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Render a configurable iMessage conversation inside a properly framed phone, then a brand end card. Uses the original send/receive sounds and a shared frame timeline for text, typing, scrolling and sound. Free local Playwright + ffmpeg assembly; optional image/music generation belongs to separate gated capabilities.
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Comprehensive guide for developing WebGPU-enabled Three.js applications using TSL (Three.js Shading Language). Covers WebGPU renderer setup, TSL syntax and node materials, compute shaders, post-processing effects, and WGSL integration. Use this skill when working with Three.js WebGPU, TSL shaders, node materials, or GPU compute in Three.js.
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Build, deploy, run, monitor, tune, and stop Simulink Real-Time applications. Use when the user wants to build a Simulink Real-Time model, load/start/stop an `.mldatx` on a target, set stop time or start options, drive root inports/playback/parameter stimulation, inspect installed or running apps, tune parameters with `getparam`/`setparam`, read ad hoc signal values with `getsignal`, manage parameter sets, control recording, or choose between file logging, live streaming, and file-log import. Covers `slbuild`, `install`, `load`, `start`, `stop`, `setStopTime`, `tg.Stimulation`, `startRecording`/`stopRecording`, `tg.FileLog.import`, `slrealtime.exportRun`, `getparam`/`setparam`, `getsignal`, and installed app management for Speedgoat targets and Simulink Real-Time Linux devices.
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Generate a standalone bug report that another developer can use to reproduce, investigate, and fix an issue. Use when the user says 'file a bug', 'write a bug report', 'report this issue', or asks to document a defect for handoff.
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Configure Akka.NET with .NET Aspire for local development and production deployments. Covers actor system setup, clustering, persistence, Akka.Management integration, and Aspire orchestration patterns.
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Managing local .NET tools with dotnet-tools.json for consistent tooling across development environments and CI/CD pipelines.
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Orders and orients assembled contigs into chromosome-scale scaffolds from long-range linking data, inserting N-gap spacers (adds no sequence). Covers Hi-C/Omni-C scaffolding (YaHS, SALSA2, 3D-DNA/Juicer), Hi-C read-mapping prerequisites (map each end separately, no mate rescue, dedup, enzyme-aware), reading the contact map for misjoins/inversions/false-duplications, manual curation in Juicebox/PretextView (the VGP/DToL standard), reference-guided scaffolding (RagTag) and its karyotype-erasure hazard, genetic-map (ALLMAPS) and Bionano optical-map integration, chimera-breaking before scaffolding, gap-filling, and telomere/contig-vs-scaffold-N50 QC (tidk). Use when turning contigs into chromosomes with Hi-C, integrating a linkage map or optical map, choosing a scaffolder by available linking data, or judging whether a chromosome-scale assembly is trustworthy.
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Compare gene co-expression and regulatory networks between biological conditions to find rewired relationships using DiffCorr, DiffCoEx, DINGO/iDINGO, and CoDiNA. Covers the differential-connectivity-is-not-differential-expression distinction, the pairwise multiple-testing explosion, marginal vs partial (direct) rewiring, and the underpowered-rewiring failure mode. Use when comparing co-expression networks between disease vs control, treatment, or developmental stages, or finding hub genes that rewire without changing mean expression. For single-condition modules see coexpression-networks; for differential expression of means see differential-expression/de-results.
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Simulate transcription factor perturbation effects on cell state in silico with CellOracle and Dynamo, and predict transcriptional responses to genetic perturbations with GEARS, scGen, and CPA. Covers the direction-not-magnitude principle, local-linear validity, the GRN/velocity error it inherits, baseline discipline (mean and additive baselines), and the validation gap. Use when predicting TF knockout or overexpression effects, ranking driver TFs for fate transitions, or planning perturbation experiments. For GRN construction see multiomics-grn; for experimental Perturb-seq see single-cell/perturb-seq.
