「ax」の検索結果

End-to-end shotgun metagenomics workflow from FASTQ to taxonomic and functional profiles, orchestrating controls/host depletion, Kraken2+Bracken classification, MetaPhlAn marker profiling, and HUMAnN functional profiling. Covers the controls-first ordering, why Kraken2 read counts are not abundances and MetaPhlAn cell fractions do not equal Bracken read fractions, and the consistent-pipeline framing. Use when profiling shotgun metagenomic samples end to end, or chaining classification, abundance, and function. For resistome see metagenomics/amr-detection; for strains see metagenomics/strain-tracking; for assembly see genome-assembly/metagenome-assembly.

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Orchestrates an end-to-end de novo genome assembly project, routing each step to the right genome-assembly skill rather than restating it. Profiles the genome first (k-mer spectrum -> size, heterozygosity, ploidy), QCs reads, chooses an assembly path by data type (SPAdes for Illumina, Flye for noisy long reads, hifiasm for HiFi, metaFlye for communities), polishes only when needed, decontaminates, scaffolds with Hi-C, and finishes with three-axis QC (contiguity + completeness + correctness). Use when assembling a genome from raw reads and deciding which assembler, whether to polish, and how to prove the result is good.

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Dereplicate a putative natural product and assign its chemical taxonomy. Use to answer "is [compound] a known natural product", "what microbe/organism produces [compound]", "what chemical class is [compound]", "dereplicate this metabolite (by formula/exact mass/InChIKey/SMILES)", or "classify this molecule into ChemOnt". Searches NPAtlas for known microbial natural products (producing organism + literature reference), assigns the ChemOnt kingdom→superclass→class→subclass hierarchy via ClassyFire, resolves systematic IUPAC names to structure via OPSIN, and cross-references identity in PubChem. NOT for general drug/compound identity or ADMET (use tooluniverse-chemical-compound-retrieval / tooluniverse-small-molecule-discovery) and NOT for metabolomics pathway/enrichment analysis (use tooluniverse-metabolomics skills).

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Dose-response / concentration-response curve fitting — IC50, EC50, Hill slope, Emax/Emin efficacy, and relative potency from paired concentration vs response data (enzyme/cell assays, drug screening, agonist/antagonist pharmacology). Fits the 4-parameter logistic (Hill sigmoidal) model. Use when you have concentrations + responses and need a potency value, to compare two compounds' potency, or to judge curve quality. NOT for image-derived dose-response (use tooluniverse-image-analysis) and NOT for survival/regression (use tooluniverse-statistical-modeling).

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Enzyme kinetics — Michaelis-Menten Km, Vmax, kcat (turnover), and kcat/Km (catalytic efficiency / specificity constant) from substrate-velocity data, plus inhibition-mechanism analysis (competitive / uncompetitive / non-competitive, Ki). Fits the MM equation by nonlinear regression (and reports Lineweaver-Burk for reference). Use when you have substrate concentrations and initial reaction velocities and need kinetic parameters or to classify an inhibitor. NOT for BRENDA database lookups of published constants (use the BRENDA tools).

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Designs PROTACs, molecular glues, and bivalent degraders with explicit handling of E3 ligase choice (VHL, CRBN, IAP, MDM2, KEAP1), linker design (length, composition, rigidity), ternary complex prediction (PRosettaC, DeepTernary, AlphaFold3 with constraints), cooperativity (alpha), DC50 / Dmax characterization, hook effect, and prediction-experiment reconciliation. Use when designing targeted protein degraders, planning linker SAR, predicting ternary complex stability, or building generative degrader workflows.

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Generate an XLSX invoice with company info, line items, subtotal/tax/total formulas, and currency formatting.

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Generate an XLSX billing statement with a merged company header, subscription line items, overages, credits, and subtotal/tax/total formulas.

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Extract receipt number, issuer, payer, date, tax, and total from Japanese receipts.

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Extract property, owner, legal description, liens, mortgages, easements, and tax status from title search reports.

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Extract merchant, date, line items, tax, and total from receipts.

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Extract employee, employer, gross pay, cotisations, tax, and net pay from French payslips.

