2,355 件 ・ 関連度順
概要と使いどころ
Use when a task needs the judgment of a correctional services manager (warden/facility administrator) — deciding how to respond to a staffing cut against safety risk, reviewing an inmate classification or housing decision, evaluating a use-of-force incident, deciding whether restrictive housing placement is justified and time-limited, or weighing security spending against programming budget under fiscal pressure.
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Use when a task needs the judgment of a corrections sergeant or shift supervisor — mandating overtime to restore a post below minimum staffing, reviewing and countersigning a subordinate's use-of-force report, running progressive discipline for a line officer, assuming incident command during a multi-officer response, or handling a first-level inmate grievance.
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Use when a task needs the judgment of a Bioinformatics Scientist — designing a differential-expression or GWAS analysis with correct multiple-testing correction, calling and triaging variants from NGS data using genotype-likelihood confidence rather than raw allele counts, interpreting a BLAST/DIAMOND homology search, choosing or building a genomics pipeline (aligner, caller, normalization method) for a specific data-generating process, or judging whether a computational-biology analysis's statistical design actually supports the biological claim being made. Distinct from a bioinformatics-technician (executes and QC-gates an established pipeline someone else designed) and a data-scientist (general product/experimentation judgment, not genomics-specific statistics) — this role owns which method and statistical model a genomics question requires, and why.
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Audit code for correctness and rigor — logic errors, silent error swallowing, wishful thinking, and unjustified fallbacks. This is not a style review; it's a logic review. Use when you want a focused correctness audit separate from the full code-police pass.
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Writes, reviews, and debugs idiomatic Rust code with memory safety and zero-cost abstractions. Implements ownership patterns, manages lifetimes, designs trait hierarchies, builds async applications with tokio, and structures error handling with Result/Option. Use when building Rust applications, solving ownership or borrowing issues, designing trait-based APIs, implementing async/await concurrency, creating FFI bindings, or optimizing for performance and memory safety. Invoke for Rust, Cargo, ownership, borrowing, lifetimes, async Rust, tokio, zero-cost abstractions, memory safety, systems programming.
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Corrosion mechanisms, electrochemical testing, and mitigation — from Pourbaix diagrams to coatings and cathodic protection.
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**WORKFLOW SKILL** — Register and generalize agent errors into reusable lessons. USE FOR: when the user corrects the agent, capturing what went wrong, analyzing root cause, generalizing the error into a lesson that prevents recurrence. Use to register errors, analyze mistakes, create lessons, generalize corrections. DO NOT USE FOR: general debugging, writing tests, code review.
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Add a short, project-specific rule, convention, or override to .unikit/RULES.md — the quick-capture inbox for this project's rules (common rules always load; topic files in .unikit/rules/ load when the work matches), automatically loaded by /unikit-implement (later promotable via /unikit-memory migrate-rules). Works only with a rule typed as a prompt — it does NOT read files, folders, URLs, or PDFs. Cross-checks against the knowledge base (RULES_INDEX.md) to avoid duplicating core/stack entries. Use for fast, one-line conventions and corrections: "add a rule", "remember this", "convention", "always do X", "never use Y", "from now on do Z", or when the user corrects agent behavior and wants it remembered; also "split the rules into topics" (optimise), "clean up the rules" (prune), "shorten RULES.md" (compact). If the user points to a source (file, folder, URL, PDF, article, book) or wants to research/document framework usage, use /unikit-memory; for architecture decisions use ARCHITECTURE.md.
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Professional typography rules for UI design, web applications, software interfaces, and all screen-based text. Enforces timeless typographic correctness that LLMs consistently get wrong: proper quote marks, dashes, spacing, hierarchy, and layout. ENFORCEMENT MODE: When generating ANY HTML, CSS, React, JSX, or UI code containing visible text, auto-apply every rule in this skill silently — do not ask, do not explain, just produce correct typography. AUDIT MODE: When reviewing or improving existing interfaces or legacy code, flag violations and provide fixes. Trigger on: any HTML/CSS/React artifact creation, "build a landing page", "create a component", "design a UI", "fix the typography", "make this look professional", "review this layout", web design, presentation design, dashboard creation, document generation, or any task producing visible text for humans. Even if the user doesn't mention typography, apply these rules whenever generating UI output.
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Discovery, download, and configuration hub for the entire aelf agent skill ecosystem. Use when the user wants to: (1) explore or list available aelf skills, (2) install/bootstrap aelf skills into Cursor, Claude Desktop, OpenClaw, Codex, or Claude Code, (3) route an aelf-related intent to the correct skill, (4) check health or audit installed skills, (5) onboard a new skill into the aelf ecosystem. Covers domains: Portkey CA wallet, Portkey EOA wallet, Awaken DEX, eForest NFT marketplace, AelfScan explorer, TomorrowDAO governance, aelf node interaction.
