「skill discovery」の検索結果

Work on bifunctional degraders and molecular glues, where potency comes from a ternary complex rather than occupancy. Use this skill to apply the property rules that govern this beyond-rule-of-five space, reason about linker length, attachment vector and E3 ligase choice, prepare inputs for ternary complex structure prediction, and interpret degradation readouts — DC50, Dmax, cooperativity, and the hook effect that makes a dose-response curve turn over. Also trigger on PROTAC, molecular glue, targeted protein degradation, E3 ligase, cereblon, VHL, ternary complex, DC50, Dmax, hook effect, cooperativity, or PROTAC-DB.

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Protein language models through the EvolutionaryScale `esm` Python SDK. Generate and embed sequences with ESM3 (multimodal sequence, structure and function prompting), extract per-residue and mean-pooled embeddings with ESM C, fold sequences with ESMFold2, and run inference locally or against the Forge and Biohub hosted clients. Use this skill for protein representation learning, variant effect and mutational scanning from likelihoods, sequence generation and inpainting, structure prediction from sequence alone, and embedding features for downstream models. Also trigger on esm, ESM3, ESMC, ESM Cambrian, ESMFold2, `from esm.models`, ESMProtein, GenerationConfig, forge.evolutionaryscale.ai, biohub.ai, or ESM_API_KEY.

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Query the FDA's public openFDA APIs for post-market drug data — FAERS adverse-event reports, Drugs@FDA approval and submission history, Structured Product Labels including boxed warnings, the National Drug Code directory, recall enforcement reports, and drug shortages. Use this skill to check what a regulator has already concluded about a molecule or its class, to date an approval and count its efficacy supplements, to read an approved indication or boxed warning, and to score a drug-event pair for disproportionate reporting with PRR, ROR, and chi-squared. Also trigger on openFDA, api.fda.gov, FAERS, Drugs@FDA, SPL, NDC, pharmacovigilance, boxed warning, adverse event report, drug recall, or safety signal.

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Molecular featurization hub with one consistent interface over 100+ featurizers. Fingerprints (ECFP/Morgan, MACCS, atom pair, topological torsion, Avalon, RDKit, ERG), RDKit and Mordred descriptor sets, pharmacophore and 3D shape descriptors, scaffold keys, and pretrained embeddings (ChemBERTa, ChemGPT, MolT5, GIN, Graphormer) through a common transformer API with caching and parallelism. Use this skill to convert SMILES into model-ready feature matrices for QSAR, virtual screening, and molecular ML, and to choose between featurizer families. Also trigger on molfeat, MoleculeTransformer, FPVecTransformer, PretrainedHFTransformer, molfeat model store, or featurizer selection.

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Search the ClinicalTrials.gov registry through its version 2 REST API for interventional and observational studies, their phases, enrolment, endpoints, sponsors, and posted results. Use this skill to survey who is developing what against an indication, date a competitor's programme, read primary and secondary outcome measures, find eligibility criteria, and distinguish a study that completed from one that was terminated or withdrawn. Also trigger on ClinicalTrials.gov, NCT number, trial registry, study phase, enrolment, primary outcome measure, recruiting status, trial sponsor, or competitive landscape.

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Turn a set of structures into absorption, distribution, metabolism, excretion, and toxicity estimates with ADMET-AI, and read them as a developability verdict rather than a table of numbers. Use this skill to run batch prediction over a library, interpret each endpoint against its DrugBank-approved percentile, and flag the liabilities that stop a series — hERG blockade, CYP inhibition, poor Caco-2 permeability, high clearance, and plasma protein binding. Also trigger on ADMET-AI, admet_ai, Chemprop-RDKit, hERG liability, CYP3A4 inhibition, Caco-2, bioavailability prediction, or developability triage.

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Design small interfering RNA and antisense oligonucleotide sequences against a transcript, and screen them for the failure modes specific to nucleic-acid drugs. Use this skill to tile a target transcript, apply positional and thermodynamic selection rules including duplex asymmetry and nearest-neighbour melting temperature, scan candidates for seed-region complementarity to off-target transcripts, and lay out a chemical modification pattern — gapmer architecture, 2'-O-methyl and 2'-MOE wings, locked nucleic acid, and phosphorothioate placement. Also trigger on siRNA, antisense oligonucleotide, ASO, gapmer, RNase H, seed region, duplex asymmetry, 2'-MOE, locked nucleic acid, phosphorothioate, or GalNAc conjugate.

