「enrichment」の検索結果

Discover RBP binding motifs from CLIP-seq peaks or single-nucleotide crosslink sites using HOMER, MEME/STREME, kpLogo, mCross (CL-position-registered motifs), PEKA (positional k-mer enrichment), RBPamp (affinity), and RNA Bind-n-Seq (RBNS) cross-validation. Use when characterizing RBP sequence specificity, registering motifs to crosslink positions, validating in vivo CLIP motifs against in vitro RBNS Kd, reconciling motif disagreements across tools, or correcting for the uracil crosslinking bias that contaminates raw CLIP motif logos.

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Designs adaptive clinical trials including group-sequential (O'Brien-Fleming, Pocock, Lan-DeMets spending), sample-size re-estimation (blinded Friede-Kieser, unblinded Cui-Hung-Wang, Mehta-Pocock promising zone), seamless Phase 2/3 with treatment-arm selection, population enrichment, and response-adaptive randomisation. Covers FDA 2019 Final Adaptive Designs Guidance, FDA 2022 Master Protocols, and ICH E20 Step 2b/3 draft (June 2025, NOT final). Use when planning interim analyses, sample-size re-estimation, or master/platform-trial designs.

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Assesses ChIP-seq quality across antibody specificity, fragmentation, enrichment, replicate concordance, and library complexity. Computes FRiP, NSC/RSC (phantompeakqualtools), library complexity (NRF/PBC1/PBC2), deepTools plotFingerprint (JS distance, AUC, synthetic JS), ChIPQC, IDR with ENCODE Nself/Nt rules, and detects hyper-ChIPable artifacts. Use when validating an antibody, diagnosing failed peak calls, deciding whether to proceed with downstream analysis, grading against ENCODE thresholds, or auditing replicate concordance.

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ATAC-seq library quality control -- TSS enrichment, FRiP, fragment-size periodicity, library complexity (NRF/PBC1/PBC2), mitochondrial fraction, and ENCODE 4 thresholds. Use when assessing whether an ATAC-seq library passes ENCODE acceptance criteria, diagnosing transposition artefacts, comparing Omni-ATAC vs standard prep quality, or selecting which replicates to drop before peak calling.

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Optional vendor skill for Parallel CLI — agent-native web search, extraction, deep research, enrichment, FindAll, and monitoring. Prefer JSON output and non-interactive flows.

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Systematically collects, categorizes, and distributes indicators of compromise (IOCs) during and after security incidents to enable detection, blocking, and threat intelligence sharing. Covers network, host, email, and behavioral indicators using STIX/TAXII formats and threat intelligence platforms. Activates for requests involving IOC collection, indicator extraction, threat indicator sharing, compromise indicators, STIX export, or IOC enrichment.

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Parse Apache and Nginx access logs to detect SQL injection attempts, local file inclusion, directory traversal, web scanner fingerprints, and brute-force patterns. Uses regex-based pattern matching against OWASP attack signatures, GeoIP enrichment for source attribution, and statistical anomaly detection for request frequency and response size outliers.

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Build an automated system to track adversary infrastructure using passive DNS, certificate transparency, WHOIS data, and IP enrichment to map and monitor threat actor command-and-control networks.

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Analyzes indicators of compromise (IOCs) including IP addresses, domains, file hashes, URLs, and email artifacts to determine maliciousness confidence, campaign attribution, and blocking priority. Use when triaging IOCs from phishing emails, security alerts, or external threat feeds; enriching raw IOCs with multi-source intelligence; or making block/monitor/whitelist decisions. Activates for requests involving VirusTotal, AbuseIPDB, MalwareBazaar, MISP, or IOC enrichment pipelines.

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Comprehensive OSINT methodology for external red-team operations and authorized attack-surface assessments. Covers the 5-stage recon pipeline (seed discovery, asset expansion, enrichment, exposure analysis, reporting), asset-graph discipline with 29 asset types, severity rubric (CRITICAL/HIGH/MEDIUM/LOW/INFO), confidence upgrade workflows, time budgeting, asset-level triage rules, scale-based tactics, identity-fabric mapping (Entra/Okta/ADFS/Google/SAML/M365 Teams+SharePoint+OAuth), API and auth-map methodology, JavaScript deep analysis, mobile attack surface, cloud attack surface, breach×identity correlation, detectability tagging, detection-aware probing (back-off, persona rotation), read-only validator discipline, WAF/CDN bypass + origin discovery, vulnerability prioritization (CVE/EPSS/KEV), phishing infrastructure planning + pretext development, bug bounty submission templates, client deliverable templates with risk translation, threat-actor investigation (incl. RU/CN pivots), cryptocurrency tracing,...

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Builds a hyperpersonalization packet for each lead by chaining company-researcher, cro-auditor, and person-researcher. The packet feeds into message-generator for Tier 3 personalized outreach.

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Enriches inbound leads with firmographic and technographic data. Takes minimal lead info and enriches via WebSearch, Apollo, or ZoomInfo to produce a complete lead record with company size, revenue, tech stack, social profiles, and decision-maker details.

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Find phone numbers for decision makers via Lemlist using Chrome DevTools MCP. Takes LinkedIn profile URLs and returns phone numbers where available.

日本語の概要は準備中です。原文の説明を表示しています。