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概要と使いどころ
Expert network engineer specializing in cloud and hybrid network architectures, security, and performance optimization. Masters network design, troubleshooting, and automation with focus on reliability, scalability, and zero-trust principles.
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Expert Kubernetes specialist mastering container orchestration, cluster management, and cloud-native architectures. Specializes in production-grade deployments, security hardening, and performance optimization with focus on scalability and reliability.
日本語の概要は準備中です。原文の説明を表示しています。
This skill should be used when conducting a scored agent-native architecture review. It launches 8 parallel sub-agents to audit action parity, context injection, CRUD completeness, capability discovery, and prompt-native features.
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Use when writing or auditing the conversational copy layer of a Salesforce bot or Agentforce agent: utterance authoring strategy, fallback message copy, escalation-criteria phrasing, and persona-consistent dialog scripting across channels. NOT for platform configuration (bot builder setup, topic metadata wiring, action mapping, or Agentforce deployment) — see architect/einstein-bot-architecture and agentforce/agentforce-persona-design for those concerns.
日本語の概要は準備中です。原文の説明を表示しています。
Expert infrastructure security engineer specializing in DevSecOps, cloud security, and compliance frameworks. Masters security automation, vulnerability management, and zero-trust architecture with emphasis on shift-left security practices.
日本語の概要は準備中です。原文の説明を表示しています。
Expert cloud architect specializing in multi-cloud strategies, scalable architectures, and cost-effective solutions. Masters AWS, Azure, and GCP with focus on security, performance, and compliance while designing resilient cloud-native systems.
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Senior backend engineer specializing in scalable API development and microservices architecture. Builds robust server-side solutions with focus on performance, security, and maintainability.
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Enhanced architecture guidance for voice-first Brazilian fintech applications. Use when designing voice interfaces, implementing PIX/Boletos, optimizing financial systems, or making technology stack decisions for Brazilian market applications. Integrates with docs/ content, MCP tools for Brazilian market research, enhanced validation scripts, and comprehensive Brazilian compliance patterns.
日本語の概要は準備中です。原文の説明を表示しています。
Expert blockchain developer specializing in smart contract development, DApp architecture, and DeFi protocols. Masters Solidity, Web3 integration, and blockchain security with focus on building secure, gas-efficient, and innovative decentralized applications.
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Multi-agent debate orchestration for Architecture Decision Records. Automatically triggers on ADR create/edit/delete. Coordinates architect, critic, independent-thinker, security, analyst, and high-level-advisor agents in structured debate rounds until consensus.
日本語の概要は準備中です。原文の説明を表示しています。
Code review: IoC, RESTful, Contracts, Security (OWASP), Clean Architecture, SOLID.
日本語の概要は準備中です。原文の説明を表示しています。
Architecture Decision Records — context, decision, consequences, supersession trail.
日本語の概要は準備中です。原文の説明を表示しています。
Tech health check: documentation, security, architecture, data analysis. Use when user requests project audit, tech debt review, or health check.
日本語の概要は準備中です。原文の説明を表示しています。
Generates RESTful API Controllers with proper routing, versioning, authorization, and MediatR integration. Follows REST conventions and Clean Architecture patterns.
日本語の概要は準備中です。原文の説明を表示しています。
Perform 12-Factor App compliance analysis on any codebase. Use when evaluating application architecture, auditing SaaS applications, or reviewing cloud-native applications against the original 12-Factor methodology.
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Cloudflare-first platform selection. Decision trees for Workers, D1, R2, KV, DO, Queues, Vectorize, Containers, Sandboxes, Flagship, Agent Memory, Workflows v2. Default stack, override conditions, auth, data patterns, reliability.
日本語の概要は準備中です。原文の説明を表示しています。
Android アプリ開発 (Kotlin) の推奨アーキテクチャリファレンス。 Jetpack, androidx, UI layer, Domain layer, Data layer, state holder, UDF, SSOT, オフラインファースト, モジュール化, ViewModel, viewModelScope, SavedStateHandle, Lifecycle, repeatOnLifecycle, collectAsStateWithLifecycle, LiveData, Hilt による DI, Paging 3 によるページング処理。
Designs pooled sgRNA libraries for CRISPR knockout, interference (CRISPRi), activation (CRISPRa), Cas12a multiplex, base-editor, and prime-editor screens. Covers on-target scoring (Rule Set 2, Azimuth, DeepSpCas9, CRISPRon), off-target scoring (CFD, MIT), TSS-relative positioning for CRISPRi/a (Horlbeck, Dolcetto, Calabrese), PAM-variant chemistries, control-guide composition, oligo cloning architecture, and library QC. Use when choosing a genome-wide library (GeCKOv2 vs Avana vs Brunello vs TKOv3 vs Inzolia), designing a focused or paralog-focused custom library, picking CRISPRi vs CRISPRa TSS windows, deciding control-guide proportions, or diagnosing library skew and dropout in a freshly cloned pool.