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Query the ChEMBL database web services for measured bioactivity data, compound records and calculated properties, targets, assays, mechanisms of action, drug indications and warnings. Use this skill to build curated SAR or QSAR datasets for a target, look compounds up by SMILES, InChIKey, name, or ChEMBL id, run similarity and substructure searches, and check what chemistry is already known against a protein. Also trigger when a query mentions ChEMBL ids (CHEMBL...), pChEMBL values, IC50/Ki/Kd/EC50 retrieval, assay confidence scores, or ebi.ac.uk/chembl.

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How to use the Adaptyv Bio Foundry API and Python SDK for protein experiment design, submission, and results retrieval. Use this skill whenever the user mentions Adaptyv, Foundry API, protein binding assays, protein screening experiments, BLI/SPR assays, thermostability assays, or wants to submit protein sequences for experimental characterization. Also trigger when code imports `adaptyv`, `adaptyv_sdk`, or `FoundryClient`, or references `foundry-api-public.adaptyvbio.com`.

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Use these skills when you need to discover and explore data assets in the Knowledge Catalog. It allows you to search for entries, lookup specific metadata, and explore aspect types to understand your data platform's assets.

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Use this skill when the user needs official desktop Obsidian CLI Bases or Bookmarks workflows, including base discovery, view/query operations, base item creation, and bookmark management. Keep this skill separate from general note CRUD, runtime admin, Sync/Publish, and devtools diagnostics.

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Use when the user explicitly asks for the Inngest REST API v2, raw HTTP, OpenAPI, API docs, API authentication, or an endpoint that the Inngest CLI does not expose. Covers api-docs.inngest.com, llms.txt, the OpenAPI v2 spec, Bearer authentication with API keys or signing keys, production and local base URLs, raw curl/fetch requests, request-shape discovery, pagination, secret redaction, and when to prefer the `inngest-api-cli` skill instead.

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Sub-skill de agent-ready-cloudflare: Implement ACP Discovery Document

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houtu-dependencies enterprise-grade Spring Cloud microservice foundational framework complete usage guide. GroupId is io.github.lujiafa, covering unified response, exception handling, parameter parsing, session authentication, permission control, signature verification, anti-replay, distributed lock, rate limiting, database field encryption, config decryption, access logging, canary routing, weighted load balancing, Feign enhancement, Sentinel circuit breaking, service discovery, Swagger documentation, crypto utilities, HTTP client, monitoring metrics, and other enterprise-grade capabilities. When the project build file (pom.xml or build.gradle/build.gradle.kts) contains io.github.lujiafa or houtu-related dependencies, or when the user mentions houtu or houtu-dependencies, this Skill must be read and code must be generated strictly following framework conventions. Even if the user is simply doing regular Spring Boot development (e.g., writing Controller, Service, Feign), as long as the project includes houtu, the houtu approach must be used instead of native Spring. When the user explicitly wants to use the houtu framework and the project has not yet included it, proactively add the BOM and required Starters; when the project already includes it, proactively identify and import required module dependencies based on business scenarios during coding, naturally integrating framework capabilities to enhance business services based on business semantics, rather than waiting for the user to specify each one.

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"Implement a web crawler pipeline covering URL discovery, fetching, parsing, and storage. Use this skill when the user needs to build a site crawler, audit website structure, or collect web data systematically — even if they say 'scrape a website', 'crawl all pages', or 'site audit spider'.".

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"Implement matrix factorization to decompose user-item interaction matrices into latent factor representations. Use this skill when the user needs scalable collaborative filtering, latent feature discovery, or dimensionality reduction for recommendation — even if they say 'SVD recommendations', 'latent factors', or 'factorize the rating matrix'.".

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OSINT and reconnaissance automation skill for passive collection, pivoting, deduplication, and graph-based analysis using subfinder, amass, dnsx, chaos, crt.sh, github-dorks, waybackurls, gau, gitleaks, trufflehog, theHarvester, h8mail, holehe, sherlock, Shodan, Censys, FOFA, and Hunter. Use for asset discovery, exposure monitoring, and authorized reconnaissance only.

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Cloud security posture skill for AWS, Azure, GCP, and multi-cloud. Covers IAM least-privilege, key and secret hygiene, network exposure, data protection, logging coverage, IaC scanning (Terraform, CloudFormation, Bicep, Pulumi), CSPM remediation, and landing-zone hardening. Use for misconfig discovery, IaC review, and automated drift-and-fix workflows on cloud accounts you own.

