359 件 ・ 関連度順
概要と使いどころ
Use before responding to pressure for agreement, manufactured urgency, authority appeals, or requests to certify unsupported claims; separate evidence from persuasion and state uncertainty.
日本語の概要は準備中です。原文の説明を表示しています。
Eliminate sycophantic agreement patterns in AI responses. Load via /skill anti-sycophancy.
日本語の概要は準備中です。原文の説明を表示しています。
Receive and act on code review feedback with technical rigor, not performative agreement or blind implementation
日本語の概要は準備中です。原文の説明を表示しています。
Recognize when disagreements reveal valuable context, preserve multiple valid approaches instead of forcing premature resolution
日本語の概要は準備中です。原文の説明を表示しています。
Data Labeling Specialist IA — Expert en annotation de données (outils, contrôle qualité, agreement inter-annotateurs, active learning)
日本語の概要は準備中です。原文の説明を表示しています。
Draft privacy policies, terms of service, disclaimers, and legal notices. Creates GDPR-compliant texts, cookie policies, and data processing agreements.
日本語の概要は準備中です。原文の説明を表示しています。
Perform cryptographic operations using Apple CryptoKit. Use when hashing data with SHA256/SHA384/SHA512, generating HMAC authentication codes, encrypting with AES-GCM or ChaChaPoly, signing with P256/P384/P521/Curve25519 keys, performing ECDH key agreement, storing keys in the Secure Enclave, or migrating from CommonCrypto to CryptoKit.
日本語の概要は準備中です。原文の説明を表示しています。
Use when receiving code review feedback, before implementing suggestions, especially if feedback seems unclear or technically questionable - requires technical rigor and verification, not performative agreement or blind implementation
日本語の概要は準備中です。原文の説明を表示しています。
Synthesize scientific evidence into a claim-to-source matrix, distinguish primary evidence from interpretation, assess disagreement and study limitations, and produce a calibrated research summary.
日本語の概要は準備中です。原文の説明を表示しています。
Mendelian randomization (MR) causal inference — does an exposure, risk factor, or biomarker CAUSALLY affect a disease/outcome, using genetic variants as instrumental variables (IEU OpenGWAS / EpiGraphDB MR-EvE). Use this whenever the user asks if X causes Y, whether an observational association is actually causal or just correlation, if a biomarker/trait is a causal risk factor, wants to triangulate epidemiology against genetic evidence, or mentions Mendelian randomization, instrumental-variable analysis, two-sample MR, or genetic causal evidence — even if they never say "MR" (e.g. "is LDL cholesterol actually causal for heart disease?", "does BMI cause type 2 diabetes or just correlate?", "is CRP a causal driver of stroke?"). Covers trait-label resolution, MR effect direction/magnitude, instrument quality (MOE score), method agreement (IVW vs MR-Egger vs weighted median), bidirectional MR for reverse causation, and distinguishing causation from genetic correlation. Not for plain GWAS association lookups (use the GWAS skills) or fitting your own instruments from raw summary statistics.
日本語の概要は準備中です。原文の説明を表示しています。
Generate an editable DOCX service agreement with parties, terms, and payment schedule.
日本語の概要は準備中です。原文の説明を表示しています。
Generate a non-disclosure agreement PDF with party names, effective date, and standard confidentiality terms.
日本語の概要は準備中です。原文の説明を表示しています。
Extract key terms from a non-disclosure agreement, then generate a compliance checklist spreadsheet tracking obligations and deadlines.
日本語の概要は準備中です。原文の説明を表示しています。
Extract tenant, property, renewal term, new rent, deposit changes, and signature fields from lease renewal notices or agreements.
日本語の概要は準備中です。原文の説明を表示しています。
Extract parties, obligations, restrictions, permitted disclosures, and expiry dates from non-disclosure agreements.
日本語の概要は準備中です。原文の説明を表示しています。
Use when receiving code review feedback, before implementing suggestions, especially if feedback seems unclear or technically questionable - requires technical rigor and verification, not performative agreement or blind implementation
日本語の概要は準備中です。原文の説明を表示しています。
Detects acquired antimicrobial-resistance determinants and chromosomal point-mutation resistance in bacterial assemblies using AMRFinderPlus, ResFinder 4.0 (acquired + PointFinder), CARD-RGI, abritAMR, staramr, and species-specific callers (TB-Profiler, Mykrobe). Harmonises cross-tool output via hAMRonization, contextualises determinants with mobile-genetic-element annotation (MOB-suite, PlasmidFinder, MobileElementFinder, ICEberg), predicts phenotype against EUCAST or CLSI breakpoints, and translates calls into WHO GLASS reporting categories. Use when screening clinical or surveillance isolates for AMR, distinguishing acquired vs intrinsic vs point-mutation resistance, calling rpoB / katG / pncA / gyrA / mgrB mutations, reconciling AMRFinderPlus vs RGI vs ResFinder disagreement, contextualising carbapenemases or mcr alleles on plasmids, predicting susceptibility from genotype against the WHO Mtb 2nd-edition catalogue, or building a hAMRonized multi-lab AMR surveillance pipeline.
