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Fits structural equation models to GWAS summary statistics using GenomicSEM (Grotzinger 2019), including common-factor models, confirmatory factor models, ESEM, common-factor GWAS with Q_SNP heterogeneity, multivariate Wald tests, and stratified GenomicSEM partitioned heritability. Reconciles results against MTAG multi-trait analysis. Handles sample overlap via the LDSC sampling-covariance matrix, identifies and resolves Heywood cases, and verifies model fit with CFI / RMSEA. Use when modeling latent genetic architecture across correlated traits, running multivariate GWAS on a shared factor, distinguishing factor-mediated from trait-specific SNP effects, or comparing GenomicSEM common-factor results against MTAG when both depend on accurate sampling covariance.

日本語の概要は準備中です。原文の説明を表示しています。

Identifies differentially bound ChIP-seq regions between conditions using DiffBind, csaw (sliding windows), DESeq2/edgeR/PyDESeq2 on count matrices, NormR (control-aware), or MAnorm2. Distinguishes three distinct normalization problems (composition bias, trended bias, global shifts) and matches each to its appropriate fix including spike-in scaling. Use when comparing ChIP-seq binding between experimental conditions, choosing normalization for global vs local changes, integrating spike-in data, or reconciling DiffBind/DESeq2 disagreement.

日本語の概要は準備中です。原文の説明を表示しています。

Designs adaptive clinical trials including group-sequential (O'Brien-Fleming, Pocock, Lan-DeMets spending), sample-size re-estimation (blinded Friede-Kieser, unblinded Cui-Hung-Wang, Mehta-Pocock promising zone), seamless Phase 2/3 with treatment-arm selection, population enrichment, and response-adaptive randomisation. Covers FDA 2019 Final Adaptive Designs Guidance, FDA 2022 Master Protocols, and ICH E20 Step 2b/3 draft (June 2025, NOT final). Use when planning interim analyses, sample-size re-estimation, or master/platform-trial designs.

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Designs Bayesian clinical trials including Phase I dose-finding (BOIN, CRM, EWOC, mTPI-2), meta-analytic-predictive (MAP) priors with robust mixtures for external data borrowing, EXNEX for basket trials, hierarchical models for safety AE (Berry-Berry), Bayesian platform trials (I-SPY 2, GBM AGILE, REMAP-CAP), and posterior probability stopping rules. Covers FDA Bayesian Devices Guidance (2010), FDA Bayesian Methodology in Drugs Draft (January 2026), BOIN Fit-for-Purpose qualification (December 2021), and Project Optimus dose-optimisation. Use when designing dose-finding studies, platform trials, or sensitivity analyses with informative priors.

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Implements missing-data sensitivity analyses for confirmatory clinical trials including MMRM under MAR (with Kenward-Roger correction), reference-based multiple imputation (J2R, CR, CIR, LMCF per Carpenter-Roger 2013), Permutt delta-adjustment / tipping-point analysis, pattern-mixture identifying restrictions (CCMV, NCMV, ACMV), and the Cro vs Bartlett variance debate. Use when handling missing primary or secondary endpoint data in regulatory submissions following NRC 2010 and ICH E9(R1).

日本語の概要は準備中です。原文の説明を表示しています。

Performs alchemical free-energy calculations including relative binding free energy (RBFE / FEP+) and absolute binding free energy (ABFE) via OpenFE, FEP+, GROMACS, AMBER pmemd, and OpenMM with explicit lambda window scheduling, soft-core potentials, REST2 enhanced sampling, MBAR/BAR analysis, and cycle closure validation. Compares ML alternatives (Boltz-2 affinity, DeepDock). Use when ranking analogs by binding affinity beyond docking accuracy, performing prospective lead optimization, or validating SAR predictions.

日本語の概要は準備中です。原文の説明を表示しています。

Calculate alignment statistics including sequence identity, conservation scores, substitution matrices, and similarity metrics. Use when comparing alignment quality, measuring sequence divergence, and analyzing evolutionary patterns.

日本語の概要は準備中です。原文の説明を表示しています。

Use this skill when the user asks anything that touches US Department of Transportation (DOT) or Federal Motor Carrier Safety Administration (FMCSA) regulation for commercial motor vehicles (CMVs) — including who's regulated, MC vs DOT number differences, operating authority, BOC-3 process agents, MCS-150 biennial updates, intrastate vs interstate distinctions, exemptions, or pointing to the right CFR section. Cite the actual regulation when answering. Don't guess; if you're not sure which Part applies, ask the user to clarify the operation type (for-hire vs private, passenger vs property, intra vs interstate, hazmat, gross weight rating).

