「ploi」の検索結果

Visualize copy number profiles, segments, allele-specific tracks, and cohort patterns from CNVkit, GATK, ASCAT, FACETS, Sequenza, and other callers. Covers genome-wide and per-chromosome log2 scatter plots, B-allele-frequency/minor-allele-fraction tracks, ideograms, cohort heatmaps, circos views, and caller-native plots. Use when creating publication CNV figures, choosing which plot answers a given question, diagnosing a wrong diploid baseline visually, displaying loss of heterozygosity, or deciding what depth-only plots cannot reveal.

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Normalize read-depth copy-ratio profiles and segment them into copy-number regions using circular binary segmentation (CBS, DNAcopy), hidden Markov models, HaarSeg, and fused-lasso methods. Covers GC-content, mappability, and replication-timing (wave-artifact) bias correction, panel-of-normals/PCA denoising, diploid-baseline centering, and algorithm selection by sequencing depth and event size. Use when choosing a segmentation algorithm, correcting depth bias, diagnosing oversegmentation or a mis-centered baseline, tuning CBS or HMM parameters, or understanding why a downstream CNV caller produced fragmented or shifted segments.

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Call copy number variants with the GATK best-practices workflows — the somatic CNV pipeline (CollectReadCounts, DenoiseReadCounts with tangent normalization, ModelSegments, CallCopyRatioSegments) and the germline GATK-gCNV pipeline (DetermineGermlineContigPloidy, GermlineCNVCaller cohort/case mode, PostprocessGermlineCNVCalls). Covers panel-of-normals construction, AnnotateIntervals/FilterIntervals, allelic-count integration, and QS-based filtering. Use when integrating CNV calling into a GATK variant pipeline, calling rare germline CNVs from an exome cohort, deciding between the somatic and germline GATK workflows, or diagnosing why tangent normalization removed a real event or why gCNV output has low precision.

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Classify constitutional (germline) copy number variants for clinical reporting using the 2019 ACMG/ClinGen technical standards points-based framework, with ClassifyCNV and AnnotSV for semi-automated scoring. Covers the separate copy-number-loss and copy-number-gain rubrics, the five-tier classification, ClinGen haploinsufficiency/triplosensitivity and dosage-sensitive regions, de novo and segregation evidence, and population-frequency benign evidence. Use when assigning pathogenic/likely-pathogenic/VUS/likely-benign/benign to a constitutional CNV, scoring a CNV against ACMG/ClinGen criteria, or distinguishing the automatable evidence from the case-specific evidence requiring manual input.

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Detects allele-specific transcription factor or histone modification binding from heterozygous-variant ChIP-seq using WASP (reference-bias filter; mandatory upstream), RASQUAL (joint QTL + bias-corrected testing), BaalChIP (Bayesian beta-binomial with copy-number-aware overdispersion), and AlleleSeq (personalized diploid genome). Handles imprinted-locus awareness, X-inactivation artifacts, cancer copy-number imbalance, and integration with downstream caQTL / bQTL mapping. Use when identifying variants with allelic effects on TF binding, fine-mapping causal regulatory variants, validating deep-learning variant predictions, or characterizing cis-acting regulatory effects.

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Designs novel molecules using REINVENT 4 (de novo, scaffold decoration, linker design, R-group, molecular optimization), MolMIM, Diffusion-based generators (DiGress, DiffSMol), and JT-VAE with explicit handling of multi-parameter optimization (MPO), goal-directed scoring functions, transfer/reinforcement/curriculum learning, synthetic accessibility scoring, and chemical space exploration vs exploitation. Use when designing new chemical matter against a target, decorating a scaffold, linking fragments, or optimizing a hit for multiple ADMET / activity properties simultaneously.

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Perform basic penetration testing and security assessments. Use reconnaissance, vulnerability discovery, and exploitation techniques. Use when validating security controls or assessing system security.

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Infrastructure-first security audit across 14 phases: attack surface mapping, secrets archaeology (git history), supply chain analysis, CI/CD pipeline security, LLM/AI threat detection, OWASP Top 10, STRIDE threat modeling. Confidence gates, exploit scenarios, parallel verification, trend tracking. Read-only.

