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Use when the user asks to run a full empirical / causal analysis in Python — by default in the style of an applied economics paper (AER / QJE / JPE / ReStud / AEJ) with DID / RD / IV / SCM / DML / matching, written-out estimating equation + identifying assumption, Table 1 / Table 2 / event-study figure / robustness gauntlet — OR in epidemiology / public health style (target-trial emulation, IPTW + g-formula + TMLE triplet, Mendelian randomization, KM/AFT survival, E-value sensitivity, STROBE/TRIPOD reporting) — OR in ML causal inference style (DML, S/T/X/R/DR meta-learners, causal forest, Dragonnet/TARNet/CEVAE, BCF, CATE distribution, policy learning, conformal causal, fairness audit, causal discovery) — OR in distributional / gap-decomposition style (Oaxaca–Blinder `sp.oaxaca`, Kitagawa `sp.kitagawa_decompose`, DiNardo–Fortin–Lemieux `sp.dfl_decompose`, Gelbach `sp.gelbach`, Fairlie `sp.fairlie`, RIF / FFL `sp.rif_decomposition`, all reachable through the `sp.decompose` dispatcher). Also covers exporting multi-column regression tables to Word / Excel / LaTeX (Stata outreg2 / esttab / R modelsummary equivalent) and bundling an entire replication appendix into one .docx / .xlsx / .tex file. Triggers on keywords "StatsPAI", "statspai", "AER empirical analysis", "applied micro pipeline", "Table 1 balance", "event study", "first-stage F", "Oster bound", "honest_did", "spec_curve", "callaway_santanna", "dragonnet", "text as treatment", "outreg2 in Python", "regression table to Word/Excel", "sp.regtable", "sp.collect", "sp.paper_tables", "sp.feols", "summary_col", "modelsummary", "AER style table", "QJE style table", "epidemiology pipeline", "target trial emulation", "g-formula", "IPTW", "TMLE", "Mendelian randomization", "STROBE", "TRIPOD", "公共健康", "流行病学", "DML", "double machine learning", "causal forest", "meta-learner", "CATE", "conformal causal", "policy learning", "因果机器学习", "ML causal", "decomposition", "Oaxaca-Blinder", "Kitagawa", "DiNardo-Fortin-Lemieux", "DFL", "Gelbach", "RIF decomposition", "wage gap decomposition", "sp.decompose", "sp.oaxaca".

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Classical end-to-end empirical analysis workflow in the traditional Stata ecosystem — native Stata + reghdfe + ivreg2 + csdid + did_imputation + eventstudyinteract + sdid + rdrobust + rddensity + synth + synth_runner + psmatch2 + teffects + ebalance + coefplot + esttab + asdoc + binscatter. **Defaults to economics empirical-paper style** (AER / QJE / AEJ) — every run produces a publication-ready output set with a multi-column regression table (M1→M6 progressive controls/FE) as the centerpiece, plus Table 1 (descriptives), mechanism / heterogeneity / robustness tables, and event-study + coefficient + trend figures. Covers the full 8-step Stata pipeline an applied economist runs on every paper — (1) data import & cleaning (use/import, destring, misstable, duplicates, merge assert), (2) variable construction (gen/egen/winsor2/xtile/xtset with L./F./D.), (3) descriptive statistics & Table 1 (tabstat/balancetable/asdoc), (4) classical diagnostic tests (sktest/swilk/hettest/imtest/xtserial/xttest3/vif/dfuller/kpss/hausman/estat overid), (5) baseline modeling (reg/xtreg/reghdfe/ivreg2/ivregress/csdid/did_imputation/eventstudyinteract/sdid/rdrobust/synth/psmatch2/teffects/heckman/qreg/ppmlhdfe), (6) robustness battery (bacondecomp/honestdid/rwolf/ritest/wildbootstrap/oster), (7) further analysis (subgroup/triple-diff/interactions/medsem/marginsplot/binscatter by group), (8) publication-ready tables & figures (esttab/outreg2/estout/coefplot/marginsplot/rdplot/twoway combined). **Also covers two parallel domain modes that share the same 8-step scaffolding** — **Mode A — Epidemiology / public health** (target-trial emulation, IPTW + g-formula + TMLE doubly-robust triplet via `teffects ipw` / `teffects ipwra` / `teffects aipw` / `eltmle`, Mendelian randomization via `mrrobust` (IVW / Egger / weighted median) and `mregger` / `mrpresso`, KM / Cox / AFT / RMST survival via `sts` / `stcox` / `streg` / `strmst2`, E-value sensitivity via `evalue` (Linden-Mathur), principal stratification — STROBE / TRIPOD reporting), and **Mode B — ML causal inference** (DML via `ddml` / `pdslasso`, S/T/X/R/DR meta-learners via `crforest` and `ddml interactive`, causal forest via `crforest` / `cforest`, BART/BCF via `bart` / `bartCause`-style externals, CATE distribution + policy tree via `crforest`, off-policy evaluation, conformal causal externals, fairness audit, DAG learning via `pcalg` / external Python callouts). Use when the user asks for a complete Stata empirical analysis, wants a reproducible .do-file pipeline, needs a Stata counterpart to the Python StatsPAI / Full-empirical-analysis-skill, or names a specific Stata step in isolation ("run reghdfe with two-way clustering", "csdid event study", "winsor2 at 1%", "esttab to LaTeX", "coefplot with CI", "ivreg2 weak-IV test", "synth_runner placebos", "teffects psmatch balance check"). Mode A triggers on "target trial emulation Stata", "teffects ipw aipw", "eltmle", "mrrobust", "mregger weighted median", "stcox AFT survival", "strmst2", "evalue Stata", "STROBE Stata", "公共健康 Stata", "流行病学 Stata". Mode B triggers on "ddml Stata", "pdslasso", "crforest causal forest Stata", "policy tree Stata", "因果机器学习 Stata".