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Designs and analyzes combinatorial CRISPR screens covering paired-Cas9 (Big Papi, Najm 2018), enhanced AsCas12a multiplex (enCas12a, DeWeirdt 2021), in4mer 4-guide-array Cas12a (Esmaeili Anvar N et al 2024 Nat Commun 15:3577) and the Inzolia paralog-pair library, paralog-buffering detection (Dede 2020 Genome Biol; Thompson 2021 Nat Commun 12:1302), genetic-interaction (GI) scoring as observed_double_LFC minus expected_additive_double_LFC, synthetic-lethal and synthetic-rescue interaction interpretation, the half-of-essentiality buffered by paralogs phenomenon, multiplex screen statistical analysis with MAGeCK MLE interaction terms, and the relationship to single-cell combinatorial Perturb-seq. Use when designing a paralog or pathway-pair screen, choosing between paired-Cas9 (Big Papi) and Cas12a multiplex (Inzolia), interpreting genetic interaction scores, identifying synthetic-lethal targets for drug development, or scaling beyond single-gene CRISPR screens.
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Quantify homologous recombination deficiency (HRD) from tumor copy number using the three genomic-scar metrics — loss of heterozygosity (LOH), large-scale state transitions (LST), and telomeric allelic imbalance (TAI) — with scarHRD, and via the whole-genome HRDetect and CHORD models. Covers the genomic instability score, the PARP-inhibitor clinical context, whole-genome-doubling correction, and the scar-versus-state distinction. Use when computing an HRD score for PARP-inhibitor eligibility, deriving LOH/LST/TAI scars from allele-specific copy number, deciding between scar-based and mutational-signature HRD methods, or interpreting an HRD result in a BRCA-reverted or low-purity tumor.
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Align protein structures using Foldseek 3Di, TM-align, US-align, DALI, or Foldmason for structural MSA. Predict, score, and superpose backbone coordinates when sequence identity is below the twilight zone or remote-homology detection is required. Use when sequence MSA fails (<25% identity), when the dark proteome is the target, when AlphaFoldDB / ESM Atlas search is needed, or when structural superposition is the goal.
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Implement, review, or improve WidgetKit widgets and controls. Use when building Home Screen, Lock Screen, StandBy, or CarPlay widgets with timeline providers; configurable widgets with AppIntentTimelineProvider; interactive widgets or Control Center controls with Button/Toggle wiring; WidgetKit push reloads, refresh budgets, deep links, Smart Stack relevance, Liquid Glass/accented rendering, widget extension setup, WidgetBundle, App Groups, and entitlements.
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Implement, review, or improve maps and location features in iOS/macOS apps using MapKit and CoreLocation. Use when working with Map views, annotations, markers, polylines, user location tracking, geocoding, reverse geocoding, search/autocomplete, directions and routes, geofencing, region monitoring, CLLocationUpdate async streams, or location authorization flows. Also use when working with maps, coordinates, addresses, places, directions, distance calculations, or location-based features in Swift apps.
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Build alternative browser engines using BrowserEngineKit. Use when developing a non-WebKit browser engine for iOS/iPadOS in supported regions, managing web content/rendering/networking extension processes, configuring GPU and networking process capabilities, checking alternative-engine device eligibility, or reviewing BrowserEngineKit entitlements and Info.plist setup.
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TikTok Shop content creation strategy and planning. Trending formats, viral hooks, product showcasing, hashtag strategy, and content calendar development. Use when the user asks about TikTok content strategy, viral content creation, TikTok marketing, or content planning.
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Brand building and positioning on TikTok Shop. Brand identity development, content pillars, community engagement, brand storytelling, and authenticity strategies. Use when the user asks about TikTok branding, brand building, brand identity, or brand positioning on TikTok.
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Trigger when: (1) User mentions "manimgl" or "ManimGL" or "3b1b manim", (2) Code contains `from manimlib import *`, (3) User runs `manimgl` CLI commands, (4) Working with InteractiveScene, self.frame, self.embed(), ShowCreation(), or ManimGL-specific patterns. Best practices for ManimGL (Grant Sanderson's 3Blue1Brown version) - OpenGL-based animation engine with interactive development. Covers InteractiveScene, Tex with t2c, camera frame control, interactive mode (-se flag), 3D rendering, and checkpoint_paste() workflow. NOT for Manim Community Edition (which uses `manim` imports and `manim` CLI).
