「20」の検索結果

Prepares statistical reports for clinical trials following CONSORT 2025, SPIRIT 2025, ICH E9(R1) estimands, and FDA 2023 covariate adjustment guidance. Covers Table 1 generation, analysis populations (ITT/FAS/PP/Safety), the 5 ICH E9(R1) intercurrent-event strategies, MMRM under MAR (mmrm), reference-based MI (rbmi J2R/CR/CIR), Permutt tipping-point sensitivity, and Rubin's-rules vs frequentist variance debate. Use when preparing regulatory submissions, defining estimands, or implementing missing-data sensitivity analyses.

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Detect syntenic blocks and structural rearrangements between genomes using MCScanX (Wang 2012), JCVI/MCScan (Tang 2008 Python), GENESPACE (Lovell 2022) for orthology-anchored riparian visualization, SyRI for structural variation, AnchorWave for sequence-level synteny, i-ADHoRe 3.0 for highly diverged species, SynNet for synteny networks, and ntSynt for multi-genome macrosynteny. Use when identifying collinear gene blocks across species, distinguishing macrosynteny from microsynteny, detecting inversions/translocations/duplications, anchoring orthology in WGD lineages, producing publication riparian plots, computing synteny block age via Ks (cross-references whole-genome-duplication), or running synteny-aware ortholog inference in polyploids.

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Designs Bayesian clinical trials including Phase I dose-finding (BOIN, CRM, EWOC, mTPI-2), meta-analytic-predictive (MAP) priors with robust mixtures for external data borrowing, EXNEX for basket trials, hierarchical models for safety AE (Berry-Berry), Bayesian platform trials (I-SPY 2, GBM AGILE, REMAP-CAP), and posterior probability stopping rules. Covers FDA Bayesian Devices Guidance (2010), FDA Bayesian Methodology in Drugs Draft (January 2026), BOIN Fit-for-Purpose qualification (December 2021), and Project Optimus dose-optimisation. Use when designing dose-finding studies, platform trials, or sensitivity analyses with informative priors.

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Builds and applies 3D pharmacophore models using RDKit Pharm3D, the apo2ph4 receptor-based workflow (Heider et al 2022/2023 J Chem Inf Model 63:147-158), Pharmer / Pharmit (search), and PharmacoForge (diffusion-based generation, Flynn et al 2025 Front Bioinform), covering ligand-based pharmacophore (from active set alignment) and receptor-based pharmacophore (from binding pocket geometry). Explicit handling of feature types, geometric tolerances, partial matching, and pharmacophore-based virtual screening. Use when identifying scaffold-hopping candidates, building shape-and-feature search queries, or transferring SAR across chemotypes.

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Analyzes CUT&RUN (Skene Henikoff 2017) and CUT&Tag (Kaya-Okur 2019) chromatin profiling data. Handles SEACR vs MACS2 peak calling (with the btaf375 2025 benchmark guidance), pA-MNase vs pA-Tn5 vs pAG-Tn5 chimera differences, E. coli spike-in carryover normalization, IgG-only control logic (no input), characteristic fragment-size signatures (25-75 bp for CUT&Tag), and lower depth requirements (5M reads typical vs 25M for ChIP). Use when calling peaks from CUT&RUN/CUT&Tag, scaling by E. coli spike-in carryover, choosing SEACR norm mode, or comparing CUT&RUN/Tag results to traditional ChIP.

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Normalizes ChIP-seq data using exogenous spike-in (ChIP-Rx with Drosophila chromatin per Orlando 2014 / Egan 2016; E. coli carryover for CUT&RUN/CUT&Tag). Distinguishes RRPM from Rx-Input scaling, integrates with DiffBind / DESeq2 / edgeR / csaw via sizeFactors and DiffBind library-size vectors, and applies the Patel et al 2024 *Nat Biotechnol* review's failure-mode framework to validate that normalization is correctly applied at the read level (not peak counts). Use when global signal shifts are expected (HDACi, BETi, EZH2i, dosage, target knockdown), when ChIPseqSpikeInFree detects post-hoc shifts, or when validating internal-control regions before publication.

