw/awesome-omni-skills☆ 1602026年7月8日 更新
独立开发者与微型 SaaS — 单人或极小团队 (≤3 人) 构建可持续订阅收入的软件产品商业, 有别于自由职业/咨询、企业级 SaaS 和开源维护: (a) 产品发现与验证 (自己的痒 vs 市场优先 Nugent/Walling; 着陆页冒烟测试; 先接 Stripe 再写代码; JTBD 访谈适配独立开发者场景; Reddit/HN/X/社区痛点挖掘; Mom Test 验证框架; 公开构建作为验证机制); (b) 独立开发者技术架构 (无聊技术论 McKinley; 单体优先; serverless vs VPS 在 ≤$100/月预算下的取舍; Rails/Django/Laravel/Next.js 等框架的出货速度选型; 托管服务优先于自建; Supabase/PlanetScale/Neon 数据库即服务; Clerk/Auth0 认证即服务; Stripe/Paddle/LemonSqueezy 支付; Vercel/Fly.io/Railway 部署; AI 辅助编码 Cursor/Copilot 作为力量倍增器); (c) 无营销团队的分发与增长 (SEO 作为微型 SaaS 护城河; Product Hunt 发布; AppSumo 终身授权利弊; 冷邮件; Twitter/X 公开构建; IndieHackers 社区分发; 集成市场 Shopify/WordPress/Zapier/Slack 应用目录; 联盟计划; 一人内容营销); (d) 定价与变现 (SaaS 定价心理学; freemium vs 免费试用 vs 纯付费; 按席位 vs 按用量 vs 固定费率; 年付折扣; 老用户保价; 微型 SaaS 流失率控制; MRR/ARR/LTV/CAC 在微型规模的含义; $10K MRR 里程碑心理学); (e) 独立创始人心智模型与生活设计 (default alive vs default dead Graham; 拉面盈利 Levels; 生活方式生意 vs 增长生意的光谱; 独立开发者倦怠预防; 时间管理与上下文切换成本; 地理套利与远程优先; 一次构建反复销售的资产思维; 社区作为支持网络 IndieHackers/WIP/MicroConf); (f) 法务与运营基础 (公司注册地选择 LLC/Ltd/GmbH 税效; Stripe Atlas vs Firstbase vs 本地律师; 服务条款与隐私政策; GDPR/CCPA 低成本合规; 知识产权基础; 首次雇人的承包商 vs 员工选择; 独立开发者会计 SaaS — Xero/QuickBooks; 多辖区税务义务)。中国独立开发者生态: 出海作为主导策略 (从中国构建面向全球市场的产品以避开国内竞争/监管); 即刻/V2EX/少数派作为社区枢纽; 微信小程序作为替代分发; 小报童/爱发电作为中文市场变现; 人民币定价心理学; 支付宝/微信支付集成; ICP 备案要求; 中国区 App Store 审核差异; 独立开发者周刊。诚实处理: 生存偏差 (每一个 Pieter Levels 背后是数千个从未达到 $1K MRR 的人), AI 对微型 SaaS 生态位的颠覆 (wrapper 产品脆弱), 独自构建的孤独与心理健康成本, 公开构建的表演性质 vs 真正透明, AppSumo 终身授权上瘾毁坏单位经济, 样板代码销售的伦理边界。不含: 企业级 SaaS (不同 GTM/销售/融资模型), 不含: 自由职业/咨询 (用时间换钱非建资产), 不含: 开源维护 (不同可持续性模型), 不含: 风投支持的创业 (不同增长期望), 不含: 无代码/低代码平台构建 (相邻但不同受众), 不含: 内容创作作为主业。 (Independent Developer and Micro-SaaS — the craft of single-person or tiny-team (≤3 people) software product businesses that generate sustainable recurring revenue without venture capital, distinct from freelancing/consulting, enterprise SaaS, and open-source maintainership: (a) product discovery and validation (scratching your own itch vs market-first Nugent/Walling; landing page smoke tests; Stripe checkout before code; Jobs-to-Be-Done interview adapted to solo context; Reddit/HN/X/community pain-point mining; idea validation frameworks Fitzpatrick Mom Test; build-in-public as validation mechanism); (b) technical architecture for solo operators (boring technology thesis Mckinley; monolith-first; serverless vs VPS tradeoffs for ≤$100/mo infra; framework selection for shipping speed — Rails/Django/Laravel/Next.js/Remix/SvelteKit; managed services over self-hosted whenever possible; database-as-a-service Supabase/PlanetScale/Neon/Turso; auth-as-a-service Clerk/Auth0/Supabase Auth; payment integration Stripe/Paddle/LemonSqueezy; deployment Vercel/Fly.io/Railway/Render; monorepo vs polyrepo for solo; AI-assisted coding Cursor/Copilot as force multiplier); (c) distribution and growth without a marketing team (SEO as moat for micro-SaaS Ahrefs-style content marketing on 1-person budget; Product Hunt launches; AppSumo lifetime deals tradeoffs; cold email outreach; Twitter/X building in public; IndieHackers community distribution; integration marketplaces Shopify/WordPress/Zapier/Slack app directories as channels; affiliate programs; content marketing at scale-of-one); (d) pricing and monetization (SaaS pricing psychology