「bli」の検索結果

Provider-independent still-image post-production skill for RAW/rendered intake, nondestructive development, exposure, white balance, tone, color, ICC proofing, masking, repair, compositing, truthful retouching by genre, generative disclosure, sharpening, noise, resampling, variants, metadata, export, QA, rights, and ethical finishing. Use when an agent must plan, perform, direct, or review still photography retouching and finishing for print, web, social, archive, publication, or client delivery; do not use for image-generation APIs, video grading, or campaign-specific production strategy.

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Generate AI lip sync and visual dubbing with Sync Labs (sync.so) — choose the right model (sync-3, lipsync-2, lipsync-2-pro, lipsync-1.9.0-beta, react-1), build the POST /v2/generate request, host inputs, handle async jobs via polling or webhooks, run batch dubbing/localization, and review output for sync accuracy and identity preservation. Use when an agent must re-voice, dub, translate, personalize, or re-time the mouth of a talking-head video (or animate a still face from audio), or must debug a failed/rejected Sync generation. Also covers consent, likeness, and rights obligations for editing a real person's face.

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Provider-independent production workflow for agents assembling, auditing, executing, and handing off ComfyUI node-graph workflows for image, video, upscale, inpaint, conditioning, and batch media generation; use when a task involves ComfyUI workflow JSON/API graphs, model and custom-node inventories, reproducibility, provenance, safety/rights review, local or cloud execution hygiene, or production QA.

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Produce audio-first podcast episodes with generative tools — design the show and episode format (interview, narrative, news brief, two-host conversational), write scripts for the ear, decide between fully-synthetic and hybrid (recorded human + synthetic) production and meet the disclosure duty each triggers, cast and direct multi-voice TTS for consistency and chemistry, build episode structure (cold open, intro/outro, segments, ad slots), assemble and edit, clear music and SFX rights, hit podcast loudness and delivery standards, ship metadata/chapters/transcripts through RSS, and pass platform AI-content policy and QA before publishing. Use this skill whenever the deliverable is a podcast episode or a podcast show bible, or when an agent must make production, rights, disclosure, or delivery decisions for spoken-word audio. Not for music tracks, single-voice notification prompts, or video where picture leads (route audio-for-video to a video skill).

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Provider-independent explainer video production for AI agents creating educational, product, concept, nonprofit/public-service, onboarding, training, animated, mixed-media, and short social explainers. Use when an agent must turn a topic, brief, research corpus, product, process, policy, dataset, or complex idea into a factual, accessible, narrated, captioned, storyboarded, generated-media-ready explainer video with claim review, localization, pacing, variants, and QA.

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Run a complete design workflow -- from establishing context through four progressive design levels (Capabilities, Components, Interactions, Contracts) to an approved blueprint. Composes knowledge-priming, context-anchoring, learning-harvest, collaborative-judgment, design-first, architecture, and domain-driven-design into one process. Handles both new features (create context doc) and resuming existing work (load context doc). Level 5 (Implementation) is delegated to code-forge. Use when starting a design, planning architecture, or when the user says 'design a feature', 'blueprint', 'start designing', 'plan the architecture', or 'let's design before coding'.

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Papers With Code MCP tools for searching and reading AI/ML papers, discovering recent and trending research, finding related work and paper lineage, browsing tasks, methods, conferences, organizations, and frameworks, and inspecting benchmark leaderboards with model-size and metric filters through the public Papers With Code catalog. Use whenever the user asks to find papers, survey literature, compare research, inspect an arXiv paper, explore AI/ML taxonomy or conferences, discover benchmarks or state-of-the-art models, or mentions Papers With Code, the PwC MCP server, or paperswithcode.co/mcp.

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Papers With Code CLI (`pwc`) for searching and reading AI/ML papers, discovering recent and trending research, finding related work and paper lineage, browsing tasks, methods, conferences, organizations, frameworks, and benchmark leaderboards, and submitting authenticated paper edits through the public Papers With Code catalog. Use whenever the user asks to find papers, survey literature, compare research, inspect an arXiv paper, explore AI/ML taxonomy or conferences, discover benchmarks or state-of-the-art models, or mentions Papers With Code, `pwc`, or `pwc-cli`.