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Generates PSR-20 Clock implementation for PHP 8.5. Creates ClockInterface implementations including SystemClock, FrozenClock, and OffsetClock for time abstraction and testing. Includes unit tests.

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Executive coaching skill that helps you plan your 2026 using research-backed process goals. Guides you through discovery questions, creates outcome goals, converts them to daily behaviors, and sets up accountability systems. Use when you want to plan your year, set goals, or need a coach to help you stay focused.

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[20] UNDERSTAND. Achieve complete clarity on goals, expectations, and success criteria. Use when starting new tasks, when requirements seem unclear, when scope is ambiguous, or anytime you need full understanding of what success looks like. Triggers on "clarify goal", "understand requirements", "what exactly needed", "define success", or when facing unclear expectations.

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Expert in 2000s-era music visualization (Milkdrop, AVS, Geiss) and modern WebGL implementations. Specializes in Butterchurn integration, Web Audio API AnalyserNode FFT data, GLSL shaders for audio-reactive visuals, and psychedelic generative art. Activate on "Milkdrop", "music visualization", "WebGL visualizer", "Butterchurn", "audio reactive", "FFT visualization", "spectrum analyzer". NOT for simple bar charts/waveforms (use basic canvas), video editing, or non-audio visuals.

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Meme coin and token security audit — rug pull detection (honeypot, hidden mint, fee manipulation, LP lock bypass), Solana SPL token analysis (freeze authority, mint authority, metadata mutability), Token-2022 extension risks (transfer hooks, permanent delegate), DEX liquidity pool attacks (sandwich amplification, LP drain, bonding curve exploits), pump.fun/Raydium/Jupiter integration risks, and real exploit examples from 2024-2025. Use for any token audit, rug pull assessment, meme coin security review, or pre-investment due diligence.

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Web検索とページ本文の抽出を使い分け、調査に必要な情報を集めるスキル。期間やサイトを絞った検索、指定URLからの関連部分の取得にも対応します。

• 期間を絞って最近のニュースを調査
• 特定サイトに絞って調べたいとき
• 指定URLの本文を取得したいとき

製造現場の規格不適合について、対象品の隔離から原因分析、処置の検討、是正・予防措置の効果確認までを整理し、管理図の読み取りや仕入先品質の改善も支援します。

• 検査で見つかった不適合を調査したいとき
• 根本原因の分析手法を選びたいとき
• 是正措置の計画作成と効果確認

Locked 1920x1080 canvas deck with React component-level free composition, not bound to a fixed template.

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Test an application against the OWASP Top 10 with Strix — autonomous AI agents that attempt real exploits for each category of the current OWASP Top 10:2025 (broken access control including SSRF, security misconfiguration, software supply chain failures, cryptographic failures, injection, insecure design, authentication failures, integrity failures, logging and alerting failures, mishandling of exceptional conditions) and report only what they could actually prove, mapped back to the category with a proof-of-concept. Also covers the OWASP API Security Top 10 (2023). Use when the user asks for an OWASP Top 10 assessment, OWASP compliance testing, or a security review mapped to OWASP categories.

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跨版本符号迁移与二进制差分。当你有旧版本的符号/逆向结果，需要快速迁移到新版本时使用。 适用场景：内核缺 PDB 用旧版符号推导、程序更新后批量迁移函数名、应用更新后快速定位新偏移。 核心方法：用 LLM 做结构化差异比对，程序化输入输出，成本极低（200 函数 ~1 元）。 触发关键词：符号迁移、bindiff、跨版本、PDB 缺失、函数偏移迁移、symbol migration、binary diff、版本对比。

