2,856 件 ・ 関連度順
概要と使いどころ
Polish assemblies and call variants from Oxford Nanopore data using medaka. Uses neural networks trained on specific basecaller versions. Use when improving ONT-only assemblies or calling variants from Nanopore data without short-read polishing.
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Statistical analysis for metabolomics data. Covers univariate testing, multivariate methods (PCA, PLS-DA), and biomarker discovery. Use when identifying differentially abundant metabolites or building classification models.
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Detect structural variants from long-read alignments using Sniffles, cuteSV, and SVIM. Use when detecting deletions, insertions, inversions, translocations, or complex rearrangements from ONT or PacBio data, especially those missed by short-read methods.
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Detects somatic mutations in circulating tumor DNA using variant callers optimized for low allele fractions with UMI-based error suppression. Reliably detects mutations at VAF above 0.5 percent using consensus-based approaches. Use when identifying tumor mutations from plasma DNA or tracking specific variants.
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Call copy number variants using GATK best practices workflow. Supports both somatic (tumor-normal) and germline CNV detection from WGS or WES data. Use when following GATK best practices or integrating CNV calling with other GATK variant pipelines.
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Query dbSNP for rsID lookups, variant annotations, and cross-references to other databases. Use when mapping between rsIDs and genomic coordinates or retrieving basic variant information.
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Analyze transcription factor motif accessibility variability using chromVAR. Use when identifying which TF motifs show variable accessibility across samples or conditions in ATAC-seq data.
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This skill should be used for time series machine learning tasks including classification, regression, clustering, forecasting, anomaly detection, segmentation, and similarity search. Use when working with temporal data, sequential patterns, or time-indexed observations requiring specialized algorithms beyond standard ML approaches. Particularly suited for univariate and multivariate time series analysis with scikit-learn compatible APIs.
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Decompose genetic effects into direct and indirect paths through mediating variables using the mediation R package. Tests whether gene expression, methylation, or other molecular phenotypes mediate the effect of genetic variants on disease. Use when testing whether a molecular phenotype mediates the genotype-to-phenotype relationship.
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Query ClinVar for variant pathogenicity classifications, review status, and disease associations via REST API or local VCF. Use when determining clinical significance of variants for diagnostic or research purposes.
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Estimate causal effects between exposures and outcomes using genetic variants as instrumental variables with TwoSampleMR. Implements IVW, MR-Egger, weighted median, and MR-PRESSO methods for robust causal inference from GWAS summary statistics. Use when testing whether an exposure causally affects an outcome using genetic instruments.
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Synthesize the three Jason Shapiro contrarian-pipeline verdicts (COT crowding, news-reaction failure, weekly price-action confirmation) into one actionable setup_status via a fail-closed precedence state machine. Pure, offline synthesis -- no network, no API keys, no computation beyond validation and precedence.
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Judge whether a market FAILED to react to news favorable to a crowded speculative position — step 2 of Jason Shapiro's COT contrarian process. Consumes a cot-contrarian-detector report (or an explicit direction) plus a Claude-curated events JSON, fetches the underlying price series with a documented fallback chain, and produces a fail-closed CONFIRMED / NOT_CONFIRMED / INSUFFICIENT_EVIDENCE verdict using a statistically validated drift-significance test (not a naive failure-ratio, which false-confirms on pure noise). Generic beyond COT — reusable for PEAD and macro-crowding news-failure checks. Use when the user asks to check news-failure confirmation, whether a crowded market "shrugged off" good/bad news, or wants to run Shapiro step 2 on a CROWDED_LONG/CROWDED_SHORT market.
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SUPERSEDED by /claudex-loop (formerly /crucible; adds a Phase 0 research/recon pass + rebuilt interview) — prefer that skill unless you explicitly want this one. Two-act plan hardening. ACT 1 (you ↔ Claude) — Claude interviews you relentlessly about a plan or design, one question at a time, recommending an answer for each and exploring the codebase when it can answer itself, until every branch of the decision tree is resolved. ACT 2 (Claude ↔ Codex) — Claude writes the locked plan to PLAN.md and OpenAI Codex adversarially reviews it in a read-only sandbox (VERDICT:APPROVED/REVISE), Claude revises and re-submits to the SAME Codex session until APPROVED or a MAX_ROUNDS cap, then you sign off before any code. Use when the user says "/grill-me-codex", "grill me then have codex review", "grill me and stress-test the plan", "interview me about this plan then get a second model on it", or is about to build something high-stakes (auth, schema, concurrency, migrations, payments) and wants both alignment AND a cross-model sanity check before implementation. Builds on Matt Pocock's grill-me (MIT). For the docs-aware variant use /grill-with-docs-codex; if you already have a plan and want only the Codex review use /codex-review. NOT for reviewing already-written code (use /codex:review) and NOT for trivial changes.
