「integration」の検索結果

Build publication-quality figures with matplotlib using the object-oriented Figure/Axes API, constrained_layout, rcParams customization, TrueType (Type-42) font embedding for journal submission, and CVD-safe palettes. Covers seaborn integration, common chart types, axis formatting, and the small gotchas that distinguish reproducible matplotlib from notebook scratch. Use when producing publication figures in Python — RNA-seq scatter, single-cell embeddings, generic biological plotting.

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Analyzes CRISPR drug-modifier (chemogenomic) screens with drugZ (Li & Hart 2019 Genome Med), a bidirectional Z-score method that identifies synthetic-lethal sensitizing genes and resistance-conferring suppressor genes from vehicle vs drug comparisons. Covers vehicle-anchored design (not Day-0), the bidirectional Z math giving 2-3x sensitivity over MAGeCK / STARS / edgeR / RIGER on drug screens, per-gene sumZ and normZ, synth (sensitizer) vs supp (suppressor) FDR, multi-dose handling, integration with control sgRNAs, and comparison with MAGeCK MLE with dose covariate. Use when running a drug-modifier CRISPR screen, identifying sensitizing or resistance genes for a drug candidate, choosing drugZ vs MAGeCK MLE for chemogenomic analysis, troubleshooting low-effect drug screens where MAGeCK lacks sensitivity, or designing a drug-screen layout (vehicle vs drug arms).

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Produce and interpret PCA, t-SNE, UMAP, and PHATE plots for high-dimensional omics data with rigor about which method preserves what (variance, local structure, manifold, transitions), hyperparameter sensitivity, and the well-documented limits of 2D embeddings. Covers PCA biplot/scree/loadings, t-SNE PCA initialization (Kobak-Berens 2019), UMAP n_neighbors/min_dist trade-offs, and the Chari-Pachter 2023 critique. Use when visualizing high-dimensional data — bulk PCA, single-cell embeddings, multi-omics integration projections.

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Call copy number variants with the GATK best-practices workflows — the somatic CNV pipeline (CollectReadCounts, DenoiseReadCounts with tangent normalization, ModelSegments, CallCopyRatioSegments) and the germline GATK-gCNV pipeline (DetermineGermlineContigPloidy, GermlineCNVCaller cohort/case mode, PostprocessGermlineCNVCalls). Covers panel-of-normals construction, AnnotateIntervals/FilterIntervals, allelic-count integration, and QS-based filtering. Use when integrating CNV calling into a GATK variant pipeline, calling rare germline CNVs from an exome cohort, deciding between the somatic and germline GATK workflows, or diagnosing why tangent normalization removed a real event or why gCNV output has low precision.

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Calculates tumor mutational burden from WES/WGS/panel data with Friends of Cancer Research harmonization equations, per-assay calibration (FDA 10/Mb = 7.8 TSO500 = 8.4 OncomineTML), synonymous/indel/germline filtering, hypermutator tiering, blood TMB, and integration with HLA-LOH and neoantigen quality (Luksza 2017 fitness). Use when assessing ICI eligibility under tumor-specific cutoffs (McGrail 2021), comparing tissue vs bTMB, or auditing TMB-H reporting against ESMO 2024 and FDA pembrolizumab pan-tumor 2020.

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Detects allele-specific transcription factor or histone modification binding from heterozygous-variant ChIP-seq using WASP (reference-bias filter; mandatory upstream), RASQUAL (joint QTL + bias-corrected testing), BaalChIP (Bayesian beta-binomial with copy-number-aware overdispersion), and AlleleSeq (personalized diploid genome). Handles imprinted-locus awareness, X-inactivation artifacts, cancer copy-number imbalance, and integration with downstream caQTL / bQTL mapping. Use when identifying variants with allelic effects on TF binding, fine-mapping causal regulatory variants, validating deep-learning variant predictions, or characterizing cis-acting regulatory effects.

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Segments the genome into chromatin states from combinatorial histone modification and chromatin factor ChIP-seq data. Uses ChromHMM (multivariate HMM on binarized signal, v1.27), Segway (Dynamic Bayesian Network on continuous signal), EpiSegMix (flexible-distribution HMM with duration modeling, 2024), EpiLogos (multi-biosample visualization), IDEAS (cell-type-aware joint), and full-stack ChromHMM (Vu Ernst 2022) for cross-cell-type segmentations. Handles state-count selection (15 vs 18 vs 25 states), binarization choice, OverlapEnrichment / NeighborhoodEnrichment downstream analysis, and cross-biosample integration. Use when learning chromatin states from a histone mark panel, characterizing learned states by genomic feature enrichment, or comparing chromatin landscapes across cell types.

