「scoring」の検索結果

Land the winning experiment from an evo run as a clean, mergeable change -- open a PR when the repo has a remote, otherwise merge into the working branch. Distills the best-scoring experiment down to the minimal diff that reproduces its behaviour, shaped for the qualities a maintainer merges on (scope discipline, test integrity, style adherence), then attaches an advisory mergeability report. Use when the user invokes /evo:ship, asks to land/merge/ship the best result, or wants to turn a finished optimization into a pull request.

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Practise the essay paper (申论) of the Chinese civil service examination (国考 / 省考): work a question from the given materials (给定资料), find the scoring points (要点), draft an answer in the expected format, and mark it the way examiners do. Use when asked 申论怎么写, 帮我批改申论, 归纳概括题怎么答, 申论大作文, 公文写作题, or practise the shenlun paper. Produces a question-type diagnosis, the points extracted from the materials with their source paragraphs, a model answer within the word limit, a marking of the person's own answer against the points, and a practice plan.

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Use when asked 5S 检查表, 6S 管理, 现场管理检查, 5S 评分标准, 车间 6S 稽核, 做一份 5S 推行计划, or design a 5S or 6S audit for a workshop, warehouse or office in a Chinese factory. Produces an audit checklist for the area with scored criteria for 整理, 整顿, 清扫, 清洁, 素养 (and 安全 for 6S), a scoring guide with photo evidence rules, a results summary and red-tag list, a corrective-action tracker with owners and dates, and an audit rota, in Chinese.

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Use when asked 积分落户怎么算, 我能不能落户上海 / 北京 / 深圳, 居转户条件, 落户积分差多少, 人才引进落户, or check eligibility for a city household registration (户口) in China. Produces the routes available in the person's city (积分落户, 居转户, 人才引进, 应届生落户 and others), a score estimate built only from the city's current official scoring table, the gap and how to close it, a document checklist and a timeline, each marked to confirm with the city's official notice.

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Hire an AI agent the way you'd hire an employee — a role spec with success criteria, a structured work-sample interview run on your real tasks, reference checks (what do actual users report), probation KPIs, and termination criteria written before day one. Use when choosing between AI agents/tools/copilots for a job, formalizing an AI pilot, or 'which agent should we use for X'. Produces the role spec, interview pack with scoring rubric, a decision record, and a probation plan.

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Help users move from reactive feature-building to strategic resource allocation by applying rigorous scoring, financial modeling, and portfolio balancing.

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Intent-based search router with trust scoring. Routes queries to optimal channels (Context7 docs, native web search, gh/glab code search, Serena local) and attaches domain trust labels. Use for search, find, lookup, reference, docs, code search, and web research.

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Use for VidSeeds MCP analytics and research - YouTube analytics, channel intelligence, video autopsy, outliers, competitors, trending/breakout discovery, keyword research, comment sentiment, and best-practices tools. Outcomes only; not internal scoring details.

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Optimize content for AI Overviews (formerly SGE), ChatGPT web search, Perplexity, and other AI-powered search experiences. Generative Engine Optimization (GEO) analysis including brand mention signals, AI crawler accessibility, llms.txt compliance, passage-level citability scoring, and platform-specific optimization. Use when user says "AI Overviews", "SGE", "GEO", "AI search", "LLM optimization", "Perplexity", "AI citations", "ChatGPT search", or "AI visibility".

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Generate competitive SEO content briefs with per-section word counts, competitor scoring, keyword density guidance, and page-type templates. Supports both new page briefs and improve-existing-page briefs. Use when user says "content brief", "write a brief", "content outline", "blog brief", "service page brief", "brief for", "writing brief", "content plan", or "outline for".

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Optimize content for AI Overviews (formerly SGE), ChatGPT web search, Perplexity, and other AI-powered search experiences. Generative Engine Optimization (GEO) analysis including brand mention signals, AI crawler accessibility, llms.txt presence (optional; ignored by Google Search), passage-level citability scoring, and platform-specific optimization. Use when user says "AI Overviews", "SGE", "GEO", "AI search", "LLM optimization", "Perplexity", "AI citations", "ChatGPT search", or "AI visibility".

