Temporal interval algebra for reasoning about time relationships in planning and knowledge representation
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Temporal interval algebra for reasoning about time relationships in planning and knowledge representation
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Compare gene co-expression and regulatory networks between biological conditions to find rewired relationships using DiffCorr, DiffCoEx, DINGO/iDINGO, and CoDiNA. Covers the differential-connectivity-is-not-differential-expression distinction, the pairwise multiple-testing explosion, marginal vs partial (direct) rewiring, and the underpowered-rewiring failure mode. Use when comparing co-expression networks between disease vs control, treatment, or developmental stages, or finding hub genes that rewire without changing mean expression. For single-condition modules see coexpression-networks; for differential expression of means see differential-expression/de-results.
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Find cross-database references between NCBI databases using Biopython Bio.Entrez (ELink). Use when navigating gene to protein/structure, sequence to publication, PubMed to GEO, BioProject to SRA runs, or discovering all link relationships for a record. Covers linkname semantics, cmd= variants, asymmetric link warnings, neighbor_history for >200 input IDs, and per-database link tables.
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Analyzes species-environment relationships with constrained ordination (CCA, RDA, db-RDA), variance partitioning, indicator species (indicspecies IndVal.g group-equalized), PERMANOVA paired MANDATORILY with PERMDISP (Anderson & Walsh 2013; dispersion confounds centroid tests), Joint Species Distribution Models (HMSC, sjSDM, gjam) with explicit rejection of "residual covariance equals biotic interaction", phylogenetic community ecology (SES_MPD/MNTD), trait-environment via RLQ + fourth-corner with corrected modeltype=6 (Dray 2014), bipartite network metrics (NODF, modularity) with curveball null (Strona 2014), and Mantel-test replacements (dbRDA, GDM) for spatial data. Use when testing how environmental gradients structure communities, identifying habitat indicator taxa, partitioning variance among predictors, deciding whether PERMANOVA significance is location vs dispersion, picking among HMSC/sjSDM/gjam, or replacing Mantel tests for landscape data.
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Infer gene regulatory networks (GRNs) from gene expression data using scalable algorithms (GRNBoost2, GENIE3). Use when analyzing transcriptomics data (bulk RNA-seq, single-cell RNA-seq) to identify transcription factor-target gene relationships and regulatory interactions. Supports distributed computation for large-scale datasets.
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Expert-level medicinal chemistry knowledge. Use when working with drug design, structure-activity relationships, ADMET properties, pharmacophores, lead optimization, target identification, drug metabolism, or pharmaceutical development. Also use when the user mentions 'SAR', 'drug design', 'pharmacophore', 'ADMET', 'lead compound', 'hit to lead', 'drug metabolism', 'bioavailability', 'selectivity', 'binding affinity', 'scaffold hopping', or 'bioisostere'.
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Use for any question about a codebase, its architecture, file relationships, or project content — especially when graphify-out/ exists, where the question should be treated as a graphify query first. Turns any input (code, docs, papers, images, videos) into a persistent knowledge graph with god nodes, community detection, and query/path/explain tools.
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Design relational database schemas (and choose when to go NoSQL) that stay maintainable and fast. Use this skill whenever the user mentions tables, DDL, entities and relationships, normalization (1NF/2NF/3NF), primary and foreign keys, UUID vs bigint IDs, indexes (B-tree, composite, covering, partial), EXPLAIN, constraints (CHECK, UNIQUE, exclusion), transactions and isolation levels, migrations (Alembic, Prisma, Flyway, expand-contract, backfilling), or SQL vs NoSQL (MongoDB, DynamoDB, Cassandra, graph databases). Also trigger for "design the database", "model this domain", "which database should I use", or writing ORM models and migration files for PostgreSQL, MySQL, SQLite, or SQL Server.
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Use when writing Eloquent models, relationships, scopes, or queries via Model:: — 'fetch users with their orders'. NOT for PHPStan output, non-Eloquent services, or raw SQL questions.
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[Code Intelligence] Use when you need to query code relationships and connections using the structural knowledge graph.