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Use when a carrier is evaluating ELD / telematics / dashcam platforms and needs an objective comparison of Samsara, Motive (formerly KeepTruckin), and Geotab. Covers ELD compliance, AI dashcams, driver scoring, integrations, pricing structure, and which fleet profile suits which platform.

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Use this skill to evaluate document retention software options. Covers compliance features, ease of use, integration, and cost.

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Use this skill when the user asks about cybersecurity for a trucking carrier — protecting ELD data, customer information, financial systems, EDI integrations, fleet telematics, ransomware risk, vendor / shipper data sharing, incident response, and FMCSA cyber-recommendations. Reference NIST + CISA cybersecurity frameworks.

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FLOW framework integration: evidence-led SEO using the Find → Leverage → Optimize → Win loop. Surfaces stage-specific AI prompts from the FLOW knowledge base (41 prompts, CC BY 4.0). Use when user says "FLOW", "FLOW framework", "seo flow", "evidence-led SEO", "find leverage optimize win", or wants stage-specific SEO prompts.

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One-time recovery when a shared checkout has drifted far from GitHub main: hundreds ahead/behind, stacked worktrees and PRs, a dirty tree nobody owns. Use when tempted to reset or force-push. NOT for the ordinary 30-minute release loop (operations/INTEGRATION_MAINTAINER.md).

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Comprehensive guide for developing WebGPU-enabled Three.js applications using TSL (Three.js Shading Language). Covers WebGPU renderer setup, node materials, compute shaders, post-processing, and WGSL integration. Use when working with Three.js WebGPU, TSL shaders, or GPU compute pipelines.

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Guide for creating effective skills. This skill should be used when users want to create a new skill (or update an existing skill) that extends Claude's capabilities with specialized knowledge, workflows, or tool integrations.

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Builds reusable Convex components with isolated tables and app-facing APIs. Use for new components, reusable backend modules, integrations, or component boundary work.

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When the user needs to integrate multiple data sources (Canvas API, user memory, file systems) to create comprehensive academic reports. This skill combines course information, assignment details, submission status, and user context to generate actionable insights. Triggers include requests that involve cross-referencing multiple data sources or creating consolidated academic reports from disparate systems.

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Use when implementing GraphQL resolvers with Absinthe. Covers resolver patterns, dataloader integration, batching, and error handling.

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Ably real-time messaging patterns, WebSocket channel management, message validation and processing, staleness filtering, error recovery strategies, collaborative editing with drag-and-drop, optimistic updates for voting, real-time board collaboration, and Ably integration best practices for ree-board project

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Manage persistent memory for autonomous coding. Use when storing/retrieving knowledge, managing Graphiti integration, persisting learnings, or accessing episodic memory.

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AI agent and chatbot patterns including personas, pipelines, and messaging integrations. Use when building conversational agents, creating AI personas, designing insight pipelines, or integrating with Slack/Kakao platforms.

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SDK installation and setup patterns for Agent-to-Agent Protocol across Python, TypeScript, Java, C#, and Go. Use when implementing A2A protocol, setting up SDKs, configuring authentication, or when user mentions SDK installation, language-specific setup, or A2A integration.

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Adds comprehensive accessibility testing to CI/CD pipelines using axe-core Playwright integration or pa11y-ci. Automatically generates markdown reports for pull requests showing WCAG violations with severity levels, affected elements, and remediation guidance. This skill should be used when implementing accessibility CI checks, adding a11y tests to pipelines, generating accessibility reports, enforcing WCAG compliance, automating accessibility scans, or setting up PR accessibility gates. Trigger terms include a11y ci, accessibility pipeline, wcag ci, axe-core ci, pa11y ci, accessibility reports, a11y automation, accessibility gate, compliance check.

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Comprehensive WCAG accessibility auditing with multi-tool testing (axe-core + pa11y + Lighthouse), TRUE PARALLEL execution with Promise.allSettled, graceful degradation, retry with backoff, context-aware remediation, learning integration, and video accessibility. Uses 3-tier browser cascade: Vibium → agent-browser → Playwright+Stealth.

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Expert in 2000s-era music visualization (Milkdrop, AVS, Geiss) and modern WebGL implementations. Specializes in Butterchurn integration, Web Audio API AnalyserNode FFT data, GLSL shaders for audio-reactive visuals, and psychedelic generative art. Activate on "Milkdrop", "music visualization", "WebGL visualizer", "Butterchurn", "audio reactive", "FFT visualization", "spectrum analyzer". NOT for simple bar charts/waveforms (use basic canvas), video editing, or non-audio visuals.

日本語の概要は準備中です。原文の説明を表示しています。