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RF Toolbox and RF Blockset in MATLAB -- S-parameter I/O, network conversions (S/Z/Y/ABCD/T/H/G, mixed-mode), cascade/de-embedding, rfbudget analysis, circuit composition, matching networks, amplifier stability, mixer spurs, rational fitting, SI channels, baseband processing, Circuit Envelope simulation. Trigger: sparameters, Touchstone, .s2p, .s4p, rfplot, smithplot, rfparam, rfwrite, zparameters, yparameters, abcdparameters, s2sdd, cascadesparams, deembedsparams, rfbudget, noise figure, OIP3, IIP3, amplifier, modulator, nport, rffilter, attenuator, seriesRLC, shuntRLC, lcladder, txline, circuit, setports, clone, matchingnetwork, stabilityk, stabilitymu, powergain, gammams, gammaml, mixerIMT, OpenIF, rational, rationalfit, stepresp, txlineWRLGC, rf.Amplifier, rf.Mixer, rf.Filter, rf.Sparameter, rfsystem, RF Blockset.
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End-to-end finite element analysis in MATLAB PDE Toolbox — geometry creation, model setup, solve, and post-processing in one skill. Use when building geometry from primitives or file import, setting up femodel with BCs/loads/materials, solving thermal/structural/EM problems, and extracting or visualizing results. Covers fegeometry, multicuboid, multicylinder, multisphere, decsg, boolean ops, mesh generation, femodel, all AnalysisTypes (thermalSteady, thermalTransient, structuralStatic, structuralTransient, structuralModal, structuralFrequency, electrostatic, magnetostatic, dcConduction, harmonic EM), materialProperties, faceBC, faceLoad, cellLoad, vertexLoad, solve, interpolation, von Mises stress, principal stress, reaction forces, heat flux, pdeplot3D visualization. Triggers on: PDE Toolbox, finite element, FEA, thermal analysis, structural analysis, electromagnetic analysis, femodel, mesh, boundary conditions, stress, displacement, heat transfer, post-processing.
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Use DuckDB from MATLAB via Database Toolbox (R2026a+) as a non-math operations engine on large tabular files (CSV/Parquet/JSON) and as a zero-config embedded database. Use when connecting to DuckDB, querying CSV, Parquet, and JSON files directly with SQL, reducing or profiling large data before MATLAB analysis, creating portable development databases, or installing DuckDB extensions. Triggers on: DuckDB, duckdb(), large CSV/Parquet/JSON, file too large for readtable, filter/aggregate at source, deduplicate, reduce before analysis, profile large file, persistent file import, analytical engine, SQL on CSV, SQL on Parquet, SQL on JSON, query CSV with SQL, query Parquet with SQL, run SQL on files, SQL queries on files, query files directly, SQL without database, in-process SQL.
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Read and write 3-D point cloud data using Lidar Toolbox file I/O. Covers PLY, PCD, LAS/LAZ, PCAP (Velodyne/Ouster/Hesai), E57, and IDC (Ibeo) formats. Use when loading point clouds from disk, saving to disk, choosing the correct reader or writer for a file format, extracting or preserving lidar point attributes, reading Ibeo IDC sensor recordings, or converting between formats.
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Extract features from signals collected on rotating machinery components, including motors, pumps, fans, gears, bearings, and shafts. Signals can include vibration, electrical, or environmental sensor measurements. Use when developing and deploying condition monitoring and fault detection applications for rotating machinery, including industrial machines, electrical vehicles, internal combustion engines, turbines, and drive trains.
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Volcengine official documentation lookup helper. Supports both document search and full-content fetch across Volcengine products, developer tools, support content, best practices, pricing, deployment, troubleshooting, API, SDK, and policy pages.
日本語の概要は準備中です。原文の説明を表示しています。