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Direct REST API access to PubMed. Advanced Boolean/MeSH queries, E-utilities API, batch processing, citation management. For Python workflows, prefer biopython (Bio.Entrez). Use this for direct HTTP/REST work or custom API implementations.

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Primary retained Python toolkit for molecular biology sequence work. Preferred for sequence manipulation, FASTA/FASTQ/GenBank parsing, Bio.Entrez, BLAST workflows, alignments, structures, and phylogenetics. For biological database evidence lookup, use bio-database-evidence. For single-cell workflows use scanpy. For direct literature REST API, use pubmed-database.

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Activate this agent for any future-oriented question that requires deep quantitative analysis, historical precedents, and structured scenario planning. Triggers include: "Will [X]?", "Who will win [X]?", "What happens to [X]?", prediction requests with high stakes, foresight analysis, STEEEP scenario planning, futures cone, competitive race analysis, technology adoption curves, geopolitical shifts, or any question about a future outcome that deserves rigorous multi-step analysis. This agent runs a 12-step deterministic pipeline: Claude handles intelligence, Python handles all arithmetic. Year is NOT required — the engine infers the horizon. REQUIRES: Bash tool + Python 3.x. Not compatible with claude.ai web (use Soft Predict Future instead).

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PLAINTEXT-ONLY: the shipped `doca_flow_grpc` server uses `grpc::InsecureServerCredentials()` with NO TLS / mTLS / token-auth knob on the binary — transport security must come from external infrastructure (e.g. an mTLS proxy / sidecar) on a trusted segment. Use this skill when bringing up, configuring, hardening, or debugging `doca_flow_grpc` — the DOCA-shipped gRPC remote-control surface in front of `doca-flow` that lets non-C++ clients (Python, Go, Rust, Java) program Flow pipes and entries over RPC instead of linking `libdoca_flow.so` directly. Trigger even when the user doesn't say 'doca-flow-grpc-server' or 'gRPC' — e.g. 'program Flow rules from Python on another host', 'remotely configure pipes on the BlueField', 'client times out connecting to the Flow server', 'where is the .proto for Flow', 'UNAUTHENTICATED / FAILED_PRECONDITION on a Flow RPC'. Route elsewhere for the underlying doca-flow API, generic gRPC tooling (protoc, language bindings), or DOCA install / BFB bring-up.

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Modify, build, test, debug, and contribute to NVIDIA cuOpt (C++/CUDA, Python, server, CI). Use for solver internals, PRs, DCO, and code conventions.

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LP, MILP, and QP (beta) with cuOpt — Python, C, and CLI. Use when the user is solving LP, MILP, or QP with any cuOpt interface.

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Install cuOpt for Python, C, or server via pip, conda, or Docker; verify the install. For building cuOpt from source, see cuopt-developer.

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Prepare azd-based Azure projects for deployment: generates azure.yaml, infrastructure (Bicep/Terraform), and Dockerfiles for the Azure Developer CLI (azd) workflow. USE ONLY when the user explicitly wants to use azd as the deployment tool, or the project already has an azure.yaml file. DO NOT USE FOR: non-azd deployments, Python App Service code-only deploys (use python-appservice-deploy), or cross-cloud migration (use azure-cloud-migrate). WHEN: prepare app for azd, create azure.yaml, set up azd infrastructure, modernize app for Azure with azd, deploy with azd, function app, timer trigger, service bus trigger, event-driven function, managed identity, generate Bicep, generate Terraform, create and deploy to Azure.