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Proactive monitoring of Aave V3 borrow positions with liquidation alerts. Queries user collateral, debt, and health factor across chains (Ethereum, Polygon, Arbitrum, etc.). Sends urgent alerts to Telegram/Discord/Slack when health factor drops below configurable thresholds (critical at 1.05, warning at 1.2). Use when you need continuous monitoring of Aave positions, want alerts before liquidation risk occurs, or need periodic summaries of your borrowing health.
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Produces structured U.S. legal audit summaries that distill compliance findings into executive-ready risk prioritization and remediation plans, covering likelihood/impact scoring, consequence analysis, and corrective actions with timelines and owners. Use for legal audits, compliance audits, regulatory audits, compliance gap analyses, risk assessments, audit report summaries, or remediation roadmaps. Trigger keywords: audit summary, compliance findings, audit report, risk prioritization, remediation plan, regulatory exposure, corrective action plan.
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Quantitative agent evaluation using 4-metric framework (correctness/step_ratio/tool_call_ratio/latency_ratio) with ideal trajectory annotation and capability-categorical taxonomy. Use when measuring agent efficiency, comparing agent variants, or gating new agents through correctness→efficiency phases. Complements harness-eval (SE benchmarks) and evaluator-optimizer (qualitative rubric).
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Applies game theory to multi-agent coordination protocols with advisory claims, repeated interactions, daemon-mediated correlation, and deviation penalties. Use for Nash equilibrium checks, folk-theorem cooperation analysis, correlated-equilibrium routing, and price-of-anarchy audits in strategic agent systems. NOT for consumer pricing, card-game strategy, or general microeconomics outside agent coordination.
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Corrects fluorophore spillover (conventional compensation) or spectral overlap (spectral unmixing) and applies variance-stabilizing transforms (logicle/biexponential, arcsinh, log) for flow and mass cytometry. Covers spillover-matrix estimation from single-stain controls, AutoSpill, the spillover spreading matrix and why panel design (not compensation) bounds resolution, compensate-then-transform ordering, and arcsinh cofactor choice (5 for CyTOF, ~150 for fluorescence, per-channel via flowVS). Use when correcting spectral overlap, preparing data for gating/clustering, choosing logicle vs arcsinh, deciding a cofactor, or distinguishing compensation from spectral unmixing.
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Normalizes and transforms RNA-seq count matrices for DE, visualization, clustering, and ML. Covers between-sample (TMM, TMMwsp, RLE/median-of-ratios, upper quartile), within-sample (TPM, FPKM/RPKM), variance-stabilizing (VST, rlog, log-CPM), GC-content correction (cqn, EDASeq), and single-cell (scran deconvolution, scanpy normalize_total). Encodes the composition-bias rationale, the "most genes not DE" assumption and its catastrophic failure modes (MYC amplification, apoptosis, viral host shutoff, prokaryotic stress), the "lengthScaledTPM is not TPM" naming trap, the "TPM is not for DE" rule, the blind=TRUE vs FALSE decision, ERCC spike-in normalization (SBN), and the single-cell zero-inflation breakdown of TMM/RLE. Use when choosing or applying normalization, debugging shifted-MA-plot diagnostics, handling zero-heavy single-cell data, or correcting GC bias.
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Extracts cfDNA fragmentomics features (DELFI genome-wide short/long ratios, WPS nucleosome positioning, Griffin GC-corrected accessibility profiles, end-motifs/MDS, OCF) for cancer detection and tissue-of-origin from plasma WGS. Centers on the nuclease-footprint reframe (every feature re-reads one nucleosome object), the mandatory GC correction, and the cross-protocol non-comparability that breaks naive classifiers. Runs FinaleToolkit (real CLI/Python, MIT) and the Griffin Snakemake pipeline; DELFI is a method, not a package. Use when deriving fragment-based signal from cfDNA, choosing a feature family for detection vs subtyping, or diagnosing why a fragmentomic model failed validation.