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Maps GWAS-implicated loci to candidate effector (causal) genes by integrating variant-to-gene (V2G) features via Open Targets L2G (Mountjoy 2021), MAGMA gene-based association (de Leeuw 2015), FUMA SNP2GENE, cS2G combined SNP-to-gene scores (Gazal 2022), Polygenic Priority Scores (PoPS, Weeks 2023), FLAMES, INQUISIT, DEPICT, and enhancer-gene predictors (ABC, ENCODE-rE2G). Use when narrowing a GWAS lead locus to a candidate causal gene, picking between proximity, eQTL-based, and similarity-based prioritizers, integrating multi-evidence streams (fine-mapping, colocalization, ABC enhancer-gene, distance, chromatin), reconciling discordant L2G vs PoPS calls, prioritizing tissue-specific eQTL evidence, or triangulating across at least three independent lines of evidence for a publication-grade effector-gene nomination.

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Exports publication-ready figures in various formats with proper resolution, sizing, and typography. Use when preparing figures for journal submission, creating vector graphics for presentations, or ensuring consistent figure styling across analyses.

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Visualize enrichment results using enrichplot package functions. Use when creating publication-quality figures from clusterProfiler results. Covers dotplot, barplot, cnetplot, emapplot, gseaplot2, ridgeplot, and treeplot.

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Build forest plots (HR, OR, RR, beta-coefficient summaries with CIs) and funnel plots (meta-analysis publication-bias diagnostics) using forestplot, metafor, ggforest, and MendelianRandomization with proper axis-scaling, summary-diamond placement, subgroup nesting, and Egger / trim-and-fill asymmetry tests. Use when summarizing effects across subgroups, trials, or instruments — meta-analysis, Mendelian randomization, subgroup HRs.

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Find cross-database references between NCBI databases using Biopython Bio.Entrez (ELink). Use when navigating gene to protein/structure, sequence to publication, PubMed to GEO, BioProject to SRA runs, or discovering all link relationships for a record. Covers linkname semantics, cmd= variants, asymmetric link warnings, neighbor_history for >200 input IDs, and per-database link tables.

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Quantifies CRISPR editing outcomes with CRISPResso2 (Clement 2019 Nat Biotechnol) across Cas9-nuclease (indels, HDR), CBE and ABE base editors (target conversion + bystander), and prime editor (pegRNA-templated) modes. Covers single-amplicon (CRISPResso), multi-sample batch (CRISPRessoBatch), pooled-amplicon (CRISPRessoPooled), WGS off-target (CRISPRessoWGS), and sample-comparison (CRISPRessoCompare) workflows; quantification-window math that controls what is called edited; substitution-vs-indel diagnostic to distinguish BE from Cas9 contamination; MMEJ deletion pattern interpretation; allele-frequency tables; and failure modes from amplicon misalignment or contamination. Use when quantifying editing from amplicon sequencing, choosing CRISPResso mode by design, distinguishing intended edits from bystanders and indel byproducts, debugging low-alignment runs, or generating publication-grade editing reports.

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End-to-end post-GWAS causal inference pipeline orchestrating heritability partitioning, genetic correlation, Mendelian randomization with CHP-aware sensitivity (CAUSE / LHC-MR), colocalization, fine-mapping with SuSiE / FOCUS, mediation, TWAS triangulation, cis-pQTL drug-target MR, effector-gene prioritization (L2G / PoPS / cS2G), and GenomicSEM common-factor GWAS. Use when triangulating causal inference across multiple complementary methods, prioritizing tissues via stratified LDSC, nominating or de-risking drug targets, mapping a lead SNP to a candidate effector gene, modeling shared genetic architecture across correlated traits, or producing a STROBE-MR-compliant publication-grade evidence battery from GWAS summary statistics.

