「pth」の検索結果

REST API security hardening with authentication, rate limiting, input validation, security headers. Use for production APIs, security audits, defense-in-depth, or encountering vulnerabilities, injection attacks, CORS issues.

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Conduct in-depth, multi-step research on a given topic by decomposing queries, finding diverse sources, cross-referencing findings, and synthesizing a comprehensive report. Use when the user requests deep research or provides relevant inputs for this workflow.

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Med peer benchmarking: select actual biotech/pharma peers via the med universe (drug/indication overlap where possible) and compare med-relevant metrics — pipeline depth, catalyst density, cash position, margins, valuation multiples.

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Think and work like an expert Geophysicist. Use when a task calls for Geophysicist judgment. Reasons from wavelength and skin-depth limits through earthquake catalogs (USGS ComCat, ObsPy/FDSN), Bouguer/IGRF gravity-magnetics, MT distortion and dimensionality, and SEG-Y reflection processing (NMO, migration) while treating statics, galvanic distortion, velocity ambiguity, and header mis-mapping as first-class failure modes.

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Think and work like an expert Carbon Cycle Scientist. Use when a task calls for Carbon Cycle Scientist judgment. Reasons from carbon mass balance across reservoirs and timescales, sign conventions, and budget closure through the Global Carbon Budget protocol, ONEFlux/REddyProc eddy-covariance processing, atmospheric inversions (CarbonTracker, CAMS, GEOS-Chem), Δ¹⁴C/δ¹³C isotopic partitioning, and ILAMB model evaluation while treating NEE sign mismatches, gap-filled GPP read as measured, fixed-depth SOC comparisons, and uncounted lateral aquatic carbon export as first-class failure modes.

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Research any topic in exhaustive depth by combining web search, academic papers, social discussions, and community conversations. Produces comprehensive briefings with evidence from every available source type, confidence scoring, and identified knowledge gaps.

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Source technical and professional talent by combining LinkedIn profiles, GitHub contributions, and company intelligence. Identifies candidates with specific skills, assesses expertise depth, and provides outreach context for recruiting teams.

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Provider-independent VFX compositing direction for generated video, ads, trailers, product films, social clips, explainers, mixed-source edits, and image/video composites. Use when an agent must plan, brief, generate, integrate, repair, or quality-check visual effects composites involving plates, alpha/mattes, keying, roto, tracking, stabilization, matchmove, lighting/color integration, grain/noise/sharpness, shadows/reflections/contact, depth/atmosphere, AI-generated elements, clean plates, editor/colorist handoff, rights/safety, or compositing QA.

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Resolve the architecture of focal oncogene amplifications — extrachromosomal DNA (ecDNA), breakage-fusion-bridge (BFB) cycles, homogeneously staining regions (HSR), and linear amplification — from whole-genome sequencing with AmpliconArchitect, the AmpliconSuite pipeline, and AmpliconClassifier. Covers copy-number seed selection, breakpoint-graph reconstruction, balanced-flow optimization, ecDNA classification, and the limits of depth-only amplification calls. Use when a focal amplification needs structural characterization, when distinguishing ecDNA from chromosomal amplification, suspecting ecDNA-driven oncogene amplification or therapy resistance, or selecting copy-number seeds for amplicon reconstruction.

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Analyzes CUT&RUN (Skene Henikoff 2017) and CUT&Tag (Kaya-Okur 2019) chromatin profiling data. Handles SEACR vs MACS2 peak calling (with the btaf375 2025 benchmark guidance), pA-MNase vs pA-Tn5 vs pAG-Tn5 chimera differences, E. coli spike-in carryover normalization, IgG-only control logic (no input), characteristic fragment-size signatures (25-75 bp for CUT&Tag), and lower depth requirements (5M reads typical vs 25M for ChIP). Use when calling peaks from CUT&RUN/CUT&Tag, scaling by E. coli spike-in carryover, choosing SEACR norm mode, or comparing CUT&RUN/Tag results to traditional ChIP.

