「based」の検索結果

Performs ML-based protein-ligand pose prediction and scoring using DiffDock-L (diffusion-based), Boltz-1 / Boltz-2 (foundation model with affinity), Chai-1, AlphaFold3 ligand, EquiBind, TANKBind, NeuralPLexer, and hybrid workflows (DiffDock pose + GNINA rescore + PoseBusters QC). Explicit handling of when ML beats classical docking, when classical beats ML, the PB-invalid pose problem, and rescoring as the standard production hybrid. Use when modern docking is needed: foundation-model ligand-pose prediction, AI rescoring of classical poses, or scaffold-hopping in cross-docking scenarios.

日本語の概要は準備中です。原文の説明を表示しています。

Detect transcription factor binding footprints in ATAC-seq using TOBIAS, HINT-ATAC, Wellington, or scprinter. Use when identifying bound TF sites within accessible regions, correcting Tn5 insertion bias before footprinting, choosing between cleavage-based and aggregate-based footprinters, or comparing differential TF activity between conditions.

日本語の概要は準備中です。原文の説明を表示しています。

Analyzes alternative splicing at single-cell resolution. The first decision is library chemistry — 10X 3' is fundamentally limited (RT primes from poly-A, R2 falls in 3' UTR, <0.1 junction read per cell per AS event). Plate-based full-length methods (Smart-seq3, FLASH-seq, VASA-seq, STORM-seq) and single-cell long-read (MAS-Iso-seq, scISOr-Seq2) are the chemistries that give per-cell isoform structure. Tools include MARVEL (R, Smart-seq integrated), BRIE2 (Bayesian PSI with regulatory features and ELBO_gain test), scQuint (junction-cluster, plate-based; not for 10X), SpliZ (annotation-free Z-score), Psix (graph-smoothness regulated AS), and Sierra (alternative polyadenylation, often confused with AS). Use when analyzing isoform usage in scRNA-seq, identifying cell-type-specific splicing, or determining whether scRNA-seq chemistry supports splicing analysis at all.

日本語の概要は準備中です。原文の説明を表示しています。

Build container-based Foundry Agents with Azure AI Projects SDK (ImageBasedHostedAgentDefinition). Use when creating hosted agents with custom container images in Azure AI Foundry.

日本語の概要は準備中です。原文の説明を表示しています。

Use this skill whenever the user wants browser-based end-to-end tests for an Adobe App Builder application. Covers Playwright E2E testing for ExC Shell SPAs, AEM extension UIs, and full-stack flows. Use when the user mentions: "E2E test", "end-to-end test", "Playwright", "browser test", "test my SPA in the browser", "test my AEM extension", "test the full flow", "integration test with UI", "headless browser test", "E2E in CI". This skill is for BROWSER-based testing only. For Jest unit tests of actions or React components, use appbuilder-testing instead.

日本語の概要は準備中です。原文の説明を表示しています。

Security checks for repository ingestion — scans repos for poisoned examples, dependency and supply-chain attacks, file/path traversal, format-based attacks, and enforces quarantine-before-commit. Load as part of the secure-* skill sequence whenever an agent reads, ingests, or learns from a GitHub repository. Also load when the user asks to check a repo for poisoned code, scan dependencies, verify supply chain safety, check for path traversal, scan repo files for attacks, or audit a repo before ingestion. Covers Issues 3, 4, 7, 8 from the agent security threat model: poisoned training data, dependency attacks, file/path attacks, and format-based attacks.

日本語の概要は準備中です。原文の説明を表示しています。

Build container-based Foundry Agents with Azure AI Projects SDK (ImageBasedHostedAgentDefinition). Use when creating hosted agents with custom container images in Azure AI Foundry.

日本語の概要は準備中です。原文の説明を表示しています。

Handles BED-format genomic intervals (BED3 through BED12, narrowPeak/broadPeak) and the coordinate-system substrate the whole interval category rests on, with bedtools (CLI) and pybedtools/pyranges/pandas (Python). Covers the 0-based half-open vs 1-based-closed convention boundary and the start-1/end-unchanged conversion, the silent failures (chrom-name mismatch, CRLF, lexicographic-vs-version sort under -sorted), genome/chrom.sizes generation, sorting contracts, BED12 block invariants, validation, makewindows, cross-assembly liftover (liftOver/CrossMap), and BED<->VCF/BAM/FASTA conversion. Use when reading, creating, validating, sorting, lifting between genome builds, or converting interval files, preparing inputs for bedtools/tabix/bigBed, or debugging an off-by-one or empty-overlap result.