日本語の概要は準備中です。原文の説明を表示しています。
Cross-method decision tree for calling hits in pooled CRISPR screens. Catalogs statistical models (MAGeCK RRA, MAGeCK MLE, BAGEL2, drugZ, JACKS, Chronos, CERES), experimental designs each is built for, failure modes outside design domain, reconciliation when methods disagree, multiple-testing and effect-size thresholds, the order of operations (count -> QC -> CN-correct -> hit-call -> validate), the second-best-sgRNA conservative rule, and consensus-hit strategy. Use when choosing among MAGeCK / BAGEL2 / drugZ / JACKS / Chronos for a given design, reconciling disagreement across two or three methods on the same screen, deciding whether to require consensus, gating downstream validation by hit-confidence tier, or interpreting unstable hit lists across reruns.
日本語の概要は準備中です。原文の説明を表示しています。
Map N6-methyladenosine (m6A) RNA modifications at single-nucleotide resolution using miCLIP (Linder 2015), miCLIP2 + m6Aboost machine learning (Kortel 2021), GLORI (Liu 2023, antibody-free chemical conversion), DART-seq (Meyer 2019, APOBEC1-YTH fusion), m6Anet (nanopore direct RNA), or MeRIP-seq with calibration. Use when distinguishing antibody-based from antibody-free m6A detection methods, applying the DRACH motif constraint, reconciling cross-method disagreements (DART 44% in DRACH vs GLORI), or detecting m6Am at the cap.
日本語の概要は準備中です。原文の説明を表示しています。
Discover RBP binding motifs from CLIP-seq peaks or single-nucleotide crosslink sites using HOMER, MEME/STREME, kpLogo, mCross (CL-position-registered motifs), PEKA (positional k-mer enrichment), RBPamp (affinity), and RNA Bind-n-Seq (RBNS) cross-validation. Use when characterizing RBP sequence specificity, registering motifs to crosslink positions, validating in vivo CLIP motifs against in vitro RBNS Kd, reconciling motif disagreements across tools, or correcting for the uracil crosslinking bias that contaminates raw CLIP motif logos.
日本語の概要は準備中です。原文の説明を表示しています。
Identifies differentially bound ChIP-seq regions between conditions using DiffBind, csaw (sliding windows), DESeq2/edgeR/PyDESeq2 on count matrices, NormR (control-aware), or MAnorm2. Distinguishes three distinct normalization problems (composition bias, trended bias, global shifts) and matches each to its appropriate fix including spike-in scaling. Use when comparing ChIP-seq binding between experimental conditions, choosing normalization for global vs local changes, integrating spike-in data, or reconciling DiffBind/DESeq2 disagreement.
日本語の概要は準備中です。原文の説明を表示しています。
Eliminate sycophantic agreement patterns in AI responses. Load via /skill anti-sycophancy.
日本語の概要は準備中です。原文の説明を表示しています。
Auto-review pipeline — reads the full CEO, design, eng, and DX review skills from disk and runs them sequentially with auto-decisions using 6 decision principles. Surfaces taste decisions (close approaches, borderline scope, codex disagreements) at a final approval gate. One command, fully reviewed plan out. Use when asked to "auto review", "autoplan", "run all reviews", "review this plan automatically", or "make the decisions for me". Proactively suggest when the user has a plan file and wants to run the full review gauntlet without answering 15-30 intermediate questions. (gstack) Voice triggers (speech-to-text aliases): "auto plan", "automatic review".
日本語の概要は準備中です。原文の説明を表示しています。
Detects acquired antimicrobial-resistance determinants and chromosomal point-mutation resistance in bacterial assemblies using AMRFinderPlus, ResFinder 4.0 (acquired + PointFinder), CARD-RGI, abritAMR, staramr, and species-specific callers (TB-Profiler, Mykrobe). Harmonises cross-tool output via hAMRonization, contextualises determinants with mobile-genetic-element annotation (MOB-suite, PlasmidFinder, MobileElementFinder, ICEberg), predicts phenotype against EUCAST or CLSI breakpoints, and translates calls into WHO GLASS reporting categories. Use when screening clinical or surveillance isolates for AMR, distinguishing acquired vs intrinsic vs point-mutation resistance, calling rpoB / katG / pncA / gyrA / mgrB mutations, reconciling AMRFinderPlus vs RGI vs ResFinder disagreement, contextualising carbapenemases or mcr alleles on plasmids, predicting susceptibility from genotype against the WHO Mtb 2nd-edition catalogue, or building a hAMRonized multi-lab AMR surveillance pipeline.
日本語の概要は準備中です。原文の説明を表示しています。