日本語の概要は準備中です。原文の説明を表示しています。

Optimize content for AI Overviews (formerly SGE), ChatGPT web search, Perplexity, and other AI-powered search experiences. Generative Engine Optimization (GEO) analysis including brand mention signals, AI crawler accessibility, llms.txt compliance, passage-level citability scoring, and platform-specific optimization. Use when user says "AI Overviews", "SGE", "GEO", "AI search", "LLM optimization", "Perplexity", "AI citations", "ChatGPT search", or "AI visibility".

日本語の概要は準備中です。原文の説明を表示しています。

Use when designing or improving prompts, commands, hooks, skills, or sub-agent instructions, including output quality, reliability, and token efficiency.

日本語の概要は準備中です。原文の説明を表示しています。

Browser automation CLI for AI agents. Use when the user needs to interact with websites, including navigating pages, filling forms, clicking buttons, taking screenshots, extracting data, testing web apps, or automating any browser task. Triggers include requests to "open a website", "fill out a form", "click a button", "take a screenshot", "scrape data from a page", "test this web app", "login to a site", "automate browser actions", or any task requiring programmatic web interaction.

日本語の概要は準備中です。原文の説明を表示しています。

Use when the user wants to work with PDF files, including text/table extraction, merging, splitting, rotation, watermarking, creation, form filling, encryption/decryption, image extraction, or OCR for scanned PDFs.

日本語の概要は準備中です。原文の説明を表示しています。

Explain selected code or a specified file/function in plain language, including what it does, why it exists, and potential pitfalls

日本語の概要は準備中です。原文の説明を表示しています。

Add authentication (passkeys/OAuth) to the current Convex app, including the auth.config.ts wiring.

日本語の概要は準備中です。原文の説明を表示しています。

Prove a Convex feature works — seed, drive as multiple mocked users via convex-test, assert behavior including the negative authz cases (wrong user refused, data-scope enforced).

日本語の概要は準備中です。原文の説明を表示しています。

Plan and execute Convex schema migrations safely, including adding fields, creating tables, and data transformations. Use when schema changes affect existing data.

日本語の概要は準備中です。原文の説明を表示しています。

PHP Standards Recommendations (PSR) overview knowledge base. Provides comprehensive reference for all accepted PSRs including PSR-1,3,4,6,7,11,12,13,14,15,16,17,18,20. Use for PSR selection decisions and compliance audits.

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Generates PSR-20 Clock implementation for PHP 8.5. Creates ClockInterface implementations including SystemClock, FrozenClock, and OffsetClock for time abstraction and testing. Includes unit tests.

日本語の概要は準備中です。原文の説明を表示しています。

Expert knowledge of academic writing standards for peer-reviewed papers, including citation integrity, style compliance, clarity, and scientific writing best practices. Use when reviewing or editing academic manuscripts, papers, or research documentation.

日本語の概要は準備中です。原文の説明を表示しています。

ABP Framework application layer patterns including AppServices, DTOs, Mapperly mapping, Unit of Work, and common patterns like Filter DTOs and ResponseModel. Use when: (1) creating AppServices, (2) mapping DTOs with Mapperly, (3) implementing list filtering, (4) wrapping API responses.

日本語の概要は準備中です。原文の説明を表示しています。

When the user requests to create or customize an academic personal website from a GitHub template repository. This skill handles the complete workflow of forking academic template repositories (like academicpages.github.io), extracting structured personal information from memory or provided data, and systematically updating configuration files (_config.yml), navigation menus (_data/navigation.yml), content pages (_pages/about.md), and publication listings (_publications/). It specifically handles academic profiles including personal details, education background, research experience, publications, skills, and contact information. Triggers include requests to 'fork and customize academic homepage', 'build personal academic website', 'create research portfolio', or 'set up GitHub pages with academic template'.

日本語の概要は準備中です。原文の説明を表示しています。

Academic paper search across 14+ scholarly platforms including arXiv, PubMed, Google Scholar, Web of Science, Semantic Scholar, Sci-Hub, and more. Use for literature review, research discovery, and citation management.

日本語の概要は準備中です。原文の説明を表示しています。

ABP Framework domain layer patterns including entities, aggregates, repositories, domain services, and data seeding. Use when: (1) creating entities with proper base classes, (2) implementing custom repositories, (3) writing domain services, (4) seeding data.

日本語の概要は準備中です。原文の説明を表示しています。

ABP Framework cross-cutting patterns including authorization, background jobs, distributed events, multi-tenancy, and module configuration. Use when: (1) defining permissions, (2) creating background jobs, (3) publishing/handling distributed events, (4) configuring modules.

日本語の概要は準備中です。原文の説明を表示しています。