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Use when a security incident, data breach, or actively exploited vulnerability raises the question "who must we notify, where, and by when?" Screens one incident across the EU reporting regimes — NIS2, GDPR, DORA, and the Cyber Resilience Act — determines which duties fire for each involved entity's roles, resolves the receiving authority per regime and member state from served national law, and produces a deadline table in which every duty, authority, and deadline is cited from official publisher text fetched live through the Ansvar Gateway MCP connector. Never answers from model memory.

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Use telnet to interact with IoT device shells for pentesting operations including device enumeration, vulnerability discovery, credential testing, and post-exploitation. Use when the user needs to interact with network-accessible shells, IoT devices, or telnet services.

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Use when auditing or recalibrating game balance: build a source-driven Monte Carlo balance lab (Rust + rayon) that extracts live game data, simulates human playstyles (AFK→pro), emits win-rate/economy verdicts with confidence intervals, and bruteforce-tunes parameters. Trigger on unfair levels, unreachable shops, farm exploits, interest-curve cliffs, post-content recalibration, or CI balance JSON diffs. Keywords: balance lab, Monte Carlo, win rate, difficulty curve, economy career, playstyle simulation, Resource extraction, GDScript parser, bruteforce tuning.

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Full-spectrum Amazon competitor analysis. Compare listings, pricing, reviews, advertising strategy, and market positioning against direct competitors. Identify weaknesses to exploit and strengths to counter. Use when the user asks about competitor analysis, competitive research, ASIN comparison, pricing analysis, or how to beat competitors on Amazon.

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PTES-aligned penetration testing methodology for backend, frontend, and mobile. Provides attack taxonomy, exploit techniques per vulnerability class, and platform-specific test matrices. Use when executing pentest workflow, planning security assessments, mapping attack surfaces, or building threat models.

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Identifies dependencies at heightened risk of exploitation or takeover. Use when assessing supply chain attack surface, evaluating dependency health, or scoping security engagements.

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Perform a focused security review of pending git changes to identify high-confidence security vulnerabilities with real exploitation potential. Use this skill when the user asks for a security review, security audit, vulnerability scan, or wants to check pending changes on a branch for security issues before merging. This is NOT a general code review.

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Writing, exploit ： 将原始素材逐段塑形为一篇文章。

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Writing, exploit ： 将原始素材组装成一段节拍之旅，在节拍使用每个术语之前先将其夯实。

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Research a specific CVE or vulnerability disclosure end-to-end — what version is affected, is your code reachable, is there a public PoC, is there a patch, what's the exposure window, what's the mitigation if you can't patch immediately. Use when the user mentions 'CVE,' 'vulnerability research,' 'is this CVE relevant,' 'zero-day,' 'CISA KEV,' 'GitHub Security Advisory,' 'reachability analysis,' 'patch analysis,' 'exploit availability,' 'EPSS,' 'CVSS,' or 'should we drop everything and patch this.'

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Use when starting an engagement, before exploitation, or whenever the attack surface changes — build/validate the threat model and detect drift (new unreviewed surface) before advancing

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Use when writing security tooling, exploits, scanners, or C2 in Python/C/Go/Rust/ASM — systems & network programming, automation, cryptography implementation

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Use when starting any offensive-security engagement or task — establishes how to find and invoke the right skill before any action (including clarifying questions, recon, exploitation, or reporting)

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Use when attacking an AI/ML system or model — prompt injection & jailbreaks (Crescendo, Skeleton Key, Best-of-N), RAG/vector poisoning, agentic/MCP exploitation (CVE-2025-54136), ML supply-chain RCE (pickle CVE-2025-32434), model extraction / membership inference / adversarial suffixes (GCG)

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Use when starting, planning, or running a multi-phase pentest or red-team engagement — to sequence the Cyber Kill Chain phases with quality gates instead of jumping straight to exploitation

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Use when turning a memory-corruption bug into a working PoC — stack/ROP, glibc heap & FSOP, format strings, browser/JIT type confusion & UAF, Linux/Windows kernel LPE against ASLR/DEP/CFG/CET/V8-Sandbox

日本語の概要は準備中です。原文の説明を表示しています。