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CP-7 retrospective: audit checkpoints, evidence quality, action items, and harvest candidates. Closes the V-model cycle and feeds the next run. Use via /retro after ship, escalate, or significant session.

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Run a large, multi-session goal (e.g. shipping a whole side product) through the full V-model closed loop, one phase at a time, with cross-session state and a final north-star acceptance gate. Ultragoals never downgrade the lane: every phase runs CP-1→CP-6 with adversarial verification. Opt-in: invoke with /ultragoal or by calling something a long-running goal. Ordinary work does not run this.

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Use when the contribution of an American Economic Journal: Microeconomics (AEJ: Micro) manuscript is fuzzy or oversold relative to the closest existing results. Stakes the theorem-relative delta against the nearest theory; it does not build the model (see aejmic-theory-model) or frame the prose (see aejmic-writing-style).

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Use when positioning the contribution of an American Economic Review: Insights (AER: Insights) short-format manuscript against the closest published work in one or two tight paragraphs. Stakes the gap concisely; it does not write the full literature review (there is no room for one).

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Pipeline analysis composite. Pulls deal/meeting data from any CRM or tracking system, analyzes the pipeline over a user-defined period (weekly, fortnightly, monthly, quarterly), and produces both an executive summary and a detailed diagnostic report. Covers volume, qualification rates, source effectiveness, stage velocity, stuck deals, and actionable recommendations. Tool-agnostic — works with any CRM (Salesforce, HubSpot, Pipedrive, Close, Supabase, CSV).

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Assemble a stop-motion hand-swatch-cycle product-demo ad from a config — a sequence of still PLATES (one hand swiping a single-barrel product across a test surface, the barrel + swatch changing per plate while the hand, background, crop, and lighting stay locked) is PNG→mp4 loop-encoded at each plate's own stop-motion hold (fast motion frames 150–250ms, per-shade ~380ms, hero beats 1100–1800ms), concat-demuxed with HARD cuts into a silent master, closed on a Playwright HTML-rendered branded end card (serif tagline + sans subtitle + real logo SVG over a hero BG, never AI-rendered text), and muxed with a pre-sourced music track playing under the end card with a fade tail (no VO). This is the FREE deterministic assembly stage (loop-encode + concat-demux + end-card render + music mux); the master-anchor plate, shade plates, and end-card BG come from create-image-gpt-image-fal and the track from create-music-elevenlabs. Use for the stopmotion-hand-swatch-cycle format.

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Assemble an editorial-motion podcast-clip ad from a config — a real clipped podcast MP3 carries the narrative while N flat limited-palette editorial-illustration keyframes (one look pack) are animated NOT by generative i2v but by DETERMINISTIC ffmpeg ken-burns (zoompan) + hard cuts (no crossfades, which expose geometric drift), each beat snapped to its spoken line, the real audio muxed, Whisper-driven captions burned only mid-sentence, and closed on a PIL brand end card — never AI-rendered text. This is the FREE deterministic assembly stage (ffmpeg ken-burns + hard concat + audio mux + captions + end card); the real audio is clipped from source and the keyframes come from create-image-fal. Use for the editorial-motion-podcast format.

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Assemble a multi-scene GRWM beauty-demo ad from a config — a locked-identity creator applies ~5 products step by step while a SEPARATE ElevenLabs voiceover narrates and every scene cut is snapped to the VO's product-name word-starts (Whisper word-level timestamps), then ~5 Playwright product overlay cards (real PDP-verified taglines) are composited onto the master each on its product-NAME word-start, the SEPARATE VO is mixed on top of a ducked music bed at loudnorm I=-14, clean-white 3-words/cue captions are burned, and the video closes on a flat-lay end card. This is the FREE deterministic assembly stage (re-cut to the VO word-starts, hard-concat, Playwright card render + card composite, VO plus music mix, caption burn, flat-lay end card); the VO, scene clips, product cutouts, and music come from create-music-elevenlabs / create-image-gpt-image-fal / create-video-fal. Use for the glassy-matte-grwm format.

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Assemble a cartoon / animated / hand-crafted music-video ad from a config — a sung song carries the whole narrative while N per-bar i2v clips (one recurring animated character, one look pack) are each cut to their BAR window from librosa beat-tracking and hard-concatenated on the bar, VEED-whisper white bold-sans captions in the BOTTOM third (Alignment 2, above the logo bug, no pill) burned from the song's word timings re-spelled against the locked lyrics, a persistent brand logo bug held over the body (suppressed on the end card), and closed on a solid-brand-color PIL end card with the song still playing under it — never AI-rendered text. This is the FREE deterministic assembly stage (cut-to-bar + hard concat + logo bug + captions + end card + song mux); the song, character, keyframes, and clips come from create-music-elevenlabs / create-image-fal / create-video-fal. Use for the cartoon-music-video format.