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Visualize copy number profiles, segments, allele-specific tracks, and cohort patterns from CNVkit, GATK, ASCAT, FACETS, Sequenza, and other callers. Covers genome-wide and per-chromosome log2 scatter plots, B-allele-frequency/minor-allele-fraction tracks, ideograms, cohort heatmaps, circos views, and caller-native plots. Use when creating publication CNV figures, choosing which plot answers a given question, diagnosing a wrong diploid baseline visually, displaying loss of heterozygosity, or deciding what depth-only plots cannot reveal.

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Infer integer allele-specific copy number, tumor purity, and ploidy from tumor sequencing by jointly modeling read depth (logR) and B-allele frequency (BAF) with ASCAT, Sequenza, FACETS, PURPLE, and PureCN (tumor-only). Covers the purity-ploidy identifiability problem, the diploid-baseline (dipLogR) anchor, major/minor copy number, loss of heterozygosity, sunrise/contour fit diagnostics, and reconciliation of conflicting fits. Use when tumor analysis needs absolute copy number rather than relative log2, when estimating purity and ploidy, calling LOH or copy-neutral LOH, resolving whole-genome doubling, running tumor-only allele-specific calling, or choosing among ASCAT, Sequenza, FACETS, and PureCN.

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Apply security-conscious thinking when generating or modifying code. Enforces trust boundary awareness, input validation, injection prevention, secrets management, and defense-in-depth authorization. Use when generating code that handles user input, authentication, authorization, database queries, external APIs, or file operations, or when the user mentions 'security review', 'secure this', 'check for vulnerabilities', 'trust boundary', 'input validation', or 'OWASP'. Loaded automatically by the code-generating molecules (code-forge, refactor-safely, bug-fix). This skill governs the security posture of generated code -- not architecture (see architecture) and not code craft (see clean-code).

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Use for writing, reviewing, debugging, or testing Pandera schemas and runtime validation for Polars DataFrame or LazyFrame pipelines installed with pandera[polars]. Trigger on pandera.polars DataFrameSchema, DataFrameModel, Column, Field, Check, PolarsData, decorators, coercion, strictness, lazy error collection, and validation-depth decisions. Do not use for pandas-backed Pandera, Pydantic object models, Polars transformations without Pandera, static dataframe typing alone, or generic data-quality platforms.

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Find academic papers across up to 8 sources (OpenAlex / Semantic Scholar / CrossRef / PubMed / arXiv for English, OpenReview for AI venues, plus native-Chinese retrieval via NSSD 国家哲社文献中心 + yiigle 中华医学期刊) with adjustable depth — Quick scan (5 min) to Audit prep (3 hr). Use when the user wants to find papers, run a literature search, gather references, scope a research topic, search Chinese-language / 中文原生 literature (中文文献/中文核心/CSSCI/C刊/国内研究/国内文献/中华××期刊/心理学报/经济研究), or filter results by journal tier (中科院分区/一区/几区, Q1, JCR/SJR quartile, 影响因子/impact factor, 期刊分区, 顶刊/top journal, '按分区筛'), or export paste-ready professional search strategies / 检索式 for external databases (PubMed / WOS / Scopus / Embase / 知网 CNKI / 万方 / SinoMed — '写检索式', '导出检索式', 'WOS 检索式', '知网专业检索', 'search strategy', 'boolean search strategy'). Triggers on search verbs ('find papers', 'literature search', 'papers about X'), review types ('scoping review', 'systematic review', 'SR prep', 'literature review', 'lit review', 'help me write a lit review'), Chinese ('找文献', '找论文', '论文搜索', '学术检索', '文献检索', '文献综述', '综述前期', '求文献', '中文文献', '中文核心', 'CSSCI', 'C刊', '国内研究', '找中文的'). Outputs Shadcn HTML report + BibTeX/RIS/CSV + PRISMA-S log. Do NOT use for: concept explanations ('what is X' / 'X 是什么', e.g. '影响因子怎么算'), writing ('帮我写' / 'help me write a paragraph'), single-paper interpretation or PDF download with metadata (use paper-downloader-portable), or when the user already has a literature set (use literature-set-review).

