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概要と使いどころ
Detect and correct for horizontal pleiotropy in Mendelian randomization analyses using MR-PRESSO for outlier removal, MR-Egger regression for directional pleiotropy, and Steiger filtering for variant directionality. Use when validating MR results, detecting pleiotropic instrum...
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Decompose genetic effects into direct and indirect paths through mediating variables using the mediation R package. Tests whether gene expression, methylation, or other molecular phenotypes mediate the effect of genetic variants on disease. Use when testing whether a molecular...
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Matches a user’s biomedical research direction, disease problem, study aim, data modality, and resource constraints to the most relevant recent algorithms and method papers. Always search real recent algorithm literature first, prioritize the last 12 months, expand to 1–3 years only when needed, and add canonical baselines only when necessary. Every formal algorithm recommendation must include the verified primary method paper, plus published downstream papers that actually cite/use the algorithm when such papers are found, with DOI when available. Never fabricate papers, algorithm names, authors, journals, years, DOI, PMID, links, or benchmark claims. If no directly verified algorithm paper is found, say so explicitly.
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Converts a biomedical study storyline into a graphical abstract and, when direct image capability is available, generates the graphical abstract directly; otherwise it falls back to prompts, Mermaid flowcharts, or designer-facing briefs.
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Reference for multi-hop / triangulated currency conversion on batch rate tapes. When a rate row carries an explicit "via" currency, the row's rate is only one leg of the conversion, and the via currency may ITSELF be quoted through another via — so the effective rate is the product of every leg, resolved by walking the chain until a direct quote is reached. Useful when an FX feed lists some pairs directly to the reporting currency and others as triangulated (or doubly-triangulated) quotes through vehicle currencies.
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Expert C4 Code-level documentation specialist. Analyzes code directories to create comprehensive C4 code-level documentation including function signatures, arguments, dependencies, and code structure. Use when documenting code at the lowest C4 level for individual directories and code modules.
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Japanese (and other non-Hollywood) screenwriting methods (日本编剧方法/原创剧本实战) — distilled from ten Japanese directors and writers in ゼロからの脚本術; Kosawa Ryota (three acts as 起承转合, speed by jumping), Uchida Kenji (beautiful structure, time-axis tricks), Miki Satoshi (small-material notebook, theme emerges later), Sono Sion, Omiya Ellie (dialogue from inner monologue), Kakei Masaya ("if + moreover"), Fukuda Yuichi (character = actor + flaw, audience as tsukkomi), Yokohama Satoko, Takahashi Izumi ("pain"), Yukisada Isao (situation-born originals); plus Arai Haruhiko (IP adaptation, "write what you're ashamed of"). Neighbours; sw-korean-french-screenwriting, ozu-screenplay-style. Use when writing an original Japanese-style script or TV drama, working from small material and fragments, choosing between structure-first and character-first methods, building a Japanese 企画書, designing comedy tsukkomi systems, or when Hollywood models feel wrong for a quiet, daily-life, non-goal-driven story.
Motion-first AI video director for topic-to-video creation. Use when the user gives a theme, idea, article, script, or brief and wants AI to freely create a real animated video instead of a PPT/slideshow-style explainer; when deciding visual metaphors, motion grammar, scene beats, component choices, generated image needs, HyperFrames/Remotion implementation strategy, and anti-PPT QC.
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Propose or directly apply edits to Arkon wiki pages, including proposing brand new pages. Contributors create drafts for review; editors/admins can edit/create directly. Triggers on: update wiki, fix this page, propose edit, edit wiki page, correct the KB, improve wiki, resubmit my draft, withdraw my draft, create new wiki page, propose new page.
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Migrates Claude Code personal memory (the per-project memory/ directory) into tool-agnostic reference docs so other AI CLIs that auto-load AGENTS.md (Codex primarily) can read the same user profile and preferences. Use when the user says "migrate my memory", "my memory is locked to Claude Code", "make Codex/Cursor read my profile", or reports memory has grown bloated with content that should be shared across tools. Also use it to retire a project's auto memory entirely (turn it off, move everything into documents, archive the directory).
