「trial」の検索結果

Think and work like an expert Animal Scientist. Use when a task calls for Animal Scientist judgment. Reasons from NRC nutrient requirements, ad libitum intake, energy/protein partitioning, and genotype x environment x management through ration software (CNCPS, NDS, NRC), pen-blocked trials with mixed models (lme4, PROC MIXED), and BCS, NIR, and rumen/BHBA diagnostics while treating intake collapse, milk fat depression, acidosis, heat stress, wrong experimental unit, and violated withdrawal times as first-class failure modes.

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Think and work like an expert Agricultural Entomologist. Use when a task calls for Agricultural Entomologist judgment. Reasons from pest population dynamics, economic injury levels and thresholds, and degree-day phenology through systematic scouting, IRAC mode-of-action rotation, RCBD efficacy trials, and conservation biocontrol while treating misidentification, secondary pest flares from enemy removal, resistance under repeated MoA, and trap-catch-without-field-verification as first-class failure modes.

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Think and work like an expert Behavioral Neuroscientist. Use when a task calls for Behavioral Neuroscientist judgment. Reasons from contingency structure, deprivation state, and latent arousal/motivation variables through Morris water maze, contextual/cued fear conditioning, operant schedules on Med Associates rigs, and DeepLabCut/SLEAP/SimBA tracking validated against ethograms, while treating thigmotaxis-as-anxiety, locomotor confounds of memory deficits, peripheral CNO sedation, and trials-as-n pseudoreplication as first-class failure modes.

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Think and work like an expert Astrobiologist. Use when a task calls for Astrobiologist judgment. Reasons from habitability, redox disequilibrium, and Bayesian biosignature frameworks through Mars (Perseverance, Viking perchlorate lessons), Europa Clipper ocean worlds, agnostic signatures and the Ladder of Life Detection, while treating abiotic mimics, preservation, and LUCA phylogenomics as constraints—not templates—for extraterrestrial life.

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Think and work like an expert Agroecologist. Use when a task calls for Agroecologist judgment. Reasons from socio-ecological farm systems, functional diversity, soil-biology-mediated fertility, and yield-service trade-offs through mother-baby and mixed-model trials, N/P/C mass balances, PLFA/amplicon and pollinator surveys, and NDVI/FRAGSTATS landscape analysis, while treating edge-effect and plot-size artifacts, weather-year confounding, surface-only soil carbon, and ignored labor/tenure adoption constraints as first-class failure modes.

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Think and work like an expert Astrostatistician. Use when a task calls for Astrostatistician judgment. Reasons from selection functions, censored flux limits, and look-elsewhere trial factors through Cobaya/emcee/dynesty cosmology, GP-coupled exoplanet inference, Landy–Szalay clustering, photo-z σNMAD calibration, and SBI (sbi/LtU-ILI) while treating Malmquist bias, prior-driven tensions, and detrend-then-fit transit bias as first-class failure modes.

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Think and work like an expert Astroparticle Physicist. Use when a task calls for Astroparticle Physicist judgment. Reasons from flux times cross section times acceptance, Poisson counting over structured backgrounds, and Cherenkov photoelectron budgets through SkyLLH unbinned likelihoods, Geant4/CORSIKA chains validated on through-going-muon and calibration samples, and Feldman-Cousins/CLs limits, while treating atmospheric-neutrino and downgoing-muon contamination, ER/NR leakage and the neutrino fog, and look-elsewhere trials as first-class failure modes.

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Computes and interprets treatment effect measures (OR, RR, RD, HR, NNT) with calibrated confidence intervals (Wilson, Newcombe, Miettinen-Nurminen, MOVER, profile likelihood, Bender NNT) and reports marginal vs conditional estimands per FDA 2023 covariate adjustment guidance. Use when reporting treatment effects in confirmatory trials, comparing effect sizes across studies, or constructing forest plots.

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Build Sankey, alluvial, river, and CONSORT-style flow diagrams to visualize cohort transitions, cell-state changes, or pipeline filtering using ggalluvial, networkD3, plotly, and consort. Use when showing how entities move between categories across timepoints (cell states, drug response classes, patient flow through a trial) or filtering pipelines (variants filtered through QC stages).

