「calc」の検索結果

Read and write Cal.com: list bookings and event types, create bookings. Trigger phrases: cal.com, my bookings, schedule a call.

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Calculates statistical power for high-dimensional genomics experiments (bulk RNA-seq, scRNA-seq, ATAC-seq, ChIP-seq, methylation, proteomics) under negative-binomial count models using RNASeqPower, PROPER, and simulation via powsimR, distinguishing per-gene from marginal (transcriptome-wide) power, the role of mean expression and dispersion, and the sequencing-depth-versus-replicate tradeoff. Covers simulation as the honest default for overdispersed counts, FDR-aware average power versus single-test power, observed/post-hoc power as an anti-pattern, and the winner's-curse / Type-S / Type-M consequences of underpowering. Use when planning replicate number for a sequencing experiment, deciding whether to add depth or samples, choosing closed-form versus simulation power, estimating power from pilot dispersions, or justifying replication in a grant. For clinical-trial power see clinical-biostatistics/power-and-sample-size; for the inverse sample-size question see experimental-design/sample-size.

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Estimates the minimum biological replicates (or cells/events) for a target power at a target FDR in genomics experiments using ssizeRNA, PROPER, powsimR for scRNA-seq, and pilot-data dispersion estimation from DESeq2/edgeR. Covers the biological-versus-technical replication distinction (technical replicates do not add degrees of freedom for biological inference), replicate-number-versus-sequencing-depth budgeting, scRNA-seq sample-versus-cell allocation under a pseudobulk model, and the critique that "n=3" is a publication convention rather than a power calculation. Use when budgeting a sequencing experiment, writing the sample-size justification in a grant, estimating replicates from pilot data, allocating a fixed budget between samples and depth, or planning scRNA-seq cohort size. For clinical-trial sample size see clinical-biostatistics/power-and-sample-size; for the power-given-n direction see experimental-design/power-analysis.

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Constructs and validates polygenic risk scores using LDpred2-auto, SBayesRC, MegaPRS, PRS-CS, PROSPER, MUSSEL, BridgePRS, JointPRS, PRSmix, or PGS Catalog Calculator with ancestry-aware reference panels (HapMap3, UKB-LD), ancestry-conditional calibration, and PRS-RS reporting standards. Use when computing PRS for cohorts, applying absolute-risk transformation, assessing cross-ancestry portability (Martin 2017 / Ding 2023 continuous ancestry), or auditing PRS manuscripts against the 22-item PRS-RS reviewer checklist.

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Calculates tumor mutational burden from WES/WGS/panel data with Friends of Cancer Research harmonization equations, per-assay calibration (FDA 10/Mb = 7.8 TSO500 = 8.4 OncomineTML), synonymous/indel/germline filtering, hypermutator tiering, blood TMB, and integration with HLA-LOH and neoantigen quality (Luksza 2017 fitness). Use when assessing ICI eligibility under tumor-specific cutoffs (McGrail 2021), comparing tissue vs bTMB, or auditing TMB-H reporting against ESMO 2024 and FDA pembrolizumab pan-tumor 2020.

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Calculates molecular fingerprints (ECFP/Morgan, FCFP, MACCS, RDKit, AtomPair, TopologicalTorsion, Avalon, MAP4, MHFP6) and physicochemical descriptors (Lipinski, QED, TPSA, Crippen LogP, 3D shape) with explicit choice tables, bit vs count semantics, and partial-charge model selection. Use when featurizing molecules for similarity, QSAR, virtual screening, or ML, or selecting the correct fingerprint for a chemotype-aware task.

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Reads, writes, and converts molecular file formats (SMILES, InChI, SDF V2000/V3000, MOL2, PDB, and BinaryCIF) using RDKit and Open Babel with rigorous handling of aromaticity perception, stereochemistry, implicit/explicit hydrogens, kekulization, and salt/fragment separation. Use when loading chemical libraries, debugging parse failures, or preparing molecules for downstream standardization, descriptor calculation, or docking.

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Calculate alignment statistics including sequence identity, conservation scores, substitution matrices, and similarity metrics. Use when comparing alignment quality, measuring sequence divergence, and analyzing evolutionary patterns.

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Generate alignment statistics using samtools flagstat, stats, depth, coverage, and mosdepth. Use when assessing alignment quality, calculating coverage, or generating QC reports.

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Generate pileup data for variant calling using samtools mpileup and pysam. Use when preparing data for variant calling, analyzing per-position read data, or calculating allele frequencies.

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Implement, review, or improve maps and location features in iOS/macOS apps using MapKit and CoreLocation. Use when working with Map views, annotations, markers, polylines, user location tracking, geocoding, reverse geocoding, search/autocomplete, directions and routes, geofencing, region monitoring, CLLocationUpdate async streams, or location authorization flows. Also use when working with maps, coordinates, addresses, places, directions, distance calculations, or location-based features in Swift apps.

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Use when tasks involve creating, editing, analyzing, or formatting spreadsheets (`.xlsx`, `.csv`, `.tsv`) with formula-aware workflows, cached recalculation, and visual review.