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Search Experience Optimization: reads Google SERPs backwards to detect page-type mismatches, derives user stories from search intent signals, and scores pages from multiple persona perspectives. Identifies why well-optimized pages fail to rank by analyzing what Google rewards for each keyword. Use when user says "SXO", "search experience", "page type mismatch", "SERP analysis", "user story", "persona scoring", "why isn't my page ranking", "intent mismatch", or "wireframe".

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Add a new platform writer module in src/writers/ that generates and writes agent config files for a supported platform. Each writer exports a function that accepts a config interface, creates directories (rules/, skills/, mcp configs), writes files with proper formatting and frontmatter, and returns string[] of written file paths. Use when adding platform support for a new agent, integrating a new code AI tool, or extending caliber to support new targets. Do NOT use for modifying existing writers, refactoring scoring logic, or changing how writers are invoked.

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Detect buying signals across TAM companies and watchlist personas. Three-phase architecture: (1) free diff-based signals from existing data (headcount growth, tech stack changes, funding rounds), (2) Apify-powered signals (job postings, LinkedIn content analysis, profile changes), and (3) post-processing with dedup, scoring, and lead status updates. Writes signals to Supabase signals table for downstream activation.

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Multi-provider waterfall lead enrichment. Takes an email (+ optional name) and returns person + company data by cross-referencing cheap APIs first, using expensive AI agents only as fallback. Cost-efficient (~$0.04-$0.10/lead) with confidence scoring and full error visibility.

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Predict peptide-MHC class I binding and natural presentation with MHCflurry, NetMHCpan-4.1, and MixMHCpred to nominate candidate CD8 T-cell epitopes. Covers the binding-affinity (BA) vs eluted-ligand (EL/presentation) distinction, why %Rank beats raw nM for cross-allele work, the MS abundance bias that misranks low-expression neoantigens, allele-coverage inequity, and length bias. Use when scanning a protein or peptide set for class I epitopes, scoring neoantigen candidates, or choosing a binding predictor. For CD4/HLA class II see mhc-class-ii-prediction.

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Tests whether two genomic interval sets overlap (colocalize) more than expected by chance using a permutation test against a structured-genome null model. Covers bedtools fisher (analytic 2x2 screen), bedtools shuffle + jaccard permutation, GAT (isochore/GC-conditioned simulation with FDR), regioneR (flexible permutation, randomizeRegions vs circularRandomizeRegions, localZScore), LOLA (universe-relative Fisher against a region database), and GREAT/rGREAT (regulatory-domain binomial + hypergeometric for ontology-from-regions). Stresses the universe/background choice, matched background, blacklist exclusion, and multiple-testing control. Use when asking whether peaks/regions are enriched at enhancers/TFBS/features, scoring region-set colocalization or region-set enrichment, comparing CNV/SV concordance, or turning an overlap count into a defensible p-value.

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Rank and prioritize neoantigen/epitope candidates by likely T-cell response using NeoFox feature annotation, PRIME2.0, BigMHC-IM, the Łuksza/Balachandran fitness model (agretopicity + foreignness), and pVACtools tiering. Encodes the field's hard truths that immunogenicity is the least-solved layer (dedicated scores ~AUROC 0.6-0.7, modest PPV), that scores are valid only for RANKING within one patient (never absolute go/no-go or cross-patient), that DAI has anchor-inflation and WT-denominator traps, and that stacking weak correlated scores into one number is a red flag. Use when ordering a candidate list for a vaccine. Binding lives in mhc-binding-prediction; calling in neoantigen-prediction.

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Nominates and assesses CRISPR off-target sites genome-wide. Enumerates candidate sites by mismatch and bulge tolerance with Cas-OFFinder/CRISPRitz, ranks them with the published CFD score (SpCas9-only, relative ranker) or MIT/CRISTA/energy models, runs variant-aware screening against gnomAD/individual genomes (CRISPRme), and frames the empirical genome-wide discovery assays (GUIDE-seq, CIRCLE-seq, CHANGE-seq, DISCOVER-seq, Digenome-seq) and high-fidelity nuclease choice (HiFi Cas9, Sniper-Cas9, eSpCas9, SpCas9-HF1). Use when assessing guide RNA specificity, choosing among candidate guides, screening a therapeutic guide against population variation, or planning empirical off-target validation. Distinguishes predicted vs detected vs validated. On-target activity scoring and deaminase (Cas-independent) base/prime-editor off-targets are separate skills.