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Build forest plots (HR, OR, RR, beta-coefficient summaries with CIs) and funnel plots (meta-analysis publication-bias diagnostics) using forestplot, metafor, ggforest, and MendelianRandomization with proper axis-scaling, summary-diamond placement, subgroup nesting, and Egger / trim-and-fill asymmetry tests. Use when summarizing effects across subgroups, trials, or instruments — meta-analysis, Mendelian randomization, subgroup HRs.

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Tests associations between categorical variables in clinical data using chi-square, Fisher's exact, Boschloo, Cochran-Mantel-Haenszel, and modern McNemar variants with calibrated confidence intervals (Wilson, Newcombe, Miettinen-Nurminen). Use when analyzing categorical outcomes, paired binary endpoints, or testing treatment-outcome independence in confirmatory or exploratory clinical trials.

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Produce an intensive, cited analytical report: executive summary, multi-angle findings, contrarian views, open questions, and full sources. Use only when the user needs rigorous synthesis of a complex topic (scientific, technical, policy, or market-analytical) that cannot be answered with a short search, and wants a formal written report, not a recommendation list. Do not use for product picks, top-N lists, quick lookups, or routine "find out about X" tasks. If the request does not clearly need this kind of report, do not use this skill. Do not use for a literature review over published papers. This skill collects evidence from the open web. A request for the literature on a biomedical, clinical, life-science, or other scientific topic — papers, studies, trials, preprints — belongs to firecrawl-research-papers, which queries Firecrawl's paper index (PubMed, bioRxiv, medRxiv, arXiv) instead of searching websites.

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Expert in entertainment industry concept art workflows, from initial ideation through final production-ready deliverables. Combines traditional art fundamentals with modern digital workflows used at AAA studios and film production houses. Draws from methodologies of industry masters: Feng Zhu's efficient design process, Scott Robertson's perspective and vehicle design systems, Sparth's graphic shape language, and Syd Mead's industrial design thinking. Use when "concept art, visual development, vis dev, keyframe, color script, production design, mood board, thumbnail sketch, environment concept, character concept, prop design, callout sheet, orthographic views, design exploration, photobash, speedpaint, concept-art, visual-development, game-art, film-art, pre-production, ideation, design" mentioned.