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Design a controlled dynamic-pricing or repricing system for ecommerce products. Use when a seller asks for demand-based, inventory-based, competitor-responsive, or time-based price rules; SKU eligibility; price floors and ceilings; automation approvals; simulations; monitoring; or rollback plans across Amazon, Shopify, TikTok Shop, Walmart, eBay, or other channels. Do not use for a one-time optimal-price calculation or to change live prices without explicit authorization.

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Cross-platform PPC strategy planner for ecommerce businesses. Analyzes your product and margins, recommends the right advertising platforms (Google Ads, Meta Ads, TikTok Ads), calculates ROAS targets, allocates budget across channels, and generates platform-specific campaign briefs with ad copy and creative direction. Two modes: (A) Build — design a multi-platform ad strategy from scratch, (B) Optimize — audit existing cross-platform campaigns and reallocate budget. Works for Shopify, WooCommerce, standalone stores, and marketplace sellers expanding to external traffic. No API key required.

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Etsy pricing — cost calculation, competitor pricing, perceived value, shipping cost integration, sales and coupons

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Analyze financial data, calculate financial ratios, and generate analysis reports. Use when the user asks about revenue, costs, profits, margins, ROI, financial metrics, or needs financial analysis of a company or project.

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Calculate a productivity score using actual Agent Monitor metrics — session completion rates, cache efficiency (cache_read vs input), compaction pressure (baseline tokens), turn velocity (turn_count / total_turn_duration_ms), tool success ratio (PreToolUse vs PostToolUse), and the workflow intelligence API's complexity and effectiveness scores.

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Organize a Power BI or Analysis Services semantic model end to end so it is ready for report authors, Excel users and Copilot - table groups, display folders, Title Case business names and naming conventions, hierarchies, sort-by columns, hiding, Analyze in Excel (IsAvailableInMDX), descriptions, format strings, data categories, context annotations, DAX formatting and UDFs, calculated-object justification, duplicate removal, perspectives, translations and security roles. Use whenever the user asks to "organize", "tidy", "clean up", "polish", "prepare", "standardize" or "make report-ready" a model or one table in it (for example "organize the date table"), to "fix naming conventions", "rename fields", "make names human readable" or "fix abbreviations", even when they name only one of these aspects, and whenever a model is driven through the Tabular Editor 3 MCP or the te CLI for that purpose. Not for DAX performance tuning (dax skill) or model design and star-schema changes (semantic-model skill).

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This skill should be used whenever the user mentions a "semantic model", "data model", or "dataset", or asks to "build", "model", "design", "optimize", "review", or "audit" one, or to "add a measure", "add a relationship", "create a role" / "set up RLS", "add a calculation group", "set up incremental refresh", "fix a star schema", "reduce model size", "prepare a model for Copilot / AI", or "check model quality". Covers the full lifecycle (design, build, refresh, review) and drives every operation through the `te` CLI first, then TOM (connect-pbid) or a model MCP, then TMDL authoring (the tmdl skill). Not for report visuals (use pbir-cli) or isolated DAX query tuning (use the dax skill).

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Direct TMDL file authoring and BIM-to-TMDL conversion for semantic models in PBIP projects. Automatically invoke when the user asks to "edit TMDL", "add a measure in TMDL", "TMDL syntax", "fix formatString", "fix summarizeBy", "TMDL indentation", "convert BIM to TMDL", "add a column description", "create a calculated column in TMDL", or mentions .tmdl file editing or BIM-to-TMDL migration.

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Writing and executing C# scripts and macros against Power BI semantic models using Tabular Editor 2/3. Automatically invoke when the user mentions "C# script", "Tabular Editor script", "TOM scripting", "MacroActions.json", "XMLA", or asks to "automate model changes", "bulk update measures", "create calculation groups", "write a macro", "format DAX expressions", "manage model metadata".

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Comprehensive spreadsheet creation, editing, and analysis with support for formulas, formatting, data analysis, and visualization. When Claude needs to work with spreadsheets (.xlsx, .xlsm, .csv, .tsv, etc) for: (1) Creating new spreadsheets with formulas and formatting, (2) Reading or analyzing data, (3) Modify existing spreadsheets while preserving formulas, (4) Data analysis and visualization in spreadsheets, or (5) Recalculating formulas

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Comprehensive global knowledge worker salary data with total market value calculations, sector breakdowns, geographic comparisons, and authoritative sources. USE WHEN discussing knowledge worker compensation, salary benchmarking, economic analysis of professional labor markets, or AI impact on wages.

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Integrates Amazon Location Service APIs for AWS applications. Use this skill when users want to add maps (interactive MapLibre or static images); geocode addresses to coordinates or reverse geocode coordinates to addresses; calculate routes, travel times, or service areas; find places and businesses through text search, nearby search, or autocomplete suggestions; retrieve detailed place information including hours, contacts, and addresses; monitor geographical boundaries with geofences; or track device locations. Covers authentication, SDK integration, and all Amazon Location Service capabilities.

日本語の概要は準備中です。原文の説明を表示しています。