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主动渗透测试工具链。覆盖信息收集、端口扫描、漏洞扫描、Web 渗透、SQL 注入、目录爆破、密码破解等场景。 通过 MCP server（pentestMCP / mcp-security-hub）将 20+ 安全工具暴露给 AI agent。 触发关键词：渗透测试、端口扫描、Nmap、漏洞扫描、Nuclei、SQL 注入、SQLMap、目录爆破、FFUF、密码破解、Hashcat、信息收集、子域名、Web 渗透、ZAP、Burp。

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Exploits privileged pods, host mounts, runC CVEs, and exposed Docker sockets to break out of a container and reach the underlying host during an authorized container-security assessment. Use when executing an approved breakout test, demonstrating the real impact of a privileged or hostPath workload, or validating that escape mitigations actually hold. Keywords: container breakout, privileged, hostPath, docker.sock, runC CVE-2019-5736, CVE-2024-21626, release_agent, nsenter. Do not use for defensive detection of these techniques - use detecting-container-escape-attempts.

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Detect API enumeration attacks (BOLA/IDOR, OWASP API1:2023) by writing SIEM detection rules that flag sequential or UUID identifier iteration, parameter tampering, and mixed 200/401/403 response patterns from API gateway and WAF logs. Use when investigating suspected object-level authorization abuse, building threat-hunting queries for API access-control bypass, or hardening API logging/rate-limiting against enumeration.

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Prepare a defense-contractor environment for CMMC Level 2 certification: scope CUI and FCI, implement the 110 NIST SP 800-171 Rev 2 security requirements across 14 families, compute the SPRS score with the DoD Assessment Methodology, manage a compliant POA&M, and ready the organization for a C3PAO assessment. Use when an organization handles Controlled Unclassified Information (CUI) under a DoD contract, when a contract carries DFARS clause 252.204-7012/7019/7020/7021, when preparing for or responding to a CMMC assessment, when computing or improving an SPRS score, when building a System Security Plan or POA&M for 800-171, or when scoping which systems are in the CUI boundary. Keywords: CMMC, CMMC Level 2, NIST 800-171, SP 800-171 Rev 2, CUI, FCI, SPRS, DFARS 7012, C3PAO, POA&M, System Security Plan, DoD Assessment Methodology, 110 controls, defense industrial base, DIB, FedRAMP equivalency.

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Router/index for the 15 regulatory & quality-management skills bundled in this plugin (ISO 13485 QMS, EU MDR 2017/745, FDA submissions under QMSR, ISO 14971 risk, CAPA, document control, ISO 27001/ISMS, ISO 42001 AIMS, EU AI Act, GDPR/DSGVO, SOC 2, auditing). Use when a compliance request doesn't obviously match one skill and you need to pick the right one (e.g., 'prepare us for an ISO 13485 audit', 'is my AI system high-risk under the AI Act').

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Compliance OS — meta-orchestrator that lets compliance teams CONFIGURE which frameworks apply, COMPUTE cross-framework control overlap, SIMULATE internal audits, and CONSOLIDATE evidence across multiple frameworks. Four decisions: (1) Given a company profile, which of the 12 supported frameworks apply (ISO 27001/13485/42001/14971, EU AI Act, MDR 745, GDPR, SOC 2, FDA QSR, NIST CSF 2.0, NIS2, HIPAA)? (2) Across selected frameworks, which controls overlap and how much evidence reuses? (3) For a given framework + scope, what does a realistic mock audit produce — drawing from the 205-scenario library? (4) Across selected frameworks, what's the unified evidence checklist with reuse map? Use when standing up a multi-framework program, planning the annual audit calendar, or preparing for certification stage 1. Does NOT replace per-framework skills (it orchestrates them).

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/cs:fda-qsr-audit-prep <scope> — FDA 21 CFR 820 (QSR / QMSR) audit 6-question forcing interrogation. Post-Feb 2026 substantially harmonized with ISO 13485. Use before annual internal QSR audit, pre-FDA-inspection readiness, or Form 483 response.

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锁死 1920×1080 画布, React 组件级自由组合, 不绑模板

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