Route BayesianOptimization package tasks for black-box Bayesian optimization, HPO, acquisition functions, constraints, typed domains, domain reduction, and checkout maintenance.
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Route BayesianOptimization package tasks for black-box Bayesian optimization, HPO, acquisition functions, constraints, typed domains, domain reduction, and checkout maintenance.
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Implements NIST SP 800-88 Rev. 1 media sanitization procedures including Clear, Purge, and Destroy methods for all media types. Covers certificate of destruction generation, verification procedures, vendor management for third-party destruction, and chain of custody documentation. Activate for data destruction, media sanitization, secure erasure, certificate of destruction queries.
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Implements HIPAA Privacy Rule requirements under 45 CFR §164.500-534 for covered entities and business associates. Covers minimum necessary standard, treatment-payment-operations exceptions, directory opt-out, personal representative rules, and authorization requirements. Keywords: HIPAA Privacy Rule, PHI, minimum necessary, TPO, authorization, covered entity.
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Guides audit findings remediation program management including finding prioritization by severity (critical, high, medium, low), owner assignment, remediation planning, deadline tracking, verification testing, closure criteria, escalation protocols, and management reporting. Covers remediation lifecycle from finding issuance to verified closure. Keywords: audit remediation, finding management, prioritization, verification testing, closure criteria, remediation tracking.
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Applies the reasoning style of Kaiming He, computer vision pioneer and creator of ResNet. Use this skill whenever you are designing deep learning architectures, debugging neural network optimization, formulating generative AI problems, or bridging AI with other scientific domains. Trigger this skill for discussions on network depth, weight initialization, residual learning, flow matching, or when reframing discriminative tasks as conditional generation. It emphasizes simplicity in complex visual problems, end-to-end optimization, and viewing AI as a universal language for science.
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Fix slow Flutter app startup caused by blocking network operations during initialization. Use when: (1) App takes several seconds to show first frame, (2) Startup logs show sequential network operations (WebSocket connections, API calls), (3) Services initialize during startup that aren't needed until user authenticates. Covers: converting sequential network ops to parallel with Future.wait(), deferring service initialization until actually needed (lazy init), and identifying blocking operations in Riverpod/provider initialization chains.
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Instruments authentication, authorization, and input-handling code paths to monitor security-relevant events and states at runtime. Use this skill when developers need to add security monitoring and logging to their code, including tracking authentication attempts (login/logout), authorization decisions (access control checks), input validation failures, session management events, and other security-critical operations. Supports Python, JavaScript/TypeScript, and Java with structured logging patterns. Triggers when users ask to add security instrumentation, monitor security events, log authentication/authorization, track security-sensitive operations, or add security observability to their codebase.
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Analyzes and optimizes code for better performance, memory usage, and efficiency. Use when code is slow, memory-intensive, or inefficient. Supports Python and Java optimization including execution speed improvements, memory reduction, database query optimization, and I/O efficiency. Provides before/after examples with detailed explanations of why optimizations work, complexity analysis, and measurable performance improvements.
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Takes an app from hardcoded strings to a localized, continuously translated one with i18next (Locize optional): stack detection, config, wrapping strings in t(), key extraction, Locize sync, and AI translation. Use when the user asks to add or set up i18n, internationalization, localization, translations, or multi-language support, including phrasings like "add i18n", "internationalize my app", "make my app multilingual", "make my app translatable", "localize my app", "find hardcoded strings", "wrap my strings", and library-specific ones like "set up i18next", "add react-i18next", "use next-i18next". Also use when the user names languages they want to support ("I want German and French", "support more languages"), when an app already has i18next but strings are still hardcoded, or when translations need to move to a managed backend. Do not use for translating or reviewing strings in a project whose i18n is already set up.
日本語の概要は準備中です。原文の説明を表示しています。
Think and work like an expert Cheminformatician. Use when a task calls for Cheminformatician judgment. Reasons from Standard InChI identity and RDKit sanitization through ChEMBL pChEMBL harmonization, Morgan/ECFP fingerprints, scaffold splits and applicability domains, while treating tautomer collapse, KNIME-vs-Python canonicalization drift, and random-split QSAR leakage as first-class failure modes.
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Plan, implement, or review vs code extension localization work in an existing codebase with compatibility, security, and verification controls. Use when the user explicitly requests vs code extension localization work.