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Build Azure Cosmos DB NoSQL services with Python/FastAPI following production-grade patterns. Use when implementing database client setup with dual auth (DefaultAzureCredential + emulator), service layer classes with CRUD operations, partition key strategies, parameterized queries, or TDD patterns for Cosmos. Triggers on phrases like "Cosmos DB", "NoSQL database", "document store", "add persistence", "database service layer", or "Python Cosmos SDK".

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Build AI applications using the Azure AI Projects Python SDK (azure-ai-projects). Use when working with Foundry project clients, creating versioned agents with PromptAgentDefinition, running evaluations, managing connections/deployments/datasets/indexes, or using OpenAI-compatible clients. This is the high-level Foundry SDK - for low-level agent operations, use azure-ai-agents-python skill.

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Diagnoses and resolves Amazon RDS for Oracle connectivity, authentication, networking, and driver troubleshooting. Applicable to any RDS-for-Oracle question including connecting a Python Lambda to RDS Oracle in a VPC with pooling and cold-start optimization, EKS pods to RDS Oracle via the Secrets Manager CSI driver with IRSA and SecretProviderClass, ORA-12170 cross-VPC timeouts from EC2, DPI-1047 cannot-locate-64-bit-Oracle-Client errors, and Oracle Connection Manager (CMAN) on EC2 as a proxy with HA across two AZs. Covers python-oracledb thin vs thick mode, init_oracle_client, RDS Proxy does NOT support RDS Oracle, port 1521, VPC peering, Transit Gateway, Kerberos with AWS Managed Microsoft AD, SSL/TLS/NNE, SSM port forwarding, EC2/ECS Fargate/EKS/Lambda, SQL Developer/DBeaver/Toad/SQLcl, and Secrets Manager.

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Upgrades an MWAA environment to a newer Airflow version — within 2.x, within 3.x, or across the 2.x-to-3.x boundary. Computes the version-jump path, inserting the 2.11.x stepping-stone and Python-transition step when needed. Chooses an approach by whether run history and the same environment (URL/ARN) must be kept: a new-environment upgrade (blue-green), a rehearsed in-place upgrade validated on a test copy, or a direct in-place upgrade. Runs Ruff scanning and deprecation-warning log scans for 3.x moves, plus Docker validation, batched deployment, and switchover. Saves a resumable upgrade plan for multi-session work. Triggers on: upgrade MWAA, upgrade Airflow, migrate to Airflow 3, MWAA Airflow 3, Airflow 2 to 3, preserve Airflow history, keep same MWAA environment, blue-green cutover, validation environment before cutover. Not for authoring new DAGs (authoring-mwaa-workflow), debugging unrelated DAG failures (debugging-mwaa-workflow), or MWAA Serverless YAML workflows (provisioned Python DAGs only).

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Pythonic code with modern type hints, dataclasses, async patterns, packaging, and testing

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使用pytest的Python测试策略，包括TDD方法、夹具、模拟、参数化和覆盖率要求。

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使用 pytest、TDD 方法论、固件（Fixtures）、模拟（Mocking）、参数化及覆盖率要求的 Python 测试策略。

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使用 pytest、TDD 方法论、测试夹具（Fixtures）、模拟（Mocking）、参数化（Parametrization）以及覆盖率要求的 Python 测试策略。

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Advanced Biopython modules for motifs, population genetics, sequence utilities, restriction analysis, clustering, and GenomeDiagram visualization; use when you need extended bioinformatics analysis beyond basic sequence I/O and alignment.

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Sequence alignment and alignment file processing with Biopython (Bio.Align/Bio.AlignIO), triggered when you need global/local pairwise alignment, MSA read/write/format conversion, or alignment statistics/filtering.

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Use Biopython to read/write/convert biological sequence files (FASTA/GenBank/FASTQ, etc.) and perform basic sequence operations; use when you need reliable sequence I/O, lightweight sequence manipulation, or scalable processing of large sequence datasets.

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Bootstrap MCP server with Python SDK, transport configuration, tool/resource handlers, and proper project structure.

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Generate Click-based Python CLI applications with decorators, groups, context, and modern Python patterns. Creates complete scaffolded CLI with proper project structure.

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Generate argparse-based Python CLI applications with subparsers, type converters, and standard library patterns. Creates lightweight Python CLIs without external dependencies.

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