日本語の概要は準備中です。原文の説明を表示しています。

Parses, queries, converts, and extracts from GTF and GFF3 gene-model annotation files - walking the gene/transcript/exon/CDS hierarchy with gffutils (queryable SQLite DB), converting formats and extracting transcript/CDS/protein FASTA with gffread, slurping to dataframes with gtfparse/pyranges, and sanitizing malformed files with AGAT. Covers the 1-based-inclusive vs 0-based BED coordinate conversion (start-1 only), deriving implicit features (introns/UTRs/TSS), phase-not-frame, the stop-codon-in-or-out-of-CDS convention, and the chr1-vs-1 seqid and gene-ID-version mismatches that silently produce all-zero count matrices and dropped joins. Use when extracting features or sequences from an annotation, converting GTF<->GFF3 or GTF->BED, traversing the gene tree, or diagnosing a coordinate/provenance mismatch upstream of counting or DE.

日本語の概要は準備中です。原文の説明を表示しています。

Quality control for flow, spectral, and mass cytometry - time-based anomaly cleaning (flowAI, flowCut, PeacoQC, flowClean), margin/boundary event removal, signal-drift detection, dead-cell exclusion, CyTOF Gaussian/DNA/event-length checks, instrument calibration/standardization (MESF, CS&T, peak-2), and batch-level outlier flagging. Use when assessing acquisition quality, choosing a cleaning tool, ordering QC relative to compensation, deciding margin removal before density-based steps, or flagging problematic samples before clustering or differential analysis.

日本語の概要は準備中です。原文の説明を表示しています。

Performs ML-based protein-ligand pose prediction and scoring using DiffDock-L (diffusion-based), Boltz-1 / Boltz-2 (foundation model with affinity), Chai-1, AlphaFold3 ligand, EquiBind, TANKBind, NeuralPLexer, and hybrid workflows (DiffDock pose + GNINA rescore + PoseBusters QC). Explicit handling of when ML beats classical docking, when classical beats ML, the PB-invalid pose problem, and rescoring as the standard production hybrid. Use when modern docking is needed: foundation-model ligand-pose prediction, AI rescoring of classical poses, or scaffold-hopping in cross-docking scenarios.

日本語の概要は準備中です。原文の説明を表示しています。

Detect transcription factor binding footprints in ATAC-seq using TOBIAS, HINT-ATAC, Wellington, or scprinter. Use when identifying bound TF sites within accessible regions, correcting Tn5 insertion bias before footprinting, choosing between cleavage-based and aggregate-based footprinters, or comparing differential TF activity between conditions.

日本語の概要は準備中です。原文の説明を表示しています。

Analyzes alternative splicing at single-cell resolution. The first decision is library chemistry — 10X 3' is fundamentally limited (RT primes from poly-A, R2 falls in 3' UTR, <0.1 junction read per cell per AS event). Plate-based full-length methods (Smart-seq3, FLASH-seq, VASA-seq, STORM-seq) and single-cell long-read (MAS-Iso-seq, scISOr-Seq2) are the chemistries that give per-cell isoform structure. Tools include MARVEL (R, Smart-seq integrated), BRIE2 (Bayesian PSI with regulatory features and ELBO_gain test), scQuint (junction-cluster, plate-based; not for 10X), SpliZ (annotation-free Z-score), Psix (graph-smoothness regulated AS), and Sierra (alternative polyadenylation, often confused with AS). Use when analyzing isoform usage in scRNA-seq, identifying cell-type-specific splicing, or determining whether scRNA-seq chemistry supports splicing analysis at all.

日本語の概要は準備中です。原文の説明を表示しています。

Recommend, create, preview, and attach Coval trace-based metrics from OpenTelemetry spans. Use when a user has Coval traces and wants custom trace metrics, trace-aware LLM judge metrics with include_traces, latency, token usage, provider failures, tool behavior, vertical-specific workflow signals, or production monitoring based on trace attributes.