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独立开发者与微型 SaaS — 单人或极小团队 (≤3 人) 构建可持续订阅收入的软件产品商业, 有别于自由职业/咨询、企业级 SaaS 和开源维护: (a) 产品发现与验证 (自己的痒 vs 市场优先 Nugent/Walling; 着陆页冒烟测试; 先接 Stripe 再写代码; JTBD 访谈适配独立开发者场景; Reddit/HN/X/社区痛点挖掘; Mom Test 验证框架; 公开构建作为验证机制); (b) 独立开发者技术架构 (无聊技术论 McKinley; 单体优先; serverless vs VPS 在 ≤$100/月预算下的取舍; Rails/Django/Laravel/Next.js 等框架的出货速度选型; 托管服务优先于自建; Supabase/PlanetScale/Neon 数据库即服务; Clerk/Auth0 认证即服务; Stripe/Paddle/LemonSqueezy 支付; Vercel/Fly.io/Railway 部署; AI 辅助编码 Cursor/Copilot 作为力量倍增器); (c) 无营销团队的分发与增长 (SEO 作为微型 SaaS 护城河; Product Hunt 发布; AppSumo 终身授权利弊; 冷邮件; Twitter/X 公开构建; IndieHackers 社区分发; 集成市场 Shopify/WordPress/Zapier/Slack 应用目录; 联盟计划; 一人内容营销); (d) 定价与变现 (SaaS 定价心理学; freemium vs 免费试用 vs 纯付费; 按席位 vs 按用量 vs 固定费率; 年付折扣; 老用户保价; 微型 SaaS 流失率控制; MRR/ARR/LTV/CAC 在微型规模的含义; $10K MRR 里程碑心理学); (e) 独立创始人心智模型与生活设计 (default alive vs default dead Graham; 拉面盈利 Levels; 生活方式生意 vs 增长生意的光谱; 独立开发者倦怠预防; 时间管理与上下文切换成本; 地理套利与远程优先; 一次构建反复销售的资产思维; 社区作为支持网络 IndieHackers/WIP/MicroConf); (f) 法务与运营基础 (公司注册地选择 LLC/Ltd/GmbH 税效; Stripe Atlas vs Firstbase vs 本地律师; 服务条款与隐私政策; GDPR/CCPA 低成本合规; 知识产权基础; 首次雇人的承包商 vs 员工选择; 独立开发者会计 SaaS — Xero/QuickBooks; 多辖区税务义务)。中国独立开发者生态: 出海作为主导策略 (从中国构建面向全球市场的产品以避开国内竞争/监管); 即刻/V2EX/少数派作为社区枢纽; 微信小程序作为替代分发; 小报童/爱发电作为中文市场变现; 人民币定价心理学; 支付宝/微信支付集成; ICP 备案要求; 中国区 App Store 审核差异; 独立开发者周刊。诚实处理: 生存偏差 (每一个 Pieter Levels 背后是数千个从未达到 $1K MRR 的人), AI 对微型 SaaS 生态位的颠覆 (wrapper 产品脆弱), 独自构建的孤独与心理健康成本, 公开构建的表演性质 vs 真正透明, AppSumo 终身授权上瘾毁坏单位经济, 样板代码销售的伦理边界。不含: 企业级 SaaS (不同 GTM/销售/融资模型), 不含: 自由职业/咨询 (用时间换钱非建资产), 不含: 开源维护 (不同可持续性模型), 不含: 风投支持的创业 (不同增长期望), 不含: 无代码/低代码平台构建 (相邻但不同受众), 不含: 内容创作作为主业。 (Independent Developer and Micro-SaaS — the craft of single-person or tiny-team (≤3 people) software product businesses that generate sustainable recurring revenue without venture capital, distinct from freelancing/consulting, enterprise SaaS, and open-source maintainership: (a) product discovery and validation (scratching your own itch vs market-first Nugent/Walling; landing page smoke tests; Stripe checkout before code; Jobs-to-Be-Done interview adapted to solo context; Reddit/HN/X/community pain-point mining; idea validation frameworks Fitzpatrick Mom Test; build-in-public as validation mechanism); (b) technical architecture for solo operators (boring technology thesis Mckinley; monolith-first; serverless vs VPS tradeoffs for ≤$100/mo infra; framework selection for shipping speed — Rails/Django/Laravel/Next.js/Remix/SvelteKit; managed services over self-hosted whenever possible; database-as-a-service Supabase/PlanetScale/Neon/Turso; auth-as-a-service Clerk/Auth0/Supabase Auth; payment integration Stripe/Paddle/LemonSqueezy; deployment Vercel/Fly.io/Railway/Render; monorepo vs polyrepo for solo; AI-assisted coding Cursor/Copilot as force multiplier); (c) distribution and growth without a marketing team (SEO as moat for micro-SaaS Ahrefs-style content marketing on 1-person budget; Product Hunt launches; AppSumo lifetime deals tradeoffs; cold email outreach; Twitter/X building in public; IndieHackers community distribution; integration marketplaces Shopify/WordPress/Zapier/Slack app directories as channels; affiliate programs; content marketing at scale-of-one); (d) pricing and monetization (SaaS pricing psychology Patel/Campbell; freemium vs free trial vs paid-only; per-seat vs usage-based vs flat-rate; annual discount strategies; grandfathering existing customers; churn reduction for micro-SaaS — Baremetrics/ProfitWell/ChartMogul analytics; MRR/ARR/LTV/CAC at micro scale; the $10K MRR milestone psychology); (e) solo founder mental model and lifestyle design (default alive vs default dead Graham; ramen profitability Levels; lifestyle business vs growth business spectrum; burnout prevention for solo operators — no team to delegate to; time management and context-switching costs; geographic arbitrage and remote-first; the 'build once sell twice' asset mindset; community as support network IndieHackers/WIP/MicroConf); (f) legal and operational basics (incorporation LLC/Ltd/Gm

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Judges whether a user's input suits the Vibe Creating style of video-prompt writing, and when it does, distills single-scene prompts, multi-shot descriptions, emotional imagery, or mixed input into prompts that are easier for a video model to generate from — while preserving any user-specified dialogue, voiceover, music, sound effects, and other hard constraints. Use when a user wants to turn an idea, story, feeling, or rough/over-specified prompt into a strong text-to-video prompt (Seedance, Sora, Kling, Veo, Runway, etc.), or asks to "rewrite", "improve", "clean up", or "vibe-ify" a video prompt. Do NOT use for long narrative films that need precise word-for-word dialogue sync, industrial shot lists meant to be executed verbatim, or functional/UI demos and step-by-step tutorials.

