「vc」の検索結果

Use when bypassing a Windows exploit/platform mitigation — ASLR/DEP/CFG/XFG/CET, ACG/CIG, WDAC/App Control, ASR/AMSI/ETW, PPL/LSA Protection, BYOVD/VBS/HVCI

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Annotate and filter VCF variants with SnpEff and SnpSift. SnpEff predicts functional effects (HIGH/MODERATE/LOW/MODIFIER), genes, transcripts, AA changes, HGVS; SnpSift filters and adds ClinVar/dbSNP. Java CLI with Python subprocess integration. Use ANNOVAR for multi-database annotation; Ensembl VEP for REST API; SnpEff for fast CLI with pre-built genomes.

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GWAS and population genetics tool. Processes PLINK (.bed/.bim/.fam), VCF, and BGEN; runs QC (MAF, HWE, missingness), IBD estimation, PCA, and linear/logistic regression GWAS. Outputs Manhattan-ready summary stats. Use regenie or SAIGE for biobanks (>100k samples) needing mixed models.

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Genomic interval ops on BED/BAM/GFF/VCF. Find overlaps, merge intervals, compute coverage, extract FASTA, find nearest features. Core for ChIP-seq peak annotation, region filtering, genome arithmetic. Use tabix for indexed single-region queries; use deeptools for normalized bigWig coverage.

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Detect somatic CNVs from WES/WGS/targeted BAMs (CNVkit v0.9.x). Bin coverage in target/antitarget regions, normalize vs reference, segment with CBS/HMM, call amps/dels, scatter/diagram plots, purity/ploidy, VCF/SEG export. CLI plus Python API (cnvlib). Use GATK CNV for deep WGS with population controls; use CNVkit for targeted/exome where antitarget bins matter.

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Read/write SAM/BAM/CRAM, VCF/BCF, FASTA/FASTQ. Region queries, pileup, variant filtering, read groups. Python htslib wrapper exposing samtools/bcftools CLI. Use STAR/BWA for alignment; GATK/DeepVariant for variant calling.

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Best practices for Docker-based ROS2 development including multi-stage Dockerfiles, docker-compose for multi-container robotic systems, DDS discovery across containers, GPU passthrough for perception, and dev-vs-deploy container patterns. Use this skill when containerizing ROS2 workspaces, setting up docker-compose for robot software stacks, debugging DDS communication between containers, configuring NVIDIA Container Toolkit for GPU workloads, forwarding X11/Wayland for rviz2 and GUI tools, or managing USB device passthrough for cameras and serial devices. Trigger whenever the user mentions Docker with ROS2, docker-compose for robots, Dockerfile for colcon workspaces, container networking for DDS, devcontainer for ROS2, multi-stage builds for ROS2, or deploying ROS2 in containers. Also trigger for CI/CD with Docker-based ROS2 builds, CycloneDDS or FastDDS configuration in containers, or shared memory in Docker. Covers Humble, Jazzy, and Rolling distributions across Ubuntu 22.04 and 24.04 base images.

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When the user wants to identify, evaluate, or prioritize potential investors for a fundraising round. Also activates when the user asks "who should I pitch?", "find me investors", "build an investor list", or mentions VC/angel targeting.

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When the user wants to write an email to an investor — cold outreach, warm intro request, follow-up after a meeting, monthly investor update, or thank-you note. Also activates for "intro email", "investor email", "follow up with VC", or "investor update".

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Use when versioning Spring MVC or WebFlux APIs in Spring Boot 3 / Spring Framework 6. Covers explicit URL, header, and media-type strategies, compatibility rules, and deprecation handling.

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Use when versioning Spring MVC or WebFlux APIs in Spring Boot 4 / Spring Framework 7. Covers built-in mapping versions, request version resolution, defaults, supported versions, and deprecation headers.

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Use when writing tests of any kind — unit, slice, or integration. Covers test structure, naming conventions, Mockito patterns, @WebMvcTest, @DataJpaTest, and Testcontainers setup.

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Use when building Spring Cloud Gateway 5 on Spring Boot 4, including WebFlux or Web MVC routes, edge authentication, trusted headers, rate limits, timeouts, and resilience. Do not use for ordinary outbound HTTP clients or domain orchestration.

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Fix black camera/microphone preview in Flutter macOS apps launched via `flutter run` from a terminal emulator (cmux, iTerm, Terminal.app, VS Code integrated terminal, Cursor, etc.). Use when: (1) camera plugin reports initialized but preview is black with no frames, (2) logs show "initialization completed via timeout" or similar first-frame timeout fallback, (3) AVCaptureSession.startRunning() returns without error but zero frames arrive, (4) the app's Info.plist has NSCameraUsageDescription and entitlements (com.apple.security.device.camera, audio-input) are correctly set, (5) no permission dialog ever appears, (6) same failure mode for microphone. Root cause is macOS TCC attributing camera/mic requests to the *responsible process* (the parent terminal) rather than the Flutter app itself. TCC refuses to prompt because the terminal is hardened-runtime without a camera entitlement, and silently denies. Not a bug in the camera plugin — would reproduce with ANY camera code.

