501 件 ・ 関連度順
概要と使いどころ
Online (incremental) covariance, correlation, and precision estimation in Python — the streaming complement to sklearn.covariance. Use when code needs a covariance/correlation matrix updated per observation, recomputes np.cov/np.corrcoef in a rolling loop, must judge or compare covariance estimates, or proposes a new covariance methodology. Points to task-specific skills.
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Use when building or auditing a radiomics or tabular clinical-ML prediction model with a classical learner (LASSO, SVM, random forest, XGBoost and similar). Enforces nested CV, dimensionality control, in-fold feature selection, feature stability, calibration and external validation.
日本語の概要は準備中です。原文の説明を表示しています。
Use Flair for NLP annotation, embeddings, text/sequence model prediction, corpus loading, training/fine-tuning, HunFlair biomedical NER/linking, and production troubleshooting.
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Use the fair-esm repository skill for protein language-model embeddings, ESMFold structure prediction, ESM-IF1 inverse folding, and zero-shot variant-effect scoring.
日本語の概要は準備中です。原文の説明を表示しています。
Routes EasyCV training, evaluation, prediction, export, and data workflows.
日本語の概要は準備中です。原文の説明を表示しています。
Use Chai Lab / Chai-1 for molecular structure prediction, input preparation, MSA/template setup, restraints, glycans, and repo-specific troubleshooting.
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Route Boltz package tasks for biomolecular structure and affinity prediction, data preparation, training, and evaluation workflows.
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Use AlphaFold 3 PyTorch for protein and biomolecular structure-prediction workflows, heterogeneous molecule inputs, PDB/mmCIF/MSA/template preparation, bounded model inference, training configuration, and local CLI or Gradio operation.
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Use this skill for AlphaFold 3 input preparation, prediction command planning, output interpretation, and Python API inspection. Covers the local AlphaFold 3 inference package, its JSON dialect, run_alphafold workflow, outputs, troubleshooting, and safe helper scripts.
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Financial trading CLIs — spot and perp trading on Hyperliquid, Binance, Coinbase, OKX. Prediction markets on Polymarket. Deposit and withdraw across chains. LLM-enriched price quotes with trend analysis. News and SEC filings. Historical backtesting with forward PnL analysis. Use when: user asks about stock/crypto prices, wants to trade, deposit, withdraw, check portfolio, or backtest a strategy.
日本語の概要は準備中です。原文の説明を表示しています。
Use to stress-test predictions by assuming they failed and working backward to identify why. Invoke when confidence is high (>80% or <20%), need to identify tail risks and unknown unknowns, or want to widen overconfident intervals. Use when user mentions premortem, backcasting, what could go wrong, stress test, or black swans.
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Applies the reasoning style of Ilya Sutskever (deep learning pioneer, co-founder of OpenAI and Safe Superintelligence Inc.) to problems involving AI architecture, scaling laws, alignment, and research strategy. Reach for this skill whenever discussing machine learning paradigms, the limits of compute and data, AGI timelines, superintelligence safety, or deciding between hardcoding vs. learning. Trigger this skill for questions about next-word prediction, reinforcement learning efficiency, generalization gaps, and transitioning from brute-force scaling to fundamental research, even if the user doesn't explicitly name him.
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Identify bug-introducing commits using semantic analysis that extends traditional SZZ algorithm. Distinguishes semantic changes from refactorings or code movements using control-flow and data-flow similarity analysis. Use when analyzing bug-fix commits to trace back to bug-introducing changes, investigating software evolution, conducting empirical studies on defect prediction, or reducing false positives in bug localization. Supports git repositories and provides explanations for why commits are identified as bug-introducing.
日本語の概要は準備中です。原文の説明を表示しています。
Deploy ML models with FastAPI, Docker, Kubernetes. Use for serving predictions, containerization, monitoring, drift detection, or encountering latency issues, health check failures, version conflicts.
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Think and work like an expert Computer Architecture Researcher. Use when a task calls for Computer Architecture Researcher judgment. Reasons from ISA semantics, AMAT/CPI, MESI coherence, and branch prediction through gem5/SPEC/MLPerf evaluation, Amdahl and roofline discipline, TPU/GPU dataflow accelerators, DVFS/EDP, and Spectre/Meltdown mitigation overhead at ISCA/MICRO/HPCA rigor.
