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Segments the genome into chromatin states from combinatorial histone modification and chromatin factor ChIP-seq data. Uses ChromHMM (multivariate HMM on binarized signal, v1.27), Segway (Dynamic Bayesian Network on continuous signal), EpiSegMix (flexible-distribution HMM with duration modeling, 2024), EpiLogos (multi-biosample visualization), IDEAS (cell-type-aware joint), and full-stack ChromHMM (Vu Ernst 2022) for cross-cell-type segmentations. Handles state-count selection (15 vs 18 vs 25 states), binarization choice, OverlapEnrichment / NeighborhoodEnrichment downstream analysis, and cross-biosample integration. Use when learning chromatin states from a histone mark panel, characterizing learned states by genomic feature enrichment, or comparing chromatin landscapes across cell types.

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Perform multiple sequence alignment using MAFFT, MUSCLE5, ClustalOmega, or T-Coffee. Guides tool and algorithm selection based on dataset size, sequence divergence, and downstream application. Use when aligning three or more homologous sequences for phylogenetics, conservation analysis, or evolutionary studies.

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Use whenever a form needs to accept ONE image and produce permanent public URLs for one or more platform-specific sizes (OG image, social posts, avatars, logos, favicons, app icons). Replaces every legacy image-URL input, single-size uploader, and base64-data-URL flow. Triggers when you see a manual `<input type="url">` for an image, a single-size uploader, or anywhere a `dataUrl` could leak into a clipboard or a saved record.

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Build a complete brand identity for a solopreneur business from scratch or refresh an existing one. Covers brand personality, voice and tone, visual identity system (colors, typography, logo direction, imagery style), tagline crafting, and a brand guidelines document. Use when creating a new brand, rebranding, or needing to make brand decisions consistent. Trigger on "create my brand", "brand identity", "brand guidelines", "define my brand voice", "brand personality", "what should my brand look like", "brand strategy", "rebrand", "brand tone".

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Create HTML-based video compositions, animated title cards, social overlays, captioned talking-head videos, audio-reactive visuals, and shader transitions using HyperFrames. HTML is the source of truth for video. Use when the user wants a rendered MP4/WebM from an HTML composition, wants to animate text/logos/charts over media, needs captions synced to audio, wants TTS narration, or wants to convert a website into a video.

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Implements Blazor auth flows -- login/logout, AuthorizeView, Identity UI, OIDC.

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Use when wiring shadcn/ui primitives, forms or admin UI in site-os — the component mechanics, the VBField validation layer, and the UI bugs that have actually shipped here. For brand identity (colour, type, logo, voice) load brand instead; that skill wins on any disagreement.

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Apply this site's visual identity — colours, type, logo files and fixed brand strings. Use for any page, component, social asset or document that should look like the site.

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Detect abuse of service accounts through anomalous interactive logons, privilege escalation, lateral movement, and unauthorized access patterns.

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Detect Pass-the-Hash attacks by analyzing NTLM authentication patterns, identifying Type 3 logons with NTLM where Kerberos is expected, and correlating with credential dumping.

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Detect NTLM relay attacks through Windows Security Event correlation by analyzing Event 4624 LogonType 3 for IP-to-hostname mismatches, identifying Responder/LLMNR poisoning artifacts, auditing SMB and LDAP signing enforcement across the domain, and detecting NTLM downgrade attacks from NTLMv2 to NTLMv1 using event log analysis.

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Detect RDP brute force attacks by analyzing Windows Security Event Logs for failed authentication patterns (Event ID 4625), successful logons after failures (Event ID 4624), NLA failures, and source IP frequency analysis.

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Configures Windows Event Logging with advanced audit policies to generate high-fidelity security events for threat detection and forensic investigation. Use when enabling audit policies for logon events, process creation, privilege use, and object access to feed SIEM detection rules. Activates for requests involving Windows audit policy, event log configuration, security logging, or detection-oriented logging.

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Create any visual design using Adobe Express templates — including flyers, posters, banners, social media posts (Instagram stories, Facebook posts, LinkedIn graphics), business cards, invitations, greeting cards, resumes, cover letters, brochures, newsletters, certificates, presentations, YouTube thumbnails, email headers, logos, menus, labels, and more. Use this skill whenever the user wants to make, design, create, or build any visual — even if they just say "make me a flyer", "design a poster", "I need something for Instagram", "create an event invite", "make a business card", or any similar request. Also handles requests to find or browse templates, edit text/copy, change background colors, or animate a design. Access: 🔐 Signed-In required | Gen AI: ❌

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Hunt Session Management vulnerabilities — session fixation (no regeneration on login), insufficient invalidation on logout / password-change / email-change, predictable or low-entropy session IDs, JWT-as-session with no exp/revocation, refresh-token rotation/reuse-detection gaps, OAuth/SSO session linkage, device-bound-session (DBSC) downgrade, and cookie attribute issues (Secure/HttpOnly/SameSite/__Host-). Validate with TWO real sessions (attacker A + victim B), body-diff every 200, and OOB confirmation for theft chains. Medium to Critical (fixation→admin hijack, no-invalidation→persistent ATO).

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Comprehensive persistence tradecraft for authorized red team engagements covering Windows and Linux mechanisms. Windows techniques include registry Run/RunOnce keys, scheduled tasks, WMI event subscriptions, DLL search order hijacking, COM object hijacking, Startup folder drops, service creation, Security Support Provider (SSP) DLL injection, and Active Directory persistence (AdminSDHolder abuse, DCShadow, Golden Ticket, Silver Ticket, Skeleton Key, SID History injection). Linux techniques include cron and at jobs, systemd timers and services, SSH authorized_keys injection, shell profile backdoors (.bashrc/.bash_profile), PAM module backdoors, LD_PRELOAD hijacking, kernel module rootkits, web shells, and Git hook abuse. Provides operator-ready command sequences for SharPersist, Impacket ticketer, schtasks, sc.exe, crontab, and systemctl with OPSEC considerations for each method. Maps to MITRE ATT&CK T1547 (Boot or Logon Autostart), T1053 (Scheduled Task/Job), T1546 (Event Triggered Execution), T1556 (Modi...

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Interact with Bitwarden password manager using the bw CLI. Covers authentication (login/unlock/logout/status), vault operations (list/get/create/edit/delete/restore items, folders, attachments, collections), password/passphrase generation, organization management, and Send/receive. Use for "bitwarden", "bw", "password safe", "vaultwarden", "vault", "password manager", "generate password", "get password", "unlock vault", "share send".

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Handle images with ImageMagick (magick) — read metadata, resize, crop, rotate, convert format, combine images (side-by-side or grids with montage), overlay logos/watermarks, and losslessly compress with oxipng before sending. Use when the user sends an image to process, when you produce an image to deliver, or before attaching any image to a message or upload — compressing first keeps transfers fast and tokens low. Core discipline - always compress before delivering, never expose local file paths to the user, and fail open (if a tool is missing or a step errors, pass the original through unchanged; never block the task).

日本語の概要は準備中です。原文の説明を表示しています。