「binding」の検索結果

Align preprocessed CLIP-seq reads (eCLIP, iCLIP, iCLIP2, PAR-CLIP) to genome with STAR or bowtie2 using crosslink-preserving parameters, choosing between unique-mapper-only and multi-mapper-aware alignment for repeat-binding RBPs, deciding STAR vs HISAT2 memory trade-offs, and applying ENCODE-compatible filters. Use when turning preprocessed CLIP FASTQ into a deduplicated, MAPQ-filtered BAM ready for peak calling or crosslink-site detection.

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ChIP-seq peak calling and downstream interpretation with MACS3, signal track export, annotation, motif analysis, and differential binding review.

日本語の概要は準備中です。原文の説明を表示しています。

Protein design quality control, filtering thresholds, and ranking guidance. Use this skill when: (1) Evaluating design quality for binding, expression, or structure, (2) Setting filtering thresholds for pLDDT, ipTM, PAE, (3) Checking sequence liabilities (cysteines, deamidation, polybasic clusters), (4) Creating multi-stage filtering pipelines, (5) Computing PyRosetta interface metrics (dG, SC, dSASA), (6) Checking biophysical properties (instability, GRAVY, pI), (7) Ranking designs with composite scoring. This skill provides research-backed thresholds from binder design competitions and published benchmarks.

日本語の概要は準備中です。原文の説明を表示しています。

All-atom protein design using BoltzGen diffusion model. Use this skill when: (1) Need side-chain aware design from the start, (2) Designing around small molecules or ligands, (3) Want all-atom diffusion (not just backbone), (4) Require precise binding geometries, (5) Using YAML-based configuration. For backbone-only generation, use rfdiffusion. For sequence-only design, use proteinmpnn. For structure validation, use boltz.

日本語の概要は準備中です。原文の説明を表示しています。

Quality control metrics and filtering thresholds for protein design. Use this skill when: (1) Evaluating design quality for binding, expression, or structure, (2) Setting filtering thresholds for pLDDT, ipTM, PAE, (3) Checking sequence liabilities (cysteines, deamidation, polybasic clusters), (4) Creating multi-stage filtering pipelines, (5) Computing PyRosetta interface metrics (dG, SC, dSASA), (6) Checking biophysical properties (instability, GRAVY, pI), (7) Ranking designs with composite scoring. This skill provides research-backed thresholds from binder design competitions and published benchmarks.

日本語の概要は準備中です。原文の説明を表示しています。

Build serverless applications with Azure Functions. Create HTTP and event-driven functions with input/output bindings, configure triggers for queues, timers, and blob storage. Use Durable Functions for stateful orchestration workflows.

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Symbol-level navigation of a local checkout using tree-sitter ASTs. Answers where a symbol is defined, what lines it spans, which symbols a file exposes, what a directory holds, and where a name is referenced — every answer carries exact line ranges to feed straight into a scoped read. Use for "where is X defined", "who calls X", "find the function/class named", "what's in this file", "give me the line range for", "show me the source of", "list the symbols in", or before editing a file you have not read. Each invocation auto-scans and is self-contained. Not for first-encounter repo orientation (use exploring-codebases), for what a codebase DOES rather than what it contains (featuring), for binding-resolved Python caller sets (searching-codebases), or for literal text and regex matching (plain ripgrep).

日本語の概要は準備中です。原文の説明を表示しています。

Binding-resolved Python symbol queries via pyright — every true caller (--refs), the real definition (--def), or an inferred signature (--hover) of a .py symbol, excluding the same-named false positives text search cannot tell apart. Use when a task needs ALL callers or users of a named Python symbol and grep would over-match. Python only, and only for the caller/definition question: measured 2026-07-04 on real issue-localization tasks, plain ripgrep tied or beat the semantic and indexed-regex tiers at 4-60x less wall-clock, so those tiers survive below without being a default.

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Semantic Python code queries via a stdio LSP client driving pyright-langserver. Provides binding-resolved go-to-definition, find-references, hover types, type diagnostics, file symbol outlines, and project-wide symbol search — name resolution and type inference that tree-sitter and ripgrep cannot do. Use when you need to follow an import to a definition, find all real uses of a symbol (excluding same-named-but-unrelated ones), get an inferred type, surface type errors, outline a file, or search symbols across a project. Triggers on "go to definition", "find references", "what type is", "resolve this symbol", "symbol outline", "find symbol in project", "pyright", "type-check this file".