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Assemble a narrated-UGC "stitch reply" ad from a config — a single spoken VO carries a verbatim testimonial while ~30 per-cut i2v clips (one creator across ~5 wardrobes in ~3 worlds, plus product B-roll) are each trimmed to their EDL window built from the VO's Whisper word boundaries and hard-concatenated via filter_complex concat (never the demuxer, which drops audio on a duration mismatch), the VO mixed over an optional sidechain-ducked instrumental bed (−20dB, 20 to 1) so the VO stays on top, karaoke-pop captions burned on every word throughout (VEED Whisper preset, re-spelled against the locked script), a landing-page scroll rendered as FFmpeg zoompan over a Playwright PNG (not i2v), and closed on the brand's real end-card PNG — never AI-rendered text. This is the FREE deterministic assembly stage (trim-to-EDL + filter_complex concat + VO and music mix + karaoke captions + landing-page zoompan + end-card append), run with the shared stitch-videos-ffmpeg montage.py helper that installs with this package; the VO, creator, start-frames, and clips come from create-vo-elevenlabs / create-image-gpt-image-fal / create-image-fal / create-video-fal. Use for the narrated-ugc-wardrobe-stitch format.

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Assemble a song-driven music-video ad from a config — a generated sung track carries the whole narration across N tableaux (one keyframe -> one i2v clip per lyric beat) with NO separate voiceover, captions synced to the song's OWN word timings (script-window, never Whisper) and the hook word landing on the chorus drop, closed on a PIL brand end card. This is the FREE deterministic assembly stage (clip cut-to-timeline + captions + end card + FFmpeg composite); the song, keyframes, and clips come from create-music-elevenlabs / create-image-fal / create-video-fal. Use for the song-driven-music-video format.

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Render an 'Instagram-Live social-proof gallery' video from a config — ~5 real brand product stills each framed as an Instagram-LIVE card (IG gradient-ring avatar, username, verified check, red LIVE badge, viewer count, close X, a short claim-free live-comment feed, an empty 'Add a comment…' bar, and reaction hearts floating up the right edge), with a brand-approved benefit sentence building one phrase per slide and a clean logo endcard, rendered deterministically with PIL frames plus FFmpeg — FREE (the music bed comes from create-music-elevenlabs), products and wordmark stay crisp. Use for the ig-live-gallery format.

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Assemble a cinematic live-action-style music-video ad from a config — an original sung anthem carries the whole narrative while N 35mm-film-look i2v clips are each cut to their lyric window and hard-concatenated on the beat as a 3-act arc, the anthem muxed at loudnorm I=-14, cinematic lower-third serif captions built from the song's OWN word timings (never Whisper) with the hook line landing on the chorus drop, and closed on a brand end card composited from the real asset — never AI-rendered text. This is the FREE deterministic assembly stage (cut-to-window + hard concat + anthem mux + captions + end card); the anthem, keyframes, and clips come from create-music-elevenlabs / create-image-gpt-image-fal / create-video-fal. Use for the cinematic-music-video format.

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Specify plant models for closed-loop simulation: system specs, architecture, build plans, validation plans. Use when creating, updating, or reviewing plant model specifications, planning plant model architecture, or planning plant model validation.

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Use this skill when the user asks to summarize, or asks why Simulink Coverage objectives are missing, unsatisfied, or uncovered on a coverage result they already have — why specific decision, condition, MCDC, relational-boundary, or saturation/overflow outcomes weren't exercised, whether uncovered logic is dead code, or how to close the gap (a test, a coverage filter, or a design change). It reads an existing cvdata, .cvt file, sim-with-coverage output, or Simulink Test result; it never runs cvsim to collect coverage.

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Handles BED-format genomic intervals (BED3 through BED12, narrowPeak/broadPeak) and the coordinate-system substrate the whole interval category rests on, with bedtools (CLI) and pybedtools/pyranges/pandas (Python). Covers the 0-based half-open vs 1-based-closed convention boundary and the start-1/end-unchanged conversion, the silent failures (chrom-name mismatch, CRLF, lexicographic-vs-version sort under -sorted), genome/chrom.sizes generation, sorting contracts, BED12 block invariants, validation, makewindows, cross-assembly liftover (liftOver/CrossMap), and BED<->VCF/BAM/FASTA conversion. Use when reading, creating, validating, sorting, lifting between genome builds, or converting interval files, preparing inputs for bedtools/tabix/bigBed, or debugging an off-by-one or empty-overlap result.

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Transfers gene annotations between genome assemblies via coordinate liftover (UCSC liftOver, CrossMap for same-species version updates) or feature/sequence projection (Liftoff for same/close species, miniprot for protein-level cross-species, TOGA/GeMoMa/CAT for distant clades). Covers the coordinate-vs-projection decision by divergence, why a successful lift is not biological confirmation, reference bias, the silent-dropping of unmapped features, build/PAR/MHC/inversion hazards, and transfer-vs-de-novo validation. Use when annotating a new assembly of a species with an existing reference, harmonizing coordinates across builds, or mapping annotations across related species.