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Think and work like an expert Animal Geneticist & Breeder. Use when a task calls for Animal Geneticist & Breeder judgment. Reasons from additive genetic variance, response to selection (R = i h sigma_A), accuracy, and inbreeding depression through REML/BLUP and ssGBLUP pipelines (BLUPF90, ASReml, WOMBAT), economic selection indices, optimum-contribution mate allocation, and Interbull MACE while treating confounded contemporary groups, prediction bias/dispersion, popular-sire inbreeding and rising deleterious haplotypes, GxE reranking, and pedigree or genotype-calling errors as first-class failure modes.
日本語の概要は準備中です。原文の説明を表示しています。
Predict B-cell and T-cell epitopes using BepiPred, IEDB tools, and structure-based methods for vaccine and antibody design. Identify immunogenic regions in antigens. Use when designing vaccines, mapping antibody binding sites, or predicting immunogenic peptides.
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Query the Ensembl REST API for gene/transcript/protein lookup, sequence retrieval, comparative genomics (Compara), variant effect prediction (VEP), regulatory features, and cross-species ortholog/paralog calls. Use when pulling Ensembl-native data (Ensembl Gene IDs, version-pinned releases, archive endpoints for reproducibility), gene/transcript/exon structure with stable IDs, or VEP for variant annotation. Encodes the 15 req/sec rate limit, archive (e110.rest.ensembl.org) for reproducibility, Ensembl divisions (vertebrates / plants / fungi / metazoa / bacteria), and the symbol-vs-ID stability problem.
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Performs alchemical free-energy calculations including relative binding free energy (RBFE / FEP+) and absolute binding free energy (ABFE) via OpenFE, FEP+, GROMACS, AMBER pmemd, and OpenMM with explicit lambda window scheduling, soft-core potentials, REST2 enhanced sampling, MBAR/BAR analysis, and cycle closure validation. Compares ML alternatives (Boltz-2 affinity, DeepDock). Use when ranking analogs by binding affinity beyond docking accuracy, performing prospective lead optimization, or validating SAR predictions.
日本語の概要は準備中です。原文の説明を表示しています。
Predict enhancer-gene regulatory connections from ATAC-seq using ABC, ENCODE-rE2G, HiChIP, or Cicero. Use when linking distal enhancers to target genes, choosing between contact-aware (ABC, ENCODE-rE2G), accessibility-only (Cicero), and orthogonal (HiChIP H3K27ac, EpiMap) approaches, validating predictions against CRISPRi-FlowFISH gold-standard, or building cell-type-specific regulatory maps for fine-mapping or therapeutic target discovery.
日本語の概要は準備中です。原文の説明を表示しています。
Sequence-based deep learning for ATAC-seq using chromBPNet, BPNet, scBasset, or EnFormer. Use when correcting Tn5 bias with neural networks beyond k-mer models, predicting per-base accessibility profiles, scoring in silico variant effects at GWAS or rare-variant SNPs, discovering motifs via DeepLIFT/TF-MoDISco from a trained model, or generating cell-type-specific accessibility predictions for unobserved cell states.
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Detect single-nucleotide crosslink (CL) sites in CLIP-seq data using truncation patterns (iCLIP/eCLIP CITS), crosslink-induced mutations (HITS-CLIP CIMS deletions, PAR-CLIP T-to-C), or HMM/kernel-density methods (PureCLIP, PARalyzer, CTK). Use when single-nucleotide resolution is required for motif registration (mCross), allele-specific binding (BEAPR), variant-effect prediction, or comparing crosslink chemistry across CLIP variants.
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Design guides for cytosine and adenine base editing using editing window optimization and BE-Hive outcome prediction. Select optimal positions for C-to-T or A-to-G conversions without double-strand breaks. Use when designing base editor experiments for precise nucleotide changes.
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Detects allele-specific transcription factor or histone modification binding from heterozygous-variant ChIP-seq using WASP (reference-bias filter; mandatory upstream), RASQUAL (joint QTL + bias-corrected testing), BaalChIP (Bayesian beta-binomial with copy-number-aware overdispersion), and AlleleSeq (personalized diploid genome). Handles imprinted-locus awareness, X-inactivation artifacts, cancer copy-number imbalance, and integration with downstream caQTL / bQTL mapping. Use when identifying variants with allelic effects on TF binding, fine-mapping causal regulatory variants, validating deep-learning variant predictions, or characterizing cis-acting regulatory effects.
日本語の概要は準備中です。原文の説明を表示しています。