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When the user wants help with pricing decisions, packaging, or monetization strategy. Also use when the user mentions 'pricing,' 'pricing tiers,' 'freemium,' 'free trial,' 'packaging,' 'price increase,' 'value metric,' 'Van Westendorp,' 'willingness to pay,' 'monetization,' 'how much should I charge,' 'my pricing is wrong,' 'pricing page,' 'annual vs monthly,' 'per seat pricing,' or 'should I offer a free plan.' Use this whenever someone is figuring out what to charge or how to structure their plans.

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Applies the operational and scientific frameworks of Stacey Gabriel (genomicist and sequencing platform leader at the Broad Institute). Use this skill whenever the user is designing large-scale biomedical research, operationalizing lab workflows, standardizing data governance, or transitioning from bespoke academic experiments to industrial-scale science. It is highly relevant for queries involving genomics, precision medicine, multiomics, cellular perturbation pipelines, or building massive datasets to fuel AI. Trigger this skill to shift the user's focus from 'hand-to-hand combat' one-off studies to systematic, standardized, and scalable data generation.

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Applies the epidemiological and aging research frameworks of Tamara B. Harris (epidemiologist, National Institutes of Health). Use this skill whenever analyzing health metrics in older populations, designing longitudinal studies, evaluating body composition (muscle quality vs. mass), assessing dementia risk factors, or interpreting paradoxical risk factors in geriatrics. Trigger this skill when the user asks about aging, longevity, functional decline, socioeconomic health disparities, or when evaluating clinical trial data where reverse causation or subgroup stratification might skew results.

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Applies the practical, systems-level, and commercially-driven reasoning of Thomas Edison (founder of General Electric, inventor and industrialist). Use this skill whenever the user is navigating product commercialization, systems engineering, R&D strategy, scaling new technologies, evaluating patent decisions, or struggling with repeated iterative failures. Edison's approach shifts the focus from isolated 'genius' inventions to building entire profitable ecosystems, treating failure as a necessary process of elimination, and prioritizing relentless execution over pure theory.

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Use this skill whenever you are reasoning about nutritional epidemiology, dietary guidelines, chronic disease prevention, or public health policy. It channels the thinking of Meir J. Stampfer, epidemiologist and nutrition expert at Harvard University. Trigger this skill when evaluating lifestyle factors, comparing observational data versus randomized controlled trials (RCTs), analyzing macronutrient substitutions, or assessing long-term health outcomes. Stampfer's approach is essential when users ask about "good" vs. "bad" foods, seek longevity advice, or need to interpret complex, population-level dietary data without falling for the "magic bullet" fallacy.

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Use this skill whenever you need to reason like John D. Rockefeller, founder of Standard Oil and American oil industrialist. Reach for this skill when the user is facing situations involving market consolidation, economies of scale, aggressive cost-cutting, supply chain leverage, or structuring large-scale philanthropy. It is highly applicable for questions about eliminating operational waste, dealing with fierce competition, negotiating from a position of immense scale, or building self-sustaining charitable foundations. Trigger this skill for topics like monopolies, ruthless efficiency, corporate PR crises, and strategic acquisitions, even if the user doesn't explicitly name Rockefeller.

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Suede-owned signup conversion discipline. Use when auditing or redesigning account creation, registration, or trial-start flows, including field friction, progressive profiling, identity options, mobile behavior, abandonment, and measurement. NOT FOR: post-signup activation (use suede-onboarding), lead-capture forms (use suede-site-alchemy), or deploying auth and compliance changes without review.

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Suede-affiliated in-product monetization design for paywall screens, feature gates, trial-expiry states, usage-limit prompts, and free-to-paid upgrade moments. Use when the user needs trigger timing, message structure, plan presentation, or experiment design after users have experienced value. NOT FOR: public pricing pages (use suede-site-alchemy), tier architecture (use suede-pricing), or cancellation and save flows (use suede-churn-prevention).

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Suede-owned pricing and packaging discipline. Use when deciding what to charge, structuring tiers, choosing a value metric, comparing free trials with freemium, researching willingness to pay, planning a price increase, or tearing down a pricing page for clarity and AI-readability. NOT FOR: in-product upgrade screens (use suede-paywalls), offer bonuses and guarantees (use suede-offers), or executing billing changes.

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