日本語の概要は準備中です。原文の説明を表示しています。

Create a new find-XXXX preprocessor Python script from scratch (no existing SKILL.md), add configs/<GAMEVER>.yaml skill and symbol entries. Covers xref-string-based and LLM_DECOMPILE-based discovery patterns. Use when a GitHub issue or user instruction specifies a new function to find.

日本語の概要は準備中です。原文の説明を表示しています。

Convert an existing find-XXXX SKILL.md into a preprocessor Python script, updating configs/<GAMEVER>.yaml and removing the old SKILL.md. Covers xref-string-based and LLM_DECOMPILE-based discovery patterns.

日本語の概要は準備中です。原文の説明を表示しています。

Review database schema design and detect anti-patterns. Based on common RDB design knowledge and best practices. Supports Prisma, Drizzle, Rails, Django, Laravel, TypeORM, Sequelize, SQLAlchemy, and raw SQL (DDL). Use when the user says "review DB design", "check schema", "review table design", "review migration", "check for anti-patterns", "DB設計をレビューして", "スキーマを見て", "テーブル設計を確認して", "マイグレーションをレビューして", "アンチパターンがないか調べて", "この設計で問題ないか見て".

Build container-based Foundry Agents with Azure AI Projects SDK (ImageBasedHostedAgentDefinition). Use when creating hosted agents with custom container images in Azure AI Foundry.

日本語の概要は準備中です。原文の説明を表示しています。

Implement secure authentication and authorization systems with JWT, OAuth2, Session-based auth, and RBAC. Use when: (1) implementing user login/signup, (2) setting up JWT tokens, (3) OAuth2 integration (Google, GitHub, etc.), (4) role-based access control (RBAC), (5) password hashing and validation, (6) session management, (7) API authentication middleware, (8) 2FA/MFA setup. Triggers: "authentication", "login", "JWT", "OAuth", "session", "password hash", "RBAC", "permissions", "2FA".

日本語の概要は準備中です。原文の説明を表示しています。

Build and run multi-agent content production teams on OpenClaw with single-repo architecture, symlink-based file sharing, role-specialized AGENTS.md, and automated review-fix-score loops. Use when: (1) Setting up a team of 3+ agents with writer/reviewer/scorer/fixer roles for content creation, (2) Creating a quality-controlled publishing pipeline, (3) Bootstrapping agent workspaces with symlinks and tool configs from scratch, (4) Running multi-round review→fix→score cycles until a quality threshold is met, (5) Debugging agent spawn permissions, tool-call loops, or symlink issues. Based on real production experience building a 6-agent content team (2026-03-30).

日本語の概要は準備中です。原文の説明を表示しています。

Create professional posters and visual designs using AI image generation. Supports event posters, product showcases, announcements, and social media graphics. Integrates with Gemini image generation API to create visuals based on templates and user content. Use when the user wants to design posters, generate marketing visuals, create promotional materials, or produce image-based content for events, products, or announcements.

日本語の概要は準備中です。原文の説明を表示しています。

This skill should be used when working on Nuxt projects (v3+). Use it for building Vue applications with Nuxt's file-based routing, server-side rendering, and auto-import features. Trigger when working with .vue or .ts files in Nuxt directories (pages/, server/, composables/, middleware/), nuxt.config.ts, or when the project contains a nuxt dependency in package.json. Also trigger for questions about Nuxt concepts like composables, auto-imports, server routes, SSR/SSG patterns, or file-based routing.

日本語の概要は準備中です。原文の説明を表示しています。

Pricing strategy for technical products. Use when choosing usage-based vs seat-based, designing freemium thresholds, structuring enterprise pricing conversations, deciding when to raise prices, or using price as a positioning signal.

日本語の概要は準備中です。原文の説明を表示しています。

Formats content to be eligible for featured snippets and SERP features. Creates snippet-optimized content blocks based on best practices. Use PROACTIVELY for question-based content.

日本語の概要は準備中です。原文の説明を表示しています。