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Designs pegRNAs and nicking guides for prime editing (PE) -- choosing the nick/strand, tuning the primer-binding site (PBS) and reverse-transcription template (RTT) as a per-locus panel, selecting the PE system (PE2/PE3/PE3b/PE4/PE5/PEmax/PE7), adding MMR-evading and PAM-disrupting silent edits, appending epegRNA 3' motifs (tevopreQ1/mpknot), and ranking with PRIDICT/DeepPrime. Covers twinPE/PASTE for large insertions and the prime-vs-base-editing decision. Use when designing a scarless point mutation, small insertion/deletion, or any of the 12 base conversions without a double-strand break, when efficiency is low and MMR inhibition or pegRNA stabilization is needed, or when routing a large insertion to an integrase method. Generic guide scoring and base editing are separate skills.

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Identify tumor neoantigens from somatic variants with pVACtools (pVACseq/pVACfuse/pVACbind/pVACvector/pVACview) for personalized cancer vaccines and checkpoint biomarkers. Encodes the field's hard truth that binding prediction is the easy, near-solved part and single-digit-percent PPV lives downstream — so it centers clonality/CCF, HLA LOH (the silent invalidator), expression, proximal-variant phasing, agretopicity/foreignness quality, and the predicted->presented->immunogenic validation tiers. Use when nominating vaccine targets, ranking neoantigens, or building a tumor-to-candidate pipeline. Binding details in mhc-binding-prediction; ranking in immunogenicity-scoring.

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Designs cytosine (CBE, C-to-T) and adenine (ABE, A-to-G) base-editor guides by positioning the target base at the activity-peak of the editing window (protospacer positions ~5-7, PAM-distal numbering), minimizing bystander edits for product purity, reading dinucleotide context (APOBEC1 TC favored / GC disfavored), and selecting the editor variant (BE4max, ABEmax, ABE8e, YE1/SECURE, TadCBE, CGBE, SpG/SpRY-BE). Covers knockout by premature stop (CRISPR-STOP/iSTOP) and splice-site disruption, the three off-target classes (Cas-dependent, Cas-independent DNA, RNA), outcome prediction (BE-Hive/DeepBE), and the base-vs-prime-vs-HDR decision. Use when installing a transition mutation without a double-strand break, knocking out a gene without indels, or choosing CBE vs ABE. Generic guide scoring, prime editing, and HDR donors are separate skills.

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Predict peptide-MHC class II (HLA-DR/DQ/DP) binding and presentation for CD4 T-cell epitopes with NetMHCIIpan-4.3 and MixMHC2pred-2.0. Covers why class II is far less reliable than class I (open binding groove, 9-mer register ambiguity, sparse noisy training data, DR>DP>DQ accuracy asymmetry), the DQ/DP heterodimer alpha/beta pairing trap, and the looser 1%/5% %Rank thresholds. Use when predicting CD4 epitopes for vaccine help, mapping class II neoantigens, or scoring long peptides against DR/DQ/DP. For CD8/class I see mhc-binding-prediction.

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Infer gene regulatory networks from bulk or general expression data with mutual-information (ARACNe) and tree-ensemble (GENIE3, GRNBoost2) methods, and infer transcription-factor protein activity from regulons with VIPER and msVIPER. Covers the activity-not-edges paradigm, the undirected-association caveat, the DREAM5 wisdom-of-crowds and method-complementarity result, AUPRC-over-AUROC evaluation, and gold-standard incompleteness. Use when inferring a regulatory network from a bulk expression matrix, finding master regulators, or scoring TF activity from a signature. For single-cell motif-pruned regulons see scenic-regulons; for co-expression modules see coexpression-networks.

日本語の概要は準備中です。原文の説明を表示しています。