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Think and work like an expert Logician. Use when a task calls for Logician judgment. Reasons from syntax-versus-semantics and object-versus-metalanguage discipline, the ⊢/⊨ distinction, and matching each logic to its intended semantics through natural deduction and sequent calculus (cut-elimination, subformula property), compactness and Löwenheim–Skolem, forcing and diagonalization, and proof assistants (Lean 4/mathlib, Coq, Isabelle/HOL, Agda) with Z3/CVC5/Vampire/Mace4 automation while treating use–mention conflation, second-order misuse of compactness, mis-stated incompleteness hypotheses (ω-consistency vs consistency), and Gödel philosophical overreach as first-class failure modes.

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Think and work like an expert Geomagnetist. Use when a task calls for Geomagnetist judgment. Reasons from spherical-harmonic main-field theory and remanence physics through IGRF-14/WMM2025 vs CHAOS-8 SV, INTERMAGNET baseline adoption (IBFV2.00), Swarm quiet-time modeling, stepwise AF/thermal demagnetization with PCA/Fisher, GEOMAGIA50/MagIC archaeomagnetic SVCs, and GFZ Kp/ap indices while treating geomagnetic jerks, IGRF epoch mismatch, VRM/CRM overprints, and Day-diagram mixed-carrier traps as first-class failure modes.

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Think and work like an expert Formal Methods Researcher. Use when a task calls for Formal Methods Researcher judgment. Reasons from operational semantics and temporal logics through SPIN/TLA+/PRISM, Coq/Lean/Isabelle, Z3/CVC5, refinement and separation logic, vacuity and false-positive diagnosis, and Dafny/F* versus property-based testing boundaries.

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Think and work like an expert Gene Therapy Scientist. Use when a task calls for Gene Therapy Scientist judgment. Reasons from vector biology, biodistribution, linked potency, and integration risk through ddPCR titer, empty/full analytics, ISA and off-target NGS (GUIDE-seq, CIRCLE-seq), and ICH S12 nonclinical design while treating pre-existing capsid neutralizing antibodies, RCV/RCA/RCR positivity, gonadal vector genome, and oligoclonal VCN expansion as first-class failure modes.

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Generate consensus FASTA sequences by applying VCF variants to a reference using bcftools consensus. Use when creating sample-specific reference sequences or reconstructing haplotypes.

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Resolves rsIDs, navigates RsMergeArch/SNPHistory merge chains, and converts between rsID, SPDI, HGVS, and VCF representations using the dbSNP Build 156 JSON architecture. Use when normalizing variant identifiers, joining variant databases by cluster ID, or tracking deprecated rsIDs through historical merges.

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Applies ACMG/AMP 2015 framework with ClinGen SVI specifications, Tavtigian 2018/2020 Bayesian point system, Abou Tayoun 2018 PVS1 decision tree, Pejaver 2022 calibrated PP3/BP4 thresholds for REVEL/BayesDel/AlphaMissense, Brnich 2020 PS3/BS3 OddsPath, Walker 2023 SpliceAI splicing framework, and AMP/ASCO/CAP 2017 tumor tiers. Use when classifying germline variants P / LP / VUS / LB / B, applying VCEP-specific CSpec rules, computing Whiffin BS1, or assigning cancer Tier I-IV per Li 2017.

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Build Spring Boot 4.x applications following the best practices. Use this skill: * When developing Spring Boot applications using Spring MVC, Spring Data JPA, Spring Modulith, Spring Security * To create recommended Spring Boot package structure * To implement REST APIs, entities/repositories, service layer, modular monoliths * To use Thymeleaf view templates for building web applications * To write tests for REST APIs and Web applications * To write ArchUnit tests for testing architecture * To configure the recommended plugins and configurations to improve code quality, and testing while using Maven. * To use Spring Boot's Docker Compose support for local development * To create Taskfile for easier execution of common tasks while working with a Spring Boot application

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Data Version Control for ML projects. Track large datasets and models alongside Git, build reproducible ML pipelines, and run experiments with metric comparison. Works with any storage backend including S3, GCS, Azure, and local filesystems.

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World-class Kubernetes operations - deployments, debugging, Helm charts, and the battle scars from managing clusters that serve millions of requestsUse when "kubernetes, k8s, kubectl, helm, pod, deployment, service, ingress, configmap, secret, statefulset, daemonset, hpa, pvc, crashloopbackoff, imagepullbackoff, oomkilled, liveness probe, readiness probe, kubernetes, k8s, containers, docker, helm, deployment, devops, cloud-native" mentioned.

日本語の概要は準備中です。原文の説明を表示しています。