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概要と使いどころ
Call copy number variants using GATK best practices workflow. Supports both somatic (tumor-normal) and germline CNV detection from WGS or WES data. Use when following GATK best practices or integrating CNV calling with other GATK variant pipelines.
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ChIP-seq peak calling using MACS3 (or MACS2). Call narrow peaks for transcription factors or broad peaks for histone modifications. Supports input control, fragment size modeling, and various output formats including narrowPeak and broadPeak BED files. Use when calling peaks from ChIP-seq alignments.
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Infer gene regulatory networks (GRNs) from gene expression data using scalable algorithms (GRNBoost2, GENIE3). Use when analyzing transcriptomics data (bulk RNA-seq, single-cell RNA-seq) to identify transcription factor-target gene relationships and regulatory interactions. Supports distributed computation for large-scale datasets.
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Read, write, and convert multiple sequence alignment files using Biopython Bio.AlignIO. Supports Clustal, PHYLIP, Stockholm, FASTA, Nexus, and other alignment formats for phylogenetics and conservation analysis. Use when reading, writing, or converting alignment file formats.
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Screen US stocks for high-quality dividend opportunities combining value characteristics (P/E ratio under 20, P/B ratio under 2), attractive yields (3% or higher), and consistent growth (dividend/revenue/EPS trending up over 3 years). Supports two-stage screening using FINVIZ Elite API for efficient pre-filtering followed by FMP API for detailed analysis. Use when user requests dividend stock screening, income portfolio ideas, or quality value stocks with strong fundamentals.
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Analyzes market breadth using Monty's Uptrend Ratio Dashboard data to diagnose the current market environment. Generates a 0-100 composite score from 5 components (breadth, sector participation, rotation, momentum, historical context). Use when asking about market breadth, uptrend ratios, or whether the market environment supports equity exposure. No API key required.
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Evaluates market bubble risk through quantitative data-driven analysis using the revised Minsky/Kindleberger framework v2.1. Prioritizes objective metrics (Put/Call, VIX, margin debt, breadth, IPO data) over subjective impressions. Features strict qualitative adjustment criteria with confirmation bias prevention. Supports practical investment decisions with mandatory data collection and mechanical scoring. Use when user asks about bubble risk, valuation concerns, or profit-taking timing.
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Statistical arbitrage tool for identifying and analyzing pair trading opportunities. Detects cointegrated stock pairs within sectors, analyzes spread behavior, calculates z-scores, and provides entry/exit recommendations for market-neutral strategies. Use when user requests pair trading opportunities, statistical arbitrage screening, mean-reversion strategies, or market-neutral portfolio construction. Supports correlation analysis, cointegration testing, and spread backtesting.
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Calculate risk-based position sizes for long stock trades. Use when user asks about position sizing, how many shares to buy, risk per trade, Kelly criterion, ATR-based sizing, fractional-share sizing, or portfolio risk allocation. Supports stop-loss distance calculation, volatility scaling, and sector concentration checks.
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Screen post-earnings gap-up stocks for PEAD (Post-Earnings Announcement Drift) patterns. Analyzes weekly candle formation to detect red candle pullbacks and breakout signals. Supports two input modes - FMP earnings calendar (Mode A) or earnings-trade-analyzer JSON output (Mode B). Use when user asks about PEAD screening, post-earnings drift, earnings gap follow-through, red candle breakout patterns, or weekly earnings momentum setups.
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This skill retrieves upcoming earnings announcements for US stocks using the Financial Modeling Prep (FMP) API. Use this when the user requests earnings calendar data, wants to know which companies are reporting earnings in the upcoming week, or needs a weekly earnings review. The skill focuses on mid-cap and above companies (over $2B market cap) that have significant market impact, organizing the data by date and timing in a clean markdown table format. Supports multiple environments (CLI, Desktop, Web) with flexible API key management.
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Validate data quality in market analysis documents and blog articles before publication. Use when checking for price scale inconsistencies (ETF vs futures), instrument notation errors, date/day-of-week mismatches, allocation total errors, and unit mismatches. Supports English and Japanese content. Advisory mode -- flags issues as warnings for human review, not as blockers.
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Configures and runs agents with different adapters including Claude, OpenAI, CrewAI, Lyzr, and GitHub Models. Supports local execution, remote git repos, and one-shot prompts. Use when the user wants to run an agent, switch LLM providers, configure adapter settings, or launch agents from git repositories.
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Build and deploy full-stack web and mobile apps with AWS Amplify Gen2 (TypeScript code-first). Covers auth (Cognito), data (AppSync/DynamoDB), storage (S3), functions, APIs, and AI (Amplify AI Kit with Bedrock). Supports React, Next.js, Vue, Angular, React Native, Flutter, Swift, and Android. Always use this skill for Amplify Gen2 topics — even for questions you think you know — it contains validated, version-specific patterns that prevent common mistakes. TRIGGER when: user mentions Amplify Gen2; project has amplify/ directory or amplify_outputs; code imports @aws-amplify packages; user asks about defineBackend, defineAuth, defineData, defineStorage, defineFunction, or npx ampx. SKIP: Amplify Gen1 (amplify CLI v6), standalone SAM/CDK without Amplify (use aws-serverless), direct Bedrock without Amplify AI Kit (use bedrock).