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Search DigiKey for electronic components and download datasheets — primary source for prototype orders and the preferred API method for fetching datasheets. Find parts by keyword or MPN, check pricing/stock, download datasheets via API, analyze specifications. Sync and maintain a local datasheets directory — extract components from schematics, download missing datasheets, keep them up to date. Also supports batch MPN-list seeding (`--mpn-list`) for bulk workflows without a KiCad project. Use when the user asks about electronic components, part specs, datasheets, pricing, stock, footprints, or needs to download a datasheet — even without mentioning "DigiKey". Also for "sync datasheets", "download datasheets for my board/project", or mentions a datasheets directory. DigiKey is the default distributor for prototyping. For BOM workflows, see the bom skill.
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Search Newark, Farnell, and element14 for electronic components — find parts by MPN or distributor part number, check pricing/stock, download datasheets, analyze specifications. One unified API covers all three storefronts (Newark for US, Farnell for UK/EU, element14 for APAC). Free API key, simple query-parameter auth, no OAuth. Datasheets download directly from farnell.com CDN with no bot protection. Sync and maintain a local datasheets directory for a KiCad project, or use batch MPN-list seeding (`--mpn-list`) for bulk workflows without a project. Use this skill when the user mentions Newark, Farnell, element14, needs parts from a non-US distributor, wants to compare pricing across regions, or needs datasheets from a source that doesn't require complex API auth. For package cross-reference tables and BOM workflow, see the `bom` skill.
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Create visual concepts, image-generation prompts, and optional AI-generated images for product hero images, marketing creatives, social posts, ads, ecommerce PDP visuals, and general visual design tasks. Use when the user asks for visual strategy, image prompt writing, product/marketing image direction, or direct text-to-image generation. In Codex environments use the built-in imagegen tool; elsewhere use the bundled script backed by the apiz CLI.
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Используй только внутри активного Codex Project Autopilot-проекта, когда уже выбрана проектная фаза и нужен design direction по плану автопилота.
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Search Newark, Farnell, and element14 for electronic components — find parts by MPN or distributor part number, check pricing/stock, download datasheets, analyze specifications. One unified API covers all three storefronts (Newark for US, Farnell for UK/EU, element14 for APAC). Free API key, simple query-parameter auth, no OAuth. Datasheets download directly from farnell.com CDN with no bot protection. Sync and maintain a local datasheets directory for a KiCad project, or use batch MPN-list seeding (`--mpn-list`) for bulk workflows without a project. Use this skill when the user mentions Newark, Farnell, element14, needs parts from a non-US distributor, wants to compare pricing across regions, or needs datasheets from a source that doesn't require complex API auth. For package cross-reference tables and BOM workflow, see the `bom` skill.
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Safely validate, publish, and track a local SKILL.md directory across GitHub, Awesome Codex Plugins, HOL Registry, skills.sh, SkillsMP, LobeHub, ClawHub, and Cursor Directory. Use when the user asks to publish, update, register, or synchronize an agent skill across marketplaces.
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Search DigiKey for electronic components and download datasheets — primary source for prototype orders and the preferred API method for fetching datasheets. Find parts by keyword or MPN, check pricing/stock, download datasheets via API, analyze specifications. Sync and maintain a local datasheets directory — extract components from schematics, download missing datasheets, keep them up to date. Also supports batch MPN-list seeding (`--mpn-list`) for bulk workflows without a KiCad project. Use when the user asks about electronic components, part specs, datasheets, pricing, stock, footprints, or needs to download a datasheet — even without mentioning "DigiKey". Also for "sync datasheets", "download datasheets for my board/project", or mentions a datasheets directory. DigiKey is the default distributor for prototyping. For BOM workflows, see the bom skill.
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Manages Power BI semantic models, including tables, columns, measures, relationships, field parameters, DAX, Import, DirectQuery and Direct Lake designs, sources, connections, permissions, refresh, and deployment. Load this skill before acting on a semantic model, unless it is part of publishing a PBIP project, which powerbi-report-cli owns. For natural-language data questions use fabriciq; for visuals use powerbi-report-cli.
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Orchestrate Project Osmos for long-running Fabric and OneLake data-engineering outcomes, including task status, messages, follow-ups, cancellation, and deletion. Osmos tasks are remote service tasks, not local background agents. In Fabric portal Copilot, direct interaction is unsupported; point users to GitHub Copilot CLI. Use spark-cli for direct non-Osmos Spark work. Triggers: "Project Osmos", "Project Osmos task status", "check my Osmos task".