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The spec-to-plan bridge. /feature supplies an approved spec; initial full-lane HTML sprint review may supply a ready draft only through draft_for_pair. Creates the same-format plan with exact paths, tests, dependencies and complete criterion coverage. The initial paired review has no execution authority until one real user reply approves both artifacts. Ordinary sequential planning retains approved-source binding and plan approval.

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Use a headed browser to automatically complete DingTalk channel integration for QwenPaw. Applicable when the user mentions DingTalk, developer console, Client ID, Client Secret, bot, Stream mode, binding or configuring a channel. Supports pausing when a login page is detected and resuming after the user logs in.

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Use when reviewing Go changes - net/http and Fiber handlers, database/sql and GORM queries, os/exec, filepath and os.Root, html/template, crypto, TLS and SSH clients, JSON binding

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Use when reviewing Java or Kotlin server changes on Spring or Quarkus - security config and method security, JPA/JPQL and JdbcTemplate queries, request binding, deserialization, XML parsers, SpEL, templates, Actuator, JNDI and reflection

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Use when the diff adds or changes an endpoint, resolver, RPC, job or query that takes an object id, a role check, a request binding or a tenant filter - BOLA/IDOR, function-level authorization, mass assignment and tenant scoping

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Use when adding controls, menus, HUD, subtitles or effects - input through named actions with rebinding and controller support per engine, input buffering, and the accessibility floor (remapping, colour-blind safe cues, subtitles, text scale, reduced motion and flashes).

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Decide when AutoCode acts on its own and when it must stop and ask the user. Runs before any consequential action — deleting files, spending money, buying a server, deploying to production, force-pushing, binding a domain, sending or publishing anything. Ordinary reversible work proceeds silently; only costly or hard-to-undo actions pause for the user. Powered by I-Lang v5.0 vector judgment.

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Guides Cloudflare Wrangler CLI usage for Workers, bindings, deploys, local dev, and config. Use when running or reviewing wrangler commands.

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Expert skill for building CLI applications with Cobra and Viper, authored by spf13 — the original creator of both libraries. Covers command-first architecture, decoupled business logic, configuration management, environment variable binding, context-aware commands, and in-memory CLI testing. Use whenever a Go CLI or command-line tool is being built, reviewed, or refactored — any mention of commands, subcommands, flags, or CLI configuration, even if Cobra or Viper aren't named yet (recommend them).

日本語の概要は準備中です。原文の説明を表示しています。

Read a repository's tasks and binding constraints, claim work, and finish it with proof. Use when working in a repo that has a .ank/ directory.

日本語の概要は準備中です。原文の説明を表示しています。

Reviews SwiftUI code for view composition, state management, performance, and accessibility. Use when reviewing .swift files containing SwiftUI views, property wrappers (@State, @Binding, @Observable), or UI code.

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Author the narrowest R8/ProGuard keep rule for a JNI binding, serializable nav route, or proto-lite class. Use when adding one of those or triaging missing_rules.txt after a release build.

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Build applications with Univer Office SDK, covering the Web SDK (embedded Sheets, Docs, Slides, Boards, Bases and PDFs editors), Server SDK (self-hosted OT collaboration, storage, auth, Office import/export), AI SDK (agent-operated Office CLIs, reviewable Worktrees), and Binding SDK (plain HTML pages bound to live Sheet data). Use when starting or designing any Univer-based app or choosing Univer packages, including when the user describes a spreadsheet, document, collaboration, or AI-office need without naming a Univer package.

日本語の概要は準備中です。原文の説明を表示しています。

Execute Guidewire primary workflow: Policy lifecycle management in PolicyCenter. Use when implementing quoting, binding, issuing, endorsing, or renewing policies. Trigger with phrases like "policycenter workflow", "create policy", "bind submission", "issue policy", "policy endorsement", "quote insurance".

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Design or audit Kubernetes RBAC — roles, bindings, service accounts, and least-privilege model. Use when asked to "audit Kubernetes RBAC", "apply least privilege in K8s", or "review service account permissions".

日本語の概要は準備中です。原文の説明を表示しています。