Patel/Campbell; freemium vs free trial vs paid-only; per-seat vs usage-based vs flat-rate; annual discount strategies; grandfathering existing customers; churn reduction for micro-SaaS — Baremetrics/ProfitWell/ChartMogul analytics; MRR/ARR/LTV/CAC at micro scale; the $10K MRR milestone psychology); (e) solo founder mental model and lifestyle design (default alive vs default dead Graham; ramen profitability Levels; lifestyle business vs growth business spectrum; burnout prevention for solo operators — no team to delegate to; time management and context-switching costs; geographic arbitrage and remote-first; the 'build once sell twice' asset mindset; community as support network IndieHackers/WIP/MicroConf); (f) legal and operational basics (incorporation LLC/Ltd/Gm
日本語の概要は準備中です。原文の説明を表示しています。
swaylq/master-skill☆ 1552026年9月6日 更新
Threat-model a sensitive design with STRIDE on request. Read-only analysis of threats, controls, and implementation constraints.
日本語の概要は準備中です。原文の説明を表示しています。
arbiterForge/codeArbiter☆ 1482026年10月13日 更新
Design the structure, hierarchy, and navigation model for a product's content and features.
日本語の概要は準備中です。原文の説明を表示しています。
Infrasity-Labs/dev-gtm-claude-skills☆ 1362026年6月29日 更新
Generate professional diagrams as valid draw.io XML — flowcharts, architecture, C4 models, ER diagrams, sequence diagrams, mind maps, and swimlanes. Don't use for Excalidraw or Mermaid output, hand-drawn sketch styles, or slide decks/presentations.
日本語の概要は準備中です。原文の説明を表示しています。
luongnv89/skills☆ 1322026年10月14日 更新
Generate diagrams as valid Excalidraw JSON — flowcharts, architecture, ER diagrams, mind maps, sequence diagrams, wireframes, C4 models, and more. Don't use for draw.io/Mermaid output, slide decks, or pixel-perfect brand graphics.
日本語の概要は準備中です。原文の説明を表示しています。
luongnv89/skills☆ 1322026年10月14日 更新
Reach for this skill whenever you are discussing reinforcement learning, agentic AI systems, AI alignment, continual learning, or the philosophical limits of large language models. This skill channels the thinking of Richard S. Sutton (reinforcement learning pioneer, University of Alberta, Keen Technologies, 2024 Turing Award). Use it to evaluate AI architectures, make long-term AI prognostications, or design systems that learn from runtime experience rather than static datasets. Apply his frameworks when users ask about AGI, the 'Bitter Lesson' of computation, the Reward Hypothesis, or decentralized cooperation versus centralized AI control.
日本語の概要は準備中です。原文の説明を表示しています。
K-Dense-AI/mimeographs☆ 1302026年8月19日 更新
Applies the reasoning, AI safety frameworks, and deep learning principles of Yoshua Bengio (Turing Award winner, Mila). Reach for this skill whenever you are discussing AI safety, existential risk, deep learning architecture, representation learning, or AI governance. Trigger this skill when the user asks about mitigating AI risks, designing safe-by-design systems, evaluating frontier models, international AI coordination, or the fundamental mechanisms of intelligence (like compositionality and distributed representations). Use it to shift the focus from agentic reward-maximization to non-agentic 'Scientist AI', apply the precautionary principle to catastrophic risks, and emphasize mathematically rigorous guardrails.