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Three modes for CS-conference papers (CVPR/ICCV/ECCV vision, ACL/EMNLP/NAACL NLP, ICLR/NeurIPS/ICML/AAAI ML). DIRECT-EDIT mode (common): the user describes a change in Chinese or English and the manuscript (LaTeX or Markdown) is edited directly through a CS-venue writing toolkit with author sign-off (use for 改这段 / 把中文想法写成 latex / polish / de-AI / translate / compress a passage). REVIEW mode (occasional, pre-submission): harden the paper through an adversarial courtroom review engine (N holistic domain reviewers / contestability routing / two-sided trial / three-way verdict / clerk-converged multi-round loop) with consensus-gated, author-signed revisions (use for review / critique / 审稿 / 评审 / mock-review). AUTO mode (unattended, opt-in via /goal): run the review-revise loop toward a verifiable goal, applying safe fixes under a drift-bounded policy and queueing risky ones. Resolves all inputs at runtime, no hardcoded paths. Not a from-scratch drafter (use ml-paper-writing) and not an official-venue rebuttal.
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Query protein-protein and gene interaction databases (STRING, BioGRID, IntAct, SIGNOR, Reactome, HuRI, HuMAP, OmniPath, ConsensusPathDB, DIP). Use when building PPI networks, choosing between physical vs functional vs genetic interactions, signed/directed vs undirected, high-throughput vs curated, picking confidence thresholds, aggregating across resources, or navigating license constraints. Encodes the database decision matrix, STRING v12 channel semantics, OmniPath as meta-database, SIGNOR for signed signaling, and per-resource rate limits.
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Analyzes single-cell pooled CRISPR screens (Perturb-seq, CROP-seq, Perturb-CITE-seq, ECCITE-seq, multiome) where each cell carries an sgRNA and a scRNA-seq / surface-protein / chromatin readout. Covers experimental design (direct-capture Perturb-seq Dixit 2016 vs CROP-seq 3'UTR-barcoded Datlinger 2017 vs ECCITE-seq vs Multiome), MOI for sgRNA assignment, escaper-cell filtering (Mixscape, Papalexi 2021), SCEPTRE NB GLM + permutation for low-MOI (Barry 2024 Genome Biol 25:124), the Pertpy framework, factor decomposition, genome-scale Perturb-seq (Replogle 2022 Cell, 2.5M cells), and per-perturbation single-cell DE. Use when running a single-cell CRISPR screen, choosing direct-capture vs CROP-seq architecture, filtering escaper cells, performing single-cell DE, integrating Perturb-seq with pathway analysis, scaling to GW CRISPRi via Replogle protocol, or analyzing multi-omics screens.
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Analyzes CRISPR drug-modifier (chemogenomic) screens with drugZ (Colic et al. 2019 Genome Med), a bidirectional Z-score method that identifies synthetic-lethal sensitizing genes and resistance-conferring suppressor genes from vehicle vs drug comparisons. Covers vehicle-anchored design (not Day-0), the bidirectional Z math giving greater sensitivity to small-effect hits than MAGeCK / STARS / edgeR / RIGER on drug screens, per-gene sumZ and normZ, synth (sensitizer) vs supp (suppressor) FDR, multi-dose handling, integration with control sgRNAs, and comparison with MAGeCK MLE with dose covariate. Use when running a drug-modifier CRISPR screen, identifying sensitizing or resistance genes for a drug candidate, choosing drugZ vs MAGeCK MLE for chemogenomic analysis, troubleshooting low-effect drug screens where MAGeCK lacks sensitivity, or designing a drug-screen layout (vehicle vs drug arms).
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Decompose total effects into direct and indirect paths through mediators using mediation, CMAverse 4-way, HIMA/HIMA2 high-dimensional, BAMA, two-step / MVMR mediation, or double-ML medDML. Use when testing whether a molecular phenotype (expression, methylation, protein) mediates a treatment-outcome relationship, decomposing exposure-mediator interaction via VanderWeele 4-way, screening high-dimensional EWAS mediators, or running MR-based mediation when sequential ignorability is implausible.
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