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Extract carrier invoice, shipment references, rates, accessorials, taxes, and total charges from freight bills.

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Extract employee, employer, earnings, deductions, tax, and net pay from Spanish or Latin American payroll slips.

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Extract employee, department, expense lines, tax, totals, and approval fields from Japanese expense settlement forms.

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Extract employee, employer, gross wage, tax deductions, social insurance, and net wage from German payslips.

日本語の概要は準備中です。原文の説明を表示しています。

Extract employee, employer, allowances, deductions, taxes, and net pay from Japanese payslips.

日本語の概要は準備中です。原文の説明を表示しています。

Runs Scenic probabilistic scenarios against a running CARLA server with the `scenic FILE --simulate --2d` CLI — the carlaChallenge1-10 traffic scenarios shipped by ScenarioRunner (`model srunner.scenic.models.model`) and by Scenic itself (`model scenic.simulators.carla.model`) — bounding the run, sampling scenes headlessly first to tell a map problem from a syntax problem, and restoring the world afterwards. Use when the user asks to "run a Scenic scenario", "run carlaChallenge", "test a .scenic file", "scenic --simulate", or reports a Scenic scenario that rejects every sample or cannot find blueprints.

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Taxonomia de 86 layouts de apresentação/marketing (hero, pricing, auth, nav, CTA, testimonials, footer, FAQ, onboarding, blog, contact, stats, bento, states) adaptada do VibeUI. Consultar ANTES de construir landing pages, onboarding flows, auth screens, ou qualquer UI de camada de apresentação. Complementa o design-library/solutions (que cobre módulos verticais de produto).

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Use when you need to run real accessibility tests — Playwright keyboard interactions, axe-core scanning, visual regression, and WCAG 2.2 compliance checks. The measurement layer that feeds evidence into a11y-critic reviews.

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Use when you need to design, review, or improve validation in Quarkus applications — including Bean Validation on JAX-RS resources, @Valid on parameters and CDI beans, constraint groups, @ConfigMapping validation, custom constraints, nested DTO validation, and ExceptionMapper-based error mapping. This should trigger for requests such as Add validation support in Quarkus; Review Quarkus validation rules; Improve request validation in Quarkus REST APIs; Add custom validation constraints in Quarkus; Validate Quarkus @ConfigMapping properties. Part of cursor-rules-java project

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Use when you need to design, review, or improve REST APIs with Quarkus REST (Jakarta REST) — including resource classes, HTTP methods, status codes, request/response DTOs, Bean Validation, exception mappers, optional runtime OpenAPI exposure (SmallRye), contract-first generation from OpenAPI, content negotiation, pagination, sorting and filtering, API versioning, idempotency (Idempotency-Key), optimistic concurrency (ETag / If-Match), HTTP caching (Cache-Control), API deprecation (Sunset / Deprecation headers), RFC 7807 Problem Details, ISO-8601 for time in contracts, and security-aware boundaries. This should trigger for requests such as Review or improve JAX-RS resources in a Quarkus project; Design HTTP APIs with validation and error handling on Quarkus; Add API versioning, idempotency, ETag concurrency, or deprecation headers; Implement pagination, sorting, or RFC 7807 Problem Details error responses. Part of cursor-rules-java project

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5-level verification pyramid: static→unit→Playwright E2E (homepage-first, 6bp)→AI visual→post-deploy. 8-check quality gate. Multi-agent testing (functional/security/a11y/performance). Playwright v1.59+ AI agents (Planner/Generator/Healer). WCAG 2.2 AA via axe-core v4.11. Percy+Chromatic visual regression. ADA Title II 2027/2028 deadlines.

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毎月の給与から引かれる源泉所得税(月額表の甲欄)の目安を、国税庁が公表する電算機計算の特例の式で計算する。社会保険料等控除後の月給と扶養人数から税額を出し、令和8年分(2026年支給分)と令和9年分(2027年支給分)の違いも示せる。年末調整・賞与・乙欄・日額表・住民税は対象外。税額表の金額と一致しないことがある点を必ず伝える。