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SUPERSEDED by /claudex-loop (formerly /crucible; its docs-aware mode covers this variant) — prefer that skill unless you explicitly want this one. Two-act plan hardening with living documentation. ACT 1 (you ↔ Claude) — Claude interviews you relentlessly about a plan, one question at a time, challenging it against your project's existing domain model and glossary (CONTEXT.md), sharpening fuzzy terms, stress-testing with concrete scenarios, cross-referencing code, and updating CONTEXT.md + ADRs inline as decisions crystallise. ACT 2 (Claude ↔ Codex) — Claude writes the locked plan to PLAN.md and OpenAI Codex adversarially reviews it in a read-only sandbox (VERDICT:APPROVED/REVISE), Claude revises and re-submits to the SAME Codex session until APPROVED or a MAX_ROUNDS cap, then you sign off before any code. Use when the user says "/grill-with-docs-codex", "grill me against the docs then have codex review", "stress-test this against our domain model then get a second model on it", or is about to build something high-stakes in a project with established terminology/ADRs and wants alignment, documentation, AND a cross-model sanity check. Builds on Matt Pocock's grill-with-docs (MIT). NOT for reviewing already-written code (use /codex:review) and NOT for trivial changes.
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Use when the user asks to "design an A/B test", "set up a creative/landing test", "run an incrementality test", or "is this result statistically and practically material?"; produces a hypothesis, variant matrix, sample-size/duration/power plan, and a documented effect/uncertainty read from own exported results. It applies only a precommitted owner-approved action rule; the statistical helper never chooses a business action. Not for producing variants — use ad-creative-builder; not for reading back one shipped change — use paid-measurement-loop. 广告AB测试设计/实验设计/显著性判定/增效测试
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Use when the user asks to "write the email", "draft subject lines", or "build email creative"; produces the pre-click unit — subject-line variants + preheader, body copy, one clear CTA, and a plain-text alt — message-matched to the destination page and claims-ledger-aware. Not for pre-scoring or ranking subject-line variants (spam/truncation/render pre-score) — use subject-line-lab; not for scoring the email or computing EQS — use email-quality-auditor; not for the multi-step flow — use email-sequence-designer; not for the A/B test plan — use send-experiment-designer. 邮件文案/主题行/邮件创意
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Use when the user asks to "design an email A/B test", "set up a multivariate subject/CTA test", "run a send-time test", "build a hold-out group", or "is this email result statistically and practically material?"; produces a falsifiable hypothesis, one-variable-per-cell matrix, sample-size/MDE/duration/power plan, and an effect/uncertainty read from own ESP data. Applies only a precommitted owner-approved action rule; the helper never chooses a business action. Not for EQS/vetoes or writing the email. 邮件AB测试设计/多变量测试/发送时间测试/留出组/显著性判定
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Retrieves authoritative guidance on Amazon Timestream for InfluxDB across its supported engine variants. Applicable to any InfluxDB-on-AWS request including engine variant and licensing selection, provisioning and IAM, encryption at rest (AWS-owned and customer-managed KMS keys, key policies, and key lifecycle), schema design (tags vs fields, cardinality, HTTP/sensor/metric data modeling), migration from LiveAnalytics, Processing Engine plugins, connectivity (database endpoints and private or public access), and write/query errors.
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Choose among direct service integration, Adobe App Builder, and a dedicated queued worker using evidence about ownership, latency, scale, storage, events, and operations. Use when the task requires adobe architecture variant decision. Trigger with "choose Adobe architecture", "App Builder or microservice", or "Adobe design options".
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Notaire IA pour le droit immobilier, les successions, les donations, le droit de la famille et le droit des sociétés en France. Copilote juridique pour la préparation d'actes, le conseil patrimonial, les calculs de frais et la vérification de conformité. Couvre le calcul des frais de notaire (DMTO, émoluments, débours, CSI), la plus-value immobilière, les droits de succession et donation, le démembrement, les contrats de mariage, les PACS, les SCI, et la rédaction de projets d'actes (compromis, statuts, testaments). Triggers: notaire, frais de notaire, acte de vente, compromis, succession, donation, héritage, testament, PACS, contrat de mariage, SCI, plus-value immobilière, droits de mutation, DMTO, usufruit, nue-propriété, partage successoral, réserve héréditaire, viager, donation-partage, diagnostics immobilier, droit de préemption, acte notarié, droit immobilier
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Turn one pool of existing project media into a batch of distinct, publishable montage cuts instead of a single hero edit. Use for batch montage, one-source-many-outputs, 一源多出, 批量混剪, 批量出片, 矩阵号, 多账号分发, variant batches, deduped cuts, 去重变体, 防搬运, or when the user asks for N different versions of the same footage.
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Adversarial dual-model code review that runs two AI models in parallel, cross-references findings, and produces a consensus severity table with fix confidence ratings. Use when asked for a thorough code review, adversarial review, dual-model review, confidence-rated review, or 'Hanselman review'.
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Runs the period-end close and produces reporting — close calendar, reconciliations, accruals, variance analysis, and reporting that gets read. Use this to shorten or stabilize a monthly close, design a close checklist, investigate a variance, structure management reporting, or work out why the numbers keep changing after close.
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