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Systematically discover hidden Application Programming Interfaces (APIs), uncover undocumented endpoints (Shadow APIs), and fuzz parameters. Use this skill as the pivotal first step in API Bug Hunting, transforming a basic frontend application into a vast mapped attack surface.

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Product management workflows covering the full work lifecycle — discovery, strategy, execution, launch, and growth. Write PRDs, plan OKRs, and structure meeting notes. Useful beyond PMs — applicable to any knowledge worker managing projects, stakeholders, or strategy. Triggers: /write-prd, /plan-okrs, /meeting-notes

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Discovery-only Gaia curation for one manually selected source page. Fetches and normalizes up to five real SKILL.md candidates, deduplicates and maps them for human L4 review, then stops without evidence scoring or registry mutation.

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Discovery-only global trending extension for Gaia. Snapshots configured external skill sources, prioritizes five-candidate pages for L4 review, and stops before trust, evidence, intake, or registry mutation.

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Sales enablement, technical presales and deal acceleration for B2B SaaS revenue teams. Use this skill when planning outbound campaigns, running discovery calls, building deal strategy, creating battle cards, writing proposals, responding to RFPs, preparing a product demo, scoping a proof of concept or pilot, answering a security questionnaire or the AI annex buyers now attach to it, executing sales sequences, coaching qualification, or deciding what the website's AI chat agent is allowed to say. Also triggers on: outbound, cold outreach, reply handling, reply classification, out-of-office replies, auto-replies counted as replies, our reply rate is inflated, prospect replied remove me, opt-out by reply, is this list ready to send, launch readiness, CRM segment outbound, we emailed a current customer, outbound hit an open opportunity, ownerless leads, prospects engaging our competitors, competitor connections, displacement list, is this personalization creepy, can we mention they visited our site, signal freshness, deal strategy, pipeline, battle card, objection handling, common objections, why do we keep hearing this objection, mine call transcripts for objections, objection register, proposal, RFP, discovery call, MEDDPICC, sales sequence, qualification, sales engineer, solutions engineer, presales, demo plan, demo script, POC, proof of concept, pilot success criteria, technical evaluation, technical win, security questionnaire, vendor security review, SOC 2 questionnaire, AI security questionnaire, AI annex, AI vendor due diligence, the buyer is asking if we train on their data, do you train on customer data, which model do you use, model provider sub-processor, AI subprocessor disclosure, where does inference run, can the customer turn the AI feature off, AI-CAIQ, CSA AI Controls Matrix, ISO 42001, ISO/IEC 42001, NIST AI RMF, EU AI Act Article 50, are we a provider or a deployer, AI feature disclosure, our model vendor changed and nobody told the buyer, technical objection, mutual action plan, MAP, close plan, mutual close plan, buyer enablement, the deal is stalled, deal stalled after the demo, how do I get this deal to close, close date keeps slipping, JOLT, buyer indecision, no-decision loss, website chatbot, chat widget, AI chat agent, AI SDR, inbound AI SDR, conversational marketing, live chat, what should our chatbot be allowed to say, our chatbot quoted the wrong price, the bot promised a discount, do we have to disclose it is AI, EU AI Act chatbot disclosure, chatbot handoff to sales, chat transcript review, prompt injection on our chatbot, Drift, Qualified, Intercom.

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Create and manage Volcengine cloud resources using the Volcengine CLI (`ve` command). Supports all Volcengine services including ECS, VPC, CLB, RDS, Redis, and more. Trigger this skill whenever the user asks to create, query, modify, or delete cloud resources on Volcengine, mentions the `ve` command, says "volcengine CLI", or describes infrastructure tasks such as "create an ECS instance", "set up a VPC", "list security groups", "allocate an EIP". Also trigger on Chinese prompts mentioning "火山引擎" or "火山" (e.g., "火山引擎上有哪些 ECS"、"查一下我火山的云服务器"、 "火山引擎创建一个 VPC"、"火山的 Redis 实例列一下"). Also trigger when the user encounters errors from `ve` commands and needs troubleshooting help. Also use for TOS bucket/object operations, tosutil (sometimes written tosutils), Ark CLI / arkcli model discovery, inference, generation, endpoints, fine-tuning, plans, or usage, and TLS (日志服务) / volclog log search, analysis, ingest, export, or LogCollector collection, through `ve tosutil`, `ve arkcli` and `ve volclog`.

日本語の概要は準備中です。原文の説明を表示しています。