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Render a crouton collection schema (the field-definition JSON) into a human-readable field table + relationships sketch (HTML + PNG + a terse Markdown table), so a human can sign off on the DATA MODEL before any code is generated. Use when an agent drafts or changes a collection schema (before `crouton config` / `generate_collection`), or when asked to "review a schema", "show the data model", "check these fields".
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Design and generate Convex database schemas with proper validation, indexes, and relationships. Use when creating schema.ts or modifying table definitions.
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Explain an existing Convex app — data model + relationships, public vs internal functions, auth/ownership model, components, a request→data flow — read from the schema and function surface. Read-only.
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Explain an existing Convex app — data model + relationships, public vs internal functions, auth/ownership model, components, a request→data flow — read from the schema and function surface. Read-only.
日本語の概要は準備中です。原文の説明を表示しています。
Design and generate Convex database schemas with proper validation, indexes, and relationships. Use when creating schema.ts or modifying table definitions.
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Detect abuse of legitimate Windows binaries (LOLBins) used for living off the land attacks. Monitors process creation, command-line arguments, and parent-child relationships to identify suspicious LOLBin execution patterns.
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Correlate events across multiple log files from different sources, systems, or time periods. Build unified timelines, identify causal relationships between events, and highlight anomalies that span multiple data sources. Supports timezone normalization and gap detection. Use when analyzing logs from multiple systems (frontend, backend, database, infrastructure), investigating distributed system failures, or building event timelines across services. Triggers: "correlate these logs", "build timeline from multiple logs", "cross-system analysis", "find related events across logs", "multi-source log analysis", "distributed trace analysis"
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Knowledge base from the NASA Systems Modeling Handbook for Systems Engineering (NASA-HDBK-1009A Rev A, 2025). Use for model-based systems engineering (MBSE) wired into NASA's NPR 7123.1 SE processes: the three aspects of MBSE (language / methodology / framework), the NASA SE Engine and its two OOSEM-derived steps (Model Planning, Setting Up the Model), the Modeling Plan as a SEMP subset, the tool-agnostic NASA SE metamodel of elements and relationships across the four SysML pillars (structure / behavior / requirements / parametrics), worked SysML diagrams and tables for stakeholders, requirements, structure and V&V, generating SE work products (ConOps, MOE, MOP, TPM, V&V), the MBSE Grid framework, alternative modeling approaches (PBR, Scenario, System Specification, Verification), and the ConOps model-content template. Scope is bounded to four common technical processes (Stakeholder Expectation Definition, Technical Requirements Definition, Product Verification, Product Validation). Does NOT teach SysML itself, mandate a tool, define NPR 7123.1 processes, cover technical-management processes 10-17, or reproduce the OMG SysML specification.
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Public relations, corporate communications, and analyst relations for B2B SaaS. Use this skill for earned media and press strategy, announcements and press releases, executive and crisis communications, media relationships and briefings, and the Gartner/Forrester/IDC analyst program including Magic Quadrant and Wave evaluation submissions. Also triggers on: PR, public relations, press release, earned media, media relations, journalist, embargo, announcement, crisis comms, corporate communications, analyst relations, AR, Gartner, Forrester, IDC, Magic Quadrant, Forrester Wave, analyst briefing, inquiry.
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Expert C4 Component-level documentation specialist. Synthesizes C4 Code-level documentation into Component-level architecture, defining component boundaries, interfaces, and relationships.
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Codified expertise for managing carrier portfolios, negotiating freight rates, tracking carrier performance, allocating freight, and maintaining strategic carrier relationships.
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Design database schemas with normalization, relationships, and constraints. Use when creating new database schemas, designing tables, or planning data models for any database paradigm.
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Analyzes codebase structure, data flow, module relationships, and key patterns to generate and maintain a living architecture document (ARCHITECTURE.md).
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Use when working with Bmc Helix — bMC Helix ITSM platform management covering incident management, problem management, change management, and CMDB operations. Use when creating or updating incidents with categorization and assignment, managing problem investigation workflows, processing change requests through CAB approval, or querying CMDB for infrastructure configuration items and relationships.
日本語の概要は準備中です。原文の説明を表示しています。