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Controls error rates across thousands of simultaneous tests in genomics discovery using false-discovery-rate methods (Benjamini-Hochberg 1995; Benjamini-Yekutieli 2001 for arbitrary dependence; Storey q-value with pi0 estimation; local FDR; independent filtering Bourgon 2010; covariate-weighted FDR via IHW Ignatiadis 2016), plus family-wise error control (Bonferroni, Holm) and the GWAS genome-wide threshold. Covers the FDR-versus-FWER choice as the discovery-versus-confirmatory distinction, the dependence assumptions behind BH (PRDS) versus BY, pi0 estimation, the independent-filtering and false-coverage-rate traps, and reproducibility ranking via IDR (Li 2011). Use when correcting p-values from genome-wide tests, choosing between BH/BY/q-value/Bonferroni, setting an FDR threshold, applying IHW or independent filtering, or interpreting q-values. For confirmatory trials with few pre-specified endpoints (closed testing, graphical/gatekeeping), see clinical-biostatistics/multiplicity-graphical.

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Calculates statistical power for high-dimensional genomics experiments (bulk RNA-seq, scRNA-seq, ATAC-seq, ChIP-seq, methylation, proteomics) under negative-binomial count models using RNASeqPower, PROPER, and simulation via powsimR, distinguishing per-gene from marginal (transcriptome-wide) power, the role of mean expression and dispersion, and the sequencing-depth-versus-replicate tradeoff. Covers simulation as the honest default for overdispersed counts, FDR-aware average power versus single-test power, observed/post-hoc power as an anti-pattern, and the winner's-curse / Type-S / Type-M consequences of underpowering. Use when planning replicate number for a sequencing experiment, deciding whether to add depth or samples, choosing closed-form versus simulation power, estimating power from pilot dispersions, or justifying replication in a grant. For clinical-trial power see clinical-biostatistics/power-and-sample-size; for the inverse sample-size question see experimental-design/sample-size.

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Build and analyze pangenomes for prokaryotes (Panaroo, PPanGGOLiN, PEPPAN, GET_HOMOLOGUES, anvi'o pangenomics) and eukaryotes (Minigraph-Cactus, PGGB, vg pangenome graphs). Implement Tettelin core/accessory/cloud genome decomposition (Tettelin 2005), Heap's law open/closed pangenome modeling, gene presence/absence GWAS (Scoary, pyseer), pangenome graph variant calling (vg, PanGenie), and structural-variation graph indexing. Use when assembling species- or genus-level pan-gene catalogs, separating core from accessory/shell/cloud genes, testing gene-content associations with phenotypes, building pangenome graphs from haplotype-resolved assemblies, calling SVs from pangenome graphs, or selecting between bacterial-pangenome and eukaryotic-pangenome workflows.

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Build whole-genome alignments using Progressive Cactus (Armstrong 2020 reference-free clade-level WGA), Minigraph-Cactus (Hickey 2024 pangenome-aware), LASTZ chain/net (UCSC pipeline), MUMmer4 (Marçais 2018 pairwise), minimap2 -x asm5/10/20 (Li 2018 fast pairwise), AnchorWave (Song 2022 WGD-aware), and Mauve / progressiveMauve (bacterial). Operates the HAL toolkit (Hickey 2013) for downstream extraction including halSynteny, halLiftover, halBranchMutations, and hal2maf. Use when constructing multi-species alignments for comparative-annotation projection (TOGA), synteny detection, conservation analyses (phyloP / PhastCons), or pangenome graph construction; selecting between reference-free (Cactus) and reference-anchored (LASTZ chains/nets) approaches; tuning sensitivity for closely vs distantly related genomes; or producing HAL files for genome-wide downstream tools.

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Implements multiplicity control for confirmatory clinical trials using graphical procedures (Bretz-Maurer-Hommel), gatekeeping (parallel, serial, mixed), Hochberg/Hommel/Holm with PRDS, and the closed-testing principle (Marcus-Peritz-Gabriel; Goeman 2021 admissibility). Covers FDA Multiple Endpoints Final Guidance (October 2022), graphical procedures via R gMCP, primary + key-secondary + subgroup hierarchies, and FWER vs FDR distinction. Use when designing the multiplicity strategy for confirmatory trials with multiple primary or key secondary endpoints.

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Find out why something in a running web app does not work, when the console is empty and the code looks correct. Reads the click, the request, the store and the console together and returns the file:line to open. Use when a button does nothing, a form will not submit, data will not load, a page renders blank or stale, a modal will not close, or the user says "it's broken" and the code review says it is fine.

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Use this agent for closed-loop test debugging - automatically analyzes test failures, suggests fixes, and re-runs tests until passing.

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