日本語の概要は準備中です。原文の説明を表示しています。
Designs and analyzes pooled prime-editor (PE) screens for installing precise genetic variants without bystander confounding. Covers pegRNA design with PRIDICT and PRIDICT2 (Mathis 2023/2024) for predicting per-pegRNA editing efficiency, pegRNA architecture (spacer + scaffold + PBS + RTT), PE2 / PE3 / PE3b / PEmax / PEAR variants, MOSAIC in situ saturation mutagenesis (Hsu JY et al 2024 bioRxiv), the PRIME pooled-screen methodology (Erwood/Doman 2023 Nat Biotechnol 41:885; ~3,699 ClinVar variant screens), chromatin context as a primary determinant of PE efficiency, scaffold-incorporation and indel byproduct quantification with CRISPResso2, and the cross-modal validation strategy of PE + base-editor screens for variant function. Use when designing a pegRNA library for variant installation, choosing between BE and PE for a specific edit, predicting pegRNA efficiency before library synthesis, analyzing PE screen output, distinguishing intended-edit from scaffold-incorporation, or scaling PE screens to thousands of variants.
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Analyzes single-cell pooled CRISPR screens (Perturb-seq, CROP-seq, Perturb-CITE-seq, ECCITE-seq, multiome) where each cell carries an sgRNA and a scRNA-seq / surface-protein / chromatin readout. Covers experimental design (direct-capture Perturb-seq Dixit 2016 vs CROP-seq 3'UTR-barcoded Datlinger 2017 vs ECCITE-seq vs Multiome), MOI for sgRNA assignment, escaper-cell filtering (Mixscape, Papalexi 2021), SCEPTRE NB GLM + permutation for low-MOI (Barry 2024 Genome Biol 25:124), the Pertpy framework, factor decomposition, genome-scale Perturb-seq (Replogle 2022 Cell, 2.5M cells), and per-perturbation single-cell DE. Use when running a single-cell CRISPR screen, choosing direct-capture vs CROP-seq architecture, filtering escaper cells, performing single-cell DE, integrating Perturb-seq with pathway analysis, scaling to GW CRISPRi via Replogle protocol, or analyzing multi-omics screens.
日本語の概要は準備中です。原文の説明を表示しています。
Resolve the architecture of focal oncogene amplifications — extrachromosomal DNA (ecDNA), breakage-fusion-bridge (BFB) cycles, homogeneously staining regions (HSR), and linear amplification — from whole-genome sequencing with AmpliconArchitect, the AmpliconSuite pipeline, and AmpliconClassifier. Covers copy-number seed selection, breakpoint-graph reconstruction, balanced-flow optimization, ecDNA classification, and the limits of depth-only amplification calls. Use when a focal amplification needs structural characterization, when distinguishing ecDNA from chromosomal amplification, suspecting ecDNA-driven oncogene amplification or therapy resistance, or selecting copy-number seeds for amplicon reconstruction.
日本語の概要は準備中です。原文の説明を表示しています。
Resolves rsIDs, navigates RsMergeArch/SNPHistory merge chains, and converts between rsID, SPDI, HGVS, and VCF representations using the dbSNP Build 156 JSON architecture. Use when normalizing variant identifiers, joining variant databases by cluster ID, or tracking deprecated rsIDs through historical merges.
日本語の概要は準備中です。原文の説明を表示しています。
Estimate bivariate genetic correlation (rg) between traits from GWAS summary statistics or individual-level genotypes using cross-trait LDSC, HDL, LAVA, rho-HESS, GREML-bivariate, Popcorn, and HDL-L. Use when quantifying shared genetic architecture between two traits, screening MR validity before causal inference, distinguishing global from locus-level rg, estimating trans-ancestry rg, separating partial from full causation via LCV gcp, or producing a STROBE-MR-compliant cross-trait sensitivity battery. Cross-trait LDSC intercept absorbs sample overlap and is NOT a bias; HDL is biased under sample overlap above ~5%. High rg between exposure and outcome motivates CHP-aware MR sensitivity (CAUSE, LHC-MR).
日本語の概要は準備中です。原文の説明を表示しています。
Fits structural equation models to GWAS summary statistics using GenomicSEM (Grotzinger 2019), including common-factor models, confirmatory factor models, ESEM, common-factor GWAS with Q_SNP heterogeneity, multivariate Wald tests, and stratified GenomicSEM partitioned heritability. Reconciles results against MTAG multi-trait analysis. Handles sample overlap via the LDSC sampling-covariance matrix, identifies and resolves Heywood cases, and verifies model fit with CFI / RMSEA. Use when modeling latent genetic architecture across correlated traits, running multivariate GWAS on a shared factor, distinguishing factor-mediated from trait-specific SNP effects, or comparing GenomicSEM common-factor results against MTAG when both depend on accurate sampling covariance.
日本語の概要は準備中です。原文の説明を表示しています。