日本語の概要は準備中です。原文の説明を表示しています。
K-Dense-AI/mimeographs☆ 1302026年8月19日 更新
Suede-affiliated ethical application of behavioral science to marketing decisions, including framing, anchoring, social proof, loss aversion, choice architecture, and friction. Use when the user needs a named psychological model, an evidence-aware application, and a testable hypothesis. NOT FOR: clinical or mental-health advice, deceptive dark patterns, page implementation (use suede-site-alchemy), or pricing design (use suede-pricing).
日本語の概要は準備中です。原文の説明を表示しています。
JasonColapietro/suede-creator-skills☆ 1272026年10月12日 更新
Use this skill for any Python backend work in this project: building FastAPI endpoints, writing service functions, defining Pydantic/SQLModel schemas, running Alembic migrations, or debugging 422 errors. Essential for authentication and authorization patterns — setting up get_current_user, is_superuser checks, admin-only guards, role-based access, and dependency injection chains like Depends(). Also covers middleware, background tasks, async SQLAlchemy sessions, ORM relationship loading, and request/response design. Activate whenever the question involves Python API code, FastAPI patterns, or backend architecture in this codebase. Not for frontend, Docker, CI/CD, or infrastructure.
日本語の概要は準備中です。原文の説明を表示しています。
avibebuilder/claude-prime☆ 1192026年5月17日 更新
Deep expertise in ML/CV model selection, training pipelines, and inference architecture. Use when designing machine learning systems, computer vision pipelines, or AI-powered features.
日本語の概要は準備中です。原文の説明を表示しています。
alirezarezvani/claude-cto-team☆ 1172025年12月18日 更新
Design backend architecture for implementation with API contracts, data model changes, service boundaries, security, and observability.
日本語の概要は準備中です。原文の説明を表示しています。
itseffi/agentic-os☆ 1152026年10月7日 更新
Apply professional-grade security standards to any web application task. Use this skill when writing code that handles authentication, authorization, user input, APIs, file uploads, sessions, secrets, payments, or any data from external sources. Also use when the user asks to review, audit, or assess security of code or a web app. Covers OWASP Top 10 (2025), secure coding, threat modeling, and defensive architecture. Activate even when security is not explicitly mentioned — treat every web feature as a security surface.
日本語の概要は準備中です。原文の説明を表示しています。
EliasOulkadi/shokunin☆ 1142026年10月5日 更新
System-design thinking before any doc or code: goals/non-goals, back-of-envelope numbers, components and contracts, failure modes, operability, security, trade-offs. Use for "design this system", "architecture for X", "trade-offs for X", "how should we architect", "API design", "data model for", "service boundaries", or before an ADR. Hands off to /ship:write-docs to record the decision. Not implementation planning (/ship:design — that turns a decided design into stories).
日本語の概要は準備中です。原文の説明を表示しています。
heliohq/ship☆ 932026年7月4日 更新
Reviews BubbleTea TUI code for proper Elm architecture, model/update/view patterns, and Lipgloss styling. Use when reviewing terminal UI code using charmbracelet/bubbletea.
日本語の概要は準備中です。原文の説明を表示しています。
existential-birds/beagle☆ 822026年9月16日 更新
Design and implement an AI feature integration — model selection, architecture pattern, system prompt, data flow, error handling, cost estimate. Use when asked to "add AI to this", "LLM integration", "add Claude/GPT", or "AI-powered feature".
日本語の概要は準備中です。原文の説明を表示しています。
tonone-ai/tonone☆ 762026年10月5日 更新
Generates CQRS Queries with Handlers and Response DTOs for read operations. Uses Dapper for optimized read queries, bypassing the domain model for better performance.
日本語の概要は準備中です。原文の説明を表示しています。
ronnythedev/dotnet-clean-architecture-skills☆ 752026年7月14日 更新
Naming, navigation, a UI that mirrors the data model, confirms for irreversible changes. Use when structuring a large application or naming its entities.
日本語の概要は準備中です。原文の説明を表示しています。
dembrandt/dembrandt-skills☆ 722026年10月12日 更新
Design, create, or validate saved and transient Vapi voice assistants. Use for new phone or web agents, production system prompts and first messages, saved-versus-transient architecture, model/voice/transcriber selection, multilingual compatibility, existing tool attachment, native call-control tools, assistant hooks, and Create Assistant API validation errors.
日本語の概要は準備中です。原文の説明を表示しています。
VapiAI/skills☆ 672026年10月9日 更新