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Apply sql optimization patterns in reproducible local data workflows with version-aware APIs, explicit assumptions, and validation. Use when the user chooses sql optimization patterns or its strengths fit the task.
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Apply spark optimization in reproducible local data workflows with version-aware APIs, explicit assumptions, and validation. Use when the user chooses spark optimization or its strengths fit the task.
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Plan, implement, or review google cloud waf cost optimization work in an existing codebase with compatibility, security, and verification controls. Use when the user explicitly requests google cloud waf cost optimization work.
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Plan, implement, or review google cloud waf performance optimization work in an existing codebase with compatibility, security, and verification controls. Use when the user explicitly requests google cloud waf performance optimization work.
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Apply data visualization in reproducible local data workflows with version-aware APIs, explicit assumptions, and validation. Use when the user chooses data visualization or its strengths fit the task.
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Production guidance for converting sourced data and approved claims into truthful, accessible, deterministic animated visualizations with D3. Use for data-driven charts, maps, networks, hierarchies, transitions, annotations, responsive video variants, frame-by-frame browser rendering, and visualization QA; not for generic dashboards, unsourced decorative charts, or ordinary motion graphics without a data contract.
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Provider-independent localization and dubbing production direction for AI agents producing translated videos, dubbed ads, social clips, explainers, avatar videos, documentaries, training media, and multi-market campaigns. Use when planning or reviewing subtitle-versus-dub strategy, translation adaptation, glossary/style-guide setup, casting or voice matching, lip-sync or phrase-sync direction, synthetic dubbing boundaries, captions/subtitles handoff, accessibility, platform delivery, client review, or localization QA.
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Build forest plots (HR, OR, RR, beta-coefficient summaries with CIs) and funnel plots (meta-analysis publication-bias diagnostics) using forestplot, metafor, ggforest, and MendelianRandomization with proper axis-scaling, summary-diamond placement, subgroup nesting, and Egger / trim-and-fill asymmetry tests. Use when summarizing effects across subgroups, trials, or instruments — meta-analysis, Mendelian randomization, subgroup HRs.
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Preprocessing and harmonization of multi-omics data before integration. Covers normalization, batch correction, feature alignment, and missing value handling across data types. Use when preparing multi-omics datasets for integration analysis.
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End-to-end post-GWAS causal inference pipeline orchestrating heritability partitioning, genetic correlation, Mendelian randomization with CHP-aware sensitivity (CAUSE / LHC-MR), colocalization, fine-mapping with SuSiE / FOCUS, mediation, TWAS triangulation, cis-pQTL drug-target MR, effector-gene prioritization (L2G / PoPS / cS2G), and GenomicSEM common-factor GWAS. Use when triangulating causal inference across multiple complementary methods, prioritizing tissues via stratified LDSC, nominating or de-risking drug targets, mapping a lead SNP to a candidate effector gene, modeling shared genetic architecture across correlated traits, or producing a STROBE-MR-compliant publication-grade evidence battery from GWAS summary statistics.
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Test whether two or more traits share a causal variant at a locus using Bayesian colocalization (coloc.abf, coloc.susie, HyPrColoc, moloc, eCAVIAR, SMR/HEIDI, PWCoCo, SharePro). Use when integrating GWAS with eQTL/sQTL/pQTL/mQTL, distinguishing shared causal variants from LD-driven coincidence, handling allelic heterogeneity, choosing between single-causal vs multi-causal methods, picking PP.H4 thresholds, running sensitivity over p12, or harmonising summary statistics for colocalization.
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Docker containerization expert with deep knowledge of multi-stage builds, image optimization, container security, Docker Compose orchestration, and production deployment patterns. Use PROACTIVELY for Dockerfile optimization, container issues, image size problems, security hardening, networking, and orchestration challenges.
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Mine a per-kernel optimization trace — a git repository capturing successive versions of one kernel being optimized — into structured, gate-validated optimization-experience records for the GPU kernel wiki. Use when asked to distill an optimization run, a kernel_opt trace directory or a version ladder into wiki records; to report what such a run actually achieved; to build, extend, re-run or validate the staging store behind those records; or to explain how a trace-derived record's number, snippet or provenance was established.
日本語の概要は準備中です。原文の説明を表示しています。