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CesiumJS materials and post-processing — Material, Fabric JSON, MaterialAppearance, ImageBasedLighting, PostProcessStage, PostProcessStageLibrary, bloom, depth of field, ambient occlusion, FXAA, tonemapping, BlendingState. Use when defining Fabric materials for entities or primitives, configuring PBR image-based lighting, or adding screen-space post-processing effects.

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Trim large MetaX model directories for dummy smoke tests or real-checkpoint loading on limited GPUs. Preserve target execution paths while reducing depth; use the real-weight workflow when a loadable checkpoint is requested. Not for accuracy evaluation or model compatibility upgrades.

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Build Tier 1/2/3 cold outreach sequences differentiated by personalization depth and research signal strength during PRD v0.9 Go-to-Market. Triggers on requests to plan cold outreach, founder-led sales, or when user asks "cold email sequence", "outbound campaign", "founder outreach", "LinkedIn outreach", "Tier 1 personalization", "predictable revenue", "sales cadence", "BDR sequence". Outputs GTM-OUT-* sequence entries and lead-list references.

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Test native, React Native, hybrid, and Flutter mobile apps with Appium 3.x, Detox, Maestro, and Patrol. Covers device farm setup (BrowserStack, Sauce Labs), gesture simulation, deep link and cold-start testing, push notifications, biometric (Face ID) auth, offline/poor-network simulation, and iOS/Android permission dialog handling. Use when: "mobile test," "Appium," "Detox," "Maestro," "Patrol," "Flutter test," "iOS test," "Android test," "device farm," "deep link," "biometric," "Face ID," "permission dialog," "React Native test." Not for: device/browser matrix strategy in the abstract — use cross-browser-testing; app startup/memory/battery profiling depth — use performance-testing; mobile screenshot diffing — use visual-testing. Related: ci-cd-integration, cross-browser-testing, performance-testing, test-data-management, test-reliability.

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Expert in creating rich backstories, fictional universes, and ARGs (Alternate Reality Games). Covers world-building, mystery construction, community-driven storytelling, and transmedia narratives. Knows how to create depth that rewards exploration without overwhelming. Use when "lore, world building, backstory, ARG, mythology, fictional universe, hidden story, deep canon, " mentioned.

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Use when implementing object detection, semantic/instance segmentation, 3D vision, or video understanding - covers YOLO, SAM, depth estimation, and multi-modal visionUse when ", " mentioned.

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Expert in growing and engaging communities sustainably. Covers acquisition channels, activation strategies, engagement programs, events, content, and retention tactics. Knows that healthy growth is about depth, not just numbers. Use when "community growth, grow community, community engagement, community events, community content, member acquisition, community retention, " mentioned.

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Expert in building 3D experiences for the web - Three.js, React Three Fiber, Spline, WebGL, and interactive 3D scenes. Covers product configurators, 3D portfolios, immersive websites, and bringing depth to web experiences. Use when "3D website, three.js, WebGL, react three fiber, 3D experience, spline, product configurator, " mentioned.

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Bret Taylor 视角. Sierra 联合创始人 / CEO, OpenAI 董事会主席 (2024-), ex-Salesforce co-CEO, Google Maps 联合创造者. B2B SaaS enterprise 派代表 / outcome-based pricing 第一手提倡者 / brand-as-moat 在 agent 时代重新阐述者. 把 monetize-agents 语境从 "卖软件 access" 换成 "卖 outcome — 客户问题解决一次收一次费", 把 product 设计从 "feature breadth" 换成 "vertical depth + measurable outcome + procurement-grade trust". 用途: 当用户问 "agent 该怎么定价 / per-seat 还是 per-outcome / B2B agent 怎么 GTM / enterprise 0 到 1 / vertical 还是 horizontal / design partner 怎么搭 / 一开始要不要融大钱" 类问题时, 用 Bret Taylor 视角先把 "outcome 可不可测量 + vertical 是哪个 + 第一批 design partner 是谁" 盘清楚, 再给定价 / GTM / 融资判断. 当用户提到 "Bret Taylor" "Sierra" "outcome-based pricing" "deflection" "vertical agent" "design partner" "enterprise agent" "B2B agent GTM" "agent 定价" "agent procurement" 时使用. 即使用户只是说 "用 Sierra 思路看一下" 也应触发.

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