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Visualizes ChIP-seq data using deepTools (computeMatrix, plotHeatmap, plotProfile, bamCoverage, bamCompare), pyGenomeTracks (modern INI-driven track plots), Gviz (R browser-style), EnrichedHeatmap (ComplexHeatmap-based), ChIPseeker tag heatmaps, and IGV batch screenshots. Handles bigWig normalization choices (CPM, BPM, RPGC, spike-in scaled), bamCompare operations (log2 ratio, subtract, SES), k-means clustering of heatmaps for biological subgrouping, and spike-in-scaled tracks for global-shift experiments. Use when generating publication-quality ChIP-seq signal heatmaps, profile plots, genome-browser tracks, or comparing samples visually.

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Visualize copy number profiles, segments, allele-specific tracks, and cohort patterns from CNVkit, GATK, ASCAT, FACETS, Sequenza, and other callers. Covers genome-wide and per-chromosome log2 scatter plots, B-allele-frequency/minor-allele-fraction tracks, ideograms, cohort heatmaps, circos views, and caller-native plots. Use when creating publication CNV figures, choosing which plot answers a given question, diagnosing a wrong diploid baseline visually, displaying loss of heterozygosity, or deciding what depth-only plots cannot reveal.

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Create and use BAI/CSI indices for BAM/CRAM files using samtools and pysam. Use when enabling random access to alignment files or fetching specific genomic regions.

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Pull pre-computed ortholog calls from public databases (OrthoDB, Ensembl Compara, OMA browser, eggNOG, PANTHER, KEGG Orthology, HomoloGene) via their REST APIs. Use when orthologs are already curated upstream, when the question is "what is the X ortholog of Y" rather than "how to infer orthology de novo", when batch-mapping gene IDs across species, or when comparing the resources for consensus calls. Encodes confidence-level semantics, 1:1 vs 1:many vs many:many, HomoloGene deprecation, and when to defect to de novo computation.

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Polish genome assemblies to reduce errors using short reads (Pilon), long reads (Racon), or ONT-specific tools (medaka). Essential for improving long-read assembly accuracy. Use when improving assembly accuracy with polishing tools.

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Infer integer allele-specific copy number, tumor purity, and ploidy from tumor sequencing by jointly modeling read depth (logR) and B-allele frequency (BAF) with ASCAT, Sequenza, FACETS, PURPLE, and PureCN (tumor-only). Covers the purity-ploidy identifiability problem, the diploid-baseline (dipLogR) anchor, major/minor copy number, loss of heterozygosity, sunrise/contour fit diagnostics, and reconciliation of conflicting fits. Use when tumor analysis needs absolute copy number rather than relative log2, when estimating purity and ploidy, calling LOH or copy-neutral LOH, resolving whole-genome doubling, running tumor-only allele-specific calling, or choosing among ASCAT, Sequenza, FACETS, and PureCN.

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Identifies essential genes from CRISPR-Cas9 fitness screens using BAGEL2 (Kim & Hart 2021 Genome Med), a Bayesian classifier scoring per-gene Bayes Factors via log-likelihood ratios over per-sgRNA fold changes, calibrated against CEGv2 core-essentials (Hart 2017 G3, ~684 genes) and NEGv1 non-essentials (Hart 2014, ~927 genes). Covers the fc + bf + pr workflow, the linear-extrapolation improvement over BAGEL1 truncation, multi-target off-target correction, tumor-suppressor sensitivity (BAGEL2 detects enrichment), and BF-to-FDR calibration (BF >6 ≈ FDR 0.05 from Hart 2017). Use when classifying essential vs non-essential genes, calibrating BAGEL2 thresholds against PR curves, identifying tumor suppressors alongside essentials, comparing BAGEL2 hits to MAGeCK / drugZ, or generating publication-quality essentiality calls.

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SEC (size-exclusion chromatography) analysis with peak detection, oligomer classification, and publication-quality PDF report generation via Typst templates. Triggers on "SEC", "size exclusion", "chromatography", "oligomer analysis", "protein assembly", "SEC report".

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Workflow for spatial transcriptomics preprocessing, domain detection, deconvolution, neighborhood analysis, and publication-ready maps.

日本語の概要は準備中です。原文の説明を表示しています。