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AWS security service suitability, coverage and cost recommendations: WAF/origin overlap, AWS Network Firewall inspection coverage and policy review, VPC endpoint, Transit Gateway/Cloud WAN segmentation and DNS Firewall security-control suitability, certificate renewal ownership and monitoring, incident response triage ownership, centralized security log store (CloudWatch or Security Lake). Also factual configuration, findings, data sources and severity scoring for GuardDuty, Inspector, Security Hub V2/OCSF (Exposure, connectors, automation), Security Hub CSPM/ASFF (standards, controls), Macie, Detective, Security Lake, AWS Security Incident Response membership and case coverage, and Organizations security policies. Applies to advisory security-service choices even when one service is named. Implementation, rule or code authoring, deployment, scans and troubleshooting outside these factual procedures belong to specialist skills. Supports local AWS CLI and AWS MCP.
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Migrates vibe-coded web applications to AWS. Handles the full workflow from analysis through migration to deployment, producing deployable AWS Blocks infrastructure code. Supports full-stack apps built with vibe-coding platforms (Lovable, Bolt.new, Replit) and frontend web applications and websites: React, Vue, Angular, Next.js, Nuxt, Astro, SvelteKit, Gatsby, Vite, Svelte, Solid, Docusaurus, and others (static sites, SPAs, and SSR frameworks with static export). Triggers on: launch with AWS, launch on AWS, deploy to AWS, migrate to AWS, host my app on AWS, move my app to AWS, transfer my app to AWS. Activates when the user wants to migrate a vibe-coded app or frontend web app to AWS, even if they don't say 'migrate' explicitly.
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Performs a full AWS Well-Architected Framework review evaluating every framework question across all pillars discovered from the live AWS documentation by analyzing code, IaC, and configurations to produce evidence-backed findings with Eisenhower-prioritized remediation. Supports full reviews (every framework best practice with BP ID citations), quick reviews (question-level), pillar-scoped reviews, score-mode reviews (a maturity scorecard with per-pillar scores and filtered findings), and lens-specific reviews using lenses discovered from the live AWS documentation. Triggers on mentions of Well-Architected review, WA review, WAR, pillar assessment, architecture review across pillars, workload assessment, cloud readiness evaluation, or a Well-Architected score, grade, or scorecard request. Does not apply to single-pillar deep-dives, learning WA concepts, ADRs, or migration readiness assessments.
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Build and submit iOS and Android apps with EAS to TestFlight, the App Store, or Google Play. Supports Expo and other React Native projects, plus existing native apps. Use for eas.json setup, release pipelines, signing, app versions and build numbers, store submissions, and listing metadata. For Expo websites and API routes, use eas-hosting; for adding React Native screens to a native app, use expo-brownfield.
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Audit a Python project's installed dependencies for known CVEs by wrapping pip-audit (PyPA's official vulnerability auditor) and emitting findings in the canonical penetration-tester schema. Detects vulnerable direct AND transitive packages, normalizes pip-audit's severity output via OSV severity bands, falls back to pip list --outdated when pip-audit isn't installed, and supports requirements.txt, pyproject.toml (PEP 621), Pipfile.lock, and poetry.lock as input sources. Use when: pre-merge gate on a Python project, post-incident sweep after a PyPI compromise (e.g. ctx, request-toolbelt typosquats, ultralytics 8.3.42 compromise), SOC2 evidence collection, or inheriting an unfamiliar Python codebase. Threshold: any HIGH or CRITICAL CVE in the resolved dependency tree. MODERATE / LOW reported informationally. Trigger with: "audit python deps", "pip vulnerability scan", "check pypi packages for CVEs", "pip-audit run".
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Local speech-to-text transcription on Apple Silicon macOS. Supports wav directly and other audio formats via ffmpeg.
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Generate memes using the memegen.link API. Use when users request memes, want to add humor to content, or need visual aids for social media. Supports 100+ popular templates with custom text and styling.
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Create professional Marp presentation slides with 7 beautiful themes (default, minimal, colorful, dark, gradient, tech, business). Use when users request slide creation, presentations, or Marp documents. Supports custom themes, image layouts, and "make it look good" requests with automatic quality improvements.
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Facilitates deliberate skill development during AI-assisted coding. Offers interactive learning exercises after architectural work (new files, schema changes, refactors). Use when completing features, making design decisions, or when user asks to understand code better. Supports the user's stated goal of understanding design choices as learning opportunities.
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Create professional infographics using Nano Banana Pro AI with smart iterative refinement. Uses Gemini 3.6 Flash for quality review. Integrates research-lookup and web search for accurate data. Supports 10 infographic types, 8 industry styles, and colorblind-safe palettes.
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