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Assesses genetic health of populations for conservation with Ne estimation across time horizons (LDNe NeEstimator V2 option-file API + SNeP physical-linkage correction; recent trajectory via GONE/GONE2; deep history via Stairway Plot 2 / dadi / fastsimcoal2 / PSMC), F-statistics, runs of homozygosity binned by length class to date inbreeding, genetic-load decomposition (Bertorelle 2022 realized vs masked), the modern 100/1000 Ne rule (Frankham 2014), Ne/Nc 2-6 orders of magnitude in marine fish (Hauser & Carvalho 2008), tree-sequence forward simulations (SLiM 4 + pyslim + tskit), and the Sukumaran-Knowles caveat against MSC methods for management-unit definition. Use when estimating Ne by time horizon, detecting inbreeding via F_ROH, decomposing genetic load, justifying conservation thresholds, distinguishing ESU/MU/DPS, configuring NeEstimator V2, or correcting LDNe physical linkage.
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Detects differential alternative splicing between conditions using rMATS-turbo (binomial LRT on junction counts), leafcutter (Dirichlet-multinomial GLM on intron clusters), MAJIQ V3 deltapsi/HET (Bayesian posterior on LSVs), SUPPA2 (empirical-null on TPM-derived PSI), or Shiba (junction-imbalance-corrected, 2025 SOTA at low coverage). Reports FDR-corrected significance and delta PSI effect sizes. Tools differ in statistical model, annotation dependence, calibration regime, and replicate-count requirements. Use when comparing splicing patterns between treatment groups, tissues, or disease states.
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Detect, date, and contextualize whole-genome duplication (WGD / paleopolyploidy) events using wgd v2 (Chen et al 2024), KsRates (Sensalari 2022 substitution-rate-corrected Ks dating), DupGen_finder (Qiao 2019), MAPS (Li 2018 phylogenomic), POInT (Conant 2008 ordered-block), SLEDGe (2024 ML-based), Whale.jl (Bayesian DL+WGD), and synteny-anchored paranome construction. Use when identifying ancient polyploidy from Ks distributions and synteny block analysis, positioning WGD events relative to speciation, distinguishing tandem from segmental from WGD duplications, dating the 2R/3R vertebrate / fish / salmonid WGDs, building paranome and Ks-age mixture models, applying KsRates substitution-rate correction across lineages, or testing alternative biased-fractionation / dosage-balance models post-WGD.
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Normalize read-depth copy-ratio profiles and segment them into copy-number regions using circular binary segmentation (CBS, DNAcopy), hidden Markov models, HaarSeg, and fused-lasso methods. Covers GC-content, mappability, and replication-timing (wave-artifact) bias correction, panel-of-normals/PCA denoising, diploid-baseline centering, and algorithm selection by sequencing depth and event size. Use when choosing a segmentation algorithm, correcting depth bias, diagnosing oversegmentation or a mis-centered baseline, tuning CBS or HMM parameters, or understanding why a downstream CNV caller produced fragmented or shifted segments.
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Detect and adjust for horizontal pleiotropy in two-sample Mendelian randomization by distinguishing uncorrelated (UHP) from correlated (CHP) pleiotropy and choosing among Egger, MR-PRESSO, MR-RAPS, CAUSE, LHC-MR, LCV, MR-Clust, MR-Mix, and contamination-mixture methods. Use when validating an MR causal claim, running the STROBE-MR sensitivity battery, suspecting a shared heritable confounder, working under weak-instrument or polygenic-exposure regimes, or reconciling discordant estimates across robust methods.
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Estimates bivariate genetic correlation (rg) between traits from GWAS summary statistics or individual-level genotypes using cross-trait LDSC, HDL, LAVA, rho-HESS, GREML-bivariate, Popcorn, and HDL-L. Use when quantifying shared genetic architecture between two traits, screening MR validity before causal inference, distinguishing global from locus-level rg, estimating trans-ancestry rg, separating partial from full causation via LCV gcp, or producing a STROBE-MR-compliant cross-trait sensitivity battery. Cross-trait LDSC intercept absorbs sample overlap and is NOT a bias; HDL is biased under sample overlap above ~5%. High rg between exposure and outcome motivates CHP-aware MR sensitivity (CAUSE, LHC-MR).
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Estimates SNP heritability and partitions it across functional annotations, cell types, and loci from GWAS summary statistics or individual-level genotypes. Implements LDSC, stratified LDSC with the baseline-LD model, Finucane 2018 cell-type prioritization, LDAK SumHer, HDL, HESS local heritability, BOLT-REML, GCTA-GREML, graphREML, and Popcorn cross-population genetic correlation. Use when computing total h2_SNP from summary stats, partitioning heritability across functional categories, prioritizing trait-relevant tissues or cell types from ENCODE/Roadmap chromatin marks, reconciling LDSC vs LDAK enrichment estimates, computing local heritability with HESS, estimating genetic correlation between traits, or producing publication-grade enrichment with calibrated sensitivity to model assumptions.
日本語の概要は準備中です。原文の説明を表示しています。